Advanced search
Publication Cover
Postgraduate Medicine Volume 43, 1968 - Issue 2
Submit an article Journal homepage
32
Views
96
CrossRef citations to date
0
Altmetric
Original Articles

Intractable Hiccup

Etiologic Factors in 220 Cases

Jacques V. SouadjianMayo Clinic and Mayo Foundation, Rochester, Minnesota
, M.D. &
James C. CainMayo Clinic and Mayo Foundation, Rochester, Minnesota
, M.D.
Pages 72-77 | Published online: 18 Apr 2016

Citations (96)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Hari N Krishnakumar, Shwetha R Menon, Alireza Mirahmadizadeh & Ali Seifi. (2023) Forced inspiratory suction and swallow tool (FISST): an automation of Valsalva maneuver variants for therapeutic interventions. Expert Review of Medical Devices 20:12, pages 1027-1034.
Read now
Sanjeet S. Grewal, Andrea C. Adams & Jamie J. Van Gompel. (2018) Vagal nerve stimulation for intractable hiccups is not a panacea: a case report and review of the literature. International Journal of Neuroscience 128:12, pages 1114-1117.
Read now
Harald Fodstad & Stefan Nilsson. (1993) Intractable singultus: A diagnostic and therapeutic challenge. British Journal of Neurosurgery 7:3, pages 255-260.
Read now
Prakash S. Masand, George B. Murray, Theodore A. Stern & Anthony J. Bouckoms. (1990) Sodium Valproate for Intractable Hiccups: Case Report. Annals of Clinical Psychiatry 2:2, pages 135-137.
Read now
Shashi K. Agarwal & Dhirendra Das. (1980) Possible termination of ventricular bigeminy by hiccups. Postgraduate Medicine 67:5, pages 165-168.
Read now

Articles from other publishers (91)

Yaoyin Zhang, Wei Chen, Junming Chen, Mingmei Li, Yulan Huang & Wenjiao Min. (2024) Persistent hiccups due to aripiprazole: a case report and review of the literature. Frontiers in Pharmacology 14.
Crossref
Henrike von Schassen, Viola Andresen & Peter Layer. 2024. Therapie-Handbuch - Gastroenterologie und Hepatologie. Therapie-Handbuch - Gastroenterologie und Hepatologie 95 99 .
Henrike von Schassen, Viola Andresen & Peter Layer. 2024. Therapie-Handbuch - Neurologie. Therapie-Handbuch - Neurologie 262 266 .
Rosalyn R. Bloch, Megan R. Kempa & J'Aimee Lippert. (2023) Use of osteopathic manipulative treatment in management of intractable singultus and associated symptoms. International Journal of Osteopathic Medicine 50, pages 100668.
Crossref
Tyler A. Bahr & Derick D. Jones. (2023) 56-Year-Old Man With Hiccups. Mayo Clinic Proceedings 98:10, pages 1564-1567.
Crossref
Tamadhir Al-Mahrouqi, Fatema Al-Sabahi, Ahmed Al-Harrasi, Naser Al-Balushi & Hamed Al-Sinawi. (2023) Psychogenic hiccups in an older adult: A case report and literature review. Journal of Taibah University Medical Sciences 18:3, pages 560-565.
Crossref
Vikram Shivkumar, Dipali Nemade & Neelu Dhingra. (2023) Persistent hiccups following thalamic hemorrhage: A case report. Heliyon 9:6, pages e16409.
Crossref
Boris Zernikow, Jens Berrang, Carola Hasan, Margit Baumann-Köhler, Michael C. Frühwald, Johannes Holzapfel, Silke Kromm & Thomas Berger. 2022. Pädiatrische Palliativversorgung – Schmerzbehandlung und Symptomkontrolle. Pädiatrische Palliativversorgung – Schmerzbehandlung und Symptomkontrolle 61 122 .
Handan ALAY, Nazım DOĞAN, Zülal ÖZKURT, Nuray BİLGE, Fatma KESMEZ CAN & Ömer ARAZ. (2021) Can persistent hiccups be a progression marker in COVID-19?. Journal of Health Sciences and Medicine 4:2, pages 240-242.
Crossref
Fernando Vargas Ursúa, Cristina Ramos Hernández & Alberto Fernández Villar. (2021) Hipo persistente tras inyección epidural de betametasona: a propósito de un caso. Revista de la Sociedad Española del Dolor 28.
Crossref
K.H. von Schassen, V. Andresen & P. Layer. 2021. Therapie-Handbuch - Neurologie. Therapie-Handbuch - Neurologie 223 228 .
Ignacio Moral Cebrián, Andrés Santos Rodríguez & José María Mugüerza Huguet. (2020) Causa infrecuente de hipo crónico. Revista Colombiana de Gastroenterología 35:4, pages 542-544.
Crossref
Zachary Wilmer Reichenbach, Gregory M. Piech & Zubair Malik. (2020) Chronic Hiccups. Current Treatment Options in Gastroenterology 18:1, pages 43-59.
Crossref
Viva Nguyen, Khaled Deeb & Ranga Rathakrishnan. (2020) Hiccups: You got to be kidney me!. SAGE Open Medical Case Reports 8, pages 2050313X2096264.
Crossref
Han YangRufei ZhangJun ZhouYing ChengJuan LiQiwei XiaoZihan YinGuixing XuLing ZhaoFanrong Liang. (2019) Acupuncture therapy for persistent and intractable hiccups. Medicine 98:44, pages e17561.
Crossref
Claire van Heuven & Tobias Bonten. 2019. Kleine kwalen in de huisartsenpraktijk. Kleine kwalen in de huisartsenpraktijk 581 584 .
Eva K. Kohse, Markus W. Hollmann, Hubert J. Bardenheuer & Jens Kessler. (2017) Chronic Hiccups: An Underestimated Problem. Anesthesia & Analgesia 125:4, pages 1169-1183.
Crossref
Francisco Javier García Callejo, Jaume Redondo Martínez, Tomás Pérez Carbonell, Rafael Monzó Gandía, M. Paz Martínez Beneyto & Inés Rincón Piedrahita. (2017) Hipo. Actitud en otorrinolaringología en pacientes que consultan. Aproximación diagnóstica y terapéutica. Acta Otorrinolaringológica Española 68:2, pages 98-105.
Crossref
Francisco Javier García Callejo, Jaume Redondo Martínez, Tomás Pérez Carbonell, Rafael Monzó Gandía, M. Paz Martínez Beneyto & Inés Rincón Piedrahita. (2017) Hiccups. Attitude in Otorhinolaryngology Towards Consulting Patients. A Diagnostic and Therapeutic Approach. Acta Otorrinolaringologica (English Edition) 68:2, pages 98-105.
Crossref
Atsushi Saito, Toru Hatayama, Hiroyuki Kon, Taigen Nakamura & Tatsuya Sasaki. (2016) Microvascular decompression for intractable singultus. Journal of Clinical Neuroscience 32, pages 120-122.
Crossref
J.A.H. Eekhof, A. Knuistingh Neven & W. OpsteltenC.G. van Heuven. 2016. Kleine kwalen in de huisartsenpraktijk. Kleine kwalen in de huisartsenpraktijk 290 293 .
V. Andresen & P. Layer. 2015. Therapie-Handbuch Grundwerk inkl 6. Lfg.. Therapie-Handbuch Grundwerk inkl 6. Lfg. 1 5 .
Camielle Rizzo, Caroline Vitale & Marcos Montagnini. (2013) Management of Intractable Hiccups. American Journal of Hospice and Palliative Medicine® 31:2, pages 220-224.
Crossref
Howard D Palte, Albert Bahr & Lana Srur. (2013) Intractable hiccup cured by anaesthesia. Anaesthesia Cases 1:2, pages 72-74.
Crossref
Emilia N Moretto, Bee Wee, Philip J Wiffen & Andrew G Murchison. (2013) Interventions for treating persistent and intractable hiccups in adults. Cochrane Database of Systematic Reviews 2019:11.
Crossref
Mark E. Peacock. (2013) Transient Hiccups Associated with Oral Dexamethasone. Case Reports in Dentistry 2013, pages 1-3.
Crossref
Albert J. Bredenoord. (2013) Management of Belching, Hiccups, and Aerophagia. Clinical Gastroenterology and Hepatology 11:1, pages 6-12.
Crossref
Satoshi Okada, Sakiko Takarabe, Shigeru Nogawa, Takato Abe, Tetsuo Morishita, Masahiro Mori & Jiro Nishida. (2012) Persistent hiccups followed by cardiorespiratory arrest. The Lancet 380:9851, pages 1444.
Crossref
Seby John, Joseph Parambil, Daniel Culver & Jinny Tavee. (2012) Medullary neurosarcoidosis presenting with intractable hiccoughs. Journal of Clinical Neuroscience 19:8, pages 1193-1195.
Crossref
Emmanuel Carrera & Francois Vingerhoets. 2012. Stroke syndromes. Stroke syndromes 319 328 .
Vivek Loomba, Mayank Gupta & David Kim. (2012) Persistent Hiccups With Continuous Intrathecal Morphine Infusion. The Clinical Journal of Pain 28:2, pages 172-174.
Crossref
Arjang Abbasi, Christine M. Roque‐Dang & Gautam Malhotra. (2012) Persistent Hiccups After Interventional Pain Procedures: A Case Series and Review. PM&R 4:2, pages 144-151.
Crossref
. 2012. Conn's Current Therapy 2012. Conn's Current Therapy 2012 1 47 .
Alexander Eisenächer & Jens Spiske. (2011) Persistent Hiccups (Singultus) as the Presenting Symptom of Medullary Cavernoma. Deutsches Ärzteblatt international.
Crossref
James R. Keane. (2016) Hiccups due to Central Nervous System Disease: Analysis of 71 Inpatients. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 37:6, pages 870-872.
Crossref
Emilia N Moretto, Bee Wee, Philip J Wiffen & Andrew G Murchison. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Jean Cabane, Jean-Louis Bizec & Jean-Philippe Derenne. (2010) Le hoquet chronique est souvent une maladie œsophagienne. Une étude prospective de 184 cas. La Presse Médicale 39:6, pages e141-e146.
Crossref
Esther M. Benedetti, Rapipen Siriwetchadarak, John Stanec & Richard W. Rosenquist. (2009) Epidural steroid injections: Complications and management. Techniques in Regional Anesthesia and Pain Management 13:4, pages 236-250.
Crossref
Howard S. Smith. 2009. Palliative Medicine. Palliative Medicine 894 898 .
Azadeh Farin, Indro Chakrabarti, Steven L. Giannotta, Shoshanna Vaynman & Srinath Samudrala. (2008) MICROVASCULAR DECOMPRESSION FOR INTRACTABLE SINGULTUS. Neurosurgery 62:5, pages E1180-E1181.
Crossref
Azadeh Farin, Indro Chakrabarti, Steven L. Giannotta, Shoshanna Vaynman & Srinath Samudrala. (2008) MICROVASCULAR DECOMPRESSION FOR INTRACTABLE SINGULTUS. Neurosurgery 62:5, pages E1180-E1181.
Crossref
Monica L. Tegeler & Steven J. Baumrucker. (2008) Gabapentin for Intractable Hiccups in Palliative Care. American Journal of Hospice and Palliative Medicine® 25:1, pages 52-54.
Crossref
Xiulu Ruan, John Patrick Couch, Rinoo Shah, Frank Wang & Hai Nan Liu. (2007) Persistent Hiccup Associated with Intrathecal Morphine Infusion Pump Therapy. American Journal of Physical Medicine & Rehabilitation 86:12, pages 1019-1022.
Crossref
John A. Schuchmann & Barry A. Browne. (2007) Persistent Hiccups During Rehabilitation Hospitalization. American Journal of Physical Medicine & Rehabilitation 86:12, pages 1013-1018.
Crossref
Abbass Amirjamshidi, Kazem Abbassioun & Khosrow Parsa. (2007) Hiccup and neurosurgeons: a report of 4 rare dorsal medullary compressive pathologies and review of the literature. Surgical Neurology 67:4, pages 395-402.
Crossref
John M. Connors. 2007. xPharm: The Comprehensive Pharmacology Reference. xPharm: The Comprehensive Pharmacology Reference 1 5 .
Cheng-Chiang Chang, Shin-Tsu Chang, Tsung-Ying Li, Shang-Lin Chiang, Kao-Chung Tsai & Jiann-Chyun Lin. (2006) Resolution of Intractable Hiccups after Near-Infrared Irradiation of Relevant Acupoints. The American Journal of the Medical Sciences 332:2, pages 93-96.
Crossref
M.C. Goñi Murillo. (2006) Actitud ante un paciente con hipo en Atención Primaria. SEMERGEN - Medicina de Familia 32:5, pages 233-236.
Crossref
Nakechand Pooran, David Lee & Kostas Sideridis. (2006) Protracted Hiccups due to Severe Erosive Esophagitis. Journal of Clinical Gastroenterology 40:3, pages 183-185.
Crossref
Rachel J. Homer, Joanna M. Davies & Laurie B. Amundsen. (2005) Persistent Hiccups After Attempted Interscalene Brachial Plexus Block. Regional Anesthesia and Pain Medicine 30:6, pages 574-576.
Crossref
Anne McGregorVictoria LidstoneRhian Owen, John WelshAnne Reid, Jorge Curto, BJA LairdCJ Sugden, SK WilcoxPo Tin Lam, Man Wah Kwok, Chun Yan Tse, Yun Hoi Lui & Ka Lai Lee. (2016) Letters to the editor. Palliative Medicine 19:7, pages 566-570.
Crossref
Russell K. McAllister, Andrew J. McDavid, Tricia A. Meyer & Timothy M. Bittenbinder. (2005) Recurrent Persistent Hiccups After Epidural Steroid Injection and Analgesia with Bupivacaine. Anesthesia & Analgesia 100:6, pages 1834-1836.
Crossref
Bryan Rankin Payne, Robert Lyons Tiel, Mary Say Payne & Bruce Fisch. (2005) Vagus nerve stimulation for chronic intractable hiccups. Journal of Neurosurgery 102:5, pages 935-937.
Crossref
Sang-Jun NaSang In LeeTae-Sub ChungYoung-Chul ChoiKyung-Yul Lee. (2005) Pneumomediastinum Due to Intractable Hiccup as the Presenting Symptom of Multiple Sclerosis. Yonsei Medical Journal 46:2, pages 292.
Crossref
Tetsuya Nagayama, Masatomo Kaji, Hirofumi Hirano, Masaki Niiro & Jun-ichi Kuratsu. (2004) Intractable hiccups as a presenting symptom of cerebellar hemangioblastoma. Journal of Neurosurgery 100:6, pages 1107-1110.
Crossref
Chul Ho ShinSuk Joo SeoHyung Gyu ChoiDoo Sik KimSie Jeong RyuTae Ho Jang. (2004) Management of Intractable Hiccups -A report of 3 cases-. The Korean Journal of Pain 17:1, pages 88.
Crossref
Howard S. Smith & Atichat Busracamwongs. (2016) Management of hiccups in the palliative care population. American Journal of Hospice and Palliative Medicine® 20:2, pages 149-154.
Crossref
Michael Fetter & Christopher Kennard. 2003. Neurological Disorders. Neurological Disorders 185 189 .
Curtis W. Slipman, Carl H. Shin, Rajeev K. Patel, Debra L. Braverman, David A. Lenrow, Mark I. Ellen & M. Ali Nematbakhsh. (2001) Persistent Hiccup Associated with Thoracic Epidural Injection. American Journal of Physical Medicine & Rehabilitation 80:8, pages 618-621.
Crossref
I. Funakawa & A. Terao. (2009) Case report Intractable hiccups and syncope in multiple sclerosis. Acta Neurologica Scandinavica 98:2, pages 136-139.
Crossref
Paul Walker, Sharon Watanabe & Eduardo Bruera. (1998) Baclofen, A Treatment for Chronic Hiccup. Journal of Pain and Symptom Management 16:2, pages 125-132.
Crossref
Dennis F Thompson & Jacques P Landry. (2017) Drug-Induced Hiccups. Annals of Pharmacotherapy 31:3, pages 367-369.
Crossref
P. A. Federspil, J. Zenk & H. Iro. 1997. HNO Praxis Heute. HNO Praxis Heute 107 125 .
Nancy L. Friedman. (2012) Hiccups: A Treatment Review. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 16:6, pages 986-995.
Crossref
S Perry & J Stevenson. (1996) An unusual cause of hiccups.. Emergency Medicine Journal 13:5, pages 361-362.
Crossref
Dirk De Ruysscher. (2016) Treatment of intractable hiccup in a terminal cancer patient with nebulized saline. Palliative Medicine 10:2, pages 166-167.
Crossref
François Vingerhoets & Julien Bogousslavsky. (1994) RESPIRATORY DYSFUNCTION IN STROKE. Clinics in Chest Medicine 15:4, pages 729-737.
Crossref
Paul Rousseau. (2016) Hiccups in terminal disease. American Journal of Hospice and Palliative Medicine® 11:6, pages 7-10.
Crossref
Andrew Krahn & S.Brian Penner. (1994) Use of baclofen for intractable hiccups in uremia. The American Journal of Medicine 96:4, pages 391.
Crossref
I. Funakawa, K. Hara, T. Yasuda & A. Terao. (1993) Intractable hiccups and sleep apnea syndrome in multiple sclerosis: report of two cases. Acta Neurologica Scandinavica 88:6, pages 401-405.
Crossref
B. J. HANSEN & J. ROSENBERG. (2008) Persistent postoperative hiccups: a review. Acta Anaesthesiologica Scandinavica 37:7, pages 643-646.
Crossref
Johannes Lang. (1993) Surgical Anatomy of the Brain Stem. Neurosurgery Clinics of North America 4:3, pages 367-403.
Crossref
J. Cabane, V. Desmet, J.Ph. Derenne, T. Similowski, S. Launois, J.L. Bizec & B. Orcel. (1992) Le hoquet chronique. La Revue de Médecine Interne 13:6, pages 454-459.
Crossref
Saleh M. Al Deeb, H. Sharif, K. Al Moutaery & N. Biary. (1991) Intractable hiccup induced by brainstem lesion. Journal of the Neurological Sciences 103:2, pages 144-150.
Crossref
Paul W Kolodzik & Mark A Filers. (1991) Hiccups (Singultus): Review and approach to management. Annals of Emergency Medicine 20:5, pages 565-573.
Crossref
P H Jansen, E M Joosten & H M Vingerhoets. (1990) Persistent periodic hiccups following brain abscess: a case report.. Journal of Neurology, Neurosurgery & Psychiatry 53:1, pages 83-84.
Crossref
T. Fest, J. Gutknecht, B. de Wazières & J.L. Dupond. (1989) Le hoquet: à la (re)découverte d'un signe souvent négligé. La Revue de Médecine Interne 10:6, pages 521-525.
Crossref
MONTE BOBELE. (2004) Interactional Treatment of Intractable Hiccups. Family Process 28:2, pages 191-206.
Crossref
Francis M Fesmire. (1988) Termination of intractable hiccups with digital rectal massage. Annals of Emergency Medicine 17:8, pages 872.
Crossref
Monte Bobele. (2016) Nonmedical Management of Intractible Hiccups: A Brief Review of the Literature. Psychological Reports 61:1, pages 225-226.
Crossref
Jeffrey S. Jones, Thomas Lloyd & Louis Cannon. (1987) Persistent hiccups as an unusual manifestation of hyponatremia. The Journal of Emergency Medicine 5:4, pages 283-287.
Crossref
. (2016) Drug Information Analysis Service. Drug Intelligence & Clinical Pharmacy 21:3, pages 258-261.
Crossref
A. Hartmann & J. Wappenschmidt. 1986. Surgery in and around the Brain Stem and the Third Ventricle. Surgery in and around the Brain Stem and the Third Ventricle 105 128 .
. (2005) Case 3, 1986. Movement Disorders 1:4, pages 289-297.
Crossref
Steven S. Shay, Robert L. Myers & Lawrence F. Johnson. (1984) Hiccups associated with reflux esophagitis. Gastroenterology 87:1, pages 204-207.
Crossref
Peter A. Lewitt, Norman W. Barton & Jerome B. Posner. (2004) Hiccup with dexamethasone therapy. Annals of Neurology 12:4, pages 405-406.
Crossref
Richard J. Lederman, Anthony C. Breuer, Maurice R. Hanson, Anthony J. Furlan, Floyd D. Loop, Delos M. Cosgrove, F. George Estafanous & Richard L. Greenstreet. (2004) Peripheral nervous system complications of coronary artery bypass graft surgery. Annals of Neurology 12:3, pages 297-301.
Crossref
Mark S. Wagner & J. Stephan Stapczynski. (1982) Persistent hiccups. Annals of Emergency Medicine 11:1, pages 24-26.
Crossref
Robert J. Stine & Sally J. Trued. (1979) Hiccups: An unusual manifestation of an abdominal aortic aneurysm. Journal of the American College of Emergency Physicians 8:9, pages 368-370.
Crossref
. (1971) Granulated Sugar as Treatment for Hiccups in Conscious Patients. New England Journal of Medicine 285:26, pages 1489-1489.
Crossref
Carl Theohar & F.Patrick McKegney. (1970) Hiccups of psychogenic origin: A case report and review of the literature. Comprehensive Psychiatry 11:4, pages 377-384.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.