Advanced search
Publication Cover
Postgraduate Medicine Volume 127, 2015 - Issue 2
Submit an article Journal homepage
286
Views
33
CrossRef citations to date
0
Altmetric
Original Research

rsfMRI effects of KB220Z™ on neural pathways in reward circuitry of abstinent genotyped heroin addicts

Kenneth BlumDepartment of Psychiatry & McKnight Brain Institute, University of Florida, College of Medicine, Gainesville, FL, USA;Department of Psychiatry, Human Integrated Services Unit, University of Vermont Center for Clinical & Translational Science, College of Medicine, Burlington, VT, USA;Dominion Diagnostics, LLC, North Kingstown, RI, USA;RDSolutions, LLC, La Jolla, CA, USA;Victory Nutrition, LLC, Lederoch, PA, USA;Department of Clinical Neurology, Path Foundation NY, New York, NY, USA;Department of Addiction Research & Therapy, Malibu Beach Recovery Center, Malibu Beach, CA, USACorrespondence[email protected]
,
Yijun LiuDepartment of Psychiatry & McKnight Brain Institute, University of Florida, College of Medicine, Gainesville, FL, USA;School of Life Science and Technology, Xidian University, Xi’an, Shaanxi 710071, China
,
Wei WangDepartment of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China
,
Yarong WangDepartment of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China
,
Yi ZhangDepartment of Psychiatry & McKnight Brain Institute, University of Florida, College of Medicine, Gainesville, FL, USA;School of Life Science and Technology, Xidian University, Xi’an, Shaanxi 710071, China
,
Marlene Oscar-BermanDepartment of Psychiatry, Boston University School of Medicine, Boston, MA, USA
,
Andrew SmolenInstitute for Behavioral Genetics, University of Colorado, Boulder, CO, USA
,
Marcelo FeboDepartment of Psychiatry & McKnight Brain Institute, University of Florida, College of Medicine, Gainesville, FL, USA
,
David HanDepartment of Management Science and Statistics, University of Texas at San Antonio, San Antonio, TX, USA
,
Thomas SimpaticoDepartment of Psychiatry, Human Integrated Services Unit, University of Vermont Center for Clinical & Translational Science, College of Medicine, Burlington, VT, USA
,
Frans J. CronjéUniversity of Stellenbosch, Cape Town, South Africa
,
Zsolt DemetrovicsInstitute of Psychology, Eötvös Loránd University, Budapest, Hungary
&
Mark S GoldDepartment of Psychiatry & McKnight Brain Institute, University of Florida, College of Medicine, Gainesville, FL, USA
 show all
Pages 232-241 | Published online: 16 Dec 2014

Citations (33)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Kenneth Blum, Bruce Steinberg, Marjorie C Gondre-Lewis, David Baron, Edward J Modestino, Rajendra D Badgaiyan, B William Downs, Debasis Bagchi, Raymond Brewer, Thomas McLaughlin, Abdalla Bowirrat & Mark Gold. (2021) A Review of DNA Risk Alleles to Determine Epigenetic Repair of mRNA Expression to Prove Therapeutic Effectiveness in Reward Deficiency Syndrome (RDS): Embracing “Precision Behavioral Management”. Psychology Research and Behavior Management 14, pages 2115-2134.
Read now

Articles from other publishers (32)

Yu Kyung Lee, Mark S. Gold, Kenneth Blum, Panayotis K. Thanos, Colin Hanna & Brian S. Fuehrlein. (2024) Opioid use disorder: current trends and potential treatments. Frontiers in Public Health 11.
Crossref
Andrea Miuli, Carlotta Marrangone, Ornella Di Marco, Arianna Pasino, Gianfranco Stigliano, Alessio Mosca, Mauro Pettorruso, Fabrizio Schifano & Giovanni Martinotti. (2023) Could Cariprazine Be a Possible Choice for High Functioning Autism? A Case Report. Future Pharmacology 3:4, pages 908-915.
Crossref
Panayotis K. Thanos, Colin Hanna, Abrianna Mihalkovic, Aaron Hoffman, Alan Posner, John Butsch, Kenneth Blum, Lesley Georger, Lucy D. Mastrandrea & Teresa Quattrin. (2023) Genetic Correlates as a Predictor of Bariatric Surgery Outcomes after 1 Year. Biomedicines 11:10, pages 2644.
Crossref
Kenneth Blum, Abdalla Bowirrat, Luis Llanos Gomez, B. William Downs, Debasis Bagchi, Debmalya Barh, Edward J. Modestino, David Baron, Thomas McLaughlin, Panayotis Thanos, Mauro Ceccanti, Igor Elman, Rajendra D. Badgaiyan, Catherine Dennen, Ashim Gupta, Eric R. Braverman & Mark S. Gold. (2022) Why haven't we solved the addiction crisis?. Journal of the Neurological Sciences 442, pages 120404.
Crossref
Kenneth Blum, Catherine A. Dennen, Igor Elman, Abdalla Bowirrat, Panayotis K. Thanos, Rajendra D. Badgaiyan, B. William Downs, Debasis Bagchi, David Baron, Eric R. Braverman, Ashim Gupta, Richard Green, Thomas McLaughlin, Debmalya Barh & Mark S. Gold. (2022) Should Reward Deficiency Syndrome (RDS) Be Considered an Umbrella Disorder for Mental Illness and Associated Genetic and Epigenetic Induced Dysregulation of Brain Reward Circuitry?. Journal of Personalized Medicine 12:10, pages 1719.
Crossref
Anish Bajaj, Kenneth Blum, Abdalla Bowirrat, Ashim Gupta, David Baron, David Fugel, Ayo Nicholson, Taylor Fitch, B. William Downs, Debasis Bagchi, Catherine A. Dennen & Rajendra D. Badgaiyan. (2022) DNA Directed Pro-Dopamine Regulation Coupling Subluxation Repair, H-Wave® and Other Neurobiologically Based Modalities to Address Complexities of Chronic Pain in a Female Diagnosed with Reward Deficiency Syndrome (RDS): Emergence of Induction of “Dopamine Homeostasis” in the Face of the Opioid Crisis. Journal of Personalized Medicine 12:9, pages 1416.
Crossref
Kenneth Blum, David Han, David Baron, Shan Kazmi, Igor Elman, Luis Llanos Gomez, Marjorie C. Gondre -Lewis, Panyotis K Thanos, Eric R Braverman & Rajendra D Badgaiyan. (2022) Nicotinamide Adenine Dinucleotide (NAD+) and Enkephalinase Inhibition (IV1114589NAD) Infusions Significantly Attenuate Psychiatric Burden Sequalae in Substance Use Disorder (SUD) in Fifty Cases. Current Psychiatry Research and Reviews 18:2, pages 125-143.
Crossref
Kenneth Blum, Diwanshu Soni, Rajendra D. Badgaiyan & David Baron. (2022) Overcoming reward deficiency syndrome by the induction of “dopamine homeostasis” instead of opioids for addiction: illusion or reality?. Journal of Osteopathic Medicine 122:7, pages 333-337.
Crossref
Margaret Madigan, Ashim Gupta, Abdalla Bowirrat, David Baron, Rajendra Badgaiyan, Igor Elman, Catherine Dennen, Eric Braverman, Mark Gold & Kenneth Blum. (2022) Precision Behavioral Management (PBM) and Cognitive Control as a Potential Therapeutic and Prophylactic Modality for Reward Deficiency Syndrome (RDS): Is There Enough Evidence?. International Journal of Environmental Research and Public Health 19:11, pages 6395.
Crossref
Eszter Kótyuk, Róbert Urbán, Borbála Hende, Mara Richman, Anna Magi, Orsolya Király, Csaba Barta, Mark D Griffiths, Marc N Potenza, Rajendra D Badgaiyan, Kenneth Blum & Zsolt Demetrovics. (2022) Development and validation of the Reward Deficiency Syndrome Questionnaire (RDSQ-29). Journal of Psychopharmacology 36:3, pages 409-422.
Crossref
Brittany Richardson, Sabrina Swenson, John Hamilton, Ken Leonard, Foteini Delis, Mark Gold, Ken Blum & Panayotis K. Thanos. (2022) Chronic neuroleptic treatment combined with a high fat diet elevated [3H] flunitrazepam binding in the cerebellum. Progress in Neuro-Psychopharmacology and Biological Psychiatry 112, pages 110407.
Crossref
Kenneth Blum, Mark S. Gold, Luis Llanos-Gomez, Rehan Jalali, Panayotis K. Thanos, Abdalla Bowirrat, William B. Downs, Debasis Bagchi, Eric R. Braverman, David Baron, Alphonso Kenison RoyIIIIII & Rajendra D. Badgaiyan. (2021) Hypothesizing Nutrigenomic-Based Precision Anti-Obesity Treatment and Prophylaxis: Should We Be Targeting Sarcopenia Induced Brain Dysfunction?. International Journal of Environmental Research and Public Health 18:18, pages 9774.
Crossref
Bernard W. Downs, Steve Kushner, Manashi Bagchi, Kenneth Blum, Rajendra D. Badgaiyan, Sanjoy Chakraborty & Debasis Bagchi. (2021) Etiology of Neuroinflammatory Pathologies in Neurodegenerative Diseases: A Treatise. Current Psychopharmacology 10:2, pages 123-137.
Crossref
Kenneth Blum, Edward J. Modestino, David Baron, Raymond Brewer, Panayotis Thanos, Igor Elman, Rajendra D. Badgaiyan, B. William Downs, Debasis Bagchi, Thomas McLaughlin, Abdalla Bowirrat, A. Kenison Roy & Mark S. Gold. (2021) Endorphinergic Enhancement Attenuation of Post-traumatic Stress Disorder (PTSD) via Activation of Neuro-immunological Function in the Face of a Viral Pandemic. Current Psychopharmacology 10:2, pages 86-97.
Crossref
Kenneth Blum, Jag Khalsa, Jean Lud Cadet, David Baron, Abdalla Bowirrat, Brent Boyett, Lisa Lott, Raymond Brewer, Marjorie Gondré-Lewis, Gregory Bunt, Shan Kazmi & Mark S. Gold. (2021) Cannabis-Induced Hypodopaminergic Anhedonia and Cognitive Decline in Humans: Embracing Putative Induction of Dopamine Homeostasis. Frontiers in Psychiatry 12.
Crossref
Kenneth Blum, Shan Kazmi, Edward J. Modestino, Bill William Downs, Debasis Bagchi, David Baron, Thomas McLaughlin, Richard Green, Rehan Jalali, Panayotis K. Thanos, Igor Elman, Rajendra D. Badgaiyan, Abdalla Bowirrat & Mark S. Gold. (2021) A Novel Precision Approach to Overcome the “Addiction Pandemic” by Incorporating Genetic Addiction Risk Severity (GARS) and Dopamine Homeostasis Restoration. Journal of Personalized Medicine 11:3, pages 212.
Crossref
Raymond Brewer, Kenneth Blum, Abdalla Bowirrat, Edward J. Modestino, David Baron, Rajendra D. Badgaiyan, Mark Moran, Brent Boyett & Mark S. Gold. (2020) Transmodulation of Dopaminergic Signaling to Mitigate Hypodopminergia and Pharmaceutical Opioid-induced Hyperalgesia. Current Psychopharmacology 9:3, pages 164-184.
Crossref
Mark S. Gold, David Baron, Abdalla Bowirrat & Kenneth Blum. (2020) Neurological correlates of brain reward circuitry linked to opioid use disorder (OUD): Do homo sapiens acquire or have a reward deficiency syndrome?. Journal of the Neurological Sciences 418, pages 117137.
Crossref
Kenneth Blum, Alphonse Kenison Roy, Arwen Podesta, Edward J. Modestino, Bruce Steinberg, Marjorie C. Gondré-Lewis, David Baron, Panayotis K. Thanos, Lisa Lott, Sampada Badgaiyan, Jessica Valdez Ponce, Brent Boyett, David Siwicki, Mark Moran, Drew Edwards, Thomas McLaughlin, Eric R. Braverman, Thomas A. Simpatico, Mary Hauser, Bernard William Downs & Rajendra D. Badgaiyan. 2020. The Cambridge Handbook of Substance and Behavioral Addictions. The Cambridge Handbook of Substance and Behavioral Addictions 297 306 .
. 2020. The Cambridge Handbook of Substance and Behavioral Addictions. The Cambridge Handbook of Substance and Behavioral Addictions 295 425 .
. 2020. The Cambridge Handbook of Substance and Behavioral Addictions. The Cambridge Handbook of Substance and Behavioral Addictions.
Lyle Fried, Edward J. Modestino, David Siwicki, Lisa Lott, Panayotis K. Thanos, David Baron, Rajendra D. Badgaiyan, Jessica V. Ponce, James Giordano, William B. Downs, Marjorie C. Gondré-Lewis, Steinberg Bruce, Eric R. Braverman, Brent Boyett & Kenneth Blum. (2020) Hypodopaminergia and “Precision Behavioral Management” (PBM): It is a Generational Family Affair. Current Pharmaceutical Biotechnology 21:6, pages 528-541.
Crossref
Naimesh Solanki, Tomilowo Abijo, Carine Galvao, Philippe Darius, Kenneth Blum & Marjorie C. Gondré-Lewis. (2020) Administration of a putative pro-dopamine regulator, a neuronutrient, mitigates alcohol intake in alcohol-preferring rats. Behavioural Brain Research 385, pages 112563.
Crossref
Kenneth Blum, David Baron, Thomas McLaughlin & Mark S. Gold. (2020) Molecular neurological correlates of endorphinergic/dopaminergic mechanisms in reward circuitry linked to endorphinergic deficiency syndrome (EDS). Journal of the Neurological Sciences 411, pages 116733.
Crossref
Xiaotong Li, Hang Su, Na Zhong, Tianzhen Chen, Jiang Du, Ke Xiao, Ding Xu, Weidong Song, Haifeng Jiang & Min Zhao. (2020) Aberrant Resting-State Cerebellar-Cerebral Functional Connectivity in Methamphetamine-Dependent Individuals After Six Months Abstinence. Frontiers in Psychiatry 11.
Crossref
Kenneth Blum, M. C. Gondré-Lewis, E. J. Modestino, L. Lott, D. Baron, D. Siwicki, T. McLaughlin, A. Howeedy, M. H. Krengel, M. Oscar-Berman, P. K. Thanos, I. Elman, M. Hauser, L. Fried, A. Bowirrat & R. D. Badgaiyan. (2019) Understanding the Scientific Basis of Post-traumatic Stress Disorder (PTSD): Precision Behavioral Management Overrides Stigmatization. Molecular Neurobiology 56:11, pages 7836-7850.
Crossref
Igor Elman & David Borsook. (2019) The failing cascade: Comorbid post traumatic stress- and opioid use disorders. Neuroscience & Biobehavioral Reviews 103, pages 374-383.
Crossref
Kenneth Blum, Marjorie C. Gondré-Lewis, David Baron, Panayotis K. Thanos, Eric R. Braverman, Jennifer Neary, Igor Elman & Rajendra D. Badgaiyan. (2018) Introducing Precision Addiction Management of Reward Deficiency Syndrome, the Construct That Underpins All Addictive Behaviors. Frontiers in Psychiatry 9.
Crossref
Thomas McLaughlin, Kenneth Blum, Bruce Steinberg, Edward J. Modestino, Lyle Fried, David Baron, David Siwicki, Eric R. Braverman & Rajendra D. Badgaiyan. (2018) Pro-dopamine regulator, KB220Z, attenuates hoarding and shopping behavior in a female, diagnosed with SUD and ADHD. Journal of Behavioral Addictions 7:1, pages 192-203.
Crossref
Marcelo Febo, Kenneth Blum, Rajendra D. Badgaiyan, Pablo D. Perez, Luis M. Colon-Perez, Panayotis K. Thanos, Craig F. Ferris, Praveen Kulkarni, John Giordano, David Baron & Mark S. Gold. (2017) Enhanced functional connectivity and volume between cognitive and reward centers of naïve rodent brain produced by pro-dopaminergic agent KB220Z. PLOS ONE 12:4, pages e0174774.
Crossref
Mark S. Gold, Rajendra D. Badgaiyan & Kenneth Blum. (2015) A Shared Molecular and Genetic Basis for Food and Drug Addiction. Psychiatric Clinics of North America 38:3, pages 419-462.
Crossref
Kenneth Blum, Mary Hauser, James Fratantonio & Rajendra D. Badgaiyan. (2015) Molecular Genetic Testing in Pain and Addiction: Facts, Fiction and Clinical Utility. Addiction Genetics 2:1.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.