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Clinical Features - Review

SGLT2 inhibitors: are they safe?

, ORCID Icon & ORCID Icon
Pages 72-82 | Received 23 Sep 2017, Accepted 16 Oct 2017, Published online: 27 Oct 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

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Brian M Inouye, Francis M Hughes$suffix/text()$suffix/text(), Huixia Jin, Robin Lütolf, Kunal C Potnis, Jonathan C Routh, Douglas C Rouse, Wen-Chi Foo & J Todd Purves. (2018) Diabetic bladder dysfunction is associated with bladder inflammation triggered through hyperglycemia, not polyuria. Research and Reports in Urology 10, pages 219-225.
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Sempastian Filippas-Ntekouan, Vasilios Tsimihodimos, Theodosios Filippatos, Theodora Dimitriou & Moses Elisaf. (2018) SGLT-2 inhibitors: pharmacokinetics characteristics and effects on lipids. Expert Opinion on Drug Metabolism & Toxicology 14:11, pages 1113-1121.
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Jingbo Hu, Aiping Deng & Yufen Zhao. (2018) Ertugliflozin as a monotherapy for the treatment of type 2 diabetes. Expert Opinion on Pharmacotherapy 19:16, pages 1841-1847.
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Sepideh Parchami Ghazaee, Viktor Tumanov, Natalia Voloshyna, Kateryna Marchenko-Tolsta & Murtaza Hameed. (2023) A Review of the Novel Antidiabetic Medications: Efficacy, Safety and Innovation. New Emirates Medical Journal 4:1.
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Jacob E. Pruett, Damian G. Romero & Licy L. Yanes Cardozo. (2023) Obesity-associated cardiometabolic complications in polycystic ovary syndrome: The potential role of sodium-glucose cotransporter-2 inhibitors. Frontiers in Endocrinology 14.
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Sheng Chen. (2022) circ_000166/miR-296 Aggravates the Process of Diabetic Renal Fibrosis by Regulating the SGLT2 Signaling Pathway in Renal Tubular Epithelial Cells. Disease Markers 2022, pages 1-10.
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Muhammad Akbar Baig & Joshua Nogar. (2022) Euglycemia despite a sodium glucose co-transporter 2 inhibitor overdose. World Journal of Emergency Medicine 13:2, pages 147.
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Zay M Htet & Mahzuz Karim. (2021) Sodium-glucose co-transporter 2 inhibitors: game changers when handled with care?. Journal of the Royal Society of Medicine 114:7, pages 351-358.
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Hakan KORKMAZ. (2021) COVID-19 ve Diabetes Mellitus YönetimiCOVID-19 and Diabetes Mellitus Management. SDÜ Tıp Fakültesi Dergisi 28:COVİD-19 ÖZEL SAYI, pages 171-175.
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I. Agra Montava, M. Seres Roig & V. Jodar Manzaneda. (2021) Cetoacidosis diabética euglucémica, ¿más iatrogenia?. Medicina de Familia. SEMERGEN 47:2, pages 135-136.
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Lihua Ni, Cheng Yuan, Guopeng Chen, Changjiang Zhang & Xiaoyan Wu. (2020) SGLT2i: beyond the glucose-lowering effect. Cardiovascular Diabetology 19:1.
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Morten Hasselstrøm Jensen, Claus Dethlefsen, Ole Hejlesen & Peter Vestergaard. (2019) Association of severe hypoglycemia with mortality for people with diabetes mellitus during a 20-year follow-up in Denmark: a cohort study. Acta Diabetologica 57:5, pages 549-558.
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Canan ERSOY. (2020) SGLT 2 inhibitors: Antidiabetic agents with promising effects beyond glucose control. Turkish Journal of Internal Medicine 2:1, pages 1-4.
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In Hee Lee & Dong Jik Ahn. (2020) Dapagliflozin-associated euglycemic diabetic ketoacidosis in a patient with type 2 diabetes mellitus. Medicine 99:21, pages e20228.
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Habib Yaribeygi, Thozhukat Sathyapalan, Mina Maleki, Tannaz Jamialahmadi & Amirhossein Sahebkar. (2020) Molecular mechanisms by which SGLT2 inhibitors can induce insulin sensitivity in diabetic milieu: A mechanistic review. Life Sciences 240, pages 117090.
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S. S. Bolevich, P. F. Litvitsky, V. Jakovljevic & S. B. Bolevich. (2019) Long-term use of dipeptyl peptidase-4 inhibitors suppresses systemic oxidative stress in rats with type 2 diabetes. Sechenov Medical Journal 10:4, pages 21-30.
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Haiyan Fu, Silvia Liu, Sheldon I. Bastacky, Xiaojie Wang, Xiao-Jun Tian & Dong Zhou. (2019) Diabetic kidney diseases revisited: A new perspective for a new era. Molecular Metabolism 30, pages 250-263.
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Janet B. McGill & Savitha Subramanian. (2019) Safety of Sodium-Glucose Co-Transporter 2 Inhibitors. The American Journal of Cardiology 124, pages S45-S52.
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Atsunori Kashiwagi, Marina V. Shestakova, Yuichiro Ito, Masahiro Noguchi, Wim Wilpshaar, Satoshi Yoshida & John P. H. Wilding. (2019) Safety of Ipragliflozin in Patients with Type 2 Diabetes Mellitus: Pooled Analysis of Phase II/III/IV Clinical Trials. Diabetes Therapy 10:6, pages 2201-2217.
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Kenan Çadırcı, Özlem Özdemir Tozlu & Hasan Türkez. (2019) The in vitro cytotoxicity, genotoxicity and oxidative damage potential of dapagliflozin, on cultured human blood cells. Turkish Journal of Biochemistry 44:5, pages 692-698.
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Lev M. Berstein. (2019) Is cancer incidence modified by SGLT2 inhibitors?. Diabetes mellitus 22:4, pages 399-402.
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Priyanka A. Shah, Pranav S. Shrivastav, Vinay Sharma & Manish S. Yadav. (2019) Challenges in simultaneous extraction and chromatographic separation of metformin and three SGLT-2 inhibitors in human plasma using LC–MS/MS. Journal of Pharmaceutical and Biomedical Analysis 175, pages 112790.
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Janet B. McGill & Savitha Subramanian. (2019) Safety of Sodium-Glucose Co-Transporter 2 Inhibitors. The American Journal of Medicine 132:10, pages S49-S57.e5.
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Amr Dokmak, Mohammad Almeqdadi, Hirsh Trivedi & Sandeep Krishnan. (2019) Rise of sodium-glucose cotransporter 2 inhibitors in the management of nonalcoholic fatty liver disease. World Journal of Hepatology 11:7, pages 562-573.
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Md. Mahbubur Rahman Bhuiyan & Anawara Begum. (2019) Promise, peril, and possible new treatment options incurred by sodium glucose co-transporter 2 (SGLT2) inhibitors: A precise review up to 2018. Obesity Medicine 14, pages 100099.
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Patricia Keresztes & Annette Peacock-Johnson. (2019) CE: Type 2 Diabetes: A Pharmacologic Update. AJN, American Journal of Nursing 119:3, pages 32-40.
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Manash P Baruah & Sanjay Kalra. (2019) Comparative Efficacy and Safety Among Sodium-glucose Cotransporter-2 Inhibitors in Type 2 Diabetes – Results from a Retrospective Single-centre Study. European Endocrinology 15:2, pages 113.
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Emanuel Raschi, Elisabetta Poluzzi, Gian Paolo Fadini, Giulio Marchesini & Fabrizio De Ponti. (2018) Observational research on sodium glucose co‐transporter‐2 inhibitors: A real breakthrough?. Diabetes, Obesity and Metabolism 20:12, pages 2711-2723.
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V. Tsimihodimos, T.D. Filippatos & M.S. Elisaf. (2018) SGLT2 inhibitors and the kidney: Effects and mechanisms. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 12:6, pages 1117-1123.
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André J. Scheen. (2018) GLP-1 receptor agonists and cardiovascular protection: A class effect or not?. Diabetes & Metabolism 44:3, pages 193-196.
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Kanwal Rehman, Kiran Saeed, Syeda Mehak Munawar & Muhammad Sajid Hamid Akash. (2018) Resveratrol regulates hyperglycemia-induced modulations in experimental diabetic animal model. Biomedicine & Pharmacotherapy 102, pages 140-146.
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A.-J. Scheen. (2018) Place des inhibiteurs des SGLT2 dans le traitement du patient diabétique de type 2. Médecine des Maladies Métaboliques 12:1, pages 22-30.
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