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Clinical Focus: Neurological & Psychiatric Disorders - Review

Glycemia management in acute ischemic stroke: current concepts and novel therapeutic targets

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Pages 423-437 | Received 08 May 2019, Accepted 30 Jul 2019, Published online: 12 Aug 2019

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Chengxiang Yuan, Siyan Chen, Yiting Ruan, Yuntao Liu, Haoran Cheng, Yaying Zeng, Yunbin Chen, Qianqian Cheng, Guiqian Huang, Weilei He & Jincai He. (2021) The Stress Hyperglycemia Ratio is Associated with Hemorrhagic Transformation in Patients with Acute Ischemic Stroke. Clinical Interventions in Aging 16, pages 431-442.
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Zhonglun Chen, Mouxiao Su, Zhaokun Li, Hongcai Du, Shanshan Zhang, Mingjun Pu & Yun Zhang. (2020) Metabolic Syndrome Predicts Poor Outcome in Acute Ischemic Stroke Patients After Endovascular Thrombectomy. Neuropsychiatric Disease and Treatment 16, pages 2045-2052.
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Articles from other publishers (27)

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Takashi Mitsuhashi, Kohsuke Teranishi, Joji Tokugawa, Takumi Mitsuhashi, Makoto Hishii & Hidenori Oishi. (2024) Prognostic Determinants of Anterior Large Vessel Occlusion in Acute Stroke in Elderly Patients. Geriatrics 9:1, pages 13.
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Tao Tang, Di Li, Tie-Ping Fan, Cong-Jie Bi, Aline M. Thomas, Man-Hong Zhao & Shen Li. (2023) Postoperative blood glucose increase is associated with futile recanalization in patients with successful thrombectomy: a retrospective study. BMC Neurology 23:1.
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Zaib Ali Shaheryar, Mahtab Ahmad Khan, Huma Hameed, Muhammad Naveed Mushtaq, Sajjad Muhammad, Gamal A. Shazly, Ali Irfan & Yousef A. Bin Jardan. (2023) Natural Fatty Acid Guards against Brain Endothelial Cell Death and Microvascular Pathology following Ischemic Insult in the Presence of Acute Hyperglycemia. Biomedicines 11:12, pages 3342.
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Zaib Ali Shaheryar, Mahtab Ahmad Khan, Huma Hameed, Syed Awais Ali Zaidi, Irfan Anjum & Muhammad Shafeeq Ur Rahman. (2023) Lauric acid provides neuroprotection against oxidative stress in mouse model of hyperglycaemic stroke. European Journal of Pharmacology 956, pages 175990.
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Qinglin Li, Lei Chi, Weiying Zhao, Lei Wu, Chuanxu Jiao, Xue Zheng, Kaiyue Zhang & Xiaoning Li. (2023) Machine learning prediction of motor function in chronic stroke patients: a systematic review and meta-analysis. Frontiers in Neurology 14.
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Alexander O. Shpakov, Inna I. Zorina & Kira V. Derkach. (2023) Hot Spots for the Use of Intranasal Insulin: Cerebral Ischemia, Brain Injury, Diabetes Mellitus, Endocrine Disorders and Postoperative Delirium. International Journal of Molecular Sciences 24:4, pages 3278.
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Daniel Santana, Alejandra Mosteiro, Leire Pedrosa, Laura Llull, Ramón Torné & Sergi Amaro. (2022) Clinical relevance of glucose metrics during the early brain injury period after aneurysmal subarachnoid hemorrhage: An opportunity for continuous glucose monitoring. Frontiers in Neurology 13.
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Giovanni Merlino, Sara Pez, Yan Tereshko, Gian Luigi Gigli, Simone Lorenzut, Andrea Surcinelli & Mariarosaria Valente. (2022) Stress Hyperglycemia Does Not Affect Clinical Outcome of Diabetic Patients Receiving Intravenous Thrombolysis for Acute Ischemic Stroke. Frontiers in Neurology 13.
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Yun Cai, Hongtao Zhang, Qiang Li & Peilan Zhang. (2022) Correlation Between Blood Glucose Variability and Early Therapeutic Effects After Intravenous Thrombolysis With Alteplase and Levels of Serum Inflammatory Factors in Patients With Acute Ischemic Stroke. Frontiers in Neurology 13.
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Guangyong Chen, Junli Ren, Honghao Huang, Jiamin Shen, Chenguang Yang, Jingyu Hu, Wenjing Pan, Fangyue Sun, Xinbo Zhou, Tian Zeng, Shengqi Li, Dehao Yang & Yiyun Weng. (2022) Admission Random Blood Glucose, Fasting Blood Glucose, Stress Hyperglycemia Ratio, and Functional Outcomes in Patients With Acute Ischemic Stroke Treated With Intravenous Thrombolysis. Frontiers in Aging Neuroscience 14.
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Ingrid Lovise Augestad, Doortje Dekens, Dimitra Karampatsi, Osama Elabi, Alexander Zabala, Hiranya Pintana, Martin Larsson, Thomas Nyström, Gesine Paul, Vladimer Darsalia & Cesare Patrone. (2021) Normalisation of glucose metabolism by exendin‐4 in the chronic phase after stroke promotes functional recovery in male diabetic mice. British Journal of Pharmacology 179:4, pages 677-694.
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J N Ngiam, C W S Cheong, A S T Leow, Y -T Wei, J K X Thet, I Y S Lee, C -H Sia, B Y Q Tan, C -M Khoo, V K Sharma & L L L Yeo. (2022) Stress hyperglycaemia is associated with poor functional outcomes in patients with acute ischaemic stroke after intravenous thrombolysis. QJM: An International Journal of Medicine 115:1, pages 7-11.
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Federica Ferrari, Antonio Moretti & RobertoFederico Villa. (2022) Hyperglycemia in acute ischemic stroke: physiopathological and therapeutic complexity. Neural Regeneration Research 17:2, pages 292.
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Carlos Perez-Vega, Ricardo A Domingo, Shashwat Tripathi, Andres Ramos-Fresnedo, Samir Kashyap, Alfredo Quinones-Hinojosa, Michelle P Lin, W Christopher Fox & Rabih G Tawk. (2021) Influence of glucose levels on clinical outcome after mechanical thrombectomy for large-vessel occlusion: a systematic review and meta-analysis. Journal of NeuroInterventional Surgery, pages neurintsurg-2021-017771.
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Sung-Chun Tang, Shyang-Rong Shih, Shin-Yi Lin, Chih-Hao Chen, Shin-Joe Yeh, Li-Kai Tsai, Wei-Shiung Yang & Jiann-Shing Jeng. (2021) A randomized trial to investigate the efficacy and safety of insulin glargine in hyperglycemic acute stroke patients receiving intensive care. Scientific Reports 11:1.
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Elena Spronk, Gina Sykes, Sarina Falcione, Danielle Munsterman, Twinkle Joy, Joseph Kamtchum-Tatuene & Glen C. Jickling. (2021) Hemorrhagic Transformation in Ischemic Stroke and the Role of Inflammation. Frontiers in Neurology 12.
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Giovanni Merlino, Carmelo Smeralda, Gian Luigi Gigli, Simone Lorenzut, Sara Pez, Andrea Surcinelli, Alessandro Marini & Mariarosaria Valente. (2020) Stress hyperglycemia is predictive of worse outcome in patients with acute ischemic stroke undergoing intravenous thrombolysis. Journal of Thrombosis and Thrombolysis 51:3, pages 789-797.
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Yaya Bao & Dadong Gu. (2021) Glycated Hemoglobin as a Marker for Predicting Outcomes of Patients With Stroke (Ischemic and Hemorrhagic): A Systematic Review and Meta-Analysis. Frontiers in Neurology 12.
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Lina Palaiodimou, Vasileios-Arsenios Lioutas, Vaia Lambadiari, Aikaterini Theodorou, Marios Themistocleous, Laura Aponte, Georgia Papagiannopoulou, Aikaterini Foska, Eleni Bakola, Rodrigo Quispe, Laura Mendez, Magdy Selim, Vera Novak, Elias Tzavellas, Panagiotis Halvatsiotis, Konstantinos Voumvourakis & Georgios Tsivgoulis. (2021) Glycemic variability of acute stroke patients and clinical outcomes: a continuous glucose monitoring study. Therapeutic Advances in Neurological Disorders 14, pages 175628642110458.
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Noel van Horn, Helge Kniep, Hannes Leischner, Rosalie McDonough, Milani Deb-Chatterji, Gabriel Broocks, Goetz Thomalla, Caspar Brekenfeld, Jens Fiehler, Uta Hanning & Fabian Flottmann. (2021) Predictors of poor clinical outcome despite complete reperfusion in acute ischemic stroke patients. Journal of NeuroInterventional Surgery 13:1, pages 14-18.
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Blanca Fuentes, Silvia Pastor-Yborra, Raquel Gutiérrez-Zúñiga, Noemí González-Pérez de Villar, Elena de Celis, Jorge Rodríguez-Pardo, Mari Carmen Gómez-de Frutos, Fernando Laso-García, María Gutiérrez-Fernández, MÁngeles Ortega-Casarrubios, Alfonso Soto, María López-Fernández, María Santamaría, Noemí Díez-González, Mar M. Freijo, Beatriz Zandio, Raquel Delgado-Mederos, Ana Calleja, Juan Carlos Portilla-Cuenca, Arturo Lisbona, Laura Otero-Ortega & Exuperio Díez-Tejedor. (2020) Glycemic variability: prognostic impact on acute ischemic stroke and the impact of corrective treatment for hyperglycemia. The GLIAS-III translational study. Journal of Translational Medicine 18:1.
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Zhi-Xin Huang, Yan Huang, Jie Zeng, Hong Hao, Greg F. Petroski, Haike Lu, Xintong Liu & Zhenguo Liu. (2020) Admission Glucose Levels May Increase the Risk for Early Neurological Deterioration in Females With Acute Ischemic Stroke. Frontiers in Neurology 11.
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Entesar F. Amin, Rehab A. Rifaai & Rania G. Abdel‐latif. (2020) Empagliflozin attenuates transient cerebral ischemia/reperfusion injury in hyperglycemic rats via repressing oxidative–inflammatory–apoptotic pathway. Fundamental & Clinical Pharmacology 34:5, pages 548-558.
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Chenghe Sun, Chuanjie Wu, Wenbo Zhao, Longfei Wu, Di Wu, Weili Li, Dongmei Wei, Qingfeng Ma, Hong Chen & Xunming Ji. (2020) Glycosylated Hemoglobin A1c Predicts Intracerebral Hemorrhage with Acute Ischemic Stroke Post-Mechanical Thrombectomy. Journal of Stroke and Cerebrovascular Diseases 29:9, pages 105008.
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