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Clinical Focus: Cardiometabolic Conditions - Review

Combination therapy with SGLT-2 inhibitors and GLP-1 receptor agonists as complementary agents that address multi-organ defects in type 2 diabetes

Pages 555-565 | Received 15 Mar 2019, Accepted 17 Sep 2019, Published online: 03 Oct 2019

Keep up to date with the latest research on this topic with citation updates for this article.

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Song Wen, Thiquynhnga Nguyen, Min Gong, Xinlu Yuan, Chaoxun Wang, Jianlan Jin & Ligang Zhou. (2021) An Overview of Similarities and Differences in Metabolic Actions and Effects of Central Nervous System Between Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs) and Sodium Glucose Co-Transporter-2 Inhibitors (SGLT-2is). Diabetes, Metabolic Syndrome and Obesity 14, pages 2955-2972.
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Theocharis Koufakis, Evangelos N. Liberopoulos, Alexander Kokkinos, Pantelis Zebekakis & Kalliopi Kotsa. (2023) Weight Loss Versus Glycemic Control as the Primary Treatment Target in Newly Diagnosed Type 2 Diabetes: Why Choose When You Can Have Both?. Drugs 83:6, pages 469-477.
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Simone A. Melander, Anna Katri, Morten A. Karsdal & Kim Henriksen. (2023) Improved metabolic efficacy of a dual amylin and calcitonin receptor agonist when combined with semaglutide or empagliflozin. European Journal of Pharmacology 938, pages 175397.
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Nour-Mounira Z. Bakkar, Ibrahim AlZaim & Ahmed F. El-Yazbi. (2022) Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease. Clinical Science 136:22, pages 1631-1651.
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Tingting Liang, Xinqiang Xie, Lei Wu, Longyan Li, Lingshuang Yang, He Gao, Zhenshan Deng, Xiangqian Zhang, Xuefeng Chen, Jumei Zhang, Yu Ding & Qingping Wu. (2022) Comparative analysis of the efficacies of probiotic supplementation and glucose-lowering drugs for the treatment of type 2 diabetes: A systematic review and meta-analysis. Frontiers in Nutrition 9.
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Marla J. Hayes. (2022) Overcoming Therapeutic Inertia in Type 2 Diabetes: Combination GLP-1 Agonist and SGLT-2 Inhibitor Therapy Offers Hope. ADCES in Practice 10:3, pages 32-34.
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José Ignacio Martínez-Montoro, José Luis Pinzón-Martín, Miguel Damas-Fuentes, Andrea Fernández-Valero & Francisco J. Tinahones. (2022) Combination Therapy With Semaglutide and Dapagliflozin as an Effective Approach for the Management of Type A Insulin Resistance Syndrome: A Case Report. Frontiers in Endocrinology 13.
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Pavel H. Lugo-Fabres, Leslie M. Otero-Sastre, Johanna Bernáldez-Sarabia, Tanya A. Camacho-Villegas, Noemi Sánchez-Campos, Janeth Serrano-Bello, Luis A. Medina, Saé Muñiz-Hernández, Lizbeth de la Cruz, Isabel Arenas, Antonio Barajas-Martínez, David E. Garcia, Linda Nuñez-Garcia, Jorge González-Canudas & Alexei F. Licea-Navarro. (2021) Potential Therapeutic Applications of Synthetic Conotoxin s-cal14.2b, Derived from Californiconus californicus, for Treating Type 2 Diabetes. Biomedicines 9:8, pages 936.
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Burkhard Göke. (2020) Die Behandlung des Diabetes mellitus: Mythen und EvidenzThe treatment of diabetes mellitus: myths and evidence. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 63:5, pages 512-520.
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