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Clinical Focus: Pain Management - Review

Utility of lidocaine as a topical analgesic and improvements in patch delivery systems

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Pages 28-36 | Received 11 Sep 2019, Accepted 05 Dec 2019, Published online: 03 Jan 2020

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (11)

Kefah Al-Hayk, Mahmoud M Smadi, Lina M Elsalem, Ahmed Yassin, Suha Aqaileh, Deema H Obiedat, Ahmad Kefah Al-Hayk, Majdi Al Qawasmeh, Raid Kofahi & Khalid El-Salem. (2023) Effect of 2% Topical Lidocaine Gel on Discomfort from Electrical Stimulation During Nerve Conduction Studies- A Prospective Double-Blind Placebo-Controlled Study. Local and Regional Anesthesia 16, pages 153-163.
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Jayshil A Bhatt, Hui Wei, Armita Azarpanah, Kenneth R Morris & Qing Cai. (2023) Quantitative Chromatographic Method Development for Residual Lidocaine in Topical Systems and Biological Samples. Bioanalysis 15:10, pages 553-566.
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Edmundo Gónima Valero, Walter Antanas Sosa Mendoza, Diana A. Sarmiento & Sebastian Amaya. (2023) Analgesic Treatment Approach for Postherpetic Neuralgia: A Narrative Review. Journal of Pain & Palliative Care Pharmacotherapy 37:2, pages 184-193.
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Jeffrey Fudin, Kip Vought, Kalpana Patel, Dmitri Lissin & Howard Maibach. (2022) Open-Label Adhesion Performance Study of a Prescription Lidocaine Topical System 1.8% versus Three Lidocaine-Containing Over-the-Counter Patches in Healthy Subjects. Journal of Pain Research 15, pages 2051-2065.
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Kip Vought, Emileigh Greuber, Kalpana Patel, Charles Argoff & Dmitri Lissin. (2021) A Randomized, Crossover, Adhesion Performance and Pharmacokinetic Study of a Lidocaine Topical System Under Conditions of Water Exposure in Healthy Subjects. Journal of Pain Research 14, pages 2459-2467.
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Jeffrey Gudin, Lynn R Webster, Emileigh Greuber, Kip Vought, Kalpana Patel & Louis Kuritzky. (2021) Open-Label Adhesion Performance Studies of a New Lidocaine Topical System 1.8% versus Lidocaine Patches 5% and Lidocaine Medicated Plaster 5% in Healthy Subjects. Journal of Pain Research 14, pages 513-526.
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Sana Hanif, Rai Muhammad Sarfraz, Muhammad Ali Syed, Asif Mahmood, Muhammad Usman Minhas & Muhammad Irfan. (2021) Development and optimization of tibezonium iodide and lignocaine hydrochloride containing novel mucoadhesive buccal tablets: a pharmacokinetic investigation among healthy humans. Drug Development and Industrial Pharmacy 47:8, pages 1209-1222.
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Srinivas Nalamachu & Jeffrey Gudin. (2020) Characteristics of Analgesic Patch Formulations. Journal of Pain Research 13, pages 2343-2354.
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Jeffrey Gudin, Charles Argoff, Jeffrey Fudin, Emileigh Greuber, Kip Vought, Kalpana Patel & Sri Nalamachu. (2020) A Randomized, Open-Label, Bioequivalence Study of Lidocaine Topical System 1.8% and Lidocaine Patch 5% in Healthy Subjects. Journal of Pain Research 13, pages 1485-1496.
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Articles from other publishers (31)

Akifumi Kanai, Masatomo Ara, Ryusei Saito, Toshiaki Mishima & Yuichiro Takahashi. (2024) Subcutaneous injection of lidocaine around ischemic ankle provides safe and effective foot analgesia in patients with critical limb ischemia. Vascular.
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Peng Mao, Yi Zhang, Botao Liu, Yifan Li, Yaping Chang, Meng Zhu, Yuan Zhang & Bifa Fan. (2024) Effect and safety profile of topical lidocaine on post-surgical neuropathic pain and quality of life: A systematic review and meta-analysis. Journal of Clinical Anesthesia 92, pages 111219.
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Emily E. Leppien, Erin E. Pauling, Eric Smith, Brady Wisniewski, Abigayle Carpenter & Nicholas C. Schwier. (2024) Pain management considerations in patients living with both pain syndromes and cardiovascular diseases and disorders. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 44:2, pages 184-196.
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Matin Bidares, Borna Safari-Kish, Mahsa Aziz, Niloufar Azarbayejani & Fatemeh Azizi-Soleiman. (2023) A Review on the Pain-Reducing Effects of Lidocaine Patches in Patients Undergoing Gastrointestinal Surgeries. Middle East Journal of Rehabilitation and Health Studies 11:3.
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Thomas Birngruber, Kip Vought, Simon Schwingenschuh, Peter Reisenegger, Howard Maibach & Dmitri Lissin. (2023) Topical Delivery Systems Effectively Transport Analgesics to Areas of Localized Pain via Direct Diffusion. Pharmaceutics 15:11, pages 2563.
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Cassio N. S. Silva, Maurício V. Cruz, Kátia F. Fernandes & Karla A. Batista. (2023) Production of anti-inflammatory films based on cashew gum polysaccharide and polyvinyl alcohol for wound dressing applications. 3 Biotech 13:9.
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Guy H. Hans, Dima Almeshal, Lotte Vanlommel, Ella Roelant, Iris Verhaegen, Elke Smits, Koen Van Boxem, Robert Fontaine & The PELICAN Investigators Team. (2023) Considerations on the Obstacles That Lead to Slow Recruitment in a Pain Management Clinical Trial: Experiences from the Belgian PELICAN (PrEgabalin Lidocaine Capsaicin Neuropathic Pain) Pragmatic Study. Pain Research and Management 2023, pages 1-13.
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Sana Hanif, Muhammad Ali Syed, Ahmad Junaid Rashid, Tareq Nafea Alharby, Mohammad M. Algahtani, Muteb Alanazi, Jowaher Alanazi & Rai Muhammad Sarfraz. (2023) Validation of a Novel RP-HPLC Technique for Simultaneous Estimation of Lignocaine Hydrochloride and Tibezonium Iodide: Greenness Estimation Using AGREE Penalties. Molecules 28:8, pages 3418.
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Yufan Qian, Yingjie Xu, Xiaohong Jin & Jiong Jiong Guo. (2022) Short-term clinical effectiveness of 5% lidocaine patch after arthroscopic rotator cuff repair: study protocol for a randomized, double-blinded, placebo-controlled clinical trial. Trials 23:1.
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Hong-min Ahn, Heung-Kwon Oh, Duck-Woo Kim, Sung-Bum Kang, Bon-Wook Koo & Pyung-Bok Lee. (2022) Efficacy and safety of 5% lidocaine patches for postoperative pain management in patients undergoing unilateral inguinal hernia repair: study protocol for a prospective, double-blind, randomized, controlled clinical trial. Trials 23:1.
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