7,904
Views
97
CrossRef citations to date
0
Altmetric
Clinical focus: Pulmonary and Respiratory Conditions -Review

JAK-STAT Pathway Inhibition and their Implications in COVID-19 Therapy

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 489-507 | Received 16 Oct 2020, Accepted 23 Nov 2020, Published online: 16 Dec 2020

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Shan Li, Fengdi Zhang, Ritian Lin, Qinjuan Sun, Lihong Qu & Lan Zhong. (2024) Shared Immune Associations Between COVID-19 and Inflammatory Bowel Disease: A Cross-Sectional Observational Study in Shanghai, China. Journal of Inflammation Research 17, pages 1929-1940.
Read now
Nora Mostafa, May Elsherbiny  Badr, Olfat G. Shaker, Ghada Elsaid, Rasha Samir Shemies, Doaa Khedr, Hend Gamal Abuelfadl & Mona Elhelaly Elsherbeny. (2023) The association of Sirtuin1 (SIRT1) polymorphism and downregulation of STAT4 gene expression with increased susceptibility to COVID-19 infection. Egyptian Journal of Basic and Applied Sciences 10:1, pages 711-721.
Read now
Xinyue Wang, Yuqing Wei, Zhijiao He, Di Wang, Leidan Zhang, Juan Du, Mengyuan Zhang, Meiqing Jiang, Na Chen, Meiju Deng, Bei Li, Chuan Song, Danying Chen, Huan Liu, Jiang Xiao, Hongyuan Liang, Hongxin Zhao & Yaxian Kong. (2023) CD70-induced differentiation of proinflammatory Th1/17/22/GM lymphocytes associated with disease progression and immune reconstitution during HIV infection. Emerging Microbes & Infections 12:2.
Read now
Haseeb Nisar, Bilal Wajid, Faria Anwar, Ashfaq Ahmad, Anum Javaid, Syed Awais Attique, Wardah Nisar, Amir Saeed, Samiah Shahid & Saima Sadaf. (2023) Bioinformatics and systems biology analysis revealed PMID26394986-Compound-10 as potential repurposable drug against covid-19. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-14.
Read now
Tufan Tukek, Sacide Pehlivan, Alpay Medetalibeyoglu, Istemi Serin, Yasemin Oyacı, Huzeyfe Arıcı, Naci Senkal, Mustafa Pehlivan, Ummuhan Isoglu-Alkac & Murat Kose. (2023) The suppressor of cytokine signaling-1 (SOCS1) gene polymorphism and promoter methylation correlate with the course of COVID-19. Pathogens and Global Health 117:4, pages 392-400.
Read now
Noel Roig-Marín & Pablo Roig-Rico. (2022) Cardiac auscultation predicts mortality in elderly patients admitted for COVID-19. Hospital Practice 50:3, pages 228-235.
Read now
Maryam A. Adas, Edward Alveyn, Emma Cook, Mrinalini Dey, James B Galloway & Katie Bechman. (2022) The infection risks of JAK inhibition. Expert Review of Clinical Immunology 18:3, pages 253-261.
Read now
Mingran Qi, Bin Liu, Shuai Li, Zhaohui Ni & Fan Li. (2021) Construction and Investigation of Competing Endogenous RNA Networks and Candidate Genes Involved in SARS-CoV-2 Infection. International Journal of General Medicine 14, pages 6647-6659.
Read now

Articles from other publishers (89)

Murat Bektaş, Mustafa Ay, Muhammed Hamdi Uyar & Muhammed İkbal Kılıç. (2024) Combination therapy of high-dose intravenous anakinra and baricitinib in patients with critical COVID-19: Promising results from retrospective observational study. International Immunopharmacology 129, pages 111586.
Crossref
Utid Suriya, Panupong Mahalapbutr, Athina Geronikaki, Victor Kartsev, Alexsander Zubenko, Liudmila Divaeva, Victoria Chekrisheva, Anthi Petrou, Lipika Oopkaew, Phitchakorn Somngam, Kiattawee Choowongkomon & Thanyada Rungrotmongkol. (2024) Discovery of furopyridine-based compounds as novel inhibitors of Janus kinase 2: In silico and in vitro studies. International Journal of Biological Macromolecules 260, pages 129308.
Crossref
Heba M. Mansour. (2024) The interference between SARS-COV-2 and Alzheimer’s disease: Potential immunological and neurobiological crosstalk from a kinase perspective reveals a delayed pandemic. Ageing Research Reviews 94, pages 102195.
Crossref
Shuo Yang, Zixin Fan, Xiaofeng Lu, Hui Liu, Ziying Zhou, Hui Qi, Jian Zeng, Mianying Zheng, Xuan Zou, Shisong Fang & Guoming Zhang. (2024) Response of Human Retinal Microvascular Endothelial Cells to Influenza A (H1N1) Infection and the Underlying Molecular Mechanism. Investigative Opthalmology & Visual Science 65:1, pages 38.
Crossref
Hui Huang, Ruxuan Chen, Yan Xu, Nan Fang, Chi Shao, Kai Xu & Mengzhao Wang. (2024) The Clinical Analysis of Checkpoint Inhibitor Pneumonitis with Different Severities in Lung Cancer Patients: A Retrospective Study. Journal of Clinical Medicine 13:1, pages 255.
Crossref
Kazuya Fujimoto, Yoshikazu Kameda, Yuta Nagano, Sayaka Deguchi, Takuya Yamamoto, Rafal P. Krol, Peter Gee, Yasufumi Matsumura, Toru Okamoto, Miki Nagao, Kazuo Takayama & Ryuji Yokokawa. (2024) SARS-CoV-2-induced disruption of a vascular bed in a microphysiological system caused by type-I interferon from bronchial organoids. Lab on a Chip.
Crossref
Gestina Aliska, Andani Eka Putra, Fenty Anggrainy & Mutia Lailani. (2024) The exploration of glucocorticoid pathway based on disease severity in COVID-19 patients. Heliyon 10:1, pages e23579.
Crossref
Harshdeep Kaur & Minni Singh. (2023) Functional foods as immunomodulators: Tackling the SARS-CoV-2 related cytokine storm–A review. Food Chemistry Advances 3, pages 100407.
Crossref
Sirui Li, Kok Wai Wong, Dengya Zhu & Chun Che Fung. (2023) Drug-CoV: a drug-origin knowledge graph discovering drug repurposing targeting COVID-19. Knowledge and Information Systems 65:12, pages 5289-5308.
Crossref
Mrinal K. Ghosh, Shaheda Tabassum & Malini Basu. (2023) COVID‐19 and cancer: Dichotomy of the menacing dilemma. MedComm – Oncology 2:4.
Crossref
A. A. Novikov, E. N. Aleksandrova, G. E. Bajmakanova, G. V. Lukina, N. A. Bodunova, V. I. Vechorko, O. V. Averkov, S. N. Shcherbo, M. I. Savina, T. I. Turkina & I. E. Khatkov. (2023) Cytokines in predicting JAK inhibitors clinical efficacy for COVID-19. Medical alphabet:23, pages 7-10.
Crossref
Ying Li, Liqin Han, Peiluan Li, Jing Ge, Yun Xue & Luonan Chen. (2023) Potential network markers and signaling pathways for B cells of COVID-19 based on single-cell condition-specific networks. BMC Genomics 24:1.
Crossref
Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Athanasios Alexiou & Gaber El-Saber Batiha. (2023) Cannabinoids Receptors in COVID-19: Perpetrators and Victims. Current Medicinal Chemistry 30:34, pages 3832-3845.
Crossref
David Kartchner, Kevin McCoy, Janhvi Dubey, Dongyu Zhang, Kevin Zheng, Rushda Umrani, James J. Kim & Cassie S. Mitchell. (2023) Literature-Based Discovery to Elucidate the Biological Links between Resistant Hypertension and COVID-19. Biology 12:9, pages 1269.
Crossref
Aitor Gonzaga, Etelvina Andreu, Luis M. Hernández-Blasco, Rut Meseguer, Karima Al-Akioui-Sanz, Bárbara Soria-Juan, Jose Carlos Sanjuan-Gimenez, Cristina Ferreras, Juan R. Tejedo, Guillermo Lopez-Lluch, Rosa Goterris, Loreto Maciá, Jose M. Sempere-Ortells, Abdelkrim Hmadcha, Alberto Borobia, Jose L. Vicario, Ana Bonora, Cristobal Aguilar-Gallardo, Jose L. Poveda, Cristina Arbona, Cristina Alenda, Fabian Tarín, Francisco M. Marco, Esperanza Merino, Francisco Jaime, José Ferreres, Juan Carlos Figueira, Carlos Cañada-Illana, Sergio Querol, Manuel Guerreiro, Cristina Eguizabal, Alejandro Martín-Quirós, Ángel Robles-Marhuenda, Antonio Pérez-Martínez, Carlos Solano & Bernat Soria. (2023) Rationale for combined therapies in severe-to-critical COVID-19 patients. Frontiers in Immunology 14.
Crossref
Simin Almasi, Azadeh Rashidi, Manizhe Ataee Kachuee, Bentolhoda Mohammad Shirazi, Shirin Izadi, Sara Ghaffarpour, Mehdi Azimi, Mohammad Mehdi Naghizadeh, Mahin Jamshidi Makiani, Mitra Ranjbar, Manizheh Goudarzi, Neda Rahimian & Tooba Ghazanfari. (2023) Effect of tofacitinib on clinical and laboratory findings in severe and resistant patients with COVID-19. International Immunopharmacology 122, pages 110565.
Crossref
Mengze Hu, Rong Liu, Juanjuan Li, Lei Zhang, Jing Cao, Mei Yue, Dixiao Zhong & Ruihong Tang. (2023) Clinical features and prognosis of pediatric acute lymphocytic leukemia with JAK-STAT pathway genetic abnormalities: a case series. Annals of Hematology 102:9, pages 2445-2457.
Crossref
Jialin Li, Siyu Guo, Yingying Tan, Jingyuan Zhang, Zhishan Wu, Antony StalinFanqin Zhang, Zhihong Huang, Chao Wu, Xinkui Liu, Jiaqi Huang & Jiarui Wu. (2023) Integrated network pharmacology analysis and in vitro validation revealed the underlying mechanism of Xiyanping injection in treating coronavirus disease 2019. Medicine 102:34, pages e34866.
Crossref
Leila Ghanbari Naeini, Laleh Abbasi, Farzaneh Karimi, Pajman Kokabian, Fahimeh Abdi Abyaneh & Delaram Naderi. (2023) The Important Role of Interleukin-2 in COVID-19. Journal of Immunology Research 2023, pages 1-13.
Crossref
Vignesh Balaji Easwaran, Sairaj Satarker, Tanvi V Gujaran, Jeena John, Anuranjana Putiya Veedu, Krupa Thankam George, Divya Kunhi Purayil, Fathima Beegum, Anna Mathew, RJA Vibhavari, Sneha Sunil Chaudhari & K Sreedhara Ranganath Pai. (2023) Expediting Molecular Translational Approach of Mesenchymal Stem Cells in COVID-19 Treatment. Current Stem Cell Research & Therapy 18:5, pages 653-675.
Crossref
K.M. Gopika, S. Sivajith, Aadharsa Sugunan & M.S. Sudheesh. (2023) Therapeutic Approaches for Intravascular Microthrombi-induced Acute Respiratory Distress Syndrome (ARDS) in COVID-19 Infection. Current Pharmaceutical Biotechnology 24:8, pages 970-987.
Crossref
Aleena Ashraf, Afrose Liaquat, Sana Shabbir, Saleem Ahmed Bokhari, Zainab Tariq, Zainab Furrukh, Afraz Ahmad Raja & Muhammad Jawad Khan. (2023) High level of lactate dehydrogenase and ischaemia–reperfusion injury regulate the multiple organ dysfunction in patients with COVID-19. Postgraduate Medical Journal 99:1172, pages 576-581.
Crossref
Yiying Xue, Husheng Mei, Yisa Chen, James D. Griffin, Qingsong Liu, Ellen Weisberg & Jing Yang. (2023) Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2. MedComm 4:3.
Crossref
Sareh Kakavandi, Iman Zare, Maryam VaezJalali, Masoud Dadashi, Maryam Azarian, Abdullatif Akbari, Marzieh Ramezani Farani, Hamidreza Zalpoor & Bahareh Hajikhani. (2023) Structural and non-structural proteins in SARS-CoV-2: potential aspects to COVID-19 treatment or prevention of progression of related diseases. Cell Communication and Signaling 21:1.
Crossref
Prasada Chowdari Gurram, Suman Manandhar, Sairaj Satarker, Jayesh Mudgal, Devinder Arora & Madhavan Nampoothiri. (2023) Dopaminergic Signaling as a Plausible Modulator of Astrocytic Toll-Like Receptor 4: A Crosstalk between Neuroinflammation and Cognition. CNS & Neurological Disorders - Drug Targets 22:4, pages 539-557.
Crossref
Somayeh Hashemi Sheikhshabani, Zeinab Amini-Farsani, Parastoo Modarres, Zahra Amini-Farsani, Sharareh Khazaei Feyzabad, Nasibeh Shaygan, Bashdar Mahmud Hussen, Mir Davood Omrani & Soudeh Ghafouri-Fard. (2023) In silico identification of potential miRNAs -mRNA inflammatory networks implicated in the pathogenesis of COVID-19. Human Gene 36, pages 201172.
Crossref
Katrin Hufnagel, Anahita Fathi, Nadine Stroh, Marco Klein, Florian Skwirblies, Ramy Girgis, Christine Dahlke, Jörg D. Hoheisel, Camille Lowy, Ronny Schmidt, Anne Griesbeck, Uta Merle, Marylyn M. Addo & Christoph Schröder. (2023) Discovery and systematic assessment of early biomarkers that predict progression to severe COVID-19 disease. Communications Medicine 3:1.
Crossref
Suo-wen Xu, Iqra Ilyas & Jian-ping Weng. (2022) Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies. Acta Pharmacologica Sinica 44:4, pages 695-709.
Crossref
Tingyu Wang, Yiman Zhai, Hao Xue, Wei Zhou, Yan Ding & Hongguang Nie. (2023) Regulation of Epithelial Sodium Transport by SARS-CoV-2 Is Closely Related with Fibrinolytic System-Associated Proteins. Biomolecules 13:4, pages 578.
Crossref
Nem Kumar Jain, Mukul Tailang, Hemant Kumar Jain, Balakumar Chandrasekaran, Biswa Mohan Sahoo, Anandhalakshmi Subramanian, Neelaveni Thangavel, Afaf Aldahish, Kumarappan Chidambaram, M. Alagusundaram, Santosh Kumar & Palani Selvam. (2023) Therapeutic implications of current Janus kinase inhibitors as anti-COVID agents: A review. Frontiers in Pharmacology 14.
Crossref
Tony Pan, Guoshuai Cao, Erting Tang, Yu Zhao, Pablo Penaloza-MacMaster, Yun Fang & Jun Huang. (2023) A single-cell atlas reveals shared and distinct immune responses and metabolic profiles in SARS-CoV-2 and HIV-1 infections. Frontiers in Genetics 14.
Crossref
Dušanka Obradović, Milica Popović, Maja Banjac, Jelena Bulajić, Vladimir Đurović, Ivana Urošević & Aleksandra Milovančev. (2023) Outcomes in COVID-19 Patients with Pneumonia Treated with High-Flow Oxygen Therapy and Baricitinib—Retrospective Single-Center Study. Life 13:3, pages 755.
Crossref
Alessia Ferrarini, Angelo Vacca, Antonio Giovanni Solimando, Marcello Tavio, Rossella Acquaviva, Marco Rocchi, Cinzia Nitti, Aldo Salvi, Vincenzo Menditto, Michele Maria Luchetti Gentiloni, Alessandro Russo, Marco Moretti, Marianna Pavani, Andrea Giacometti, Martina Bonifazi, Lina Zuccatosta, Laura Romani, Vito Racanelli, Gianluca Moroncini, Armando Gabrielli & Giovanni Pomponio. (2022) Early administration of tofacitinib in COVID ‐19 pneumonitis: An open randomised controlled trial . European Journal of Clinical Investigation 53:2.
Crossref
Manish Purohit, Gaurav Gupta, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sami I. Alzarea, Imran Kazmi, Waleed Hassan Almalki, Monica Gulati, Indu Pal Kaur, Sachin Kumar Singh & Kamal Dua. (2023) Janus kinase/signal transducers and activator of transcription (JAK/STAT) and its role in Lung inflammatory disease. Chemico-Biological Interactions 371, pages 110334.
Crossref
Babak Arjmand, Sepideh Alavi-Moghadam, Masoumeh Sarvari, Mostafa Rezaei-Tavirani, Ahmad Rezazadeh- Mafi, Rasta Arjmand, Mohsen Nikandish, Ensieh Nasli‐Esfahani & Bagher Larijani. (2023) Critical roles of cytokine storm and bacterial infection in patients with COVID-19: therapeutic potential of mesenchymal stem cells. Inflammopharmacology 31:1, pages 171-206.
Crossref
Angamuthu Selvapandiyan, Niti Puri, Pankaj Kumar, Anwar Alam, Nasreen Zafar Ehtesham, George Griffin & Seyed Ehtesham Hasnain. (2023) Zooming in on common immune evasion mechanisms of pathogens in phagolysosomes: potential broad-spectrum therapeutic targets against infectious diseases. FEMS Microbiology Reviews 47:1.
Crossref
Seyed Mohammad Reza Hashemian & Tayebeh Farhadi. (2023) A narrative review on tofacitinib: The properties, function, and usefulness to treat coronavirus disease 2019. International Journal of Critical Illness and Injury Science 13:4, pages 192-198.
Crossref
Septyana Eka Rahmawati, Jusak Nugraha & S. Theresia Indah Budhy. The role of IL-21 and IL-27 in COVID-19 patients receiving convalescent plasma. The role of IL-21 and IL-27 in COVID-19 patients receiving convalescent plasma.
Maximilian Kutschera, Gottfried Novacek, Walter Reinisch, Christoph Högenauer, Wolfgang Petritsch, Thomas Haas, Alexander Moschen & Clemens Dejaco. (2022) Tofacitinib in the treatment of ulcerative colitis. Wiener klinische Wochenschrift 135:1-2, pages 1-13.
Crossref
Ansab Akhtar, Jaspreet Kaur, Mei Nee Chiu & Sangeeta Pilkhwal Sah. 2023. Drug Repurposing for Emerging Infectious Diseases and Cancer. Drug Repurposing for Emerging Infectious Diseases and Cancer 395 421 .
Kacper Pizon, Savita Hampal, Kamila Orzechowska & Shahid Nazir Muhammad. 2023. Biomedical Visualisation. Biomedical Visualisation 41 57 .
Rui‐Sheng Wang & Joseph Loscalzo. (2023) Uncovering common pathobiological processes between COVID‐19 and pulmonary arterial hypertension by integrating Omics data. Pulmonary Circulation 13:1.
Crossref
Xiuxing Liu, Qi Jiang, Jianjie Lv, Shizhao Yang, Zhaohao Huang, Runping Duan, Tianyu Tao, Zhaohuai Li, Rong Ju, Yingfeng Zheng & Wenru Su. (2022) Insights gained from single-cell analysis of immune cells in tofacitinib treatment of Vogt-Koyanagi-Harada disease. JCI Insight 7:23.
Crossref
Jalpa Suthar & Jhanvi Patel. 2022. COVID-19 Drug Development - Recent Advances, New Perspectives and Applications. COVID-19 Drug Development - Recent Advances, New Perspectives and Applications.
Yizhou Jiang, Limor Rubin, Zhiwei Zhou, Haibo Zhang, Qiaozhu Su, Sheng-Tao Hou, Philip Lazarovici & Wenhua Zheng. (2022) Pharmacological therapies and drug development targeting SARS-CoV-2 infection. Cytokine & Growth Factor Reviews 68, pages 13-24.
Crossref
Ali Razaghi, Attila Szakos, Marwa Alouda, Béla Bozóky, Mikael Björnstedt & Laszlo Szekely. (2022) Proteomic Analysis of Pleural Effusions from COVID-19 Deceased Patients: Enhanced Inflammatory Markers. Diagnostics 12:11, pages 2789.
Crossref
Mohammad Mahboubi Mehrabani, Mohammad Sobhan Karvandi, Pedram Maafi & Mohammad Doroudian. (2022) Neurological complications associated with Covid‐19; molecular mechanisms and therapeutic approaches. Reviews in Medical Virology 32:6.
Crossref
Sidharth Jain, Samantha Rego, Steven Park, Yiran Liu, Simone Parn, Kush Savsani, David S. Perlin & Sivanesan Dakshanamurthy. (2022) RNASeq profiling of COVID19‐infected patients identified an EIF2AK2 inhibitor as a potent SARS‐CoV‐2 antiviral. Clinical and Translational Medicine 12:11.
Crossref
Jiefeng Zhao, Jinfeng Zhu, Chao Huang, Xiaojian Zhu, Zhengming Zhu, Qinrong Wu & Rongfa Yuan. (2022) Uncovering the information immunology journals transmitted for COVID-19: A bibliometric and visualization analysis. Frontiers in Immunology 13.
Crossref
Mahsa Eshkevar Vakili, Zahra Saleh, Dieter Kabelitz & Kurosh Kalantar. (2022) Targeting Citrate Carrier (CIC) in Inflammatory Macrophages as a Novel Metabolic Approach in COVID-19 Patients: A Perspective. Endocrine, Metabolic & Immune Disorders - Drug Targets 22:12, pages 1149-1153.
Crossref
Zahra Malekinejad, Amir Baghbanzadeh, Ailar Nakhlband, Behzad Baradaran, Sevda Jafari, Yasin Bagheri, Faezeh Raei, Soheila Montazersaheb & Raheleh Farahzadi. (2022) Recent clinical findings on the role of kinase inhibitors in COVID-19 management. Life Sciences 306, pages 120809.
Crossref
Amelia Barilli, Rossana Visigalli, Francesca Ferrari, Giulia Recchia Luciani, Maurizio Soli, Valeria Dall’Asta & Bianca Maria Rotoli. (2022) The JAK1/2 Inhibitor Baricitinib Mitigates the Spike-Induced Inflammatory Response of Immune and Endothelial Cells In Vitro. Biomedicines 10:9, pages 2324.
Crossref
Yujie Jiang, Tingmei Zhao, Xueyan Zhou, Yu Xiang, Pedro Gutierrez‐Castrellon & Xuelei Ma. (2022) Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions. MedComm 3:3.
Crossref
Jin Huang, Chi Zhou, Jinniu Deng & Jianfeng Zhou. (2022) JAK inhibition as a new treatment strategy for patients with COVID-19. Biochemical Pharmacology 202, pages 115162.
Crossref
Sonu Abraham, Shamitha Alisa Manohar, Rushin Patel, Anu Mariam Saji, Sourbha S. Dani & Sarju Ganatra. (2022) Strategies for Cardio-Oncology Care During the COVID-19 Pandemic. Current Treatment Options in Cardiovascular Medicine 24:8, pages 137-153.
Crossref
Doris Loh & Russel J. Reiter. (2022) Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19. International Journal of Molecular Sciences 23:15, pages 8122.
Crossref
David Andaluz-Ojeda, Pablo Vidal-Cortes, Álvaro Aparisi Sanz, Borja Suberviola, Lorena Del Río Carbajo, Leonor Nogales Martín, Estefanía Prol Silva, Jorge Nieto del Olmo, José Barberán & Ivan Cusacovich. (2022) Immunomodulatory therapy for the management of critically ill patients with COVID-19: A narrative review. World Journal of Critical Care Medicine 11:4, pages 269-297.
Crossref
Yanhong Ni, Jun T. Low, John Silke & Lorraine A. O’Reilly. (2022) Digesting the Role of JAK-STAT and Cytokine Signaling in Oral and Gastric Cancers. Frontiers in Immunology 13.
Crossref
Balasaheb D Bande. (2022) Use of Tofacitinib in the Management of COVID-19 Pneumonia. Indian Journal of Critical Care Medicine 25:10, pages 1089-1090.
Crossref
Balakumar Chandrasekaran & Muthupandian Saravanan. (2022) Editorial: Pharmacological and Biochemical Perspectives of Kinase Inhibitors in Cancer and COVID-19 Therapeutics, Volume I. Frontiers in Pharmacology 13.
Crossref
Jiajing Zheng, Jiameng Miao, Rui Guo, Jinhe Guo, Zheng Fan, Xianbin Kong, Rui Gao & Long Yang. (2022) Mechanism of COVID-19 Causing ARDS: Exploring the Possibility of Preventing and Treating SARS-CoV-2. Frontiers in Cellular and Infection Microbiology 12.
Crossref
Zhenjie Zhuang, Xiaoying Zhong, Qianying Chen, Huiqi Chen & Zhanhua Liu. (2022) Bioinformatics and System Biology Approach to Reveal the Interaction Network and the Therapeutic Implications for Non-Small Cell Lung Cancer Patients With COVID-19. Frontiers in Pharmacology 13.
Crossref
Mohaddeseh Bahmani, Rojin Chegini, Elham Ghanbari, Elham Sheykhsaran, Parisa Shiri Aghbash, Hamed Ebrahimzadeh Leylabadlo, Ehsan Moradian, Amir Masoud Kazemzadeh Houjaghan & Hossein Bannazadeh Baghi. (2022) Severe acute respiratory syndrome coronavirus 2 infection: Role of interleukin-6 and the inflammatory cascade. World Journal of Virology 11:3, pages 113-128.
Crossref
Efstratios Gavriilidis, Christina Antoniadou, Akrivi Chrysanthopoulou, Maria Ntinopoulou, Andreas Smyrlis, Iliana Fotiadou, Nikoleta Zioga, Dionysios Kogias, Anastasia-Maria Natsi, Christos Pelekoudas, Evangelia Satiridou, Stefania-Aspasia Bakola, Charalampos Papagoras, Ioannis Mitroulis, Paschalis Peichamperis, Dimitrios Mikroulis, Vasileios Papadopoulos, Panagiotis Skendros & Konstantinos Ritis. (2022) Combined administration of inhaled DNase, baricitinib and tocilizumab as rescue treatment in COVID-19 patients with severe respiratory failure. Clinical Immunology 238, pages 109016.
Crossref
Paulina Niedźwiedzka-Rystwej, Adam Majchrzak, Sara Kurkowska, Paulina Małkowska, Olga Sierawska, Rafał Hrynkiewicz & Miłosz Parczewski. (2022) Immune Signature of COVID-19: In-Depth Reasons and Consequences of the Cytokine Storm. International Journal of Molecular Sciences 23:9, pages 4545.
Crossref
Jinhuan Wei, Rui Shang, Jiaqi Wang, Shengze Zhu, JianQiang Yin, Ying Chen, Yayu Zhao & Gang Chen. (2022) ACE2 overexpressing mesenchymal stem cells alleviates COVID-19 lung injury by inhibiting pyroptosis. iScience 25:4, pages 104046.
Crossref
Mostafa Akbarzadeh-Khiavi, Mitra Torabi, Leila Rahbarnia & Azam Safary. (2021) Baricitinib combination therapy: a narrative review of repurposed Janus kinase inhibitor against severe SARS-CoV-2 infection. Infection 50:2, pages 295-308.
Crossref
Andrés López-Cortés, Santiago Guerrero, Esteban Ortiz-Prado, Verónica Yumiceba, Antonella Vera-Guapi, Ángela León Cáceres, Katherine Simbaña-Rivera, Ana María Gómez-Jaramillo, Gabriela Echeverría-Garcés, Jennyfer M. García-Cárdenas, Patricia Guevara-Ramírez, Alejandro Cabrera-Andrade, Lourdes Puig San Andrés, Doménica Cevallos-Robalino, Jhommara Bautista, Isaac Armendáriz-Castillo, Andy Pérez-Villa, Andrea Abad-Sojos, María José Ramos-Medina, Ariana León-Sosa, Estefanía Abarca, Álvaro A. Pérez-Meza, Karol Nieto-Jaramillo, Andrea V. Jácome, Andrea Morillo, Fernanda Arias-Erazo, Luis Fuenmayor-González, Luis Abel Quiñones & Nikolaos C. Kyriakidis. (2022) Pulmonary Inflammatory Response in Lethal COVID-19 Reveals Potential Therapeutic Targets and Drugs in Phases III/IV Clinical Trials. Frontiers in Pharmacology 13.
Crossref
Annalisa Marcuzzi, Erika Rimondi, Elisabetta Melloni, Arianna Gonelli, Antonio Giacomo Grasso, Egidio Barbi & Natalia Maximova. (2022) New Applications of JAK/STAT Inhibitors in Pediatrics: Current Use of Ruxolitinib. Pharmaceuticals 15:3, pages 374.
Crossref
Murat Bektaş & Gökhan Özdemir. (2022) Protracted or recurrent COVID-19 associated cytokine storm in a patient with chronic lymphocytic leukemia receiving rituximab-based chemotherapy. Clinical Immunology 236, pages 108936.
Crossref
Sepideh Zununi Vahed, Seyed Mahdi Hosseiniyan Khatibi, Elham Ahmadian & Mohammadreza Ardalan. (2022) Targeting chronic COVID-19 lung injury; Tofacitinib can be used against tissue-resident memory T cells. Biomedicine & Pharmacotherapy 147, pages 112614.
Crossref
Cheng-Wei Yang, Yue-Zhi Lee, Hsing-Yu Hsu, Guan-Hao Zhao & Shiow-Ju Lee. (2022) Tyrphostin AG1024 Suppresses Coronaviral Replication by Downregulating JAK1 via an IR/IGF-1R Independent Proteolysis Mediated by Ndfip1/2_NEDD4-like E3 Ligase Itch. Pharmaceuticals 15:2, pages 241.
Crossref
Abhishek Chandra & Ashu Johri. (2022) A Peek into Pandora’s Box: COVID-19 and Neurodegeneration. Brain Sciences 12:2, pages 190.
Crossref
Sara La Manna, Ilaria De Benedictis & Daniela Marasco. (2022) Proteomimetics of Natural Regulators of JAK–STAT Pathway: Novel Therapeutic Perspectives. Frontiers in Molecular Biosciences 8.
Crossref
Mark Garton & Clive Kelly. (2022) Is Janus Kinase Inhibition the Future of the Management of Rheumatoid Arthritis-associated Interstitial Lung Disease?. US Respiratory & Pulmonary Diseases 7:2, pages 38.
Crossref
Lingbo Xu, Huiping Zhang, Yanhua Wang, Anning Yang, Xiaoyan Dong, Lingyu Gu, Dayue Liu, Ning Ding & Yideng Jiang. (2022) FABP4 activates the JAK2/STAT2 pathway via Rap1a in the homocysteine-induced macrophage inflammatory response in ApoE mice atherosclerosis. Laboratory Investigation 102:1, pages 25-37.
Crossref
Rui‐kun Zhang, Qi Xiao, Sheng‐lang Zhu, Hai‐yan Lin & Ming Tang. (2021) Using different machine learning models to classify patients into mild and severe cases of COVID‐19 based on multivariate blood testing. Journal of Medical Virology 94:1, pages 357-365.
Crossref
Alexandrea Bass, Yiran Liu & Sivanesan Dakshanamurthy. (2021) Single-Cell and Bulk RNASeq Profiling of COVID-19 Patients Reveal Immune and Inflammatory Mechanisms of Infection-Induced Organ Damage. Viruses 13:12, pages 2418.
Crossref
Ahmed A. Al-Karmalawy, Raya Soltane, Ayman Abo Elmaaty, Mohamed A. Tantawy, Samar A. Antar, Galal Yahya, Amani Chrouda, Rami Adel Pashameah, Muhamad Mustafa, Mobarak Abu Mraheil & Ahmed Mostafa. (2021) Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview. Vaccines 9:11, pages 1317.
Crossref
Nathan D. Pfeifer, Arthur Lo, David L. Bourdet, Kenneth Colley & Dave Singh. (2021) Phase I study in healthy participants to evaluate safety, tolerability, and pharmacokinetics of inhaled nezulcitinib, a potential treatment for COVID‐19. Clinical and Translational Science 14:6, pages 2556-2565.
Crossref
Ching-Yi Chen, Wang-Chun Chen, Chi-Kuei Hsu, Chien-Ming Chao & Chih-Cheng Lai. (2021) Clinical efficacy and safety of Janus kinase inhibitors for COVID-19: A systematic review and meta-analysis of randomized controlled trials. International Immunopharmacology 99, pages 108027.
Crossref
Darja Kanduc. (2021) From Anti-SARS-CoV-2 Immune Response to the Cytokine Storm via Molecular Mimicry. Antibodies 10:4, pages 36.
Crossref
Min-Tser Liao, Chia-Chao Wu, Shu-Fang Vivienne Wu, Mei-Chen Lee, Wan-Chung Hu, Kuo-Wang Tsai, Chung-Hsiang Yang, Chien-Lin Lu, Sheng-Kang Chiu & Kuo-Cheng Lu. (2021) Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 Patients. Antioxidants 10:9, pages 1440.
Crossref
Alena Liskova, Lenka Koklesova, Marek Samec, Basma Abdellatif, Kevin Zhai, Manaal Siddiqui, Miroslava Šudomová, Sherif T.S. Hassan, Erik Kudela, Kamil Biringer, Frank A. Giordano, Dietrich Büsselberg, Olga Golubnitschaja & Peter Kubatka. (2021) Targeting phytoprotection in the COVID-19-induced lung damage and associated systemic effects—the evidence-based 3PM proposition to mitigate individual risks. EPMA Journal 12:3, pages 325-347.
Crossref
Deanna J. Buehrle, Robert R. Sutton, Erin L. McCann & Aaron E. Lucas. (2021) A Review of Treatment and Prevention of Coronavirus Disease 2019 among Solid Organ Transplant Recipients. Viruses 13:9, pages 1706.
Crossref
Lan Yang, Xueru Xie, Zikun Tu, Jinrong Fu, Damo Xu & Yufeng Zhou. (2021) The signal pathways and treatment of cytokine storm in COVID-19. Signal Transduction and Targeted Therapy 6:1.
Crossref
Paula Montero, Javier Milara, Inés Roger & Julio Cortijo. (2021) Role of JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular Mechanisms. International Journal of Molecular Sciences 22:12, pages 6211.
Crossref
Julian Heuberger, Jakob Trimpert, Daria Vladimirova, Christian Goosmann, Manqiang Lin, Rosa Schmuck, Hans‐Joachim Mollenkopf, Volker Brinkmann, Frank Tacke, Nikolaus Osterrieder & Michael Sigal. (2021) Epithelial response to IFN‐γ promotes SARS‐CoV‐2 infection. EMBO Molecular Medicine 13:4.
Crossref
Pukar Khanal, Taaza Duyu, B. M. Patil, Yadu Nandan Dey, Ismail Pasha, Rohini S. Kavalapure, Sharad Chand & Shailendra Gurav. (2021) Screening of JAK-STAT modulators from the antiviral plants of Indian traditional system of medicine with the potential to inhibit 2019 novel coronavirus using network pharmacology. 3 Biotech 11:3.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.