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Original

Cystatin C reduces the in vitro formation of soluble Aβ1‐42 oligomers and protofibrils

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Pages 179-190 | Received 13 Jun 2006, Accepted 07 Sep 2006, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Ye Hua, Hui Zhao, Xiaojie Lu, Yuenan Kong & Huihan Jin. (2012) Meta-Analysis of the Cystatin C(CST3) Gene G73A Polymorphism and Susceptibility to Alzheimer's Disease. International Journal of Neuroscience 122:8, pages 431-438.
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Efrat Levy. (2008) Cystatin C: a potential target for Alzheimer’s treatment. Expert Review of Neurotherapeutics 8:5, pages 687-689.
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Articles from other publishers (44)

Justyna Żygowska, Marta Orlikowska, Igor Zhukov, Wojciech Bal & Aneta Szymańska. (2024) Copper interaction with cystatin C: effects on protein structure and oligomerization. The FEBS Journal.
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Adriana Żyła, Anne Martel, Przemysław Jurczak, Augustyn Moliński, Aneta Szymańska & Maciej Kozak. (2023) Human cystatin C induces the disaggregation process of selected amyloid beta peptides: a structural and kinetic view. Scientific Reports 13:1.
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Bartłomiej Stańczykiewicz, Tomasz M. Goszczyński, Paweł Migdał, Marta Piksa, Krzysztof Pawlik, Jakub Gburek, Krzysztof Gołąb, Bogusława Konopska & Agnieszka Zabłocka. (2023) Effect of Ovocystatin on Amyloid β 1-42 Aggregation—In Vitro Studies. International Journal of Molecular Sciences 24:6, pages 5433.
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Vladimir F. Lazarev, Elizaveta A. Dutysheva, Igor E. Kanunikov, Irina V. Guzhova & Boris A. Margulis. (2023) Protein Interactome of Amyloid-β as a Therapeutic Target. Pharmaceuticals 16:2, pages 312.
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Wan-Yi Ge, Xudong Deng, Wen-Pu Shi, Wen-Juan Lin, Liang-Liang Chen, Huan Liang, Xue-Ting Wang, Tuo-Di Zhang, Feng-Zhu Zhao, Wei-Hong Guo & Da-Chuan Yin. (2022) Amyloid Protein Cross-Seeding Provides a New Perspective on Multiple Diseases In Vivo . Biomacromolecules 24:1, pages 1-18.
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Bartlomiej Stanczykiewicz, Jakub Gburek, Maria Rutkowska, Marta Lemieszewska, Krzysztof Gołąb, Katarzyna Juszczyńska, Aleksandra Piotrowska, Tadeusz Trziszka, Piotr Dzięgiel, Marzenna Podhorska-Okołów, Agnieszka Zabłocka & Joanna Rymaszewska. (2022) Ovocystatin Induced Changes in Expression of Alzheimer’s Disease Relevant Proteins in APP/PS1 Transgenic Mice. Journal of Clinical Medicine 11:9, pages 2372.
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Xueping Chen, Yan Huang, Ting Bao, Fu Jia, Ruwei Ou, Qianqian Wei, Yongping Chen, Jiao Liu, Jing Yang & Huifang Shang. (2022) Changes in Serum Cystatin C Levels and the Associations With Cognitive Function in Alzheimer's Disease Patients. Frontiers in Aging Neuroscience 13.
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Sookhee Bang, Jeong Kuen Song, Seung-Wook Shin & Kwan Hee Lee. (2022) Human serum albumin fusion protein as therapeutics for targeting amyloid beta in Alzheimer’s diseases. Neuroscience Letters 767, pages 136298.
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M. Mahafuzur Rahman & Christofer Lendel. (2021) Extracellular protein components of amyloid plaques and their roles in Alzheimer’s disease pathology. Molecular Neurodegeneration 16:1.
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Rocío Pérez-González, Susmita Sahoo, Sebastien A. Gauthier, Yohan Kim, Meihua Li, Asok Kumar, Monika Pawlik, Luisa Benussi, Roberta Ghidoni & Efrat Levy. (2019) Neuroprotection mediated by cystatin C-loaded extracellular vesicles. Scientific Reports 9:1.
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Hoa Quynh Do, Aveline Hewetson, Caitlyn Myers, Nazmul H. Khan, Mary Catherine Hastert, Faraz M. Harsini, Michael P. Latham, Benjamin J. Wylie, R. Bryan Sutton & Gail A. Cornwall. (2019) The Functional Mammalian CRES (Cystatin-Related Epididymal Spermatogenic) Amyloid is Antiparallel β-Sheet Rich and Forms a Metastable Oligomer During Assembly. Scientific Reports 9:1.
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Bartłomiej Stańczykiewicz, Marta Jakubik-Witkowska, Maria Rutkowska, Antoni Polanowski, Jakub Gburek, Krzysztof Gołąb, Katarzyna Juszczyńska, Tadeusz Trziszka & Joanna Rymaszewska. (2019) Beneficial effect of ovocystatin on the cognitive decline in APP/PS1 transgenic mice. Advances in Medical Sciences 64:1, pages 65-71.
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Gurjinder Kaur, Sebastien A. Gauthier, Rocio Perez-Gonzalez, Monika Pawlik, Amol Bikram Singh, Benjamin Cosby, Panaiyur S. Mohan, John F. Smiley & Efrat Levy. (2018) Cystatin C prevents neuronal loss and behavioral deficits via the endosomal pathway in a mouse model of down syndrome. Neurobiology of Disease 120, pages 165-173.
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Gunnar Brinkmalm, Simon Sjödin, Anja Hviid Simonsen, Steen Gregers Hasselbalch, Henrik Zetterberg, Ann Brinkmalm & Kaj Blennow. (2017) A Parallel Reaction Monitoring Mass Spectrometric Method for Analysis of Potential CSF Biomarkers for Alzheimer's Disease. PROTEOMICS – Clinical Applications 12:1.
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Kathrin BrockmannStefanie LercheSarah Selina DilgerJohannes Georg StirnkorbAnja ApelAnn-Kathrin HauserInga Liepelt-ScarfoneDaniela BergThomas GasserClaudia SchulteWalter Maetzler. (2017) SNPs in Aβ clearance proteins. Neurology 89:23, pages 2335-2340.
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Tyler J. Perlenfein & Regina M. Murphy. (2017) A mechanistic model to predict effects of cathepsin B and cystatin C on β-amyloid aggregation and degradation. Journal of Biological Chemistry 292:51, pages 21071-21082.
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Tyler J. Perlenfein, Jacob D. Mehlhoff & Regina M. Murphy. (2017) Insights into the mechanism of cystatin C oligomer and amyloid formation and its interaction with β-amyloid. Journal of Biological Chemistry 292:27, pages 11485-11498.
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Marta Spodzieja, Katarzyna Kalejta, Aleksandra S. Kołodziejczyk, Martyna Maszota‐Zieleniak, Sylwia Rodziewicz‐Motowidło, Wioletta Żmudzińska & Paulina Czaplewska. (2016) Characteristics of C‐terminal, β‐amyloid peptide binding fragment of neuroprotective protease inhibitor, cystatin C. Journal of Molecular Recognition 30:2.
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Rinko Grewal, Mona Haghighi, Shuai Huang, Amanda G. Smith, Chuanhai Cao, Xiaoyang Lin, Daniel C. Lee, Nancy Teten, Angela M. Hill & Maj-Linda B. Selenica. (2016) Identifying biomarkers of dementia prevalent among amnestic mild cognitively impaired ethnic female patients. Alzheimer's Research & Therapy 8:1.
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Paul M. Mathews & Efrat Levy. (2016) Cystatin C in aging and in Alzheimer’s disease. Ageing Research Reviews 32, pages 38-50.
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Sandra Whelly, Archana Muthusubramanian, Jonathan Powell, Seethal Johnson, Mary Catherine Hastert & Gail A. Cornwall. (2016) Cystatin-related epididymal spermatogenic subgroup members are part of an amyloid matrix and associated with extracellular vesicles in the mouse epididymal lumen. Molecular Human Reproduction 22:11, pages 729-744.
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Xia-Fei Wang, Dong-Xin Liu, Yue Liang, Li-Li Xing, Wen-Hui Zhao, Xiao-Xue Qin, De-Shu Shang, Bo Li, Wen-Gang Fang, Liu Cao, Wei-Dong Zhao & Yu-Hua Chen. (2016) Cystatin C Shifts APP Processing from Amyloid-β Production towards Non-Amyloidgenic Pathway in Brain Endothelial Cells. PLOS ONE 11:8, pages e0161093.
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Jinghui Luo, Sebastian K.T.S. Wärmländer, Astrid Gräslund & Jan Pieter Abrahams. (2016) Cross-interactions between the Alzheimer Disease Amyloid-β Peptide and Other Amyloid Proteins: A Further Aspect of the Amyloid Cascade Hypothesis. Journal of Biological Chemistry 291:32, pages 16485-16493.
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Tyler J. Perlenfein & Regina M. Murphy. (2016) Expression, purification, and characterization of human cystatin C monomers and oligomers. Protein Expression and Purification 117, pages 35-43.
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Aintzane Urbizu, Julia Canet‐Pons, Ana M. Munoz‐Marmol, Iban Aldecoa, Maria T. Lopez, Yaroslau Compta, Ramiro Alvarez, Lourdes Ispierto, Eduardo Tolosa, Aurelio Ariza & Katrin Beyer. (2015) Cystatin C is differentially involved in multiple system atrophy phenotypes . Neuropathology and Applied Neurobiology 41:4, pages 507-519.
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Audrey Gabelle, Susanna Schraen, Laure‐Anne Gutierrez, Cecile Pays, Olivier Rouaud, Luc Buée, Jacques Touchon, Catherine Helmer, Jean‐Charles Lambert & Claudine Berr. (2014) Plasma β‐amyloid 40 levels are positively associated with mortality risks in the elderly. Alzheimer's & Dementia 11:6, pages 672-680.
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Yuekang Xu, Ying Ding, Xinchen Li & Xiaobing Wu. (2015) Cystatin C is a disease‐associated protein subject to multiple regulation. Immunology & Cell Biology 93:5, pages 442-451.
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Atiyatul Qadeer, Nida Zaidi & Rizwan H. Khan. 2015. Proteostasis and Chaperone Surveillance. Proteostasis and Chaperone Surveillance 63 87 .
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Sandra Whelly, Gaiane Serobian, Clinton Borchardt, Jonathan Powell, Seethal Johnson, Katarina Hakansson, Veronica Lindstrom, Magnus Abrahamson, Anders Grubb & Gail A. Cornwall. (2014) Fertility Defects in Mice Expressing the L68Q Variant of Human Cystatin C. Journal of Biological Chemistry 289:11, pages 7718-7729.
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Gurjinder Kaur, Panaiyur Mohan, Monika Pawlik, Steven DeRosa, Jay Fajiculay, Shaoli Che, Anders Grubb, Stephen D. Ginsberg, Ralph A. Nixon & Efrat Levy. (2010) Cystatin C Rescues Degenerating Neurons in a Cystatin B-Knockout Mouse Model of Progressive Myoclonus Epilepsy. The American Journal of Pathology 177:5, pages 2256-2267.
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