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Original Article

Standardization of Cystatin C: Development of primary and secondary reference preparations

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Pages 67-70 | Published online: 08 Jul 2009

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Read on this site (6)

Niklas Tyrefors, Peter Michelsen & Anders Grubb. (2014) Two new types of assays to determine protein concentrations in biological fluids using mass spectrometry of intact proteins with cystatin C in spinal fluid as an example. Scandinavian Journal of Clinical and Laboratory Investigation 74:6, pages 546-554.
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James B. Wetmore, Runolfur Palsson, John M. Belmont, Gunnar Sigurdsson, Leifur Franzson & Olafur S. Indridason. (2010) Discrepancies between creatinine- and cystatin C-based equations: Implications for identification of chronic kidney disease in the general population. Scandinavian Journal of Urology and Nephrology 44:4, pages 242-250.
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Lars-Olof Hansson, Anders Grubb, Anders Lidén, Mats Flodin, Annacarin Berggren, Joris Delanghe, Veronique Stove, Hilmar Luthe, Karl-Heinz Rhode, Claus Beck & Ingrid Domke. (2010) Performance evaluation of a turbidimetric cystatin C assay on different high-throughput platforms. Scandinavian Journal of Clinical and Laboratory Investigation 70:5, pages 347-353.
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Erland J. Erlandsen & Else Randers. (2010) Performance evaluation of the Roche Tina-quant Cystatin C assay and reference interval for cystatin C in healthy blood donors. Scandinavian Journal of Clinical and Laboratory Investigation 70:4, pages 300-304.
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Ulf Nyman, Anders Grubb, Gunnar Sterner & Jonas Björk. (2009) Different equations to combine creatinine and cystatin C to predict GFR. Arithmetic mean of existing equations performs as well as complex combinations. Scandinavian Journal of Clinical and Laboratory Investigation 69:5, pages 619-627.
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Articles from other publishers (58)

George Ntaios, Jan Brederecke, Francisco M. Ojeda, Tanja Zeller, Stefan Blankenberg & Renate B. Schnabel. (2024) New race-free creatinine- and cystatin C-based equations for the estimation of glomerular filtration rate and association with cardiovascular mortality in the AtheroGene study. Internal and Emergency Medicine 19:3, pages 697-703.
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Hans Pottel, Ulf Nyman, Jonas Björk, Ulla Berg, Arend Bökenkamp, Laurence Derain Dubourg, Sandrine Lemoine, Karolien Goffin, Anders Grubb, Magnus Hansson, Anders Larsson, Karin Littmann, Kajsa Åsling-Monemi, Khosrow Adeli, Etienne Cavalier & Pierre Delanaye. (2023) Extending the cystatin C based EKFC-equation to children – validation results from Europe. Pediatric Nephrology 39:4, pages 1177-1183.
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Orlando M. Gutiérrez, Yingying Sang, Morgan E. Grams, Shoshana H. Ballew, Aditya Surapaneni, Kunihiro Matsushita, Alan S. Go, Michael G. Shlipak, Lesley A. Inker, Nwamaka D. Eneanya, Deidra C. Crews, Neil R. Powe, Andrew S. Levey, Josef Coresh, Morgan E Grams, Andrew S Levey, Lesley A Inker, Michael Shlipak, Orlando M Gutierrez, Paul Muntner, Suzanne Judd, Katharine Cheung, Josef Coresh, Yingying Sang, Nisha Bansal, Chi-yuan Hsu, James Sondheimer, Jonathan Taliercio, Milda Saunders, Elizabeth Selvin, Dan Wang, Shoshana H Ballew, Ron T Gansevoort, Tsuneo Konta, Kunihiro Matsushita, Kevan Polkinghorne, Elke Schaffner, Jingsha Chen, Aditya Surapaneni & Mark Woodward. (2022) Association of Estimated GFR Calculated Using Race-Free Equations With Kidney Failure and Mortality by Black vs Non-Black Race. JAMA 327:23, pages 2306.
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Chi-yuan HsuWei YangRishi V. ParikhAmanda H. AndersonTeresa K. ChenDebbie L. CohenJiang HeMadhumita J. MohantyJames P. LashKatherine T. MillsAnthony N. MuiruAfshin ParsaMilda R. SaundersTariq ShafiRaymond R. Townsend, Sushrut S. Waikar, Jianqiao WangMyles WolfThida C. TanHarold I. FeldmanAlan S. Go. (2021) Race, Genetic Ancestry, and Estimating Kidney Function in CKD. New England Journal of Medicine 385:19, pages 1750-1760.
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Lesley A. Inker, Sara J. Couture, Hocine Tighiouart, Alison G. Abraham, Gerald J. Beck, Harold I. Feldman, Tom Greene, Vilmundur Gudnason, Amy B. Karger, John H. Eckfeldt, Bertram L. Kasiske, Michael Mauer, Gerjan Navis, Emilio D. Poggio, Peter Rossing, Michael G. Shlipak, Andrew S. Levey, Margret B. Andresdottir, Hrefna Gudmundsdottir, Olafur S. Indridason, Runolfur Palsson, Paul Kimmel, Matt Weir, Roberto Kalil, Todd Pesavento, Anna Porter, Jonathan Taliercio, Chi-yuan Hsu, Jing Chen, Steef Sinkeler, Christina Wyatt, Zipporah Krishnasami, James Hellinger, Joseph Margolick, Lawrence Kingsley, Mallory Witt, Steven Wolinsky, Tariq Shafi, Wendy Post, Alessandro Doria & Hans-Henrik Parving. (2021) A New Panel-Estimated GFR, Including β2-Microglobulin and β-Trace Protein and Not Including Race, Developed in a Diverse Population. American Journal of Kidney Diseases 77:5, pages 673-683.e1.
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Yeli Wang, Andrew S. Levey, Lesley A. Inker, Saleem Jessani, Rasool Bux, Zainab Samad, Ali Raza Khan, Amy B. Karger, John C. Allen & Tazeen H. Jafar. (2021) Performance and Determinants of Serum Creatinine and Cystatin C–Based GFR Estimating Equations in South Asians. Kidney International Reports 6:4, pages 962-975.
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Eunjeong Kang, Seung Seok Han, Jayoun Kim, Sue Kyung Park, Wookyung Chung, Yun Kyu Oh, Dong-Wan Chae, Yong-Soo Kim, Curie Ahn & Kook-Hwan Oh. (2020) Discrepant glomerular filtration rate trends from creatinine and cystatin C in patients with chronic kidney disease: results from the KNOW-CKD cohort. BMC Nephrology 21:1.
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Yasuko Yamaguchi, Mitsuyo Itabashi, Wako Yumura & Takashi Takei. (2019) Geriatric assessment of estimated glomerular filtration rate: a cross-sectional study. Clinical and Experimental Nephrology 24:3, pages 216-224.
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Lesley A. Inker & Andrew S. Levey. 2019. Chronic Kidney Disease, Dialysis, and Transplantation. Chronic Kidney Disease, Dialysis, and Transplantation 23 41.e3 .
S. Ali Husain, Joshua Z. Willey, Yeseon Park Moon, Mitchell S. V. Elkind, Ralph L. Sacco, Myles Wolf, Ken Cheung, Clinton B. Wright & Sumit Mohan. (2018) Creatinine- versus cystatin C-based renal function assessment in the Northern Manhattan Study. PLOS ONE 13:11, pages e0206839.
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Jonas Björk, Anders Grubb, Vilmundur Gudnason, Olafur S Indridason, Andrew S Levey, Runolfur Palsson & Ulf Nyman. (2018) Comparison of glomerular filtration rate estimating equations derived from creatinine and cystatin C: validation in the Age, Gene/Environment Susceptibility-Reykjavik elderly cohort. Nephrology Dialysis Transplantation 33:8, pages 1380-1388.
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Lesley A Inker, Andrew S Levey, Hocine Tighiouart, Tariq Shafi, John H Eckfeldt, Craig Johnson, Aghogho Okparavero, Wendy S Post, Josef Coresh & Michael G Shlipak. (2018) Performance of glomerular filtration rate estimating equations in a community-based sample of Blacks and Whites: the multiethnic study of atherosclerosis. Nephrology Dialysis Transplantation 33:3, pages 417-425.
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Richard J. Glassock, David G. Warnock & Pierre Delanaye. (2016) The global burden of chronic kidney disease: estimates, variability and pitfalls. Nature Reviews Nephrology 13:2, pages 104-114.
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A. Grubb. 2017. Biomarkers of Kidney Disease. Biomarkers of Kidney Disease 225 240 .
Min He, Pei-feng Ke, Jian-hua Xu, Wei-ye Chen, Hai-biao Lin, Cheng Zhang, Yun-xiu Wang, Jun-hua Zhuang & Xian-zhang Huang. (2016) Performance evaluation of the Sysmex Cystatin C assay on the Roche Modular P Analyzer. Clinical Biochemistry 49:12, pages 915-918.
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Natalie Ebert, Pierre Delanaye, Michael Shlipak, Olga Jakob, Peter Martus, Jan Bartel, Jens Gaedeke, Markus van der Giet, Mirjam Schuchardt, Etienne Cavalier & Elke Schaeffner. (2016) Cystatin C standardization decreases assay variation and improves assessment of glomerular filtration rate. Clinica Chimica Acta 456, pages 115-121.
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Naya Huang, Meredith C. Foster, Gary F. Mitchell, Margret B. Andresdottir, Gudny Eiriksdottir, Hrefna Gudmundsdottir, Tamara B. Harris, Lenore J. Launer, Runolfur Palsson, Vilmundur Gudnason, Andrew S. Levey & Lesley A. Inker. (2016) Aortic stiffness and change in glomerular filtration rate and albuminuria in older people. Nephrology Dialysis Transplantation, pages gfw050.
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Aghogho Okparavero, Meredith C. Foster, Hocine Tighiouart, Vilmundur Gudnason, Olafur Indridason, Hrefna Gudmundsdottir, Gudny Eiriksdottir, Elias F. Gudmundsson, Lesley A. Inker & Andrew S. Levey. (2016) Prevalence and complications of chronic kidney disease in a representative elderly population in Iceland. Nephrology Dialysis Transplantation 31:3, pages 439-447.
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Nisha Bansal, Feng Lin, Eric Vittinghoff, Carmen Peralta, Joao Lima, Holly Kramer, Michael Shlipak & Kirsten Bibbins-Domingo. (2016) Estimated GFR and Subsequent Higher Left Ventricular Mass in Young and Middle-Aged Adults With Normal Kidney Function: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. American Journal of Kidney Diseases 67:2, pages 227-234.
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Ulf Nyman, Jonas Björk, Sten-Erik Bäck, Gunnar Sterner & Anders Grubb. (2015) Estimating GFR prior to contrast medium examinations—what the radiologist needs to know!. European Radiology 26:2, pages 425-435.
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Wentao XuWentao Xu. 2016. Functional Nucleic Acids Detection in Food Safety. Functional Nucleic Acids Detection in Food Safety 63 84 .
Petter Bjornstad, David Z. Cherney & David M. Maahs. (2015) Update on Estimation of Kidney Function in Diabetic Kidney Disease. Current Diabetes Reports 15:9.
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Li Fan, Andrew S. Levey, Vilmundur Gudnason, Gudny Eiriksdottir, Margret B. Andresdottir, Hrefna Gudmundsdottir, Olafur S. Indridason, Runolfur Palsson, Gary Mitchell & Lesley A. Inker. (2015) Comparing GFR Estimating Equations Using Cystatin C and Creatinine in Elderly Individuals. Journal of the American Society of Nephrology 26:8, pages 1982-1989.
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Ulla B. Berg, Ulf Nyman, Rune Bäck, Magnus Hansson, Kajsa Åsling Monemi, Maria Herthelius & Jonas Björk. (2015) New standardized cystatin C and creatinine GFR equations in children validated with inulin clearance. Pediatric Nephrology 30:8, pages 1317-1326.
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John H. Eckfeldt, Amy B. Karger, W. Greg Miller, Gregory P. Rynders & Lesley A. Inker. (2015) Performance in Measurement of Serum Cystatin C by Laboratories Participating in the College of American Pathologists 2014 CYS Survey. Archives of Pathology & Laboratory Medicine 139:7, pages 888-893.
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NES Perrin & UB Berg. (2015) Estimated glomerular filtration rates cannot replace measured GFR in type 1 diabetes patients with hyperfiltration . Acta Paediatrica 104:7, pages 730-737.
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Ana González-Antuña, Pablo Rodríguez-González, Rudiger Ohlendorf, André Henrion, Vincent Delatour & J. Ignacio García Alonso. (2015) Determination of Cystatin C in human serum by isotope dilution mass spectrometry using mass overlapping peptides. Journal of Proteomics 112, pages 141-155.
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Kook-Hwan Oh, Sue Kyung Park, Hayne Cho Park, Ho Jun Chin, Dong Wan Chae, Kyu Hun Choi, Seung Hyeok Han, Tae Hyun Yoo, Kyubeck Lee, Yong-Soo Kim, Wookyung Chung, Young-Hwan Hwang, Soo Wan Kim, Yeong Hoon Kim, Sun Woo Kang, Byung-Joo Park, Joongyub Lee & Curie Ahn. (2014) KNOW-CKD (KoreaN cohort study for Outcome in patients With Chronic Kidney Disease): design and methods. BMC Nephrology 15:1.
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Naim Issa, Aleksandra Kukla, Scott Jackson, Samy M. Riad, Meredith C. Foster, Arthur J. Matas, John H. Eckfeldt & Hassan N. Ibrahim. (2014) Comparison of Cystatin C and Creatinine-Based Equations for GFR Estimation After Living Kidney Donation. Transplantation 98:8, pages 871-877.
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Pierre Delanaye, Etienne Cavalier, Jean-Paul Cristol & Joris R. Delanghe. (2014) Calibration and precision of serum creatinine and plasma cystatin C measurement: impact on the estimation of glomerular filtration rate. Journal of Nephrology 27:5, pages 467-475.
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Hester N. Blufpand, Gertjan J.L. Kaspers & Arend Bökenkamp. (2014) Nierfunctie bij kinderen. Tijdschrift voor Kindergeneeskunde 82:4, pages 126-133.
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Andrew S Levey, Li Fan, John H Eckfeldt & Lesley A Inker. (2014) Cystatin C for Glomerular Filtration Rate Estimation: Coming of Age. Clinical Chemistry 60:7, pages 916-919.
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Anders Grubb, Masaru Horio, Lars-Olof Hansson, Jonas Björk, Ulf Nyman, Mats Flodin, Anders Larsson, Arend Bökenkamp, Yoshinari Yasuda, Hester Blufpand, Veronica Lindström, Ingrid Zegers, Harald Althaus, Søren Blirup-Jensen, Yoshi Itoh, Per Sjöström, Gunnar Nordin, Anders Christensson, Horst Klima, Kathrin Sunde, Per Hjort-Christensen, David Armbruster & Carlo Ferrero. (2014) Generation of a New Cystatin C–Based Estimating Equation for Glomerular Filtration Rate by Use of 7 Assays Standardized to the International Calibrator. Clinical Chemistry 60:7, pages 974-986.
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Li Fan, Lesley A. Inker, Jerome Rossert, Marc Froissart, Peter Rossing, Michael Mauer & Andrew S. Levey. (2014) Glomerular filtration rate estimation using cystatin C alone or combined with creatinine as a confirmatory test. Nephrology Dialysis Transplantation 29:6, pages 1195-1203.
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Andrew S. Levey, Lesley A. Inker & Josef Coresh. (2014) GFR Estimation: From Physiology to Public Health. American Journal of Kidney Diseases 63:5, pages 820-834.
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Evangelos Terpos, Dimitrios Christoulas, Efstathios Kastritis, Eirini Katodritou, Anastasia Pouli, Eurydiki Michalis, Ioannis Papassotiriou & Meletios A. Dimopoulos. (2013) The C hronic K idney D isease E pidemiology C ollaboration cystatin C ( CKD ‐ EPI ‐ C ys C ) equation has an independent prognostic value for overall survival in newly diagnosed patients with symptomatic multiple myeloma; is it time to change from MDRD to CKD ‐ EPI ‐ C ys C equations? . European Journal of Haematology 91:4, pages 347-355.
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Zeno Stanga, Stefan Nock, Pedro Medina-Escobar, Urs E. Nydegger, Martin Risch & Lorenz Risch. (2013) Factors Other than the Glomerular Filtration Rate That Determine the Serum Beta-2-Microglobulin Level. PLoS ONE 8:8, pages e72073.
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N. Bansal, E. Vittinghoff, C. A. Peralta, M. G. Shlipak, V. Grubbs, D. R. Jacobs, D. Siscovick, M. Steffes, J. J. Carr & K. Bibbins-Domingo. (2013) Estimated Kidney Function Based on Serum Cystatin C and Risk of Subsequent Coronary Artery Calcium in Young and Middle-aged Adults With Preserved Kidney Function: Results From the CARDIA Study. American Journal of Epidemiology 178:3, pages 410-417.
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Gavin Harman, Ayub Akbari, Swapnil Hiremath, Christine A. White, Tim Ramsay, Madzouka B. Kokolo, Jeffery Craig & Greg A. Knoll. (2013) Accuracy of cystatin C-based estimates of glomerular filtration rate in kidney transplant recipients: a systematic review. Nephrology Dialysis Transplantation 28:3, pages 741-757.
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Elisabet Nerpin, Johanna Helmersson-Karlqvist, Ulf Risérus, Johan Sundström, Anders Larsson, Elisabeth Jobs, Samar Basu, Erik Ingelsson & Johan Ärnlöv. (2012) Inflammation, oxidative stress, glomerular filtration rate, and albuminuria in elderly men: a cross-sectional study. BMC Research Notes 5:1.
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