Advanced search
Publication Cover
Scandinavian Journal of Clinical and Laboratory Investigation Volume 69, 2009 - Issue 1
Submit an article Journal homepage
577
Views
57
CrossRef citations to date
0
Altmetric
INVITED REVIEWS

Oxysterols as markers of neurological disease – a review

Valerio Leoni Division of Biochemistry and Genetics, National Institute of Neurology “C. Besta”, Milan, Italy
Pages 22-25 | Received 06 Aug 2008, Accepted 12 Nov 2008, Published online: 08 Jul 2009

Citations (57)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Itay Raphael, Johanna Webb, Olaf Stuve, William Haskins & Thomas Forsthuber. (2015) Body fluid biomarkers in multiple sclerosis: how far we have come and how they could affect the clinic now and in the future. Expert Review of Clinical Immunology 11:1, pages 69-91.
Read now
Elżbieta Miller, Joanna Saluk, Agnieszka Morel & Barbara Wachowicz. (2013) Long-term effects of whole body cryostimulation on uric acid concentration in plasma of secondary progressive multiple sclerosis patients. Scandinavian Journal of Clinical and Laboratory Investigation 73:8, pages 635-640.
Read now
Alan Rembach, Tim M Ryan, Blaine R Roberts, James D Doecke, William J Wilson, Andrew D Watt, Kevin J Barnham & Colin L Masters. (2013) Progress Towards a Consensus on Biomarkers for Alzheimer‘S Disease: A Review of Peripheral Analytes. Biomarkers in Medicine 7:4, pages 641-662.
Read now
Corinne M. Spickett, Ingrid Wiswedel, Werner Siems, Kamelija Zarkovic & Neven Zarkovic. (2010) Advances in methods for the determination of biologically relevant lipid peroxidation products. Free Radical Research 44:10, pages 1172-1202.
Read now
Christophe Garenc, Pierre Julien & Emile Levy. (2010) Oxysterols in biological systems: The gastrointestinal tract, liver, vascular wall and central nervous system. Free Radical Research 44:1, pages 47-73.
Read now

Articles from other publishers (52)

Ana Reis & Irundika H.K. Dias. (2024) Oxysterol sulfates in fluids, cells and tissues: how much do we know about their clinical significance, biological relevance and biophysical implications?. Essays in Biochemistry.
Crossref
Nina Sophia Decker, Theron Johnson, Johannes A. Vey, Charlotte Le Cornet, Sabine Behrens, Nadia Obi, Rudolf Kaaks, Jenny Chang-Claude & Renée Turzanski Fortner. (2023) Circulating oxysterols and prognosis among women with a breast cancer diagnosis: results from the MARIE patient cohort. BMC Medicine 21:1.
Crossref
Zuoli Sun, Jian Yang, Jia Zhou, Jingjing Zhou, Lei Feng, Yuan Feng, Yi He, Min Liu, Yuhong Li, Gang Wang & Rena Li. (2023) Tissue-Specific Oxysterols as Predictors of Antidepressant (Escitalopram) Treatment Response in Patients With Major Depressive Disorder. Biological Psychiatry Global Open Science 3:4, pages 663-672.
Crossref
Ahmed Hjazi, Maria Ahsan, Mohammed.I. Alghamdi, A.K. Kareem, Dahlia N. Al-Saidi, Maytham T. Qasim, Rosario Mireya Romero-Parra, Rahman S. Zabibah, Andrés Alexis Ramírez-Coronel, Yasser Fakri Mustafa, Seyed Reza Hosseini-Fard, Sajad Karampoor & Rasoul Mirzaei. (2023) Unraveling the impact of 27-hydroxycholesterol in autoimmune diseases: Exploring promising therapeutic approaches. Pathology - Research and Practice 248, pages 154737.
Crossref
Carla Borràs, Aina Mercer, Sònia Sirisi, Daniel Alcolea, Joan Carles Escolà-Gil, Francisco Blanco-Vaca & Mireia Tondo. (2022) HDL-like-Mediated Cell Cholesterol Trafficking in the Central Nervous System and Alzheimer’s Disease Pathogenesis. International Journal of Molecular Sciences 23:16, pages 9356.
Crossref
Shining Wang, Grace Chen, Emilio Merlo Pich, John Affinito, Michael Cwik & Hélène M. Faessel. (2022) Pharmacokinetics, pharmacodynamics and safety assessment of multiple doses of soticlestat in healthy volunteers. British Journal of Clinical Pharmacology 88:6, pages 2899-2908.
Crossref
Anna Sandebring-Matton, Julen Goikolea, Ingemar Björkhem, Laura Paternain, Nina Kemppainen, Tiina Laatikainen, Tiia Ngandu, Juha Rinne, Hilkka Soininen, Angel Cedazo-Minguez, Alina Solomon & Miia Kivipelto. (2021) 27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial. Alzheimer's Research & Therapy 13:1.
Crossref
Zuoli Sun, Lei Zhao, Qijing Bo, Zhen Mao, Yi He, Tao Jiang, Yuhong Li, Chuanyue Wang & Rena Li. (2021) Brain-Specific Oxysterols and Risk of Schizophrenia in Clinical High-Risk Subjects and Patients With Schizophrenia. Frontiers in Psychiatry 12.
Crossref
Paola Gamba, Serena Giannelli, Erica Staurenghi, Gabriella Testa, Barbara Sottero, Fiorella Biasi, Giuseppe Poli & Gabriella Leonarduzzi. (2021) The Controversial Role of 24-S-Hydroxycholesterol in Alzheimer’s Disease. Antioxidants 10:5, pages 740.
Crossref
Aditi Bhat, Harshita Dalvi, Harsha Jain, Nagarjun Rangaraj, Shashi Bala Singh & Saurabh Srivastava. (2021) Perspective insights of repurposing the pleiotropic efficacy of statins in neurodegenerative disorders: An expository appraisal. Current Research in Pharmacology and Drug Discovery 2, pages 100012.
Crossref
Toshiya Nishi, Shinichi Kondo, Maki Miyamoto, Sayuri Watanabe, Shigeo Hasegawa, Shigeru Kondo, Jason Yano, Etsurou Watanabe, Tsuyoshi Ishi, Masato Yoshikawa, Haruhi Kamisaki Ando, William Farnaby, Shinji Fujimoto, Eiji Sunahara, Momoko Ohori, Matthew J. During, Takanobu Kuroita & Tatsuki Koike. (2020) Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice. Scientific Reports 10:1.
Crossref
Achuthan C. Raghavamenon, Xueli Gao, Deidra S. Atkins-Ball, Sanjay Varikuti, Narasimham L. Parinandi & Rao M. Uppu. 2020. Measuring Oxidants and Oxidative Stress in Biological Systems. Measuring Oxidants and Oxidative Stress in Biological Systems 109 122 .
Patrick Oeckl & Markus Otto. (2019) A Review on MS-Based Blood Biomarkers for Alzheimer’s Disease. Neurology and Therapy 8:S2, pages 113-127.
Crossref
Irundika HK Dias, Khushboo Borah, Berivan Amin, Helen R. Griffiths, Khouloud Sassi, Gérard Lizard, Ane Iriondo & Pablo Martinez-Lage. (2019) Localisation of oxysterols at the sub-cellular level and in biological fluids. The Journal of Steroid Biochemistry and Molecular Biology 193, pages 105426.
Crossref
Adam Zmysłowski & Arkadiusz Szterk. (2019) Oxysterols as a biomarker in diseases. Clinica Chimica Acta 491, pages 103-113.
Crossref
Xuemei Huang, Nicholas W. Sterling, Guangwei Du, Dongxiao Sun, Christina Stetter, Lan Kong, Yusheng Zhu, Jeffery Neighbors, Mechelle M. Lewis, Honglei Chen, Raymond J. Hohl & Richard B. Mailman. (2019) Brain cholesterol metabolism and Parkinson's disease. Movement Disorders 34:3, pages 386-395.
Crossref
Paolo Rosa, Chiara Zerbinati, Alessio Crestini, Anna-Maria Canudas, Giuseppe Ragona, Annamaria Confaloni, Luigi Iuliano & Antonella Calogero. (2018) Heme Oxygenase-1 and Brain Oxysterols Metabolism Are Linked to Egr-1 Expression in Aged Mice Cortex, but Not in Hippocampus. Frontiers in Aging Neuroscience 10.
Crossref
Shinya Mochizuki, Harukata Miki, Ruyun Zhou, Yukiharu Kido, Wataru Nishimura, Motoshi Kikuchi & Yasuko Noda. (2018) Oxysterol-binding protein-related protein (ORP) 6 localizes to the ER and ER-plasma membrane contact sites and is involved in the turnover of PI4P in cerebellar granule neurons. Experimental Cell Research 370:2, pages 601-612.
Crossref
Anne Vejux, Amira Namsi, Thomas Nury, Thibault Moreau & Gérard Lizard. (2018) Biomarkers of Amyotrophic Lateral Sclerosis: Current Status and Interest of Oxysterols and Phytosterols. Frontiers in Molecular Neuroscience 11.
Crossref
Aleksandra Rutkowska, Andreas W. Sailer & Kumlesh K. Dev. (2017) EBI2 receptor regulates myelin development and inhibits LPC-induced demyelination. Journal of Neuroinflammation 14:1.
Crossref
Mike (Qingtao) Huang, Shefali Patel & Zhongping (John) Lin. 2017. Targeted Biomarker Quantitation by LC–MS. Targeted Biomarker Quantitation by LC–MS 307 319 .
Margaux Doria, Lucie Maugest, Thibault Moreau, Gérard Lizard & Anne Vejux. (2016) Contribution of cholesterol and oxysterols to the pathophysiology of Parkinson's disease. Free Radical Biology and Medicine 101, pages 393-400.
Crossref
Waldemar Kulig, Lukasz Cwiklik, Piotr Jurkiewicz, Tomasz Rog & Ilpo Vattulainen. (2016) Cholesterol oxidation products and their biological importance. Chemistry and Physics of Lipids 199, pages 144-160.
Crossref
Avinash Chandra & Yu Ming Xu. (2016) Cholesterol: A necessary evil from a multiple sclerosis perspective. Clinical and Experimental Neuroimmunology 7:2, pages 145-157.
Crossref
Hua-Long Wang, Yan-Yong Wang, Xin-Gang Liu, Sheng-Han Kuo, Na Liu, Qiao-Yun Song & Ming-Wei Wang. (2016) Cholesterol, 24-Hydroxycholesterol, and 27-Hydroxycholesterol as Surrogate Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer’s Disease: A Meta-Analysis. Journal of Alzheimer's Disease 51:1, pages 45-55.
Crossref
Akhlaq A. FarooquiAkhlaq A. Farooqui. 2016. Therapeutic Potentials of Curcumin for Alzheimer Disease. Therapeutic Potentials of Curcumin for Alzheimer Disease 1 76 .
Lenka Novakova, Markus Axelsson, Clas Malmeström, Henrik Zetterberg, Ingemar Björkhem, Virginija Danylaité Karrenbauer & Jan Lycke. (2015) Reduced cerebrospinal fluid concentrations of oxysterols in response to natalizumab treatment of relapsing remitting multiple sclerosis. Journal of the Neurological Sciences 358:1-2, pages 201-206.
Crossref
Waldemar Kulig, Agnieszka Olżyńska, Piotr Jurkiewicz, Anu M. Kantola, Sanna Komulainen, Moutusi Manna, Mohsen Pourmousa, Mario Vazdar, Lukasz Cwiklik, Tomasz Rog, George Khelashvili, Daniel Harries, Ville-Veikko Telkki, Martin Hof, Ilpo Vattulainen & Pavel Jungwirth. (2015) Cholesterol under oxidative stress—How lipid membranes sense oxidation as cholesterol is being replaced by oxysterols. Free Radical Biology and Medicine 84, pages 30-41.
Crossref
Valéria S. Nunes, Natália B. Panzoldo, Camila C. Leança, Eliane S. Parra, Vanessa S. Zago, Eliton J. da Silva, Patrícia M. Cazita, Edna R. Nakandakare, Eliana C. de Faria & Eder C.R. Quintão. (2014) Increased 27-hydroxycholesterol plasma level in men with low high density lipoprotein-cholesterol may circumvent their reduced cell cholesterol efflux rate. Clinica Chimica Acta 433, pages 169-173.
Crossref
C van de Kraats, J Killestein, V Popescu, E Rijkers, H Vrenken, D Lütjohann, F Barkhof, CH Polman & CE Teunissen. (2013) Oxysterols and cholesterol precursors correlate to magnetic resonance imaging measures of neurodegeneration in multiple sclerosis. Multiple Sclerosis Journal 20:4, pages 412-417.
Crossref
Timothy M. Hughes, Oscar L. Lopez, Rhobert W. Evans, M. Ilyas Kamboh, Jeff D. Williamson, William E. Klunk, Chester A. Mathis, Julie C. Price, Ann D. Cohen, Beth E. Snitz, Steven T. DeKosky & Lewis H. Kuller. (2014) Markers of cholesterol transport are associated with amyloid deposition in the brain. Neurobiology of Aging 35:4, pages 802-807.
Crossref
Tadashi Ikegami, Akira Honda, Teruo Miyazaki, Motoyuki Kohjima, Makoto Nakamuta & Yasushi Matsuzaki. (2014) Increased serum oxysterol concentrations in patients with chronic hepatitis C virus infection. Biochemical and Biophysical Research Communications 446:3, pages 736-740.
Crossref
S. Matysik, G. Schmitz, S. Bauer, J. Kiermaier & F.-M. Matysik. (2014) Potential of gas chromatography–atmospheric pressure chemical ionization–time-of-flight mass spectrometry for the determination of sterols in human plasma. Biochemical and Biophysical Research Communications 446:3, pages 751-755.
Crossref
Ian James Martins & W. M. A. D. Binosha Fernando. (2014) High Fibre Diets and Alzheimer’s Disease. Food and Nutrition Sciences 05:04, pages 410-424.
Crossref
Mototada Shichiri, Yasukazu Yoshida & Etsuo Niki. 2014. Omega-3 Fatty Acids in Brain and Neurological Health. Omega-3 Fatty Acids in Brain and Neurological Health 31 55 .
Erika Freemantle, Gary Gang Chen, Cristiana Cruceanu, Naguib Mechawar & Gustavo Turecki. (2013) Analysis of oxysterols and cholesterol in prefrontal cortex of suicides. International Journal of Neuropsychopharmacology 16:6, pages 1241-1249.
Crossref
Valerio Leoni & Claudio Caccia. (2013) Potential diagnostic applications of side chain oxysterols analysis in plasma and cerebrospinal fluid. Biochemical Pharmacology 86:1, pages 26-36.
Crossref
Sau‐Yeen Loke, Kazuhiro Tanaka & Wei‐Yi Ong. (2013) Comprehensive gene expression analyses of the rat prefrontal cortex after oxysterol treatment. Journal of Neurochemistry 124:6, pages 770-781.
Crossref
S Matysik, HH Klünemann & G Schmitz. (2012) Gas Chromatography–Tandem Mass Spectrometry Method for the Simultaneous Determination of Oxysterols, Plant Sterols, and Cholesterol Precursors. Clinical Chemistry 58:11, pages 1557-1564.
Crossref
Francisco J. Quintana, Ada Yeste, Howard L. Weiner & Ruxandra Covacu. (2012) Lipids and lipid-reactive antibodies as biomarkers for multiple sclerosis. Journal of Neuroimmunology 248:1-2, pages 53-57.
Crossref
Md. Omedul Islam, Yan Ting Lim, Conrad En Zuo Chan, Amaury Cazenave-Gassiot, J. Ludovic Croxford, Markus R. Wenk, Paul A. Macary & Brendon J. Hanson. (2012) Generation and Characterization of a Novel Recombinant Antibody Against 15-Ketocholestane Isolated by Phage-Display. International Journal of Molecular Sciences 13:4, pages 4937-4948.
Crossref
Mikael Ström, Faiez Al Nimer, Rickard Lindblom, Jens Randel Nyengaard & Fredrik Piehl. (2011) Naturally Occurring Genetic Variability in Expression of Gsta4 is Associated with Differential Survival of Axotomized Rat Motoneurons. NeuroMolecular Medicine 14:1, pages 15-29.
Crossref
Elżbieta Miller. 2012. Neurodegenerative Diseases. Neurodegenerative Diseases 222 238 .
Apinya Jusakul, Puangrat Yongvanit, Watcharin Loilome, Nisana Namwat & Rahul Kuver. (2011) Mechanisms of oxysterol-induced carcinogenesis. Lipids in Health and Disease 10:1.
Crossref
Fabio Di Domenico, Raffaella Coccia, D. Allan Butterfield & Marzia Perluigi. (2011) Circulating biomarkers of protein oxidation for Alzheimer disease: Expectations within limits. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1814:12, pages 1785-1795.
Crossref
Cynthia Fourgeux, Alain Bron, Niyazi Acar, Catherine Creuzot-Garcher & Lionel Bretillon. (2011) 24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma. Chemistry and Physics of Lipids 164:6, pages 496-499.
Crossref
Irena Dujmovic. (2011) Cerebrospinal Fluid and Blood Biomarkers of Neuroaxonal Damage in Multiple Sclerosis. Multiple Sclerosis International 2011, pages 1-18.
Crossref
Valérie Leduc, Stéphanie Jasmin-Bélanger & Judes Poirier. (2010) APOE and cholesterol homeostasis in Alzheimer's disease. Trends in Molecular Medicine 16:10, pages 469-477.
Crossref
Walter Maetzler & Daniela Berg. 2010. Biomarkers. Biomarkers 89 117 .
Michael Ogundare, Spyridon Theofilopoulos, Andrew Lockhart, Leslie J. Hall, Ernest Arenas, Jan Sjövall, A. Gareth Brenton, Yuqin Wang & William J. Griffiths. (2010) Cerebrospinal Fluid Steroidomics: Are Bioactive Bile Acids Present in Brain?. Journal of Biological Chemistry 285:7, pages 4666-4679.
Crossref
Hyman M. Schipper. (2010) Biological Markers and Alzheimer Disease: A Canadian Perspective. International Journal of Alzheimer's Disease 2010, pages 1-7.
Crossref
Niklas Mattsson, Kaj Blennow & Henrik Zetterberg. (2009) CSF Biomarkers. Annals of the New York Academy of Sciences 1180:1, pages 28-35.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.