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Scandinavian Journal of Clinical and Laboratory Investigation Volume 78, 2018 - Issue 4
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Original Article

Development of large-scale manufacturing of adipose-derived stromal cells for clinical applications using bioreactors and human platelet lysate

Mandana Haack-SørensenCardiology Stem Cell Centre, The Heart Centre, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark; Correspondence[email protected]
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Morten JuhlCardiology Stem Cell Centre, The Heart Centre, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark; ORCID Iconhttp://orcid.org/0000-0003-1138-9712View further author information
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Bjarke FollinCardiology Stem Cell Centre, The Heart Centre, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark; View further author information
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Rebekka Harary SøndergaardCardiology Stem Cell Centre, The Heart Centre, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark; View further author information
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Maria KirchhoffDepartment of Clinical Genetics, Rigshospitalet Copenhagen University Hospital, Copenhagen, DenmarkView further author information
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Jens KastrupCardiology Stem Cell Centre, The Heart Centre, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark; View further author information
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Annette EkblondCardiology Stem Cell Centre, The Heart Centre, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark; View further author information
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Pages 293-300 | Received 23 Aug 2017, Accepted 03 Feb 2018, Published online: 17 Apr 2018

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Alison Wilson, Andrew Webster & Paul Genever. (2019) Nomenclature and Heterogeneity: Consequences for the Use of Mesenchymal Stem Cells in Regenerative Medicine. Regenerative Medicine 14:6, pages 595-611.
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Articles from other publishers (38)

Alba López‐Fernández, Víctor Garcia‐Gragera, Martí Lecina & Joaquim Vives. (2024) Identification of critical process parameters for expansion of clinical grade human Wharton's jelly‐derived mesenchymal stromal cells in stirred‐tank bioreactors. Biotechnology Journal 19:2.
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Michael Møller‐Hansen. (2023) Mesenchymal stem cell therapy in aqueous deficient dry eye disease. Acta Ophthalmologica 101:S277, pages 3-27.
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Charlotte H. Hulme, Claire Mennan, Helen S. McCarthy, Rebecca Davies, Tian Lan, Larissa Rix, Jade Perry & Karina Wright. (2023) A comprehensive review of quantum bioreactor cell manufacture: Research and clinical applications. Cytotherapy 25:10, pages 1017-1026.
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Charlotte H. HulmeJohn K. GarciaClaire MennanJade PerrySally RobertsKevin NorrisDuncan BairdLarissa RixRobin BanerjeeCarl MeyerKarina T. Wright. (2023) The Upscale Manufacture of Chondrocytes for Allogeneic Cartilage Therapies. Tissue Engineering Part C: Methods 29:9, pages 424-437.
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Misha A. Teale, Samuel Schneider, Dieter Eibl, Christian van den Bos, Peter Neubauer & Regine Eibl. (2023) Mesenchymal and induced pluripotent stem cell–based therapeutics: a comparison. Applied Microbiology and Biotechnology 107:14, pages 4429-4445.
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Abbas Ali Qayyum, Bas van Klarenbosch, Sabina Frljak, Andraz Cerar, Gregor Poglajen, Denise Traxler‐Weidenauer, Pawel Nadrowski, Christina Paitazoglou, Bojan Vrtovec, Martin W. Bergmann, Steven A. J. Chamuleau, Wojtek Wojakowski, Mariann Gyöngyösi, Adriaan Kraaijeveld, Kristian Schultz Hansen, Karsten Vrangbæk, Erik Jørgensen, Steffen Helqvist, Francis Richard Joshi, Ellen Mønsted Johansen, Bjarke Follin, Morten Juhl, Lisbeth Drozd Højgaard, Anders Bruun Mathiasen, Annette Ekblond, Mandana Haack‐Sørensen & Jens Kastrup. (2023) Effect of allogeneic adipose tissue‐derived mesenchymal stromal cell treatment in chronic ischaemic heart failure with reduced ejection fraction – the SCIENCE trial . European Journal of Heart Failure 25:4, pages 576-587.
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Abbas Ali Qayyum, Mette Mouridsen, Brian Nilsson, Ida Gustafsson, Morten Schou, Olav Wendelboe Nielsen, Jens Dahlgaard Hove, Anders Bruun Mathiasen, Erik Jørgensen, Steffen Helqvist, Francis Richard Joshi, Ellen Mønsted Johansen, Bjarke Follin, Morten Juhl, Lisbeth Drozd Højgaard, Mandana Haack‐Sørensen, Annette Ekblond & Jens Kastrup. (2023) Danish phase II trial using adipose tissue derived mesenchymal stromal cells for patients with ischaemic heart failure. ESC Heart Failure 10:2, pages 1170-1183.
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Benedikt X. Scholz, Yusuke Hayashi, Isuru A. Udugama, Masahiro Kino-oka & Hirokazu Sugiyama. (2023) A CFD model-based design of seeding processes for two-dimensional mesenchymal stem cell cultivation. Computers & Chemical Engineering 171, pages 108157.
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Viktoria Jakl, Melanie Ehmele, Martina Winkelmann, Simon Ehrenberg, Tim Eiseler, Benedikt Friemert, Markus Thomas Rojewski & Hubert Schrezenmeier. (2023) A novel approach for large-scale manufacturing of small extracellular vesicles from bone marrow-derived mesenchymal stromal cells using a hollow fiber bioreactor. Frontiers in Bioengineering and Biotechnology 11.
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I. Banakh, Md. M. Rahman, C. L. Arellano, D. C. Marks, S. Mukherjee, C. E. Gargett, H. Cleland & S. Akbarzadeh. (2022) Platelet lysate can support the development of a 3D-engineered skin for clinical application. Cell and Tissue Research 391:1, pages 173-188.
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Charlotte Duch Lynggaard, Rosa Jersie-Christensen, Morten Juhl, Siri Beier Jensen, Christian Grønhøj, Jacob Melchiors, Søren Jacobsen, Michael Møller-Hansen, Mikkel Herly, Annette Ekblond, Jens Kastrup, Anne Fischer-Nielsen, Daniel Belstrøm & Christian von Buchwald. (2022) Intraglandular mesenchymal stem cell treatment induces changes in the salivary proteome of irradiated patients. Communications Medicine 2:1.
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Guoqiang Ren, Qiuyue Peng, Jeppe Emmersen, Vladimir Zachar, Trine Fink & Simone Porsborg. (2022) A Comparative Analysis of the Wound Healing-Related Heterogeneity of Adipose-Derived Stem Cells Donors. Pharmaceutics 14:10, pages 2126.
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Mandana Haack-Sørensen, Ellen Mønsted Johansen, Lisbeth Drozd Højgaard, Jens Kastrup & Annette Ekblond. (2022) GMP Compliant Production of a Cryopreserved Adipose-Derived Stromal Cell Product for Feasible and Allogeneic Clinical Use. Stem Cells International 2022, pages 1-12.
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Charlotte Duch Lynggaard, Christian Grønhøj, Robin Christensen, Anne Fischer-Nielsen, Jacob Melchiors, Lena Specht, Elo Andersen, Jann Mortensen, Peter Oturai, Gry Hoffmann Barfod, Eva Kannik Haastrup, Michael Møller-Hansen, Mandana Haack-Sørensen, Annette Ekblond, Jens Kastrup, Siri Beier Jensen & Christian von Buchwald. (2022) Intraglandular Off-the-Shelf Allogeneic Mesenchymal Stem Cell Treatment in Patients with Radiation-Induced Xerostomia: A Safety Study (MESRIX-II). Stem Cells Translational Medicine 11:5, pages 478-489.
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Nur Shuhaidatul Sarmiza Abdul Halim, Badrul Hisham Yahaya & Jie Lian. (2022) Therapeutic Potential of Adipose-derived Stem Cells in the Treatment of Pulmonary Diseases. Current Stem Cell Research & Therapy 17:2, pages 103-112.
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Marcella Liciani Franco, Stephany Beyerstedt & Érika Bevilaqua Rangel. (2021) Klotho and Mesenchymal Stem Cells: A Review on Cell and Gene Therapy for Chronic Kidney Disease and Acute Kidney Disease. Pharmaceutics 14:1, pages 11.
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Loubna Mazini, Mohamed Ezzoubi & Gabriel Malka. (2021) Overview of current adipose-derived stem cell (ADSCs) processing involved in therapeutic advancements: flow chart and regulation updates before and after COVID-19. Stem Cell Research & Therapy 12:1.
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Constantinos Petsoglou, Li Wen, Monira Hoque, Meidong Zhu, Monika Valtink, Gerard Sutton & Jingjing You. (2021) Effects of human platelet lysate on the growth of cultured human corneal endothelial cells. Experimental Eye Research 208, pages 108613.
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Diogo E.S. Nogueira, Joaquim M.S. Cabral & Carlos A.V. Rodrigues. (2021) Single-Use Bioreactors for Human Pluripotent and Adult Stem Cells: Towards Regenerative Medicine Applications. Bioengineering 8:5, pages 68.
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Lucas Ferioli CatelliSara Teresinha Olalla Saad. (2021) Ex Vivo Manufacture of Megakaryocytes and Platelets from Stem Cells: Recent Advances Toward Transfusion in Humans. Stem Cells and Development 30:7, pages 351-362.
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Noah Z. Laird, Timothy M. Acri, Jaidev L. Chakka, Juliana C. Quarterman, Walla I. Malkawi, Satheesh Elangovan & Aliasger K. Salem. (2021) Applications of nanotechnology in 3D printed tissue engineering scaffolds. European Journal of Pharmaceutics and Biopharmaceutics 161, pages 15-28.
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Michael Møller-Hansen, Ann-Cathrine Larsen, Peter Bjerre Toft, Charlotte Duch Lynggaard, Camilla Schwartz, Helle Bruunsgaard, Mandana Haack-Sørensen, Annette Ekblond, Jens Kastrup & Steffen Heegaard. (2021) Safety and feasibility of mesenchymal stem cell therapy in patients with aqueous deficient dry eye disease. The Ocular Surface 19, pages 43-52.
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Noah Z. Laird, Jaidev L. Chakka, Timothy M. Acri, Juliana C. Quarterman, Walla I. Malkawi, Satheesh Elangovan & Aliasger K. Salem. 2021. Handbook of Nanotechnology Applications. Handbook of Nanotechnology Applications 731 754 .
Josefine Lin Henriksen, Nana Brandborg Sørensen, Trine Fink, Vladimir Zachar & Simone Riis Porsborg. (2020) Systematic Review of Stem-Cell-Based Therapy of Burn Wounds: Lessons Learned from Animal and Clinical Studies. Cells 9:12, pages 2545.
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Coral García-Fernández, Alba López-Fernández, Salvador Borrós, Martí Lecina & Joaquim Vives. (2020) Strategies for large-scale expansion of clinical-grade human multipotent mesenchymal stromal cells. Biochemical Engineering Journal 159, pages 107601.
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Edward H. Ntege, Hiroshi Sunami & Yusuke Shimizu. (2020) Advances in regenerative therapy: A review of the literature and future directions. Regenerative Therapy 14, pages 136-153.
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Ramin Lotfi, Markus Thomas Rojewski, Philip H. Zeplin, Wolfgang Funk, Oliver Pullig, Ulrich Nöth & Hubert Schrezenmeier. (2020) Validation of Microbiological Testing of Cellular Medicinal Products Containing Antibiotics. Transfusion Medicine and Hemotherapy 47:2, pages 144-151.
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Karen Bieback, Beatriz Fernandez‐Muñoz, Shibani Pati & Richard Schäfer. (2019) Gaps in the knowledge of human platelet lysate as a cell culture supplement for cell therapy: a joint publication from the AABB and the International Society for Cell & Gene Therapy. Transfusion 59:11, pages 3448-3460.
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KAREN Bieback, BEATRIZ FERNANDEZ-MUÑOZ, SHIBANI PATI & RICHARD SCHÄFER. (2019) Gaps in the knowledge of human platelet lysate as a cell culture supplement for cell therapy: a joint publication from the AABB and the International Society for Cell & Gene Therapy. Cytotherapy 21:9, pages 911-924.
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Priyanka Gupta, Gabriella Nilsson Hall, Liesbet Geris, Frank P. Luyten & Ioannis Papantoniou. (2019) Human Platelet Lysate Improves Bone Forming Potential of Human Progenitor Cells Expanded in Microcarrier-Based Dynamic Culture. Stem Cells Translational Medicine 8:8, pages 810-821.
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Mathew Cowper, Trivia Frazier, Xiying Wu, J. Curley, Michelle Ma, Omair Mohiuddin, Marilyn Dietrich, Michelle McCarthy, Joanna Bukowska & Jeffrey Gimble. (2019) Human Platelet Lysate as a Functional Substitute for Fetal Bovine Serum in the Culture of Human Adipose Derived Stromal/Stem Cells. Cells 8:7, pages 724.
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Dinh-Toi Chu, Thuy Nguyen Thi Phuong, Nguyen Le Bao Tien, Dang Khoa Tran, Le Bui Minh, Vo Van Thanh, Pham Gia Anh, Van Huy Pham & Vu Thi Nga. (2019) Adipose Tissue Stem Cells for Therapy: An Update on the Progress of Isolation, Culture, Storage, and Clinical Application. Journal of Clinical Medicine 8:7, pages 917.
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Mimmi Patrikoski, Bettina Mannerström & Susanna Miettinen. (2019) Perspectives for Clinical Translation of Adipose Stromal/Stem Cells. Stem Cells International 2019, pages 1-21.
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Shehnaz Ahmed, Veeren M. Chauhan, Amir M. Ghaemmaghami & Jonathan W. Aylott. (2018) New generation of bioreactors that advance extracellular matrix modelling and tissue engineering. Biotechnology Letters 41:1, pages 1-25.
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Mimmi Patrikoski, Kristiina Rajala & Susanna Miettinen. 2019. Tissue Engineering in Oral and Maxillofacial Surgery. Tissue Engineering in Oral and Maxillofacial Surgery 141 157 .
Ngoc Bich Vu, Phuong Thi-Bich Le, Nhat Chau Truong & Phuc Van Pham. 2018. Stem Cell Drugs - A New Generation of Biopharmaceuticals. Stem Cell Drugs - A New Generation of Biopharmaceuticals 119 141 .

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