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Scandinavian Journal of Clinical and Laboratory Investigation Volume 36, 1976 - Issue 2
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Original Article

Thyroxine, Triiodothyronine, and Thyrotropin in Serum during Long-Term Diphenylhydantoin Therapy

K. Liewendahl Dept. of Clinical Chemistry, Helsinki University Central Hospital, Pitäjänmäki Epilepsy Centre, and Minerva Foundation Institute for Medical Research, Helsinki, Finland
&
H. Majuri Dept. of Clinical Chemistry, Helsinki University Central Hospital, Pitäjänmäki Epilepsy Centre, and Minerva Foundation Institute for Medical Research, Helsinki, Finland
Pages 141-144 | Received 03 Oct 1975, Accepted 26 Nov 1975, Published online: 28 Aug 2009

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K. Liewendahl, T. Helentus, H. Majuri, P. Ebeling & U. G. Ahlfors. (1980) Effect of anticonvulsant and antidepressant drugs on iodothyronines in serum. Scandinavian Journal of Clinical and Laboratory Investigation 40:8, pages 767-774.
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K. Rootwelt, T. Ganes & S. I. Johannessen. (1978) Effect of carbamazepine, phenytoin and phenobarbitone on serum levels of thyroid hormones and thyrotropin in humans. Scandinavian Journal of Clinical and Laboratory Investigation 38:8, pages 731-736.
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Kristian Liewendahl. (1977) On the selection of in vitro thyroid function tests. Scandinavian Journal of Clinical and Laboratory Investigation 37:5, pages 379-384.
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Articles from other publishers (29)

Margret Jona Einarsdottir, Elias Olafsson & Helga Agusta Sigurjonsdottir. (2019) Antiepileptic drugs are associated with central hypothyroidism. Acta Neurologica Scandinavica 139:1, pages 64-69.
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Yin-Xi Zhang, Chun-Hong Shen, Qi-Lun Lai, Gao-Li Fang, Wen-Jie Ming, Ru-Yi Lu & Mei-Ping Ding. (2016) Effects of antiepileptic drug on thyroid hormones in patients with epilepsy: A meta-analysis. Seizure 35, pages 72-79.
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Edward Chia‐Cheng Lai, Yea‐Huei Kao Yang, Swu‐Jane Lin & Cheng‐Yang Hsieh. (2013) Use of antiepileptic drugs and risk of hypothyroidism. Pharmacoepidemiology and Drug Safety 22:10, pages 1071-1079.
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Terje Apeland, Ole Kristensen, Roald E. Strandjord & Mohammad A. Mansoor. (2006) Thyroid function during B-vitamin supplementation of patients on antiepileptic drugs. Clinical Biochemistry 39:3, pages 282-286.
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M. Strolin Benedetti, R. Whomsley, E. Baltes & F. Tonner. (2005) Alteration of thyroid hormone homeostasis by antiepileptic drugs in humans: involvement of glucuronosyltransferase induction. European Journal of Clinical Pharmacology 61:12, pages 863-872.
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Steen S Holm, Steen H Hansen, Jens Faber & Poul Staun-Olsen. (2004) Reference methods for the measurement of free thyroid hormones in blood. Clinical Biochemistry 37:2, pages 85-93.
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Deepika Bongu, Jaswant Sachdev & Udaya M. Kabadi. (1999) Effects Of Carbamazepine On The Hypothalamic-Pituitary-Thyroid Axis. Endocrine Practice 5:5, pages 239-244.
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Mikko Tiihonen, Kristian Liewendahl, Olli Waltimo, Mikael Ojala & Matti Välimäki. (2005) Thyroid Status of Patients Receiving Long‐Term Anticonvulsant Therapy Assessed by Peripheral Parameters: A Placebo‐Controlled Thyroxine Therapy Trial. Epilepsia 36:11, pages 1118-1125.
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Adnan Yüksel, AYŞIN KARTAL, ASIM CENANI & ERDINÇ YALÇIN. (2011) Serum thyroid hormones and pituitary response to thyrotropin‐releasing hormone in epileptic children receiving anti‐epileptic medication. Pediatrics International 35:2, pages 108-112.
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GREGORY GRILLONE & DAVID MYSSIOREK. (1992) Otolaryngologic manifestations of phenytoin toxicity. Clinical Otolaryngology 17:2, pages 185-191.
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Jouko I. T. Isojärvi, Arto J. Pakarinen & Vilho V. Myllylä. (2005) Thyroid Function with Antiepileptic Drugs. Epilepsia 33:1, pages 142-148.
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ALBERT G. BURGER. (1990) Nonmonodeiodinative Pathways of Thyroxine Metabolism and Protein Binding of Thyroid Hormones. Thyroid 1:1, pages 53-54.
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R. Michael McClain. (2016) The Significance of Hepatic Microsomal Enzyme Induction and Altered Thyroid Function in Rats: Implications for Thyroid Gland Neoplasia. Toxicologic Pathology 17:2, pages 294-306.
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. (2016) Drug Information Analysis Service; Assessment of Thyroid Function during Phenytoin Therapy . Drug Intelligence & Clinical Pharmacy 22:7-8, pages 609-617.
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A. A. Connacher, D. Q. Borsey, M. C. Browning, D. L. Davidson & R. T. Jung. (1987) The effective evaluation of thyroid status in patients on phenytoin, carbamazepine or sodium valproate attending an epilepsy clinic.. Postgraduate Medical Journal 63:744, pages 841-845.
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P. J. EVANS, J. S. WOODHEAD, I. WEEKS & M. F. SCANLON. (2008) CIRCULATING TSH LEVELS MEASURED WITH AN IMMUNOCHEMILUMINOMETRIC ASSAY IN PATIENTS TAKING DRUGS INTERFERING WITH BIOCHEMICAL THYROID STATUS. Clinical Endocrinology 26:6, pages 717-721.
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U.‐B. Ericsson, Ingrid Bjerre, Marianne Forsgren & Sten A. Ivarsson. (2007) Thyroglobulin and Thyroid Hormones in Patients on Long‐Term Treatment with Phenytoin, Carbamazepine, and Valproic Acid. Epilepsia 26:6, pages 594-596.
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L. HEGEDÜS, J. M. HANSEN, K. LÜHDORF, H. PERRILD, ULLA FELDT‐RASMUSSEN & J. P. KAMPMANN. (2008) INCREASED FREQUENCY OF GOITRE IN EPILEPTIC PATIENTS ON LONG‐TERM PHENYTOIN OR CARBAMAZEPINE TREATMENT. Clinical Endocrinology 23:4, pages 423-429.
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EE Ohnhaus & H Studer. (2012) A link between liver microsomal enzyme activity and thyroid hormone metabolism in man.. British Journal of Clinical Pharmacology 15:1, pages 71-76.
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E. E. OHNHAUS, H. BÜRGI, A. BURGER & H. STUDER. (2008) The effect of antipyrine, phenobarbitol and rifampicin on thyroid hormone metabolism in man. European Journal of Clinical Investigation 11:5, pages 381-387.
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Klaus W. Wenzel. (1981) Pharmacological interference with in vitro tests of thyroid function. Metabolism 30:7, pages 717-732.
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R. E. Strandjord, S. Aanderud, O. L. Myking & S. I. Johannessen. (2009) Influence of carbamazepine on serum thyroxine and triiodothyronine in patients with epilepsy. Acta Neurologica Scandinavica 63:2, pages 111-121.
Crossref
P. V. Luoma, J. E. Heikkinen & P. R. Ylöstalo. (2016) Changes in Thyroid Function Tests During Phenobarbital Treatment in Late Pregnancy. International Journal of Gynecology & Obstetrics 17:5, pages 462-464.
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Nicholas P. Illsley & Coral A. Lamartiniere. (1979) Prenatal programming of hepatic monoamine oxidase by 5,5-diphenylhydantoin. Biochemical Pharmacology 28:17, pages 2585-2590.
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P. V. Luoma, M. I. Reunanen & E. A. Sotaniemi. (2009) Changes in Serum Triglyceride and Cholesterol Levels during Long‐Term Phenytoin Treatment for Epilepsy. Acta Medica Scandinavica 206:1-6, pages 229-231.
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H. Fichsel & G. Knöpfle. (2007) Effects of Anticonvulsant Drugs on Thyroid Hormones in Epileptic Children. Epilepsia 19:4, pages 323-336.
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K. LIEWENDAHL, H. MAJURI & TUULA HELENIUS. (2008) THYROID FUNCTION TESTS IN PATIENTS ON LONG‐TERM TREATMENT WITH VARIOUS ANTICONVULSANT DRUGS. Clinical Endocrinology 8:3, pages 185-191.
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K. Liewendahl, S. Rosengård & B.-A. Lamberg. (1978) Nuclear binding of triiodothyronine and thyroxine in lymphocytes from subjects with hyperthyroidism, hypothyroidism and resistance to thyroid hormones. Clinica Chimica Acta 83:1-2, pages 41-48.
Crossref
K. Liewendahl & Tuula Helenius. (1976) Effect of fatty acids on thyroid function tests in vitro and in vivo. Clinica Chimica Acta 72:3, pages 301-313.
Crossref

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