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Original Article

Assay of the major bile acids in serum by isotope dilution-mass spectrometry

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Pages 163-170 | Received 10 Jul 1982, Accepted 03 Dec 1982, Published online: 17 Mar 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Emanuele Porru, Erik Edström, Ahmed A. Saeed, Gösta Eggertsen, Anita Lövgren-Sandblom, Aldo Roda & Ingemar Björkhem. (2020) Further evidence for a continuous flux of bile acids into the brain: trapping of bile acids in subdural hematomas. Scandinavian Journal of Clinical and Laboratory Investigation 80:5, pages 395-400.
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Jan Gustafsson, Gunvor Alvelius, Ingemar Björkhem & Antal Nemeth. (2006) Bile Acid Metabolism in Extrahepatic Biliary Atresia. Upsala Journal of Medical Sciences 111:1, pages 131-136.
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L. S. Eriksson, R. Olsson, H. Glauman, H. Prytz, R. Befrits, B. O. Rydén, K. Einarsson, S. Lindgren, S. Wallerstedt & M. Wedén. (1997) Ursodeoxycholic Acid Treatment in Patients with Primary Biliary Cirrhosis: A Swedish Multicentre, Double-Blind, Randomized Controlled Study. Scandinavian Journal of Gastroenterology 32:2, pages 179-186.
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K. Einarsson, M. Bergström, R. Eklöf, C. E. Nord & I. Björkhem. (1992) Comparison of the proportion of unconjugated to total serum cholic acid and the [14C]-xylose breath test in patients with suspected small intestinal bacterial overgrowth. Scandinavian Journal of Clinical and Laboratory Investigation 52:5, pages 425-430.
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K. Einarsson, E. Reihnér, S. Ewerth & I. Björkhem. (1989) Serum concentrations of unconjugated and conjugated cholic acid in portal venous and systemic venous blood of fasting man. Scandinavian Journal of Clinical and Laboratory Investigation 49:1, pages 83-91.
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Oddvar Stokke, Sverre Skrede, Johan Ek & Ingemar Björkhem. (1984) Refsum's disease, adrenoleucodystrophy, and the Zellweger syndrome. Scandinavian Journal of Clinical and Laboratory Investigation 44:5, pages 463-464.
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Articles from other publishers (27)

Davide Gnocchi, Ewa C.S. Ellis, Helene Johansson, Mats Eriksson, Giovannella Bruscalupi, Knut R. Steffensen & Paolo Parini. (2020) Diiodothyronines regulate metabolic homeostasis in primary human hepatocytes by modulating mTORC1 and mTORC2 activity. Molecular and Cellular Endocrinology 499, pages 110604.
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Helene Johansson, Lisa-Mari Mörk, Meng Li, Anita L. Sandblom, Ingemar Björkhem, Jonas Höijer, Bo-Göran Ericzon, Carl Jorns, Stefan Gilg, Ernesto Sparrelid, Bengt Isaksson, Greg Nowak & Ewa Ellis. (2018) Circulating Fibroblast Growth Factor 19 in Portal and Systemic Blood. Journal of Clinical and Experimental Hepatology 8:2, pages 162-168.
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Ludger Schöls, Tim W Rattay, Peter Martus, Christoph Meisner, Jonathan Baets, Imma Fischer, Christine Jägle, Matthew J Fraidakis, Andrea Martinuzzi, Jonas Alex Saute, Marina Scarlato, Antonella Antenora, Claudia Stendel, Philip Höflinger, Charles Marques Lourenco, Lisa Abreu, Katrien Smets, Martin Paucar, Tine Deconinck, Dana M Bis, Sarah Wiethoff, Peter Bauer, Alessia Arnoldi, Wilson Marques, Laura Bannach Jardim, Stefan Hauser, Chiara Criscuolo, Alessandro Filla, Stephan Züchner, Maria Teresa Bassi, Thomas Klopstock, Peter De Jonghe, Ingemar Björkhem & Rebecca Schüle. (2017) Hereditary spastic paraplegia type 5: natural history, biomarkers and a randomized controlled trial. Brain 140:12, pages 3112-3127.
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Trond M. Kortner, Michael H. Penn, Ingemar Bj?rkhem, Kjell M?s?val & ?shild Krogdahl. (2016) Bile components and lecithin supplemented to plant based diets do not diminish diet related intestinal inflammation in Atlantic salmon. BMC Veterinary Research 12:1.
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Meng Li, Ewa EllisHelene JohanssonGreg NowakBengt IsakssonDavide GnocchiPaolo PariniJonas Axelsson. (2016) Changes in gluconeogenesis and intracellular lipid accumulation characterize uremic human hepatocytes ex vivo. American Journal of Physiology-Gastrointestinal and Liver Physiology 310:11, pages G952-G961.
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Camilla Pramfalk, Lilian Larsson, Jennifer Härdfeldt, Mats Eriksson & Paolo Parini. (2016) Culturing of HepG2 cells with human serum improve their functionality and suitability in studies of lipid metabolism. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1861:1, pages 51-59.
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Trond M. Kortner, Ingemar Björkhem, Aleksei Krasnov, Gerrit Timmerhaus & Åshild Krogdahl. (2014) Dietary cholesterol supplementation to a plant-based diet suppresses the complete pathway of cholesterol synthesis and induces bile acid production in Atlantic salmon ( Salmo salar L.) . British Journal of Nutrition 111:12, pages 2089-2103.
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Ewa C. S. Ellis, Scott Nauglers, Paolo Parini, Lisa-Mari Mörk, Carl Jorns, Helen Zemack, Anita Lövgren Sandblom, Ingemar Björkhem, Bo-Göran Ericzon, Elizabeth M. Wilson, Stephen C. Strom & Markus Grompe. (2013) Mice with Chimeric Livers Are an Improved Model for Human Lipoprotein Metabolism. PLoS ONE 8:11, pages e78550.
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Tiangang Li, Michelle Matozel, Shannon Boehme, Bo Kong, Lisa-Mari Nilsson, Grace Guo, Ewa Ellis & John Y. L. Chiang. (2011) Overexpression of cholesterol 7?-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis. Hepatology 53:3, pages 996-1006.
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Rebecca Schüle, Teepu Siddique, Han-Xiang Deng, Yi Yang, Sandra Donkervoort, Magnus Hansson, Ricardo E. Madrid, Nailah Siddique, Ludger Schöls & Ingemar Björkhem. (2010) Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis. Journal of Lipid Research 51:4, pages 819-823.
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William J. Griffiths & Jan Sjövall. (2010) Bile acids: analysis in biological fluids and tissues. Journal of Lipid Research 51:1, pages 23-41.
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Ewa C. S. Ellis & Lisa-Mari Nilsson. 2010. Hepatocytes. Hepatocytes 417 430 .
Ewa Cristine Siljevik Ellis. (2006) Suppression of bile acid synthesis by thyroid hormone in primary human hepatocytes. World Journal of Gastroenterology 12:29, pages 4640.
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Haim Rosen, Ayeleth Reshef, Nobuyo Maeda, Andrea Lippoldt, Shoshi Shpizen, Liat Triger, Gösta Eggertsen, Ingemar Björkhem & Eran Leitersdorf. (1998) Markedly Reduced Bile Acid Synthesis but Maintained Levels of Cholesterol and Vitamin D Metabolites in Mice with Disrupted Sterol 27-Hydroxylase Gene. Journal of Biological Chemistry 273:24, pages 14805-14812.
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Ewa Ellis, Bryan Goodwin, Anna Abrahamsson, Chris Liddle, Agneta Mode, Mats Rudling, Ingemar Björkhem & Curt Einarsson. (1998) Bile acid synthesis in primary cultures of rat and human hepatocytes. Hepatology 27:2, pages 615-620.
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G. M. Murphy, M. Maghsoudloo & M. Y. Qureshi. 1995. Steroid Analysis. Steroid Analysis 527 561 .
Kazuya Nagata, Magnus Axelson, Ingemar Bjoerkhem, Masao Matsutani & Kintomo Takakura. 1993. Recent Advances in Neurotraumatology. Recent Advances in Neurotraumatology 49 52 .
André P. de Leenheer & Linda M. Thienpont. (1992) Applications of isotope dilution-mass spectrometry in clinical chemistry, pharmacokinetics, and toxicology. Mass Spectrometry Reviews 11:4, pages 249-307.
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F Stellaard, S A Langelaar, R M Kok & C Jakobs. (1989) Determination of plasma bile acids by capillary gas-liquid chromatography-electron capture negative chemical ionization mass fragmentography.. Journal of Lipid Research 30:10, pages 1647-1652.
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J Gustafsson. (1988) Bile acid biosynthesis during development: hydroxylation of C27-sterols in human fetal liver.. Journal of Lipid Research 27:8, pages 801-806.
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K Prydz, B F Kase, I Björkhem & J I Pedersen. (1988) Formation of chenodeoxycholic acid from 3 alpha, 7 alpha-dihydroxy-5 beta-cholestanoic acid by rat liver peroxisomes.. Journal of Lipid Research 27:6, pages 622-628.
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A. M. Lawson & K. D. R. Setchell. 1988. The Bile Acids: Chemistry, Physiology, and Metabolism. The Bile Acids: Chemistry, Physiology, and Metabolism 167 267 .
G. M. Murphy. 1988. The Bile Acids: Chemistry, Physiology, and Metabolism. The Bile Acids: Chemistry, Physiology, and Metabolism 379 403 .
J. Sjövall & K. D. R. Setchell. 1988. The Bile Acids: Chemistry, Physiology, and Metabolism. The Bile Acids: Chemistry, Physiology, and Metabolism 1 42 .
J. I. Pedersen, B. F. Kase, K. Prydz & I. Björkhem. 1987. Peroxisomes in Biology and Medicine. Peroxisomes in Biology and Medicine 67 77 .
Johan Ek, Bengt Frode Kase, Albrecht Reith, Ingemar Björkhem & Jan I. Pedersen. (1986) Peroxisomal dysfunction in a boy with neurologic symptoms and amaurosis (Leber disease): Clinical and biochemical findings similar to those observed in Zellweger syndrome. The Journal of Pediatrics 108:1, pages 19-24.
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Staffan Euverth, Bo Angelin, Kurt Einarsson, Klas Nilsell & Ingemar Björkhem. (1985) Serum Concentrations of Ursodeoxycholic Acid in Portal Venous and Systemic Venous Blood of Fasting Humans as Determined by Isotope Dilution—Mass Spectrometry. Gastroenterology 88:1, pages 126-133.
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