106
Views
45
CrossRef citations to date
0
Altmetric
Original Article

Diffusion and polymerization determines the insulin absorption from subcutaneous tissue in diabetic patients

, MD, , , &
Pages 685-690 | Received 30 Nov 1984, Accepted 23 May 1985, Published online: 29 Mar 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Sunil Prabhu, Arthur I. Jacknowitz & Paula Jo Stout. (2002) Evaluating the Dissolution Behavior of Zinc-Complexed Protein Suspensions by Computer Modeling and Simulation. Drug Development and Industrial Pharmacy 28:6, pages 703-709.
Read now
Yie W. Chien. (1996) Human Insulin: Basic Sciences to Therapeutic Uses. Drug Development and Industrial Pharmacy 22:8, pages 753-789.
Read now
Mary H. Samuels & Robert H. Eckel. (1989) Massive insulin overdose: Detailed studies of free insulin levels and glucose requirements. Journal of Toxicology: Clinical Toxicology 27:3, pages 157-168.
Read now

Articles from other publishers (42)

Peter Kurtzhals, Søren Østergaard, Erica Nishimura & Thomas Kjeldsen. (2022) Derivatization with fatty acids in peptide and protein drug discovery. Nature Reviews Drug Discovery 22:1, pages 59-80.
Crossref
Peter Kurtzhals, Erica Nishimura, Hanne Haahr, Thomas Høeg-Jensen, Eva Johansson, Peter Madsen, Jeppe Sturis & Thomas Kjeldsen. (2021) Commemorating insulin's centennial: engineering insulin pharmacology towards physiology. Trends in Pharmacological Sciences 42:8, pages 620-639.
Crossref
Anna Katrina Jógvansdóttir Gradel, Jonas Kildegaard, Trine Porsgaard, Jens Lykkesfeldt & Hanne Hoffman Frølund Refsgaard. (2021) Food intake rather than blood glucose levels affects the pharmacokinetic profile of insulin aspart in pigs. Basic & Clinical Pharmacology & Toxicology 128:6, pages 783-794.
Crossref
Edoardo Faggionato, Michele Schiavon & Chiara Dalla Man. (2021) Modeling Between-Subject Variability in Subcutaneous Absorption of a Fast-Acting Insulin Analogue by a Nonlinear Mixed Effects Approach. Metabolites 11:4, pages 235.
Crossref
Jason P. Pitt, Olivia M. McCarthy, Thomas Hoeg-Jensen, Benjamin M. Wellman & Richard M. Bracken. (2020) Factors Influencing Insulin Absorption Around Exercise in Type 1 Diabetes. Frontiers in Endocrinology 11.
Crossref
Spencer Frank, Abdulrahman Jbaily, Ling Hinshaw, Rita Basu, Ananda Basu & Andrew J. Szeri. (2018) Modeling the acute effects of exercise on insulin kinetics in type 1 diabetes. Journal of Pharmacokinetics and Pharmacodynamics 45:6, pages 829-845.
Crossref
A. K. J. Gradel, T. Porsgaard, J. Lykkesfeldt, T. Seested, S. Gram-Nielsen, N. R. Kristensen & H. H. F. Refsgaard. (2018) Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability. Journal of Diabetes Research 2018, pages 1-17.
Crossref
Maria Thomsen, Christian Hove Rasmussen, Hanne H.F. Refsgaard, Karen-Margrethe Pedersen, Rikke K. Kirk, Mette Poulsen & Robert Feidenhans'l. (2015) Spatial distribution of soluble insulin in pig subcutaneous tissue: Effect of needle length, injection speed and injected volume. European Journal of Pharmaceutical Sciences 79, pages 96-101.
Crossref
Christian Hove Rasmussen, Rikke Meldgaard Røge, Zhulin Ma, Maria Thomsen, Rannveig Linda Thorisdottir, Jian-Wen Chen, Erik Mosekilde & Morten Colding-Jørgensen. (2014) Insulin aspart pharmacokinetics: An assessment of its variability and underlying mechanisms. European Journal of Pharmaceutical Sciences 62, pages 65-75.
Crossref
Sabrine S. Jensen, Henrik Jensen, Claus Cornett, Eva H. Møller & Jesper Østergaard. (2014) Insulin diffusion and self-association characterized by real-time UV imaging and Taylor dispersion analysis. Journal of Pharmaceutical and Biomedical Analysis 92, pages 203-210.
Crossref
Tue Søeborg, Christian Hove Rasmussen, Erik Mosekilde & Morten Colding-Jørgensen. (2012) Bioavailability and variability of biphasic insulin mixtures. European Journal of Pharmaceutical Sciences 46:4, pages 198-208.
Crossref
Christian Hove Rasmussen, Tue Søeborg, Erik Mosekilde & Morten Colding-Jørgensen. 2012. Biosimulation in Biomedical Research, Health Care and Drug Development. Biosimulation in Biomedical Research, Health Care and Drug Development 329 359 .
Luigi Meneghini, Andreas Liebl & Martin J. Abrahamson. (2010) Insulin detemir: A historical perspective on a modern basal insulin analogue. Primary Care Diabetes 4, pages S31-S42.
Crossref
Trine Schnedler ClausenPeter KaastrupBente Stallknecht. (2009) Effect of Insulin Catheter Wear-Time on Subcutaneous Adipose Tissue Blood Flow and Insulin Absorption in Humans. Diabetes Technology & Therapeutics 11:9, pages 575-580.
Crossref
Lise HøjbjerreCamilla Skov-JensenPeter KaastrupPer Elgård PedersenBente Stallknecht. (2009) Effect of Steel and Teflon Infusion Catheters on Subcutaneous Adipose Tissue Blood Flow and Infusion Counter Pressure in Humans. Diabetes Technology & Therapeutics 11:5, pages 301-306.
Crossref
Tue Søeborg, Christian Hove Rasmussen, Erik Mosekilde & Morten Colding-Jørgensen. (2009) Absorption kinetics of insulin after subcutaneous administration. European Journal of Pharmaceutical Sciences 36:1, pages 78-90.
Crossref
C. L. Stabler, C. Fraker, E. Pedraza, I. Constantinidis & A. Sambanis. (2008) Modeling and in vitro and in vivo characterization of a tissue engineered pancreatic substitute. Journal of Combinatorial Optimization 17:1, pages 54-73.
Crossref
Reinhard H.A. Becker. (2007) Insulin Glulisine Complementing Basal Insulins: A Review of Structure and Activity. Diabetes Technology & Therapeutics 9:1, pages 109-121.
Crossref
Ivana Zib & Philip Raskin. (2006) Novel insulin analogues and its mitogenic potential. Diabetes, Obesity and Metabolism 8:6, pages 611-620.
Crossref
P. Kurtzhals. (2005) How to achieve a predictable basal insulin?. Diabetes & Metabolism 31:4, pages 4S25-4S33.
Crossref
M.E. Wilinska, L.J. Chassin, H.C. Schaller, L. Schaupp, T.R. Pieber & R. Hovorka. (2005) Insulin Kinetics in Type-1 Diabetes: Continuous and Bolus Delivery of Rapid Acting Insulin. IEEE Transactions on Biomedical Engineering 52:1, pages 3-12.
Crossref
P Kurtzhals. (2004) Engineering predictability and protraction in a basal insulin analogue: the pharmacology of insulin detemir. International Journal of Obesity 28:S2, pages S23-S28.
Crossref
Irini Rakatzi, Stefanie Ramrath, Daniela Ledwig, Olaf Dransfeld, Thomas Bartels, Gerhard Seipke & Jürgen Eckel. (2003) A Novel Insulin Analog With Unique Properties. Diabetes 52:9, pages 2227-2238.
Crossref
Jian-Wen Chen, Jens Sandahl Christiansen & Torsten Lauritzen. (2003) Limitations to subcutaneous insulin administration in type 1 diabetes. Diabetes, Obesity and Metabolism 5:4, pages 223-233.
Crossref
Anders Lindholm. (2002) New insulins in the treatment of diabetes mellitus. Best Practice & Research Clinical Gastroenterology 16:3, pages 475-492.
Crossref
Sunil Prabhu, Arthur I Jacknowitz & Paula Jo Stout. (2001) A study of factors controlling dissolution kinetics of zinc complexed protein suspensions in various ionic species. International Journal of Pharmaceutics 217:1-2, pages 71-78.
Crossref
Christopher J.H. Porter & Susan A. Charman. (2000) Lymphatic Transport of Proteins After Subcutaneous Administration. Journal of Pharmaceutical Sciences 89:3, pages 297-310.
Crossref
Lawrence J. Slieker, Gerald S. Brooke, Ronald E. Chance, Li Fan, James A. Hoffmann, Daniel C. Howey, Harlan B. Long, John Mayer, James E. Shields, Karen L. Sundell & Richard D. DiMarchi. 1993. Current Directions in Insulin-Like Growth Factor Research. Current Directions in Insulin-Like Growth Factor Research 25 32 .
J.P. Vora, A. Burch, J.R. Peters & D.R. Owens. (1993) Absorption of Radiolabeled Soluble Insulin in Type 1 (Insulin-dependent) Diabetes: Influence of Subcutaneous Blood Flow and Anthropometry. Diabetic Medicine 10:8, pages 736-743.
Crossref
Marina Scavini, Angela I. Pincelli, Carla Cruciani, Beatrice Giberti, Emanuela Orsi, Gabriella Galimberti, Giovanna Petrella, Marco Cristallo, Guido Pozza & Piero Micossi. (1993) Influence of meal ingestion on insulin profiles following intraperitoneal delivery. Metabolism 42:8, pages 1013-1016.
Crossref
Kirsten Drejer. (1992) The bioactivity of insulin analogues from in vitro receptor binding to in vivo glucose uptake. Diabetes / Metabolism Reviews 8:3, pages 259-285.
Crossref
A. Michael Albisser & Marianne Sperlich. (2016) Adjusting Insulins. The Diabetes Educator 18:3, pages 211-219.
Crossref
Heinz Hartmann, Emanuel Moesus & Werner Creutzfeldt. (1992) Comparison of subcutaneously administered soluble insulin and des-(B26–B30)-insulin-B25-amide in rabbit, pig and healthy man. Diabetes Research and Clinical Practice 16:3, pages 175-181.
Crossref
D.A. Robertson, B. M. Singh, P. J. Hale, I. Jensen & M. Nattrass. (2009) Metabolic Effects of Monomeric Insulin Analogues of Different Receptor Affinity. Diabetic Medicine 9:3, pages 240-246.
Crossref
P.M. Greenhalgh, J.R. Jones, C.A. Jackson, C.C.T. Smith & J.S. Yudkin. (2009) Changes in Injection‐site Blood Flow and Plasma Free Insulin Concentrations in Response to Stress in Type 1 Diabetic Patients. Diabetic Medicine 9:1, pages 20-29.
Crossref
Dating Liu, Erik Moberg, Regina Wredling, Per-Eric Lins & Ulf Adamson. (1991) Insulin absorption is faster when keeping the infusion site in use for three days during continuous subcutaneous insulin infusion. Diabetes Research and Clinical Practice 12:1, pages 19-24.
Crossref
S.M. Furler & E.W. Kraegen. (1989) Quantitative Aspects of Subcutaneous Insulin Absorption. Diabetic Medicine 6:8, pages 657-665.
Crossref
PH Meijer, FG Russel, HJ Lier & CA Ginneken. (1989) A comparison of three mathematical models to describe the disappearance curves of subcutaneously injected 125I-labelled insulin.. British Journal of Clinical Pharmacology 27:4, pages 461-467.
Crossref
Erik Mosekilde, Klaus Skovbo Jensen, Christian Binder, Stig Pramming & Birger Thorsteinsson. (1989) Modeling absorption kinetics of subcutaneous injected soluble insulin. Journal of Pharmacokinetics and Biopharmaceutics 17:1, pages 67-87.
Crossref
J. P. Vora, D. R. Owens, J. Dolben, J. A. Atiea, J. D. Dean, S. Kang, A. Burch & J. Brange. (1988) Recombinant DNA derived monomeric insulin analogue: comparison with soluble human insulin in normal subjects.. BMJ 297:6658, pages 1236-1239.
Crossref
F. H. Ziel, M. B. Davidson, M. D. Harris & C. S. Rosenberg. (2009) The Variability in the Action of Unmodified Insulin is More Dependent on Changes in Tissue Insulin Sensitivity than on Insulin Absorption. Diabetic Medicine 5:7, pages 662-666.
Crossref
P. Hildebrandt & K. Birch. (1988) Basal Rate Subcutaneous Insulin Infusion: Absorption Kinetics and Relation to Local Blood Flow. Diabetic Medicine 5:5, pages 434-440.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.