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Original Article

Binding of alpha-2-macroglobulin trypsin complex to human monocytes in culture

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Pages 55-61 | Received 17 Apr 1986, Accepted 19 Aug 1986, Published online: 17 Mar 2010

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Poul Henning Jensen, Ole Davidsen, Jørgen Gliemann & Claus Munck Petersen. (1988) Cell association and degradation of pregnancy zone protein-chymotrypsin complex in cultured human monocytes. Scandinavian Journal of Clinical and Laboratory Investigation 48:2, pages 165-176.
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Articles from other publishers (30)

Jennifer Vandooren & Yoshifumi Itoh. (2021) Alpha-2-Macroglobulin in Inflammation, Immunity and Infections. Frontiers in Immunology 12.
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Justin P. Hart, Michael D. Gunn & Salvatore V. Pizzo. (2004) A CD91-Positive Subset of CD11c+ Blood Dendritic Cells: Characterization of the APC that Functions to Enhance Adaptive Immune Responses against CD91-Targeted Antigens. The Journal of Immunology 172:1, pages 70-78.
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Anna Kurdowska, Susanne M Alden, James M Noble, Michael D Stevens & Ferdicia K Carr. (2000) INVOLVEMENT OF α-2-MACROGLOBULIN RECEPTOR IN CLEARANCE OF INTERLEUKIN 8–α-2-MACROGLOBULIN COMPLEXES BY HUMAN ALVEOLAR MACROPHAGES. Cytokine 12:7, pages 1046-1053.
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Hiroshi Kobayashi, Kiyoshi Shibata, Michio Fujie & Toshihiko Terao. (1998) Urinary trypsin inhibitor reduces the release of histamine from rat peritoneal mast cells. Journal of Laboratory and Clinical Medicine 131:4, pages 375-385.
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Yonghe Li, Nick Wood, David Yellowlees & Peter Donnelly. (1997) Expression of α2Macroglobulin Receptor/Low Density Lipoprotein Receptor-Related Protein Is Cell Culture Density-Dependent in Human Breast Cancer Cell Line BT-20. Biochemical and Biophysical Research Communications 240:1, pages 122-127.
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Yonghe Li, Nick Wood, Peter G. Parsons, David Yellowlees & Peter K. Donnelly. (1997) Expression of α2-macroglobulin receptor/low density lipoprotein receptor-related protein on surfaces of tumour ceils: a study using flow cytometry. Cancer Letters 111:1-2, pages 199-205.
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P. STORGAARD, E. HOLM NIELSEN, E. SKRIVER, O. ANDERSEN & S.‐E. SVEHAG. (2006) Mannan‐Binding Protein Forms Complexes with α‐2‐Macroglobulin. A Proposed Model for the Interaction. Scandinavian Journal of Immunology 42:3, pages 373-380.
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Ugo Cavallaro, Anders Nykjaer, Morten Nielsen & Marco R. Soria. (2005) α 2 ‐Macroglobulin Receptor Mediates Binding and Cytotoxicity of Plant Ribosome‐Inactivating Proteins . European Journal of Biochemistry 232:1, pages 165-171.
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Massimo Conese, Ugo Cavallaro, Nicolai Sidenius, David Olson, Marco R. Soria & Francesco Blasi. (2000) PMA‐induced down‐regulation of the receptor for α2‐macroglobulin in human U937 cells. FEBS Letters 358:1, pages 73-78.
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Søren Kragh Moestrup. (1994) The receptor and epithelial glycoprotein-330: two giant receptors mediating endocytosis of multiple ligands. Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes 1197:2, pages 197-213.
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Michael Larvin, David J. Alexander, Stanislaus F. Switala & Michael J. McMahon. (1993) Impaired mononuclear phagocyte function in patients with severe acute pancreatitis: Evidence from studies of plasma clearance of trypsin and monocyte phagocytosis. Digestive Diseases and Sciences 38:1, pages 18-27.
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S�ren K. Moestrup, J�rgen Gliemann & Gorm Pallesen. (1992) Distribution of the ?2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. Cell & Tissue Research 269:3, pages 375-382.
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A Nykjaer, C.M. Petersen, B Møller, P.H. Jensen, S.K. Moestrup, T.L. Holtet, M Etzerodt, H.C. Thøgersen, M Munch & P.A. Andreasen. (1992) Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.. Journal of Biological Chemistry 267:21, pages 14543-14546.
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Sanne Fisker, Kirsten Kudahl & Ole Sonne. (1992) In vivo inflammatory stimulation induces a transient change in the binding of thrombin to rat peritoneal macrophages. Experimental Cell Research 201:1, pages 145-153.
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Søren Kragh Moestrup & Peter Hokland. (1992) Surface expression of the α2-macroglobulin receptor on human malignant blood cells. Leukemia Research 16:3, pages 227-234.
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P. D. Sibraa, R. A. Reinhardt, J. K. Dyer & L. M. DuBois. (2005) Acute‐phase protein detection and quantification in gingival crevicular fluid by direct and indirect immunodot. Journal of Clinical Periodontology 18:2, pages 101-106.
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Sanne Fisker, Kirsten Kudahl & Ole Sonne. (1990) Isolation of rat peritoneal mononuclear and polymorphonuclear leucocytes on discontinuous gradients of Nycodenz. Journal of Immunological Methods 133:1, pages 31-38.
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Søren Kragh Moestrup, Keld Kaltoft, Claus Munck Petersen, Søren Pedersen, Jørgen Gliemann & Erik Ilsø Christensen. (1990) Immunocytochemical identification of the human α2-macrogiobulin receptor in monocytes and fibroblasts: Monoclonal antibodies define the receptor as a monocyte differentiation antigen. Experimental Cell Research 190:2, pages 195-203.
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C. MUNCK PETERSEN, O. DAVIDSEN, S. K. MOESTRUP, O. SONNE, A. NYKJÆR & B. K. MØLLER. (2008) Cellular targets and receptors for interleukin‐6 II. Characterization of IL‐6 binding and receptors in peripheral blood cells and macrophages. European Journal of Clinical Investigation 20:4, pages 377-384.
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S K Moestrup, K Kaltoft, L Sottrup-Jensen & J Gliemann. (1990) The human alpha 2-macroglobulin receptor contains high affinity calcium binding sites important for receptor conformation and ligand recognition.. Journal of Biological Chemistry 265:21, pages 12623-12628.
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Anders Nykjær, Claus Munck Petersen, Erik Ilsø Christensen, Ole Davidsen & Jørgen Gliemann. (1990) Urokinase receptors in human monocytes. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1052:3, pages 399-407.
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C.Munck Petersen & S.K Moestrup. (1990) Interactions between cytokines and α2 macroglobulin. Immunology Today 11, pages 430-431.
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V. Gross, J. Sch�lmerich, H. -G. Leser, R. Salm, M. Lausen, K. R�ckauer, U. Sch�ffel, L. Lay, A. Heinisch, E. H. Farthmann & W. Gerok. (1990) Granulocyte elastase in assessment of severity of acute pancreatitis. Digestive Diseases and Sciences 35:1, pages 97-105.
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Claus Munck Petersen, Anders Nykjær, Brian S. Christiansen, Lene Heickendorff, SøRen C. Mogensen & Bjarne Møller. (2005) Bioactive human recombinant tumor necrosis factor‐α: an unstable dimer?. European Journal of Immunology 19:10, pages 1887-1894.
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W. Poller, J. Barth & B. Voss. (1989) Detection of an alteration of the ?2 gene in a patient with chronic lung disease and serum ?2 deficiency. Human Genetics 83:1, pages 93-96.
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Pertti Mörsky. (1988) Detection of lysozyme and alpha2-macroglobulin—lysozyme complexes by immunoblotting. Clinica Chimica Acta 178:3, pages 327-336.
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C. MUNCK PETERSEN, B. S. CHRISTIANSEN, L. HEICKENDORFF & J. INGERSLEV. (2008) Synthesis and secretion of α 2 ‐macroglobulin by human hepatocytes in culture . European Journal of Clinical Investigation 18:5, pages 543-548.
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Poul Henning Jensen, Søren K. Moestrup, Lars Sottrup-Jensen, Claus M. Petersen & Jørgen Gliemann. (1988) Receptors for α2-Macroglobulin- and pregnancy zone protein-proteinase complexes in the human placental syncytiotrophoblast. Placenta 9:5, pages 463-477.
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C. MUNCK PETERSEN, B. S. CHRISTIANSEN, P. H. JENSEN, S. K. MOESTRUP, J. GLIEMANN, L. SOTTRUP‐JENSEN & J. INGERSLEV. (2012) Human hepatocytes exhibit receptors for α 2 ‐macroglobulin and pregnancy zone protein‐proteinase complexes . European Journal of Clinical Investigation 18:2, pages 184-190.
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C. M. Petersen, B. S. Christiansen & K. Kaltoft. (2008) Binding, uptake and degradation of human recombinant interleukin‐2 (125 ala) in activated human T‐ and B‐lymphocytes and in monocyte‐macrophages. Tissue Antigens 29:5, pages 257-272.
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