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Scandinavian Journal of Clinical and Laboratory Investigation Volume 56, 1996 - Issue sup226
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Original Article

Androgen receptor gene amplification: A novel molecular mechanism for endocrine therapy resistance in human prostate cancer

Pasi Koivisto Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere, Tampere, Finland; Department of Clinical Chemistry, Tampere University Hospital, Tampere, Finland
,
Tapio Visakorpi Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere, Tampere, Finland; Department of Clinical Chemistry, Tampere University Hospital, Tampere, Finland
&
Olli-P. Kallioniemi Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere, Tampere, Finland; Department of Clinical Chemistry, Tampere University Hospital, Tampere, Finland; National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland, USA
Pages 57-63 | Published online: 17 Mar 2010

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Liang-Nian Song, Roger Herrell, Stephen Byers, Salimuddin Shah, Elizabeth M. Wilson & Edward P. Gelmann. (2003) β-Catenin Binds to the Activation Function 2 Region of the Androgen Receptor and Modulates the Effects of the N-Terminal Domain and TIF2 on Ligand-Dependent Transcription. Molecular and Cellular Biology 23:5, pages 1674-1687.
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Articles from other publishers (38)

Dannielle E. O’Malley, Kelsie Raspin, Phillip E. Melton, Kathryn P. Burdon, Joanne L. Dickinson & Liesel M. FitzGerald. (2023) Acquired copy number variation in prostate tumours: a review of common somatic copy number alterations, how they are formed and their clinical utility. British Journal of Cancer 130:3, pages 347-357.
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Christos E. Kyriakopoulos, Elisabeth I. Heath, Anna Ferrari, Jamie M. Sperger, Anupama Singh, Scott B. Perlman, Alison R. Roth, Timothy G. Perk, Katharina Modelska, Anthony Porcari, William Duggan, Joshua M. Lang, Robert Jeraj & Glenn Liu. (2020) Exploring Spatial-Temporal Changes in 18 F-Sodium Fluoride PET/CT and Circulating Tumor Cells in Metastatic Castration-Resistant Prostate Cancer Treated With Enzalutamide . Journal of Clinical Oncology 38:31, pages 3662-3671.
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Fangyao Chen, Hui Zhou, Chenqiuzi Wu & Hong Yan. (2018) Identification of miRNA profiling in prediction of tumor recurrence and progress and bioinformatics analysis for patients with primary esophageal cancer: Study based on TCGA database. Pathology - Research and Practice 214:12, pages 2081-2086.
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Yasuomi Shimizu, Satoshi Tamada, Minoru Kato, Yukiyoshi Hirayama, Yuji Takeyama, Taro Iguchi, Marianne Sadar & Tatsuya Nakatani. (2018) Androgen Receptor Splice Variant 7 Drives the Growth of Castration Resistant Prostate Cancer without Being Involved in the Efficacy of Taxane Chemotherapy. Journal of Clinical Medicine 7:11, pages 444.
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Xuehai Pang, Lingling Peng & Yuanwei Chen. (2017) Effect of N ‐methyl deuteration on pharmacokinetics and pharmacodynamics of enzalutamide . Journal of Labelled Compounds and Radiopharmaceuticals 60:9, pages 401-409.
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Xuehai Pang, Yingwei Wang & Yuanwei Chen. (2017) Design, synthesis, and biological evaluation of deuterated apalutamide with improved pharmacokinetic profiles. Bioorganic & Medicinal Chemistry Letters 27:12, pages 2803-2806.
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Minoru Kato, Carmen A. Banuelos, Yusuke Imamura, Jacky K. Leung, Daniel P. Caley, Jun Wang, Nasrin R. Mawji & Marianne D. Sadar. (2016) Cotargeting Androgen Receptor Splice Variants and mTOR Signaling Pathway for the Treatment of Castration-Resistant Prostate Cancer. Clinical Cancer Research 22:11, pages 2744-2754.
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Samra TurajlicCharles Swanton. (2016) Metastasis as an evolutionary process. Science 352:6282, pages 169-175.
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Frederik Holst. (2016) Estrogen receptor alpha gene amplification in breast cancer: 25 years of debate. World Journal of Clinical Oncology 7:2, pages 160.
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Joseph M Foster, Assa Oumie, Fiona S Togneri, Fabiana Ramos Vasques, Debra Hau, Morag Taylor, Emma Tinkler-Hundal, Katie Southward, Paul Medlow, Keith McGreeghan-Crosby, Iris Halfpenny, Dominic J McMullan, Phil Quirke, Katherine E Keating, Mike Griffiths, Karen G Spink & Fiona Brew. (2015) Cross-laboratory validation of the OncoScan® FFPE Assay, a multiplex tool for whole genome tumour profiling. BMC Medical Genomics 8:1.
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Wilhelm Engström, Philippa Darbre, Staffan Eriksson, Linda Gulliver, Tove Hultman, Michalis V. Karamouzis, James E. Klaunig, Rekha Mehta, Kim Moorwood, Thomas Sanderson, Hideko Sone, Pankaj Vadgama, Gerard Wagemaker, Andrew Ward, Neetu Singh, Fahd Al-Mulla, Rabeah Al-Temaimi, Amedeo Amedei, Anna Maria Colacci, Monica Vaccari, Chiara Mondello, A.Ivana Scovassi, Jayadev Raju, Roslida A. Hamid, Lorenzo Memeo, Stefano Forte, Rabindra Roy, Jordan Woodrick, Hosni K. Salem, Elizabeth Ryan, Dustin G. Brown & William H. Bisson. (2015) The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling. Carcinogenesis 36:Suppl 1, pages S38-S60.
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Akash K. Kaushik, Shaiju K. Vareed, Sumanta Basu, Vasanta Putluri, Nagireddy Putluri, Katrin Panzitt, Christine A. Brennan, Arul M. Chinnaiyan, Ismael A. Vergara, Nicholas Erho, Nancy L. Weigel, Nicholas Mitsiades, Ali Shojaie, Ganesh Palapattu, George Michailidis & Arun Sreekumar. (2013) Metabolomic Profiling Identifies Biochemical Pathways Associated with Castration-Resistant Prostate Cancer. Journal of Proteome Research 13:2, pages 1088-1100.
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Sarah A. Loddick, Sarah J. Ross, Andrew G. Thomason, David M. Robinson, Graeme E. Walker, Tom P.J. Dunkley, Sandra R. Brave, Nicola Broadbent, Natalie C. Stratton, Dawn Trueman, Elizabeth Mouchet, Fadhel S. Shaheen, Vivien N. Jacobs, Marie Cumberbatch, Joanne Wilson, Rhys D.O. Jones, Robert H. Bradbury, Alfred Rabow, Luke Gaughan, Chris Womack, Simon T. Barry, Craig N. Robson, Susan E. Critchlow, Stephen R. Wedge & A. Nigel Brooks. (2013) AZD3514: A Small Molecule That Modulates Androgen Receptor Signaling and Function In Vitro and In Vivo . Molecular Cancer Therapeutics 12:9, pages 1715-1727.
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Kai-Xin Zhang, Jessica Firus, Brenda Prieur, William Jia & Paul S. Rennie. (2011) To Die or to Survive, a Fatal Question for the Destiny of Prostate Cancer Cells after Androgen Deprivation Therapy. Cancers 3:2, pages 1498-1512.
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Yanzhong Yang, Weiying Zou, Xiangfei Kong, Hanzhou Wang, Hongliang Zong, Jianhai Jiang, Yanlin Wang, Yi Hong, Yayun Chi, Jianhui Xie & Jianxin Gu. (2010) Trihydrophobin 1 attenuates androgen signal transduction through promoting androgen receptor degradation. Journal of Cellular Biochemistry 109:5, pages 1013-1024.
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Edward P. Gelmann. 2010. Drug Management of Prostate Cancer. Drug Management of Prostate Cancer 61 70 .
Michael J. Morris, Daisy Huang, William K. Kelly, Susan F. Slovin, Ryan D. Stephenson, Caitlin Eicher, Anthony Delacruz, Tracy Curley, Lawrence H. Schwartz & Howard I. Scher. (2009) Phase 1 Trial of High-Dose Exogenous Testosterone in Patients with Castration-Resistant Metastatic Prostate Cancer. European Urology 56:2, pages 237-244.
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Sarah A. Holstein & Raymond J. Hohl. 2009. Pharmacology and Therapeutics. Pharmacology and Therapeutics 951 957 .
Jian Yang, Shuo Wei, Da-Sheng Wang, Yu-Chieh Wang, Samuel K. Kulp & Ching-Shih Chen. (2008) Pharmacological Exploitation of the Peroxisome Proliferator-Activated Receptor γ Agonist Ciglitazone To Develop a Novel Class of Androgen Receptor-Ablative Agents. Journal of Medicinal Chemistry 51:7, pages 2100-2107.
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Thomas Nelius, Stephanie Filleur, Alexander Yemelyanov, Irina Budunova, E. Shroff, Yelena Mirochnik, Arin Aurora, Dorina Veliceasa, Wuhan Xiao, Zhou Wang & Olga V. Volpert. (2007) Androgen receptor targets NFκB and TSP1 to suppress prostate tumor growth in vivo . International Journal of Cancer 121:5, pages 999-1008.
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Chih-Cheng Yang, Yu-Chieh Wang, Shuo Wei, Li-Fang Lin, Chang-Shi Chen, Cheng-Chun Lee, Cheng-Chieh Lin & Ching-Shih Chen. (2007) Peroxisome Proliferator-Activated Receptor γ–Independent Suppression of Androgen Receptor Expression by Troglitazone Mechanism and Pharmacologic Exploitation. Cancer Research 67:7, pages 3229-3238.
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Randi L. Shand & Edward P. Gelmann. (2006) Molecular biology of prostate-cancer pathogenesis. Current Opinion in Urology 16:3, pages 123-131.
Crossref
Tomasz Jaworski. (2006) Degradation and beyond: Control of androgen receptor activity by the proteasome system. Cellular and Molecular Biology Letters 11:1.
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Howard I. Scher & Charles L. Sawyers. (2005) Biology of Progressive, Castration-Resistant Prostate Cancer: Directed Therapies Targeting the Androgen-Receptor Signaling Axis. Journal of Clinical Oncology 23:32, pages 8253-8261.
Crossref
Hui Wang, Kyung Song, Tracy L. Sponseller & David Danielpour. (2005) Novel Function of Androgen Receptor-associated Protein 55/Hic-5 as a Negative Regulator of Smad3 Signaling. Journal of Biological Chemistry 280:7, pages 5154-5162.
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Evan T. Keller. (2004) Metastasis suppressor genes: a role for raf kinase inhibitor protein (RKIP). Anti-Cancer Drugs 15:7, pages 663-669.
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Koh-ichi Nakashiro, Shingo Hara, Yuji Shinohara, Miho Oyasu, Hitoshi Kawamata, Satoru Shintani, Hiroyuki Hamakawa & Ryoichi Oyasu. (2004) Phenotypic Switch from Paracrine to Autocrine Role of Hepatocyte Growth Factor in an Androgen-Independent Human Prostatic Carcinoma Cell Line, CWR22R. The American Journal of Pathology 165:2, pages 533-540.
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Rile Li, Thomas Wheeler, Hong Dai, Anna Frolov, Timothy Thompson & Gustavo Ayala. (2004) High Level of Androgen Receptor Is Associated With Aggressive Clinicopathologic Features and Decreased Biochemical Recurrence-free Survival in Prostate. The American Journal of Surgical Pathology 28:7, pages 928-934.
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Michael J. Morris, Neeta Pandit-Taskar, Chaitanya Divgi, Steven Larson & Howard I. Scher. (2004) Targeting osseous metastases: Rationale and development of radioimmunotherapy for prostate cancer. Current Oncology Reports 6:3, pages 222-229.
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Joanna Nightingale, Khurram S. Chaudhary, Paul D. Abel, Andrew P. Stubbs, Hanna M. Romanska, Stephen E. Mitchell, Gordon W.H. Stamp & El-Nasir Lalani. (2003) Ligand Activation of the Androgen Receptor Downregulates E-Cadherin-Mediated Cell Adhesion and Promotes Apoptosis of Prostatic Cancer Cells. Neoplasia 5:4, pages 347-361.
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Edward P. Gelmann. (2002) Molecular Biology of the Androgen Receptor. Journal of Clinical Oncology 20:13, pages 3001-3015.
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James N. Welch & Susan A. Chrysogelos. 2002. The Molecular Basis of Human Cancer. The Molecular Basis of Human Cancer 65 79 .
Grant Buchanan, Ryan A. Irvine, Gerhard A. Coetzee & Wayne D. Tilley. 2002. Prostate Cancer: New Horizons in Research and Treatment. Prostate Cancer: New Horizons in Research and Treatment 71 87 .
Gordon R. Macpherson, Sylvia S. W. Ng, Nehal J. Lakhani, Douglas K. Price, Jurgen Venitz & William D. Figg. 2002. Prostate Cancer: New Horizons in Research and Treatment. Prostate Cancer: New Horizons in Research and Treatment 317 330 .
Samir S. Taneja, Susan Ha & Michael J. Garabedian. (2001) Androgen stimulated cellular proliferation in the human prostate cancer cell line LNCaP is associated with reduced retinoblastoma protein expression. Journal of Cellular Biochemistry 84:1, pages 188-200.
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Jeffrey S. Montgomery, Douglas K. Price & William D. Figg. (2001) The androgen receptor gene and its influence on the development and progression of prostate cancer. The Journal of Pathology 195:2, pages 138-146.
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Shogo Iwasaki, Koji Kato, Toshio Mori, Satoru Takahashi, Mitsuru Futakuchi & Tomoyuki Shirai. (2005) Development of Androgen‐independent Carcinomas from Androgen‐dependent Preneoplastic Lesions in the Male Accessory Sex Organs of Rats Treated with 3,2′‐Dimethyl‐4‐aminobiphenyl and Testosterone Propionate. Japanese Journal of Cancer Research 90:1, pages 23-30.
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Charmian A. Quigley. 1998. Testosterone. Testosterone 33 106 .

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