118
Views
52
CrossRef citations to date
0
Altmetric
Original Article

Mathematical tools for demonstrating the clinical usefulness of biochemical markers

Pages 46-63 | Published online: 17 Mar 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Robert H. Christenson & Show-Hong Duh. (1999) Evidence based approach to practice guides and decision thresholds for cardiac markers. Scandinavian Journal of Clinical and Laboratory Investigation 59:sup230, pages 90-102.
Read now
L U Gerdes, P E Jørgenseny, E Nexø & P Wang. (1998) C-reactive protein and bacterial meningitis: a meta-analysis. Scandinavian Journal of Clinical and Laboratory Investigation 58:5, pages 383-394.
Read now

Articles from other publishers (49)

Vijay Jeyakumar, Prema Sundaram & Nithiya Ramapathiran. 2023. System Design for Epidemics Using Machine Learning and Deep Learning. System Design for Epidemics Using Machine Learning and Deep Learning 123 152 .
Maxim Sorokin, Marianna Zolotovskaia, Daniil Nikitin, Maria Suntsova, Elena Poddubskaya, Alexander Glusker, Andrew Garazha, Alexey Moisseev, Xinmin Li, Marina Sekacheva, David Naskhletashvili, Alexander Seryakov, Ye Wang & Anton Buzdin. (2022) Personalized targeted therapy prescription in colorectal cancer using algorithmic analysis of RNA sequencing data. BMC Cancer 22:1.
Crossref
М. Раевский, М. Сорокин, У. Владимирова, М. Сунцова, В. Ефимов, А. Гаража, А. Дробышев, А. Моисеев, П. Румянцев, З. Ли & А. Буздин. (2021) Основанные на молекулярном пути EGFR генные подписи клинически значимых мутаций при раке молочной железы, легких, щитовидной железы и при меланоме. Биохимия 86:11, pages 1719-1732.
Crossref
Mikhail Raevskiy, Maxim Sorokin, Uliana Vladimirova, Maria Suntsova, Victor Efimov, Andrew Garazha, Alexei Drobyshev, Aleksey Moisseev, Pavel Rumiantsev, Xinmin Li & Anton Buzdin. (2021) EGFR Pathway-Based Gene Signatures of Druggable Gene Mutations in Melanoma, Breast, Lung, and Thyroid Cancers. Biochemistry (Moscow) 86:11, pages 1477-1488.
Crossref
Maxim Sorokin, Alexander Gorelyshev, Victor Efimov, Evgenia Zotova, Marianna Zolotovskaia, Elizaveta Rabushko, Denis Kuzmin, Alexander Seryakov, Dmitry Kamashev, Xinmin Li, Elena Poddubskaya, Maria Suntsova & Anton Buzdin. (2021) RNA Sequencing Data for FFPE Tumor Blocks Can Be Used for Robust Estimation of Tumor Mutation Burden in Individual Biosamples. Frontiers in Oncology 11.
Crossref
Marianna Zolotovskaia, Victor Tkachev, Maxim Sorokin, Andrew Garazha, Ella Kim, Sven Rainer Kantelhardt, Sven-Ernö Bikar, Alja Zottel, Neja Šamec, Denis Kuzmin, Bettina Sprang, Alexey Moisseev, Alf Giese, Victor Efimov, Ivana Jovčevska & Anton Buzdin. (2021) Algorithmically Deduced FREM2 Molecular Pathway Is a Potent Grade and Survival Biomarker of Human Gliomas. Cancers 13:16, pages 4117.
Crossref
Nicolas Borisov, Anna Sergeeva, Maria Suntsova, Mikhail Raevskiy, Nurshat Gaifullin, Larisa Mendeleeva, Alexander Gudkov, Maria Nareiko, Andrew Garazha, Victor Tkachev, Xinmin Li, Maxim Sorokin, Vadim Surin & Anton Buzdin. (2021) Machine Learning Applicability for Classification of PAD/VCD Chemotherapy Response Using 53 Multiple Myeloma RNA Sequencing Profiles. Frontiers in Oncology 11.
Crossref
Nicolas Borisov, Maxim Sorokin, Victor Tkachev, Andrew Garazha & Anton Buzdin. (2020) Cancer gene expression profiles associated with clinical outcomes to chemotherapy treatments. BMC Medical Genomics 13:S8.
Crossref
M. Sorokin, K. Ignatev, V. Barbara, U. Vladimirova, A. Muraveva, M. Suntsova, N. Gaifullin, I. Vorotnikov, D. Kamashev, A. Bondarenko, M. Baranova, E. Poddubskaya & A. Buzdin. (2020) Molecular Pathway Activation Markers Are Associated with Efficacy of Trastuzumab Therapy in Metastatic HER2-Positive Breast Cancer Better than Individual Gene Expression Levels. Biochemistry (Moscow) 85:7, pages 758-772.
Crossref
Maxim Sorokin, Kirill Ignatev, Elena Poddubskaya, Uliana Vladimirova, Nurshat Gaifullin, Dmitriy Lantsov, Andrew Garazha, Daria Allina, Maria Suntsova, Victoria Barbara & Anton Buzdin. (2020) RNA Sequencing in Comparison to Immunohistochemistry for Measuring Cancer Biomarkers in Breast Cancer and Lung Cancer Specimens. Biomedicines 8:5, pages 114.
Crossref
Maxim Sorokin, Elena Poddubskaya, Madina Baranova, Alex Glusker, Lali Kogoniya, Ekaterina Markarova, Daria Allina, Maria Suntsova, Victor Tkachev, Andrew Garazha, Marina Sekacheva & Anton Buzdin. (2020) RNA sequencing profiles and diagnostic signatures linked with response to ramucirumab in gastric cancer. Molecular Case Studies 6:2, pages a004945.
Crossref
Marianna Zolotovskaia, Maxim Sorokin, Andrew Garazha, Nikolay Borisov & Anton Buzdin. 2020. Nucleic Acid Detection and Structural Investigations. Nucleic Acid Detection and Structural Investigations 207 234 .
Marianna A. Zolotovskaia, Maxim I. Sorokin, Sergey A. Roumiantsev, Nikolay M. Borisov & Anton A. Buzdin. (2019) Pathway Instability Is an Effective New Mutation-Based Type of Cancer Biomarkers. Frontiers in Oncology 8.
Crossref
Anton Buzdin, Maxim Sorokin, Andrew Garazha, Marina Sekacheva, Ella Kim, Nikolay Zhukov, Ye Wang, Xinmin Li, Souvik Kar, Christian Hartmann, Amir Samii, Alf Giese & Nicolas Borisov. (2018) Molecular pathway activation – New type of biomarkers for tumor morphology and personalized selection of target drugs. Seminars in Cancer Biology 53, pages 110-124.
Crossref
Timothy W. Armistead. 2014. Wiley StatsRef: Statistics Reference Online. Wiley StatsRef: Statistics Reference Online 1 21 .
Ivan Petrov, Maria Suntsova, Elena Ilnitskaya, Sergey Roumiantsev, Maxim Sorokin, Andrew Garazha, Pavel Spirin, Timofey Lebedev, Nurshat Gaifullin, Sergey Larin, Olga Kovalchuk, Dmitry Konovalov, Vladimir Prassolov, Alexander Roumiantsev & Anton Buzdin. (2017) Gene expression and molecular pathway activation signatures of MYCN -amplified neuroblastomas . Oncotarget 8:48, pages 83768-83780.
Crossref
Ivana Jovčevska, Neja Zupanec, Žiga Urlep, Andrej Vranič, Boštjan Matos, Clara Limbaeck Stokin, Serge Muyldermans, Michael P. Myers, Anton A. Buzdin, Ivan Petrov & Radovan Komel. (2017) Differentially expressed proteins in glioblastoma multiforme identified with a nanobody-based anti-proteome approach and confirmed by OncoFinder as possible tumor-class predictive biomarker candidates. Oncotarget 8:27, pages 44141-44158.
Crossref
Sun Bean KimKyoung Hwa LeeJi Un LeeHea Won AnnJin Young AhnYong Duk JeonJung Ho KimNam Su KuSang Hoon HanJun Yong ChoiYoung Goo SongJune Myung Kim. (2017) Long Pentraxin 3 as a Predictive Marker of Mortality in Severe Septic Patients Who Received Successful Early Goal-Directed Therapy. Yonsei Medical Journal 58:2, pages 370.
Crossref
Anton A. Buzdin, Vladimir Prassolov, Alex A. Zhavoronkov & Nikolay M. Borisov. 2017. Biological Networks and Pathway Analysis. Biological Networks and Pathway Analysis 53 83 .
Ivan Petrov, Maria Suntsova, Olga Mutorova, Maxim Sorokin, Andrew Garazha, Elena Ilnitskaya, Pavel Spirin, Sergey Larin, Olga Kovalchuk, Vladimir Prassolov, Alex Zhavoronkov, Alexander Roumiantsev & Anton Buzdin. (2016) Molecular pathway activation features of pediatric acute myeloid leukemia (AML) and acute lymphoblast leukemia (ALL) cells. Aging 8:11, pages 2936-2947.
Crossref
Ellinor I. Peerschke, Christine Moung, Melissa S. Pessin & Peter Maslak. (2015) Evaluation of new automated hematopoietic progenitor cell analysis in the clinical management of peripheral blood stem cell collections. Transfusion 55:8, pages 2001-2009.
Crossref
Nikolay M. Borisov, Nadezhda V. Terekhanova, Alexander M. Aliper, Larisa S. Venkova, Philip Yu Smirnov, Sergey Roumiantsev, Mikhail B. Korzinkin, Alex A. Zhavoronkov & Anton A. Buzdin. (2014) Signaling pathways activation profiles make better markers of cancer than expression of individual genes. Oncotarget 5:20, pages 10198-10205.
Crossref
Ksenia Lezhnina, Olga Kovalchuk, Alexander A. Zhavoronkov, Mikhail B. Korzinkin, Anastasia A. Zabolotneva, Peter V. Shegay, Dmitry G. Sokov, Nurshat M. Gaifullin, Igor G. Rusakov, Alexander M. Aliper, Sergey A. Roumiantsev, Boris Y. Alekseev, Nikolay M. Borisov & Anton A. Buzdin. (2014) Novel robust biomarkers for human bladder cancer based on activation of intracellular signaling pathways. Oncotarget 5:19, pages 9022-9032.
Crossref
Raija Uusitalo-Seppälä, Reetta Huttunen, Janne Aittoniemi, Pertti Koskinen, Aila Leino, Tero Vahlberg & Esa M. Rintala. (2013) Pentraxin 3 (PTX3) Is Associated with Severe Sepsis and Fatal Disease in Emergency Room Patients with Suspected Infection: A Prospective Cohort Study. PLoS ONE 8:1, pages e53661.
Crossref
Mari Rehu, Susanna Ahonen & Kari Punnonen. (2011) The diagnostic accuracy of the percentage of hypochromic red blood cells (%HYPOm) and cellular hemoglobin in reticulocytes (CHr) in differentiating iron deficiency anemia and anemia of chronic diseases. Clinica Chimica Acta 412:19-20, pages 1809-1813.
Crossref
Reetta Huttunen, Taru Kuparinen, Juulia Jylhävä, Janne Aittoniemi, Risto Vuento, Heini Huhtala, Janne Laine, Jaana Syrjänen & Mikko Hurme. (2011) Fatal Outcome in Bacteremia is Characterized by High Plasma Cell Free DNA Concentration and Apoptotic DNA Fragmentation: A Prospective Cohort Study. PLoS ONE 6:7, pages e21700.
Crossref
Elise Frébet, Julie Abraham, Franck Geneviève, Pascale Lepelley, Sylvie Daliphard, Valérie Bardet, Sophie Amsellem, Julien Guy, Francois Mullier, Francoise Durrieu, Marie‐Dominique Venon, Xavier Leleu, Arnaud Jaccard, Jean‐Luc Faucher, Marie C. Béné & Jean Feuillard. (2010) A GEIL flow cytometry consensus proposal for quantification of plasma cells: Application to differential diagnosis between MGUS and myeloma. Cytometry Part B: Clinical Cytometry 80B:3, pages 176-185.
Crossref
Reetta Huttunen, Mikko Hurme, Janne Aittoniemi, Heini Huhtala, Risto Vuento, Janne Laine, Juulia Jylhävä & Jaana Syrjänen. (2011) High Plasma Level of Long Pentraxin 3 (PTX3) Is Associated with Fatal Disease in Bacteremic Patients: A Prospective Cohort Study. PLoS ONE 6:3, pages e17653.
Crossref
Josef S Ozer, Raj Chetty, Gerry Kenna, Nandan Koppiker, Pandher Karamjeet, Dingzhou Li, Joe Palandra, Anne Lanevschi, Bernard E Souberbielle & Shashi Ramaiah. (2010) Recommendations to qualify biomarker candidates of drug-induced liver injury. Biomarkers in Medicine 4:3, pages 475-483.
Crossref
Reetta Huttunen, Jaana Syrjänen, Janne Aittoniemi, Simo S. Oja, Annika Raitala, Janne Laine, Marja Pertovaara, Risto Vuento, Heini Huhtala & Mikko Hurme. (2010) HIGH ACTIVITY OF INDOLEAMINE 2,3 DIOXYGENASE ENZYME PREDICTS DISEASE SEVERITY AND CASE FATALITY IN BACTEREMIC PATIENTS. Shock 33:2, pages 149-154.
Crossref
Sini Lähteenmäki, Terhi Aalto-Setälä, Jaana T Suokas, Suoma E Saarni, Jonna Perälä, Samuli I Saarni, Hillevi Aro, Jouko Lönnqvist & Jaana M Suvisaari. (2009) Validation of the Finnish version of the SCOFF questionnaire among young adults aged 20 to 35 years. BMC Psychiatry 9:1.
Crossref
Toyomi Kamesaki, Takashi Oyamada, Mitsuhiro Omine, Keiya Ozawa & Eiji Kajii. (2008) Cut‐off value of red‐blood‐cell‐bound IgG for the diagnosis of Coombs‐negative autoimmune hemolytic anemia. American Journal of Hematology 84:2, pages 98-101.
Crossref
Mari Ervasti, Sanna Kotisaari, Seppo Heinonen & Kari Punnonen. (2007) Use of advanced red blood cell and reticulocyte indices improves the accuracy in diagnosing iron deficiency in pregnant women at term. European Journal of Haematology 79:6, pages 539-545.
Crossref
Jean‐Luc Faucher, Charlotte Lacronique‐Gazaille, Elise Frébet, Franck Trimoreau, Magali Donnard, Dominique Bordessoule, Francis Lacombe & Jean Feuillard. (2007) “6 markers/5 colors” extended white blood cell differential by flow cytometry. Cytometry Part A 71A:11, pages 934-944.
Crossref
José Antonio Roldán Nofuentes & Juan de Dios Luna del Castillo. (2007) Comparison of the likelihood ratios of two binary diagnostic tests in paired designs. Statistics in Medicine 26:22, pages 4179-4201.
Crossref
Rob N.M. Weijers, Dik J. Bekedam, Henk M.J. Goldschmidt & Yvo M. Smulders. (2006) The clinical usefulness of glucose tolerance testing in gestational diabetes to predict early postpartum diabetes mellitus. Clinical Chemistry and Laboratory Medicine (CCLM) 44:1.
Crossref
J. A. Roldán Nofuentes & J. D. Luna del Castillo. (2005) Comparing the Likelihood Ratios of Two Binary Diagnostic Tests in the Presence of Partial Verification. Biometrical Journal 47:4, pages 442-457.
Crossref
B. RavinaD. EidelbergJ. E. AhlskogR. L. AlbinD. J. BrooksM. CarbonV. DhawanA. FeiginS. FahnM. GuttmanK. Gwinn-HardyH. McFarlandR. InnisR. G. KatzK. KieburtzS. J. KishN. LangeJ. W. LangstonK. MarekL. MorinC. MoyD. MurphyW. H. OertelG. OliverY. PaleschW. PowersJ. SeibylK. D. SethiC. W. ShultsP. SheehyA. J. StoesslR. Holloway. (2005) The role of radiotracer imaging in Parkinson disease. Neurology 64:2, pages 208-215.
Crossref
E. Ulvestad. (2003) Modelling Autoimmune Rheumatic Disease: A Likelihood Rationale. Scandinavian Journal of Immunology 58:1, pages 106-111.
Crossref
Matthew J McQueen. (2001) Overview of Evidence-based Medicine: Challenges for Evidence-based Laboratory Medicine. Clinical Chemistry 47:8, pages 1536-1546.
Crossref
Julian Alexander, Toshiaki Watanabe, Tsung-Teh Wu, Asif Rashid, Shuan Li & Stanley R. Hamilton. (2001) Histopathological Identification of Colon Cancer with Microsatellite Instability. The American Journal of Pathology 158:2, pages 527-535.
Crossref
P. E. Keegan. (2001) A prospective pilot evaluation of urinary and immunohistochemical markers as predictors of clinical stage of urothelial carcinoma of the bladder. BJU International 86:9, pages 1096-1096.
Crossref
Bjørn J Bolann, Jan Dag Solli, Jörn Schneede, Kjell A Grøttum, Arne Loraas, Morgan Stokkeland, Asbjørn Stallemo, Arne Schjøth, Rolf Bruun Bie, Helga Refsum & Per Magne Ueland. (2000) Evaluation of Indicators of Cobalamin Deficiency Defined as Cobalamin-induced Reduction in Increased Serum Methylmalonic Acid. Clinical Chemistry 46:11, pages 1744-1750.
Crossref
Hassan M.E. Azzazy & Robert H. Christenson. 2007. Encyclopedia of Analytical Chemistry. Encyclopedia of Analytical Chemistry.
T. Krupski, C. Moskaluk, J.C. Boyd & D. Theodorescu. (2001) A prospective pilot evaluation of urinary and immunohistochemical markers as predictors of clinical stage of urothelial carcinoma of the bladder. BJU International 85:9, pages 1027-1032.
Crossref
Matthew J. McQueen. (2000) Evidence-Based Medicine: Its Application to Laboratory Medicine. Therapeutic Drug Monitoring 22:1, pages 1-9.
Crossref
David E Shapiro. (2016) The interpretation of diagnostic tests. Statistical Methods in Medical Research 8:2, pages 113-134.
Crossref
JUAN GABRIEL RUIZ-PELÁEZ & SALIM MATTAR. (1999) Accuracy of fecal lactoferrin and other stool tests for diagnosis of invasive diarrhea at a Colombian pediatric hospital. The Pediatric Infectious Disease Journal 18:4, pages 342-346.
Crossref
Robert H Christenson, Fred S Apple, David L Morgan, Gladys L Alonsozana, Kristin Mascotti, Marilyn Olson, Robert T McCormack, Frank H WiansJr.Jr., Joseph H Keffer & Show-Hong Duh. (1998) Cardiac troponin I measurement with the ACCESS® immunoassay system: analytical and clinical performance characteristics. Clinical Chemistry 44:1, pages 52-60.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.