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Research Article

Phospholipase A2 in serum and colonic mucosa in ulcerative colitis

Pages 279-287 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Reham M. El-Meligy, Amani S. Awaad, Gamal A. Soliman, Abir B. Bacha, Ahmed M. Alafeefy & Sanaa A. Kenawy. (2015) Prophylactic and curative anti-ulcerative colitis activity and the possible mechanisms of action of some desert plants. Journal of Enzyme Inhibition and Medicinal Chemistry 30:2, pages 250-258.
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Roberto Romero, Bo Hyun Yoon, Piya Chaemsaithong, Josef Cortez, Chan-Wook Park, Rogelio Gonzalez, Ernesto Behnke, Sonia S. Hassan, Francesca Gotsch, Lami Yeo & Tinnakorn Chaiworapongsa. (2014) Secreted phospholipase A2 is increased in meconium-stained amniotic fluid of term gestations: potential implications for the genesis of meconium aspiration syndrome. The Journal of Maternal-Fetal & Neonatal Medicine 27:10, pages 975-983.
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M. M. Haapamäki, J. Grönroos, H. Nurmi, K. Irjala, H. Peuravuori & T. J. Nevalainen. (2006) Value of blood tests including serum group IIA phospholipase A2 and bactericidal/permeability‐increasing protein in Crohn's disease. Scandinavian Journal of Clinical and Laboratory Investigation 66:7, pages 585-594.
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Articles from other publishers (29)

Chantalle Crous, Anél Petzer & Jacobus P. Petzer. (2024) Interactions of small molecule inhibitors with secreted phospholipase A 2 : A review of the structural data . Chemical Biology & Drug Design 103:2.
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Milica Markovic, Shimon Ben‐Shabat & Arik Dahan. 2022. Targeted Drug Delivery. Targeted Drug Delivery 169 192 .
Milica Markovic, Shimon Ben-Shabat, Jagadeesh Nagendra Manda, Karina Abramov-Harpaz, Clil Regev, Yifat Miller, Aaron Aponick, Ellen M. Zimmermann & Arik Dahan. (2022) PLA2-Triggered Activation of Cyclosporine-Phospholipid Prodrug as a Drug Targeting Approach in Inflammatory Bowel Disease Therapy. Pharmaceutics 14:3, pages 675.
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Milica Markovic, Karina Abramov-Harpaz, Clil Regev, Shimon Ben-Shabat, Aaron Aponick, Ellen M. Zimmermann, Yifat Miller & Arik Dahan. (2022) Prodrug-Based Targeting Approach for Inflammatory Bowel Diseases Therapy: Mechanistic Study of Phospholipid-Linker-Cyclosporine PLA2-Mediated Activation. International Journal of Molecular Sciences 23:5, pages 2673.
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Vanessa Moreira, Elbio Leiguez, Priscila Motta Janovits, Rodrigo Maia-Marques, Cristina Maria Fernandes & Catarina Teixeira. (2021) Inflammatory Effects of Bothrops Phospholipases A2: Mechanisms Involved in Biosynthesis of Lipid Mediators and Lipid Accumulation. Toxins 13:12, pages 868.
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Jair Gonzalez Marques, Engy Shokry, Klara Frivolt, Katharina Julia Werkstetter, Annecarin Brückner, Tobias Schwerd, Sibylle Koletzko & Berthold Koletzko. (2021) Metabolomic Signatures in Pediatric Crohn’s Disease Patients with Mild or Quiescent Disease Treated with Partial Enteral Nutrition: A Feasibility Study. SLAS Technology 26:2, pages 165-177.
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Omaima A. Ahmedy, Sherehan M. Ibrahim, Heba H. Salem & Esraa A. Kandil. (2020) Antiulcerogenic effect of melittin via mitigating TLR4/TRAF6 mediated NF-κB and p38MAPK pathways in acetic acid-induced ulcerative colitis in mice. Chemico-Biological Interactions 331, pages 109276.
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Milica Markovic, Shimon Ben-Shabat & Arik Dahan. (2020) Prodrugs for Improved Drug Delivery: Lessons Learned from Recently Developed and Marketed Products. Pharmaceutics 12:11, pages 1031.
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Jagadeesh Nagendra Manda, Milica Markovic, Ellen M. Zimmermann, Shimon Ben‐Shabat, Arik Dahan & Aaron Aponick. (2020) Phospholipid Cyclosporine Prodrugs Targeted at Inflammatory Bowel Disease (IBD) Treatment: Design, Synthesis, and in Vitro Validation. ChemMedChem 15:17, pages 1639-1644.
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Xin Li, Chao Lu, Yanyan Yang, Chaohui Yu & Yuefeng Rao. (2020) Site-specific targeted drug delivery systems for the treatment of inflammatory bowel disease. Biomedicine & Pharmacotherapy 129, pages 110486.
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P. Kourkoulis, C. Kapizioni, G. Michalopoulos, N.P. Andreou, I. Papaconstantinou, G. Karamanolis & M. Gazouli. (2019) Novel potential biomarkers for the diagnosis and monitoring of patients with ulcerative colitis. European Journal of Gastroenterology & Hepatology 31:10, pages 1173-1183.
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Milica Markovic, Arik Dahan, Shahar Keinan, Igor Kurnikov, Aaron Aponick, Ellen M. Zimmermann & Shimon Ben-Shabat. (2019) Phospholipid-Based Prodrugs for Colon-Targeted Drug Delivery: Experimental Study and In-Silico Simulations. Pharmaceutics 11:4, pages 186.
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Milica Markovic, Shimon Ben-Shabat, Shahar Keinan, Aaron Aponick, Ellen Zimmermann & Arik Dahan. (2018) Prospects and Challenges of Phospholipid-Based Prodrugs. Pharmaceutics 10:4, pages 210.
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Arik Dahan, Milica Markovic, Shahar Keinan, Igor Kurnikov, Aaron Aponick, Ellen M. Zimmermann & Shimon Ben-Shabat. (2017) Computational modeling and in-vitro/in-silico correlation of phospholipid-based prodrugs for targeted drug delivery in inflammatory bowel disease. Journal of Computer-Aided Molecular Design 31:11, pages 1021-1028.
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Arik Dahan, Milica Markovic, Svetlana Epstein, Noa Cohen, Ellen M. Zimmermann, Aaron Aponick & Shimon Ben-Shabat. (2017) Phospholipid-drug conjugates as a novel oral drug targeting approach for the treatment of inflammatory bowel disease. European Journal of Pharmaceutical Sciences 108, pages 78-85.
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Shane O'Sullivan, Jun Wang, Maria T Pigott, Neil Docherty, Noreen Boyle, Samuel Kana Lis, John F Gilmer & Carlos Medina. (2017) Inhibition of matrix metalloproteinase‐9 by a barbiturate‐nitrate hybrid ameliorates dextran sulphate sodium‐induced colitis: effect on inflammation‐related genes. British Journal of Pharmacology 174:7, pages 512-524.
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Elizabeth A. Rondini & Maurice R. Bennink. (2012) Microarray Analyses of Genes Differentially Expressed by Diet (Black Beans and Soy Flour) during Azoxymethane-Induced Colon Carcinogenesis in Rats. Journal of Nutrition and Metabolism 2012, pages 1-17.
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Sebastiano Collino, François-Pierre J. Martin, Sunil Kochhar & Serge Rezzi. 2011. Probiotic Bacteria and Enteric Infections. Probiotic Bacteria and Enteric Infections 169 185 .
Ashok Babu, David Mauchley, Xianzhong Meng, Anirban M. Banerjee, Fabia Gamboni-Robertson, David A. Fullerton & Michael J. Weyant. (2009) The Secretory Phospholipase A2 Gene is Required for Gastroesophageal Reflux-Related Changes in Murine Esophagus. Journal of Gastrointestinal Surgery 13:12, pages 2212-2218.
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Annika Braun, Irina Treede, Daniel Gotthardt, Anke Tietje, Alexandra Zahn, Rebecca Ruhwald, Ulrike Schoenfeld, Thilo Welsch, Peter Kienle, Gerhard Erben, Wolf-Dieter Lehmann, Joachim Fuellekrug, Wolfgang Stremmel & Robert Ehehalt. (2009) Alterations of phospholipid concentration and species composition of the intestinal mucus barrier in ulcerative colitis: A clue to pathogenesis. Inflammatory Bowel Diseases 15:11, pages 1705-1720.
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Kajsa Kajander, Eveliina Myllyluoma, Sinikka Kyrönpalo, Martin Rasmussen, Pentti Sipponen, Ismo Mattila, Tuulikki Seppänen-Laakso, Heikki Vapaatalo, Matej Orešič & Riitta Korpela. (2009) Elevated pro-inflammatory and lipotoxic mucosal lipidscharacterise irritable bowel syndrome. World Journal of Gastroenterology 15:48, pages 6068.
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Ryuichi Okamoto, Kiichiro Tsuchiya, Yasuhiro Nemoto, Junko Akiyama, Tetsuya Nakamura, Takanori Kanai & Mamoru Watanabe. (2009) Requirement of Notch activation during regeneration of the intestinal epithelia. American Journal of Physiology-Gastrointestinal and Liver Physiology 296:1, pages G23-G35.
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Ashok Babu, Xianzhong Meng, Anirban M. Banerjee, Fabia Gamboni-Robertson, Joseph C. Cleveland, Sagar Damle, David A. Fullerton & Michael J. Weyant. (2008) Secretory phospholipase A2 is required to produce histologic changes associated with gastroduodenal reflux in a murine model. The Journal of Thoracic and Cardiovascular Surgery 135:6, pages 1220-1227.
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Riina A Kekkonen, Marko Sysi-Aho, Tuulikki Seppänen-Laakso, Ilkka Julkunen, Heikki Vapaatalo, Matej Orešič & Riitta Korpela. (2008) Effect of probiotic Lactobacillus rhamnosus GG intervention on global serum lipidomic profiles in healthy adults. World Journal of Gastroenterology 14:20, pages 3188.
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Massimo Triggiani, Francescopaolo Granata, Annunziata Frattini & Gianni Marone. (2006) Activation of human inflammatory cells by secreted phospholipases A2. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1761:11, pages 1289-1300.
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Noriaki Takabatake, Makoto Sata, Sumito Inoue, Yoko Shibata, Shuichi Abe, Toshihiro Wada, Jun-ichi Machiya, Guijin Ji, Tadashi Matsuura, Yasuchika Takeishi, Masaaki Muramatsu & Isao Kubota. (2005) A Novel Polymorphism in Secretory Phospholipase A 2 -IID Is Associated with Body Weight Loss in Chronic Obstructive Pulmonary Disease . American Journal of Respiratory and Critical Care Medicine 172:9, pages 1097-1104.
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Trent M. Woodruff, Thiruma V. Arumugam, Ian A. Shiels, Michelle L. Newman, Paul A. Ross, Robert C. Reid, David P. Fairlie & Stephen M. Taylor. (2005) A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis. International Immunopharmacology 5:5, pages 883-892.
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Francescopaolo Granata, Barbara Balestrieri, Angelica Petraroli, Giorgio Giannattasio, Gianni Marone & Massimo Triggiani. (2003) Secretory Phospholipases A<sub>2</sub> as Multivalent Mediators of Inflammatory and Allergic Disorders. International Archives of Allergy and Immunology 131:3, pages 153-163.
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Timo J. Nevalainen, Markku M. Haapamäki & Juha M. Grönroos. (2000) Roles of secretory phospholipases A2 in inflammatory diseases and trauma. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1488:1-2, pages 83-90.
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