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Research Article

Influence of iron deficiency anaemia on haemoglobin A2 levels: possible consequences for ß?thalassaemia screening

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Pages 65-70 | Published online: 08 Jul 2009

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Ibrahim Y. Abdel-Messih, Soha R. Youssef, Galila M. Mokhtar, Mahira I. Elmogy, Hanan M. Mahmoud, Mariz Ayoub & Shaimaa A. Pessar. (2015) Clinical to Molecular Screening Paradigm for β-Thalassemia Carriers. Hemoglobin 39:4, pages 240-246.
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Manju Mamtani, Anil Jawahirani, Kishor Das, Vinky Rughwani & Hemant Kulkarni. (2006) Bias-corrected diagnostic performance of the naked eye single tube red cell osmotic fragility test (NESTROFT): An effective screening tool for β-thalassemia. Hematology 11:4, pages 277-286.
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Articles from other publishers (28)

Preeti Tripathi, Shobhit Goel, Rajiv KumarArijit Sen. (2024) HBA2 levels in iron deficiency - Can iron deficiency mask thalassemia screening?. Indian Journal of Pathology and Oncology 11:1, pages 8-13.
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Daniel Turudic, Jerko Vucak, Svetlana Kocheva, Danko Milosevic & Ernest Bilic. (2024) Differentinating between non-transfusion dependant β-thalassemia and iron deficinecy anemia in children using ROC and logistic regression analysis: two novel discrimination indices designed for pediatric patients. Frontiers in Pediatrics 11.
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Pedro L. Moura, Teresa Mortera-Blanco, Isabel J. Hofman, Gabriele Todisco, Warren W. Kretzschmar, Ann-Charlotte Björklund, Maria Creignou, Michael Hagemann-Jensen, Christoph Ziegenhain, David Cabrerizo Granados, Indira Barbosa, Gunilla Walldin, Monika Jansson, Neil Ashley, Adam J. Mead, Vanessa Lundin, Marios Dimitriou, Tetsuichi Yoshizato, Petter S. Woll, Seishi Ogawa, Rickard Sandberg, Sten Eirik W. Jacobsen & Eva Hellström-Lindberg. (2024) Erythroid Differentiation Enhances RNA Mis-Splicing in SF3B1 -Mutant Myelodysplastic Syndromes with Ring Sideroblasts . Cancer Research 84:2, pages 211-225.
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Kasper Munch Lauridsen, Helle Pilgaard Kristiansen & Anne Winther-Larsen. (2023) Pediatric reference intervals of the hemoglobin fractions HbA2, HbF and HbA0 using high-performance liquid chromatography and capillary electrophoresis. Clinica Chimica Acta 549, pages 117557.
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Kirtijit Chakma, Rashmi Kuswaha, Geeta Yadav, U.S Singh, Wahid Ali, Ashutosh Kumar, S.P Verma, Nishant Verma & Trideep Jyoti Deori. (2023) Novel reticulocyte parameters in thalassemia and iron deficiency anemia. IP Journal of Diagnostic Pathology and Oncology 8:1, pages 30-35.
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Nathan R.N. Cruz, Thaís G. Baraldi, Fausto A. Marinho Neto, Patrícia V.A. Alvarenga, Juliana P. Oliveira, Ana C.A. Albuquerque, Helena C.D. Brito, Larissa A.B. Nascimento, Luís G. Oliveira & Aureo E. Santana. (2023) Iron interference in hemoglobin production in piglets from birth to weaning. Pesquisa Veterinária Brasileira 43.
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Farjana Akther Noor, Nusrat Sultana, Golam Sarower Bhuyan, Md Tarikul Islam, Mohabbat Hossain, Suprovath Kumar Sarker, Khaleda Islam, Waqar Ahmed Khan, Mujahida Rahman, Syeda Kashfi Qadri, Hossain Uddin Shekhar, Firdausi Qadri, Syed Saleheen Qadri & Kaiissar Mannoor. (2020) Nationwide carrier detection and molecular characterization of β-thalassemia and hemoglobin E variants in Bangladeshi population. Orphanet Journal of Rare Diseases 15:1.
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A. Yusifova, S. Alekberova & B. Asadova. (2020) Statistical Indicators of Patients With Large and Intermittent β-thalassemia in Different Regions of Azerbaijan. Bulletin of Science and Practice 6:11, pages 242-247.
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Sawsan M. Moeen, Ahmad F. Thabet & Marwa M. Thabet. (2020) Effect of iron therapy on red cell indices and hemoglobin subtypes on patients with beta-thalassemia trait who developed iron-deficiency anemia: a tertiary center experience. The Egyptian Journal of Internal Medicine 31:4, pages 741-745.
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Aly Diana, Dwi M Purnamasari, Sofa Rahmannia, Dimas E Luftimas, Jillian J Haszard, Rosalind S Gibson & Lisa A Houghton. (2019) Multimicronutrient Biomarkers Are Related to Anemia during Infancy in Indonesia: A Repeated Cross-Sectional Study. Current Developments in Nutrition 3:5, pages 3005008.
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Patrick T. McGann, Alecia C. Nero & Russell E. Ware. 2017. Gene and Cell Therapies for Beta-Globinopathies. Gene and Cell Therapies for Beta-Globinopathies 1 26 .
Orly Lavee & Giselle Kidson-Gerber. (2015) Antenatal haemoglobinopathy screening: Patterns within a large obstetric service. Working towards a standard of care. Obstetric Medicine 8:4, pages 184-189.
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P. Sharma, R. Das, A. Trehan, D. Bansal, S. Chhabra, J. Kaur, R. K. Marwaha, N. Varma & G. Garewal. (2014) Impact of iron deficiency on hemoglobin A2% in obligate β‐thalassemia heterozygotes. International Journal of Laboratory Hematology 37:1, pages 105-111.
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Shafi Mohammad KhosaMuhammad UsmanMoinuddin MoinuddinHassan Osman MehmoodKhansa Qamar. (2015) Comparative analysis of cellulose acetate hemoglobin electrophoresis and high performance liquid chromatography for quantitative determination of hemoglobin A2. Blood Research 50:1, pages 46.
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Giovanni Ivaldi, Giuseppina Barberio, Cornelis L. Harteveld & Piero Giordano. (2014) HbA2 Measurements in β-Thalassemia and in Other Conditions. Thalassemia Reports 4:2, pages 1832.
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Sarika Verma, Ruchika Gupta, Madhur Kudesia, Alka Mathur, Gopal Krishan & Sompal Singh. (2014) Coexisting Iron Deficiency Anemia and Beta Thalassemia Trait: Effect of Iron Therapy on Red Cell Parameters and Hemoglobin Subtypes. ISRN Hematology 2014, pages 1-5.
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Aysel Vehapoglu, Gamze Ozgurhan, Ayşegul Dogan Demir, Selcuk Uzuner, Mustafa Atilla Nursoy, Serdar Turkmen & Arzu Kacan. (2014) Hematological Indices for Differential Diagnosis of Beta Thalassemia Trait and Iron Deficiency Anemia. Anemia 2014, pages 1-7.
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Lucia Perseu, Stefania Satta, Paolo Moi, Franca Rosa Demartis, Laura Manunza, Maria Carla Sollaino, Susanna Barella, Antonio Cao & Renzo Galanello. (2011) KLF1 gene mutations cause borderline HbA2. Blood 118:16, pages 4454-4458.
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Muhammad UsmanMoinuddin MoinuddinSyed Azhar Ahmed. (2011) Role of iron deficiency anemia in the propagation of beta thalssemia gene. The Korean Journal of Hematology 46:1, pages 41.
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Zhanhui Ou, Qing Li, Weiqiang Liu & Xiaofang Sun. (2011) Elevated Hemoglobin A2 as a Marker for .BETA.-Thalassemia Trait in Pregnant Women. The Tohoku Journal of Experimental Medicine 223:3, pages 223-226.
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Antonino Giambona, Cristina Passarello, Disma Renda & Aurelio Maggio. (2009) The significance of the hemoglobin A2 value in screening for hemoglobinopathies. Clinical Biochemistry 42:18, pages 1786-1796.
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Martin H. Steinberg, Bernard G. Forget, Douglas R. Higgs & David J. WeatherallMartin H. Steinberg & Ronald L. Nagel. 2010. Disorders of Hemoglobin. Disorders of Hemoglobin 119 136 .
Martin H. Steinberg, Bernard G. Forget, Douglas R. Higgs & David J. Weatherall. 2010. Disorders of Hemoglobin. Disorders of Hemoglobin 1 2 .
Nadia Sardón Estévez, Martinus H. Herruer, Ruud Jansen, Ferry J. M. Bergkamp & Jozef P. M. C. Gorgels. (2009) Diagnostic value of zinc protoporphyrin in a screening strategy for α ‐thalassemia . European Journal of Haematology 82:5, pages 393-397.
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Andrea Mosca, Renata Paleari, Renzo Galanello, Carla Sollaino, Lucia Perseu, Franca Rosa Demartis, Cristina Passarello, Antonino Giambona & Aurelio Maggio. (2008) New analytical tools and epidemiological data for the identification of HbA2 borderline subjects in the screening for beta-thalassemia. Bioelectrochemistry 73:2, pages 137-140.
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Sean Lynch, Rebecca Stoltzfus & Rahul Rawat. (2016) Critical Review of Strategies to Prevent and Control Iron Deficiency in Children. Food and Nutrition Bulletin 28:4_suppl4, pages S610-S620.
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Renata Paleari, Monica Cannata, Filippo Leto, Aurelio Maggio, Franca R. Demartis, Maria F. Desogus, Renzo Galanello & Andrea Mosca. (2005) Analytical evaluation of the Tosoh HLC-723 G7 automated HPLC analyzer for hemoglobin A2 and F determination. Clinical Biochemistry 38:2, pages 159-165.
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Andrea Mosca, Renata Paleari, Valeria Scimè-Degani, Leonello Leone, Daniela Leone & Giovanni Ivaldi. (2000) Inter-Method Differences and Commutability of Control Materials for HbA2 Measurement. cclm 38:10, pages 997-1002.
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