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Scandinavian Journal of Gastroenterology Volume 35, 2000 - Issue 10
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Research Article

A Multicenter, Randomized, Double-Blind Clinical Trial Examining the Effect of Oral Human Recombinant Epidermal Growth Factor on the Healing of Duodenal Ulcers

A. Palomino, F. Hernández-Bernal, W. Haedo, S. Franco, J. A. Más, J. A. Fernández, G. Soto, A. Alonso, T. González, P. López-Saura Centre for Biological Research, Clinical Trials Division, Havana, Cuba
Pages 1016-1022 | Published online: 08 Jul 2009

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Hermann AM Mucke. (2013) Patent Highlights. Pharmaceutical Patent Analyst 2:3, pages 309-316.
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Francisco Hernández-Bernal, Donner Estenoz-García, Juan H. Gutiérrez-Ronquillo, Yenima Martín-Bauta, Karen Catasús-Álvarez, Mario Gutiérrez-Castillo, Marbelys Guevara-Rodríguez, Aliuska Castro-Jeréz, Yoandra Fuentes-González, Yulemis Pinto-Cruz, Carmen Valenzuela-Silva, Verena L. Muzio-González, Héctor Pérez-Saad, Nelvys Subirós-Martínez, Gerardo E. Guillén-Nieto & Diana Garcia-del-Barco-Herrera. (2024) Combination therapy of Epidermal Growth Factor and Growth Hormone-Releasing Hexapeptide in acute ischemic stroke: a phase I/II non-blinded, randomized clinical trial. Frontiers in Neurology 15.
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Jiaojiao Yang, Dingwei Li, Mengjiao Zhang, Gaolong Lin, Sunkuan Hu & Helin Xu. (2023) From the updated landscape of the emerging biologics for IBDs treatment to the new delivery systems. Journal of Controlled Release 361, pages 568-591.
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Lifen Wang, Jiawei Xu, Pengpeng Xue, Jiayi Liu, Lanzi Luo, Deli Zhuge, Qing Yao, Xiaokun Li, Yingzheng Zhao & Helin Xu. (2021) Thermo-sensitive hydrogel with mussel-inspired adhesion enhanced the non-fibrotic repair effect of EGF on colonic mucosa barrier of TNBS-induced ulcerative colitis rats through macrophage polarizing. Chemical Engineering Journal 416, pages 129221.
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Ernest Cheah, Zimei Wu, Sachin S. Thakur, Simon J. O'Carroll & Darren Svirskis. (2021) Externally triggered release of growth factors - A tissue regeneration approach. Journal of Controlled Release 332, pages 74-95.
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Mira Yu, Juil Kim, Jung Hoon Ahn & Yuseok Moon. (2019) Nononcogenic restoration of the intestinal barrier by E. coli–delivered human EGF. JCI Insight 4:16.
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Miho Ogawa & Takashi Tsuji. (2017) Functional Salivary Gland Regenerative Therapy for Oral Health. Current Oral Health Reports 4:1, pages 44-50.
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Miho Ogawa & Takashi Tsuji. (2015) Functional salivary gland regeneration as the next generation of organ replacement regenerative therapy. Odontology 103:3, pages 248-257.
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Yanxia Geng, Jieshou Li, Fan Wang, Qiurong Li, Xing Wang, Liqun Sun & Weiqin Li. (2013) Epidermal Growth Factor Promotes Proliferation and Improves Restoration After Intestinal Ischemia–Reperfusion Injury in Rats. Inflammation 36:3, pages 670-679.
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Hye Jin Choi, Jung Hoon Ahn, Seong-Hwan Park, Kee Hun Do, Juil Kim & Yuseok Moon. (2012) Enhanced Wound Healing by Recombinant Escherichia coli Nissle 1917 via Human Epidermal Growth Factor Receptor in Human Intestinal Epithelial Cells: Therapeutic Implication Using Recombinant Probiotics. Infection and Immunity 80:3, pages 1079-1087.
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Jorge Berlanga‐Acosta, Jorge Gavilondo‐Cowley, Pedro López‐Saura, Tania González‐López, María D Castro‐Santana, Ernesto López‐Mola, Gerardo Guillén‐Nieto & Luis Herrera‐Martinez. (2009) Epidermal growth factor in clinical practice – a review of its biological actions, clinical indications and safety implications. International Wound Journal 6:5, pages 331-346.
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Andrei Radulescu, Nicholas A Zorko, Xiaoyi Yu & Gail E Besner. (2009) Preclinical Neonatal Rat Studies of Heparin-Binding EGF-Like Growth Factor in Protection of the Intestines From Necrotizing Enterocolitis. Pediatric Research 65:4, pages 437-442.
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H Kagami, S Wang & B Hai. (2007) Restoring the function of salivary glands. Oral Diseases 14:1, pages 15-24.
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Jorge Berlanga Acosta, William Savigne, Calixto Valdez, Neobalis Franco, Jose S Alba, Amaurys del Rio, Pedro López‐Saura, Gerardo Guillén, Ernesto Lopez, Luís Herrera & José Férnandez‐Montequín. (2006) Epidermal growth factor intralesional infiltrations can prevent amputation in patients with advanced diabetic foot wounds. International Wound Journal 3:3, pages 232-239.
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Ana P. Cotrim, Fumi Mineshiba, Takayuki Sugito, Yuval Samuni & Bruce J. Baum. (2006) Salivary Gland Gene Therapy. Dental Clinics of North America 50:2, pages 157-173.
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Bruce J. Baum, Antonis Voutetakis & Jianghua Wang. (2004) Salivary glands: novel target sites for gene therapeutics. Trends in Molecular Medicine 10:12, pages 585-590.
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In-Wha Kim, Ho-Jung Yoo, Im-Sook Song, Youn-Bok Chung, Dong-Cheul Moon, Suk-Jae Chung & Chang-Koo Shim. (2003) Effect of excipients on the stability and transport of recombinant human epidermal growth factor (rhEGF) across CACO-2 cell monolayers. Archives of Pharmacal Research 26:4, pages 330-337.
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Jane CJ Chao. (2003) Effect of oral epidermal growth factor on mucosal healing in rats with duodenal ulcer. World Journal of Gastroenterology 9:10, pages 2261.
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