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Scandinavian Journal of Gastroenterology Volume 35, 2000 - Issue 6
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Research Article

Non-Invasive Assessment of Human Hepatic Mitochondrial Function through the 13C-Methionine Breath Test

A. Armuzzi Istituto di Patologia Medica, Universitá Cattolica, Policlinico Gemelli, Largo Gemelli 8, IT-00168 Roma, Italy
Pages 650-653 | Published online: 08 Jul 2009

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Klaus D. Wutzke, Anke Forberger & Marianne Wigger. (2008) Effect of alcohol consumption on the liver detoxication capacity as measured by [13C]methacetin- and [methyl-13C]methionine-breath tests. Isotopes in Environmental and Health Studies 44:2, pages 219-226.
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Anil S. Modak, Jennie M. Reid, Lori A. Williams & Gerald R. Hobbs. (2007) A simple non-invasive method to detect and monitor hypercapnia: the sodium [13C]bicarbonate breath test. Isotopes in Environmental and Health Studies 43:1, pages 23-29.
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Articles from other publishers (34)

Trevor Tabone, Peter Mooney & Clare Donnellan. (2024) Intestinal failure–associated liver disease: Current challenges in screening, diagnosis, and parenteral nutrition considerations. Nutrition in Clinical Practice.
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Biren P. Modi, David P. Galloway, Kathleen Gura, Anita Nucci, Steven Plogsted, Alyssa Tucker & Paul W. Wales. (2021) ASPEN definitions in pediatric intestinal failure. Journal of Parenteral and Enteral Nutrition 46:1, pages 42-59.
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Agostino Di Ciaula, Giuseppe Calamita, Harshitha Shanmugam, Mohamad Khalil, Leonilde Bonfrate, David Q.-H. Wang, Gyorgy Baffy & Piero Portincasa. (2021) Mitochondria Matter: Systemic Aspects of Nonalcoholic Fatty Liver Disease (NAFLD) and Diagnostic Assessment of Liver Function by Stable Isotope Dynamic Breath Tests. International Journal of Molecular Sciences 22:14, pages 7702.
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Emilio Molina-Molina, Harshitha Shanmugam, Domenica Di Palo, Ignazio Grattagliano & Piero Portincasa. 2021. Mitochondrial Regulation. Mitochondrial Regulation 179 199 .
N. Siva Subramaniam, C.S. Bawden, S.R. Rudiger, R. Yazbeck, R.L.M. Faull, R.G. Snell & G.S. Howarth. (2019) Development of a novel 13C-labelled methionine breath test protocol for potential assessment of hepatic mitochondrial function in sheep using isotope-ratio mass spectrometry. International Journal of Mass Spectrometry 442, pages 102-108.
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Roger Yazbeck, Simone Jaenisch, Michelle Squire, Catherine A. Abbott, Emma Parkinson-Lawrence, Douglas A. Brooks & Ross N. Butler. (2019) Development of a 13C Stable Isotope Assay for Dipeptidyl Peptidase-4 Enzyme Activity A New Breath Test for Dipeptidyl Peptidase Activity. Scientific Reports 9:1.
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N. Siva Subramaniam, C.S. Bawden, H. Waldvogel, R.M.L. Faull, G.S. Howarth & R.G. Snell. (2018) Emergence of breath testing as a new non-invasive diagnostic modality for neurodegenerative diseases. Brain Research 1691, pages 75-86.
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L. Bonfrate, I. Grattagliano, G. Palasciano & P. Portincasa. (2014) Dynamic carbon 13 breath tests for the study of liver function and gastric emptying. Gastroenterology Report 3:1, pages 12-21.
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Ignazio Grattagliano, Leonilde Bonfrate, Michele Lorusso, Luigi Castorani, Ornella de Bari & Piero Portincasa. 2015. Mitochondrial Regulation. Mitochondrial Regulation 137 152 .
Sven H. StüweOliver GoetzeCarsten LukasPeter KlotzRainer HoffmannMatthias BanaschMichael OrthWolfgang E. SchmidtRalf GoldCarsten Saft. (2013) Hepatic mitochondrial dysfunction in manifest and premanifest Huntington disease. Neurology 80:8, pages 743-746.
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M Banasch, M Ellrichmann, A Tannapfel, WE Schmidt & O Goetze. (2011) The non-invasive 13C-methionine breath test detects hepatic mitochondrial dysfunction as a marker of disease activity in non-alcoholic steatohepatitis. European Journal of Medical Research 16:6, pages 258.
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Debora Duro, Shimae Fitzgibbons, Clarissa Valim, Chi-Fu Jeffrey Yang, David Zurakowski, Melanie Dolan, Lori Bechard, Yong Ming Yu, Christopher Duggan & Tom Jaksic. (2010) [13C]Methionine Breath Test to Assess Intestinal Failure-Associated Liver Disease. Pediatric Research 68:4, pages 349-354.
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Ignazio Grattagliano, Bernhard H. Lauterburg, Giuseppe Palasciano & Piero Portincasa. (2010) 13 C‐breath tests for clinical investigation of liver mitochondrial function . European Journal of Clinical Investigation 40:9, pages 843-850.
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T. SternfeldA. LorenzM. SchmidA. SchlampH. DemmelmairB. KoletzkoJ.R. Bogner. (2009) [ 13 C]Methionine Breath Test as a Marker for Hepatic Mitochondrial Function in HIV-Infected Patients . AIDS Research and Human Retroviruses 25:12, pages 1243-1248.
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Srinivasan Dasarathy, Takhar Kasumov, John M. Edmison, Lourdes L. Gruca, Carole Bennett, Clarita Duenas, Susan Marczewski, Arthur J. McCullough, Richard W. Hanson & Satish C. Kalhan. (2009) Glycine and urea kinetics in nonalcoholic steatohepatitis in human: effect of intralipid infusion. American Journal of Physiology-Gastrointestinal and Liver Physiology 297:3, pages G567-G575.
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Laura Milazzo. 2008. Drug‐Induced Mitochondrial Dysfunction. Drug‐Induced Mitochondrial Dysfunction 493 506 .
Bradley F. Hamilton, Alan H. Stokes, Jon Lyon & Rick R. Adler. (2008) In vivo assessment of mitochondrial toxicity. Drug Discovery Today 13:17-18, pages 785-790.
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Matthias Banasch, Oliver Goetze, Wolfgang E. Schmidt & Juris J. Meier. (2007) Rimonabant as a novel therapeutic option for nonalcoholic steatohepatitis. Liver International 27:8, pages 1152-1155.
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James A. Dykens & Yvonne Will. (2007) The significance of mitochondrial toxicity testing in drug development. Drug Discovery Today 12:17-18, pages 777-785.
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B. Braden, B. Lembcke, W. Kuker & W.F. Caspary. (2007) 13C-breath tests: Current state of the art and future directions. Digestive and Liver Disease 39:9, pages 795-805.
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M. Dolores Parra & J. Alfredo Martinez. (2006) Nutritional Aspects of Breath Testing Based on Stable Isotopes. Nutrition Reviews 64:7, pages 338-347.
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Matthias Banasch, Oliver Goetze, Ivo Hollborn, Bettina Hochdorfer, Kerem Bulut, Renate Schlottmann, Dirk Hagemann, Norbert H Brockmeyer, Wolfgang E Schmidt & Frank Schmitz. (2005) 13C-Methionine Breath Test Detects Distinct Hepatic Mitochondrial Dysfunction in HIV-Infected Patients With Normal Serum Lactate. JAIDS Journal of Acquired Immune Deficiency Syndromes 40:2, pages 149-154.
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Jordi Casademont, Eduard Sanjurjo, Gloria Garrabou & Òscar Miró. (2005) Diagnosis of Mitochondrial Dysfunction in HIV-Infected Patients under Highly Active Antiretroviral Therapy: Possibilities beyond the Standard Procedures. Antiviral Therapy 10:2_suppl, pages 65-71.
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D. Festi. (2005) Measurement of hepatic functional mass by means of 13C-methacetin and 13C-phenylalanine breath tests in chronic liver disease: Comparison with Child-Pugh score and serum bile acid levels. World Journal of Gastroenterology 11:1, pages 142.
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B. Braden, D. Faust, U. Sarrazin, S. Zeuzem, C. F. Dietrich, W. F. Caspary & C. Sarrazin. (2005) 13 C‐methacetin breath test as liver function test in patients with chronic hepatitis C virus infection . Alimentary Pharmacology & Therapeutics 21:2, pages 179-185.
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Laura Milazzo, Manuela Piazza, Ornella Sangaletti, Nadia Gatti, Anna Cappelletti, Fulvio Adorni, Spinello Antinori, Massimo Galli, Mauro Moroni & Agostino Riva. (2005) [13C]Methionine breath test: a novel method to detect antiretroviral drug-related mitochondrial toxicity. Journal of Antimicrobial Chemotherapy 55:1, pages 84-89.
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Laura Milazzo, Agostino Riva, Ornella Sangaletti, Manuela Piazza, Spinello Antinori & Mauro Moroni. (2004) 13C-Methionine Breath Test Detects Liver Mitochondrial Impairment in HIV-Infected Patients With Antiretroviral Drug???Related Hyperlactatemia. JAIDS Journal of Acquired Immune Deficiency Syndromes 35:4, pages 429-432.
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Lynette A Gillis & Ronald J Sokol. (2003) Gastrointestinal manifestations of mitochondrial disease. Gastroenterology Clinics of North America 32:3, pages 789-817.
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Dolores Parra, Alvaro González, Luis García‐Villarreal & J. Alfredo Martínez. (2006) Methodological Characterization of the 2‐Keto [1‐ 13 C]isocaproate Breath Test to Measure in Vivo Human Mitochondrial Function: Application in Alcoholic Liver Disease Assessment . Alcoholism: Clinical and Experimental Research 27:8, pages 1293-1298.
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Cristiana Di Campli, Giuseppina Angelini, Alessandro Armuzzi, Bruno Nardo, Maria Assunta Zocco, Marcello Candelli, Angelo Santoliquido, Antonino Cavallari, Mauro Bernardi & Antonio Gasbarrini. (2003) Quantitative evaluation of liver function by the methionine and aminopyrine breath tests in the early stages of liver transplantation. European Journal of Gastroenterology & Hepatology 15:7, pages 727-732.
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Cristiana Di Campli, Giuseppina Angelini, Alessandro Armuzzi, Bruno Nardo, Maria Assunta Zocco, Marcello Candelli, Angelo Santoliquido, Antonino Cavallari, Mauro Bernardi & Antonio Gasbarrini. (2003) Quantitative evaluation of liver function by the methionine and aminopyrine breath tests in the early stages of liver transplantation. European Journal of Gastroenterology & Hepatology 15:7, pages 727-732.
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A. Armuzzi, M. Candelli, M. A. Zocco, A. Andreoli, A. De Lorenzo, E. C. Nista, L. Miele, F. Cremonini, I. A. Cazzato, A. Grieco, G. Gasbarrini & A. Gasbarrini. (2002) Breath testing for human liver function assessment. Alimentary Pharmacology & Therapeutics 16:12, pages 1977-1996.
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Stefan Russmann, Edith Junker & Bernhard H. Lauterburg. (2002) Remethylation and transsulfuration of methionine in cirrhosis: Studies with L -[ 2 H 3 -methyl-1- 13 C]methionine . Hepatology 36:5, pages 1190-1196.
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Yukimoto ISHI, Koichi ISHIKAWA & Satoshi ASAI. (2002) Evaluation of liver function with 13C-labelled amino acid using hepatectomized rat model.. Folia Pharmacologica Japonica 120:2, pages 101-106.
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