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Research Article

Helicobacter pylori Infection Is a Major Risk Factor for Gastric Carcinoma in Young Patients

Pages 255-259 | Published online: 08 Jul 2009

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Naoki Sumi, Ken Haruma, Tomoari Kamada, Mitsuhiko Suehiro, Noriaki Manabe, Takashi Akiyama, Akiko Shiotani, Yoshiyuki Yamanaka, Sohachi Fujimoto & Toshihiro Takao. (2022) Diagnosis of histological gastritis based on the Kyoto classification of gastritis in Japanese subjects – including evaluation of aging and sex difference of histological gastritis. Scandinavian Journal of Gastroenterology 57:3, pages 260-265.
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Shubin Song, Chunfeng Li, Sen Li, Xiliang Cong & Yingwei Xue. (2017) Clinicopathological features and prognoses in younger and older patients with gastric cancer. OncoTargets and Therapy 10, pages 4795-4802.
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Articles from other publishers (59)

Helge Waldum & Patricia Mjønes. (2023) The central role of gastrin in gastric cancer. Frontiers in Oncology 13.
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Hongfa Wei, Xiao-Yong Zhan, Xianying Liao, Wenchao Li, Hui Chen, Cuncan Deng, Xinghan Jin, Zhangsen Huang, Mo Yang, Changhua Zhang & Yulong He. (2023) Gastric cancer clinical characteristics and their altered trends in South China: An epidemiological study with 2,800 cases spanning 26 years. Frontiers in Oncology 13.
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Nataly V. Torrejon, Saarang Deshpande, Wei Wei, Katherine Tullio & Suneel D. Kamath. (2022) Proportion of Early-Onset Gastric and Esophagus Cancers Has Changed Over Time With Disproportionate Impact on Black and Hispanic Patients. JCO Oncology Practice 18:5, pages e759-e769.
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Shuhan Zhou, Xiaohui Xu, Jiangqin Zeng, Zhiyi Liu, Miao Wang & Wenliang Lv. (2021) Unveiling the Mechanism of Principal Drugs of Lianpu Drink on Chronic Gastritis by Network Pharmacology. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-12.
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Shuhan Zhou, Yanjun Duan, Yu Deng, Miao Wang, Chaoqun Huang, Zhiyi Liu, Xiaohui Xu & Wenliang Lv. (2021) Study on the Mechanism of Lianpu Drink for the Treatment of Chronic Gastritis Based on Network Pharmacology. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-13.
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Nazanin Khayam, Hamideh Rouhani Nejad, Fatemeh Ashrafi & Mohsen Abolhassani. (2020) Expression Profile of miRNA-17-3p and miRNA-17-5p Genes in Gastric Cancer Patients with Helicobacter pylori Infection. Journal of Gastrointestinal Cancer 52:1, pages 130-137.
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Xiaoxiang Hu, Yajun Bai, Tai-Ping Fan, Xiaohui Zheng & Yujie Cai. (2020) A novel type alanine dehydrogenase from Helicobacter aurati: Molecular characterization and application. International Journal of Biological Macromolecules 161, pages 636-642.
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Yoshiyasu Kono, Hiromitsu Kanzaki, Takao Tsuzuki, Masahiro Takatani, Junichirou Nasu, Daisuke Kawai, Ryuta Takenaka, Takehiro Tanaka, Masaya Iwamuro, Seiji Kawano, Yoshiro Kawahara, Toshiyoshi Fujiwara & Hiroyuki Okada. (2018) A multicenter observational study on the clinicopathological features of gastric cancer in young patients. Journal of Gastroenterology 54:5, pages 419-426.
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Izumi Nishikawa, Jun Kato, Satoshi Terasoma, Hiroyoshi Matsutani, Hidehiko Tamaki, Tetsuya Tamaki, Fumiaki Kuwashima, Hiroya Nakata, Tatsuji Tomeki, Hideyuki Matsunaka, Yumiko Ibata, Yasunobu Yamashita, Takao Maekita, Katsuhiko Higashi & Masao Ichinose. (2018) Nodular gastritis in association with gastric cancer development before and after Helicobacter pylori eradication . JGH Open 2:3, pages 80-86.
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Seyedeh Zahra Bakhti, Saeid Latifi-Navid, Saber Zahri, Fatemeh Sadat Bakhti, Naser Hajavi & Abbas Yazdanbod. (2017) Are Helicobacter pylori highly cytotoxic genotypes and cardia gastric adenocarcinoma linked? Lessons from Iran. Cancer Biomarkers 21:1, pages 235-246.
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Vivian E. Strong, Ashley Russo, Sam S. Yoon, Murray F. Brennan, Daniel G. Coit, Chao-Hui Zheng, Ping Li & Chang-Ming Huang. (2017) Comparison of Young Patients with Gastric Cancer in the United States and China. Annals of Surgical Oncology 24:13, pages 3964-3971.
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Shushang Liu, Fan Feng, Guanghui Xu, Zhen Liu, Yangzi Tian, Man Guo, Xiao Lian, Lei Cai, Daiming Fan & Hongwei Zhang. (2016) Clinicopathological features and prognosis of gastric cancer in young patients. BMC Cancer 16:1.
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Takuji Gotoda, Noriya Uedo, Shigetaka Yoshinaga, Tokuma Tanuma, Yoshinori Morita, Hisashi Doyama, Akira Aso, Toshiaki Hirasawa, Tomonori Yano, Kunihisa Uchita, Shiaw-Hooi Ho & Ping-Hsin Hsieh. (2016) Basic principles and practice of gastric cancer screening using high-definition white-light gastroscopy: Eyes can only see what the brain knows. Digestive Endoscopy 28, pages 2-15.
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Mick Soukavong, Jungmee Kim, Kyounghoon Park, Bo Ram Yang, Joongyub Lee, Xue-Mei Jin & Byung-Joo Park. (2016) Signal Detection of Adverse Drug Reaction of Amoxicillin Using the Korea Adverse Event Reporting System Database. Journal of Korean Medical Science 31:9, pages 1355.
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Hironori Masuyama, Naoto Yoshitake, Takako Sasai, Tetsuya Nakamura, Atsushi Masuyama, Toru Zuiki, Kentaro Kurashina, Mitsuyo Mieda, Keijiro Sunada, Hironori Yamamoto, Kazutomo Togashi, Akira Terano & Hideyuki Hiraishi. (2015) Relationship between the Degree of Endoscopic Atrophy of the Gastric Mucosa and Carcinogenic Risk. Digestion 91:1, pages 30-36.
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Xiaolin Pan, Yuqin Li, Jin Feng, Xiaoyong Wang, Bo Hao, Ruihua Shi & Guoxin Zhang. (2013) A functional polymorphism T309G in MDM2 gene promoter, intensified by Helicobacter pylori lipopolysaccharide, is associated with both an increased susceptibility and poor prognosis of gastric carcinoma in Chinese patients. BMC Cancer 13:1.
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Tae-Wang Kim, So-Young Youm, Sang-Kyung Shin, Dae Joong Kim, Jin Tae Hong, Youngsoo Kim, Sang-Yoon Nam & Byeongwoo Ahn. (2012) Chemopreventive effects of elm tree bark extract on Helicobacter pylori-associated mouse gastric carcinogenesis. Basic and Applied Pathology 5:2, pages 31-38.
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Ryo NAKASHIMA, Naoyoshi NAGATA, Kazuhiro WATANABE, Masao KOBAYAKAWA, Toshiyuki SAKURAI, Junichi AKIYAMA, Kazufusa HOSHIMOTO, Takuro SHIMBO & Naomi UEMURA. (2011) Histological features of nodular gastritis and its endoscopic classification. Journal of Digestive Diseases 12:6, pages 436-442.
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Ji Hyung Nam, Il Ju Choi, Soo-Jeong Cho, Chan Gyoo Kim, Jong Yeul Lee, Su Youn Nam, Sook Ryun Park, Myeong-Cherl Kook, Byung-Ho Nam & Young-Woo Kim. (2011) Helicobacter pylori infection and histological changes in siblings of young gastric cancer patients. Journal of Gastroenterology and Hepatology 26:7, pages 1157-1163.
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Aki Tanaka, Tomoari Kamada, Kazuhiko Inoue, Akiko Shiotani, Hiroaki Kusunoki, Noriaki Manabe, Masanori Ito, Jiro Hata & Ken Haruma. (2011) Histological evaluation of patients with gastritis at high risk of developing gastric cancer using a conventional index. Pathology - Research and Practice 207:6, pages 354-358.
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Aki Tanaka, Tomoari Kamada, Kenji Yokota, Akiko Shiotani, Jiro Hata, Keiji Oguma & Ken Haruma. (2009) Helicobacter pylori heat shock protein 60 antibodies are associated with gastric cancer. Pathology - Research and Practice 205:10, pages 690-694.
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Masanori Ito, Shunsuke Takata, Masana Tatsugami, Yoshihiro Wada, Shinobu Imagawa, Yoshiaki Matsumoto, Akemi Takamura, Shosuke Kitamura, Taiji Matsuo, Shinji Tanaka, Ken Haruma & Kazuaki Chayama. (2009) Clinical prevention of gastric cancer by Helicobacter pylori eradication therapy: a systematic review. Journal of Gastroenterology 44:5, pages 365-371.
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Noriko Nakajima, Yoko Ito, Kiyoshi Yokoyama, Akitake Uno, Noriko Kinukawa, Norimichi Nemoto & Mitsuhiko Moriyama. (2009) The Expression of Murine Double Minute 2 (MDM2) on Helicobacter pylori-Infected Intestinal Metaplasia and Gastric Cancer. Journal of Clinical Biochemistry and Nutrition 44:2, pages 196-202.
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Victoria Hurduc, Doina Plesca, Dimitrie Dragomir, Maria Sajin & Yvan Vandenplas. (2008) A randomized, open trial evaluating the effect of Saccharomyces boulardii on the eradication rate of Helicobacter pylori infection in children . Acta Paediatrica 98:1, pages 127-131.
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Tomoari Kamada, Aki Tanaka, Yoshiyuki Yamanaka, Noriaki Manabe, Hiroaki Kusunoki, Masaki Miyamoto, Shinji Tanaka, Jiro Hata, Kazuaki Chayama & Ken Haruma. (2007) NODULAR GASTRITIS WITH HELICOBACTER PYLORI INFECTION IS STRONGLY ASSOCIATED WITH DIFFUSE-TYPE GASTRIC CANCER IN YOUNG PATIENTS. Digestive Endoscopy 19:4, pages 180-184.
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Yasuo Egi, Masanori Ito, Shinji Tanaka, Shinobu Imagawa, Shunsuke Takata, Masaharu Yoshihara, Ken Haruma & Kazuaki Chayama. (2007) Role of Helicobacter pylori Infection and Chronic Inflammation in Gastric Cancer in the Cardia. Japanese Journal of Clinical Oncology 37:5, pages 365-369.
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Shinichi Nakamura, Atsushi Mitsunaga, Ryujiro Imai, Ichiro Ishikawa, Izumi Shirato, Shohei Shimizu, Maiko Kishino, Hiroyuki Konishi, Itaru Oi & Keiko Shiratori. (2007) CLINICAL EVALUATION OF NODULAR GASTRITIS IN ADULTS. Digestive Endoscopy 19:2, pages 74-79.
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Minako Hirahashi, Takashi Yao, Takayuki Matsumoto, Ken-ichi Nishiyama, Masafumi Oya, Mitsuo Iida & Masazumi Tsuneyoshi. (2007) Intramucosal gastric adenocarcinoma of poorly differentiated type in the young is characterized by Helicobacter pylori infection and antral lymphoid hyperplasia. Modern Pathology 20:1, pages 29-34.
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T. KAWAI, K. KAWAKAMI, M. KATAOKA, K. TAKEI, S. TAIRA, T. ITOI, F. MORIYASU, Y. TAKAGI, T. AOKI, H. SERIZAWA, E. RIMBARA, N. NOGUCHI & M. SASATSU. (2007) Correlation of serum pepsinogen with histological atrophy following successful Helicobacter pylori eradication. Alimentary Pharmacology & Therapeutics 24, pages 23-30.
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T. KAWAI, K. KAWAKAMI, M. KATAOKA, K. TAKEI, S. TAIRA, T. ITOI, F. MORIYASU, Y. TAKAGI, T. AOKI, H. SERIZAWA, E. RIMBARA, N. NOGUCHI & M. SASATSU. (2006) Correlation of serum pepsinogen with histological atrophy following successful Helicobacter pylori eradication. Alimentary Pharmacology <html_ent glyph="@amp;" ascii="&"/> Therapeutics Symposium Series 2:1, pages 23-30.
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K. Sugiu, T. Kamada, M. Ito, S. Kaya, A. Tanaka, H. Kusunoki, J. Hata & K. Haruma. (2006) Anti-parietal cell antibody and serum pepsinogen assessment in screening for gastric carcinoma. Digestive and Liver Disease 38:5, pages 303-307.
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Tomoari Kamada, Jiro Hata, Aki Tanaka, Hiroaki Kusunoki, Masaki Miyamoto, Kazuhiko Inoue, Yoshito Sadahira & Ken Haruma. (2006) NODULAR GASTRITIS AND GASTRIC CANCER. Digestive Endoscopy 18:2, pages 79-83.
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Teresa Starzynska, Katarzyna Ferenc, Thomas Wex, Thilo Kahne, Jan Lubinski, Malgorzata Lawniczak, Krzysztof Marlicz & Peter Malfertheiner. (2006) The Association Between the Interleukin-1 Polymorphisms and Gastric Cancer Risk Depends on the Family History of Gastric Carcinoma in the Study Population. The American Journal of Gastroenterology 101:2, pages 248-254.
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Masanori Ito, Shinji Tanaka, Tomoari Kamada, Ken Haruma & Kazuaki Chayama. (2006) Causal role of Helicobacter pylori infection and eradication therapy in gastric carcinogenesis . World Journal of Gastroenterology 12:1, pages 10.
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Jun Tanabe, Naoki Kawai, Takashi Abe, Nariyuki Ueshima, Shin Mizutani, Masahiko Tsujimoto, Haruya Meren, Sunao Kawano, Tomoari Kamada & Ken Haruma. (2006) A CASE OF DIFFUSE-TYPE EARLY GASTRIC CANCER WITH NODULAR GASTRITIS. Digestive Endoscopy 18:1, pages 67-70.
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Tomoari Kamada, Kuniaki Sugiu, Jiro Hata, Hiroaki Kusunoki, Hiroshige Hamada, Soichiro Kido, Yuichi Nagashima, Yuzuru Kawamura, Shinji Tanaka, Kazuaki Chayama & Ken Haruma. (2006) Evaluation of endoscopic and histological findings in Helicobacter pylori -positive Japanese young adults . Journal of Gastroenterology and Hepatology 21:1, pages 258-261.
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Anya N A Milne, Ralph Carvalho, Folkert M Morsink, Alex R Musler, Wendy W J de Leng, Ari Ristimäki & G Johan A Offerhaus. (2006) Early-onset gastric cancers have a different molecular expression profile than conventional gastric cancers. Modern Pathology 19:4, pages 564-572.
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Tomohiko Shimatani, Masaki Inoue, Keiko Iwamoto, Hideyuki Hyogo, Michiya Yokozaki, Toshinari Saeki, Susumu Tazuma, Yoko Horikawa & Nobue Harada. (2005) Gastric Acidity in Patients with Follicular Gastritis is Significantly Reduced, but Can be Normalized After Eradication for Helicobacter pylori. Helicobacter 10:3, pages 256-265.
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T. Kamada, J. Hata, K. Sugiu, H. Kusunoki, M. Ito, S. Tanaka, K. Inoue, Y. Kawamura, K. Chayama & K. Haruma. (2005) Clinical features of gastric cancer discovered after successful eradication of Helicobacter pylori: results from a 9-year prospective follow-up study in Japan. Alimentary Pharmacology and Therapeutics 21:9, pages 1121-1126.
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M. Ito, S. Tanaka, S. Takata, S. Oka, S. Imagawa, H. Ueda, Y. Egi, Y. Kitadai, W. Yasui, M. Yoshihara, K. Haruma & K. Chayama. (2005) Morphological changes in human gastric tumours after eradication therapy of Helicobacter pylori in a short-term follow-up. Alimentary Pharmacology and Therapeutics 21:5, pages 559-566.
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Pei-Fang Ning. (2005) Dynamic expression of pepsinogen C in gastric cancer, precancerous lesions and Helicobacter pylori associated gastric diseases . World Journal of Gastroenterology 11:17, pages 2545.
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Ralph Carvalho, Anya NA Milne, Bastiaan P van Rees, Eric Caspers, Luís Cirnes, Céu Figueiredo, G Johan A Offerhaus & Marian AJ Weterman. (2004) Early‐onset gastric carcinomas display molecular characteristics distinct from gastric carcinomas occurring at a later age. The Journal of Pathology 204:1, pages 75-83.
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Takashi Kawai, Kohei Kawakami, Taku Kudo, Kazuo Takei, Fuminori Moriyasu, Yuu Takagi, Tatsuya Aoki, Yasuhisa Koyanagi, Hiromi Serizawa, Emiko Rinbara, Masahisa Noguchi & Masanori Sasatsu. (2004) Correlation between serum pepsinogen levels and gastric mucosal histological findings before and after Helicobacter pylori eradication therapy. Digestive Endoscopy 16:2, pages 122-128.
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S Kim, K Haruma, M Ito, S Tanaka, M Yoshihara & K Chayama. (2004) Magnifying gastroendoscopy for diagnosis of histologic gastritis in the gastric antrum. Digestive and Liver Disease 36:4, pages 286-291.
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Atsunori Sasaki, Yasuhiko Kitadai, Masanori Ito, Shinji Tanaka, Masaharu Yoshihara, Ken Haruma & Kazuaki Chayama. (2004) Mucin Phenotype and Background Mucosa of Intramucosal Differentiated-Type Adenocarcinoma of the Stomach. Oncology 66:5, pages 379-387.
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