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Scandinavian Journal of Gastroenterology Volume 37, 2002 - Issue 3
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Research Article

In vitro Studies Indicate that Acid Catalysed Generation of N-Nitrosocompounds from Dietary Nitrate Will be Maximal at the Gastro-oesophageal Junction and Cardia

A. Moriya
,
J. Grant
,
C. Mowat
,
C. Williams
,
A. Carswell
,
T. Preston
,
S. Anderson
,
K. Iijima
&
K. E. L. McColl
 show all
Pages 253-261 | Published online: 08 Jul 2009

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Fumitake Ishiyama, Katsunori Iijima, Kiyotaka Asanuma, Nobuyuki Ara, Jun Yoshitake, Yasuhiko Abe, Tomoyuki Koike, Akira Imatani, Shuichi Ohara & Tooru Shimosegawa. (2009) Exogenous luminal nitric oxide exacerbates esophagus tissue damage in a reflux esophagitis model of rats. Scandinavian Journal of Gastroenterology 44:5, pages 527-537.
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Jonathan J. Manning, Angela A. Wirz & Kenneth E. L. Mccoll. (2007) Nitrogenous chemicals generated from acidification of saliva influence transient lower oesophageal sphincter relaxations. Scandinavian Journal of Gastroenterology 42:12, pages 1413-1421.
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K. Iijima, V. Fyfe & K. E. L. McColl. (2003) Studies of Nitric Oxide Generation from Salivary Nitrite in Human Gastric Juice. Scandinavian Journal of Gastroenterology 38:3, pages 246-252.
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Articles from other publishers (25)

Ji Baik, Ji Min, Sung Ju, Jae Ahn, Sung Ko, Hyun Chon, Min Kim & Yong Shin. (2022) Effects of Fermented Garlic Extract Containing Nitric Oxide Metabolites on Blood Flow in Healthy Participants: A Randomized Controlled Trial. Nutrients 14:24, pages 5238.
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Zahra Bahadoran, Parvin Mirmiran, Khosrow Kashfi & Asghar Ghasemi. (2021) Lost-in-Translation of Metabolic Effects of Inorganic Nitrate in Type 2 Diabetes: Is Ascorbic Acid the Answer?. International Journal of Molecular Sciences 22:9, pages 4735.
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Yonne Peters, Ali Al-Kaabi, Nicholas J. Shaheen, Amitabh Chak, Andrew Blum, Rhonda F. Souza, Massimiliano Di Pietro, Prasad G. Iyer, Oliver Pech, Rebecca C. Fitzgerald & Peter D. Siersema. (2019) Barrett oesophagus. Nature Reviews Disease Primers 5:1.
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Oksana S. Khukhlina, Viktoriia Yu. Drozd, Alona A. Antoniv, Tamara H. Kopchuk & Zoriana Ia. Kotsiubiichuk. (2019) PATHOGENETIC ROLE OF NITROGEN MONOXIDE EFFICIENCY OF PHARMACOTHERAPY IN PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE AND STABLE ANGINA OF TENSION. Wiadomości Lekarskie 72:5, pages 753-756.
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Chetan P. S. Ahada & Surindra Suthar. (2018) Groundwater nitrate contamination and associated human health risk assessment in southern districts of Punjab, India. Environmental Science and Pollution Research 25:25, pages 25336-25347.
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Christine C. Helms, Xiaohua Liu & Daniel B. Kim-Shapiro. (2017) Recent insights into nitrite signaling processes in blood. Biological Chemistry 398:3, pages 319-329.
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E. L. Nikonov, S. V. Kashin, N. S. Vidyaeva & E. A. Krainova. (2017) Barrett's oesophagus: the modern approaches to diagnostics, therapy, and reduction of the risk of cancer development. Dokazatel'naya gastroenterologiya 6:4, pages 4.
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Katsunori Iijima & Tooru Shimosegawa. (2014) Involvement of luminal nitric oxide in the pathogenesis of the gastroesophageal reflux disease spectrum. Journal of Gastroenterology and Hepatology 29:5, pages 898-905.
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Nathan S. Bryan, Dominik D. Alexander, James R. Coughlin, Andrew L. Milkowski & Paolo Boffetta. (2012) Ingested nitrate and nitrite and stomach cancer risk: An updated review. Food and Chemical Toxicology 50:10, pages 3646-3665.
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Grietje Holtrop, Alexandra M. Johnstone, Claire Fyfe & Silvia W. Gratz. (2012) Diet Composition Is Associated with Endogenous Formation of N-Nitroso Compounds in Obese Men. The Journal of Nutrition 142:9, pages 1652-1658.
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Pablo Gomes Ferreira, Maria Angélica Suedan Souza Lima, Robert Alvin Bernedo-Navarro, Rogério Arcuri Conceição, Edlaine Linhares, Alexandra Christine Helena Frankland Sawaya, Tomomasa Yano & Ione Salgado. (2011) Stimulation of Acidic Reduction of Nitrite to Nitric Oxide by Soybean Phenolics: Possible Relevance to Gastrointestinal Host Defense. Journal of Agricultural and Food Chemistry 59:10, pages 5609-5616.
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Emily A. Hutton, Rasa Pauliukaitė, Samo B. Hocevar, Božidar Ogorevc & Malcolm R. Smyth. (2010) Amperometric microsensor for direct probing of ascorbic acid in human gastric juice. Analytica Chimica Acta 678:2, pages 176-182.
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Bárbara S. Rocha, Bruno Gago, Rui M. Barbosa & João Laranjinha. (2010) Diffusion of nitric oxide through the gastric wall upon reduction of nitrite by red wine: Physiological impact. Nitric Oxide 22:3, pages 235-241.
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Bárbara S. Rocha, Bruno Gago, Rui M. Barbosa & João Laranjinha. (2009) Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation. Toxicology 265:1-2, pages 41-48.
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Anjana, Shahid Umar & Muhammad Iqbal. 2009. Sustainable Agriculture. Sustainable Agriculture 533 549 .
D. Pietraforte, G. Brambilla, S. Camerini, G. Scorza, L. Peri, A. Loizzo, M. Crescenzi & M. Minetti. (2008) Formation of an adduct by clenbuterol, a β-adrenoceptor agonist drug, and serum albumin in human saliva at the acidic pH of the stomach: Evidence for an aryl radical-based process. Free Radical Biology and Medicine 45:2, pages 124-135.
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Bruno Gago, Jon O. Lundberg, Rui M. Barbosa & João Laranjinha. (2007) Red wine-dependent reduction of nitrite to nitric oxide in the stomach. Free Radical Biology and Medicine 43:9, pages 1233-1242.
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Shahid Umar Anjana & Muhammad Iqbal. (2007) Nitrate accumulation in plants, factors affecting the process, and human health implications. A review. Agronomy for Sustainable Development 27:1, pages 45-57.
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Sarah Vogt, Katharina Fuchs & Elmar Richter. (2006) Genotoxic effects of myosmine in a human esophageal adenocarcinoma cell line. Toxicology 222:1-2, pages 71-79.
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Paul A. Atherfold & Janusz A. Jankowski. (2006) Molecular biology of Barrett's cancer. Best Practice & Research Clinical Gastroenterology 20:5, pages 813-827.
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S. MEHTA, I. T. JOHNSON & M. RHODES. (2005) Systematic review: the chemoprevention of oesophageal adenocarcinoma. Alimentary Pharmacology & Therapeutics 22:9, pages 759-768.
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Vicki Strugala, Erika J. Kennington, Robert J. Campbell, Gudmund Skjåk-Bræk & Peter W. Dettmar. (2005) Inhibition of pepsin activity by alginates in vitro and the effect of epimerization. International Journal of Pharmaceutics 304:1-2, pages 40-50.
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Laura Peri, Donatella Pietraforte, Giuseppe Scorza, Aurora Napolitano, Vincenzo Fogliano & Maurizio Minetti. (2005) Apples increase nitric oxide production by human saliva at the acidic pH of the stomach: A new biological function for polyphenols with a catechol group?. Free Radical Biology and Medicine 39:5, pages 668-681.
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Cyrille A.M. Krul, Marco J. Zeilmaker, Ronald C. Schothorst & Robert Havenaar. (2004) Intragastric formation and modulation of N-nitrosodimethylamine in a dynamic in vitro gastrointestinal model under human physiological conditions. Food and Chemical Toxicology 42:1, pages 51-63.
Crossref
K. Iijima, E. Henry, A. Moriya, A. Wirz, A.W. Kelman & K.E.L. McColl. (2002) Dietary nitrate generates potentially mutagenic concentrations of nitric oxide at the gastroesophageal junction. Gastroenterology 122:5, pages 1248-1257.
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