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Research Article

Fatal Hepatic Failure After Emergence of the Hepatitis B Virus Mutant During Lamivudine Therapy in a Patient with Liver Cirrhosis

Pages 366-369 | Published online: 08 Jul 2009

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Moon Kyung Joo, Jong Eun Yeon, Ji Hoon Kim, Young Kul Jung, Sun Jae Lee, Jeong Han Kim, Hyung Joon Yim, Kwan Soo Byun, Jong-Jae Park, Jae Seon Kim & Young-Tae Bak. (2008) Chronic cirrhotic hepatitis B patients with a high incidence of hepatic decompensation after viral breakthrough with lamivudine-resistant mutants and during rescue treatment. Scandinavian Journal of Gastroenterology 43:12, pages 1514-1521.
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Carla S. Coffin, Scott K. Fung, Fernando Alvarez, Curtis L. Cooper, Karen E. Doucette, Claire Fournier, Erin Kelly, Hin Hin Ko, Mang M Ma, Steven R Martin, Carla Osiowy, Alnoor Ramji, Edward Tam & Jean Pierre Villeneuve. (2018) Management of Hepatitis B Virus Infection: 2018 Guidelines from the Canadian Association for the Study of Liver Disease and Association of Medical Microbiology and Infectious Disease Canada. Canadian Liver Journal 1:4, pages 156-217.
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Ali Karimi, Loghman Salimzadeh & Nader Bagheri. (2014) Hepatitis B Virus Genotyping Among Chronic Hepatitis B Individuals With Resistance to Lamivudine in Shahrekord, Iran. Jundishapur Journal of Microbiology 7:5.
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Hong Peng, Junying Liu, Min Yang, Shiwen Tong, Wenwei Yin, Hui Tang, Peng Hu, Huaidong Hu & Hong Ren. (2014) Efficacy of lamivudine combined with adefovir dipivoxil versus entecavir monotherapy in patients with hepatitis B-associated decompensated cirrhosis: A meta-analysis. The Journal of Clinical Pharmacology 54:2, pages 189-200.
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Feng Wu, Min-Jin Wu, Xiao-Lin Zhuge, Shao-Ming Zhu & Biao Zhu. (2012) Correlation of the occurrence of YMDD mutations with HBV genotypes, HBV-DNA levels, and HBeAg status in Chinese patients with chronic hepatitis B during lamivudine treatment. Hepatobiliary & Pancreatic Diseases International 11:2, pages 172-176.
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Chen Wei, Chong Yu-tian, Wen Ji-zhi, Li Yong-wei & Li Gang. (2011) Characterization of hepatitis virus B isolated from a multi-drug refractory patient. Virus Research 155:1, pages 254-258.
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Stephen Locarnini & Fabien Zoulim. (2010) Molecular Genetics of HBV Infection. Antiviral Therapy 15:3_suppl, pages 3-14.
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Ruth Chin, Ulrich Nachbur, Linda Earnest-Silveira, Aleksandra Bankovacki, Bernd Koeberlein, Hanswalter Zentgraf, C.-Thomas Bock, John Silke & Joseph Torresi. (2010) Dysregulation of hepatocyte cell cycle and cell viability by hepatitis B virus. Virus Research 147:1, pages 7-16.
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F. Ntziora, D. Paraskevis, C. Haida, E. Magiorkinis, E. Manesis, G. Papatheodoridis, S. Manolakopoulos, A. Beloukas, S. Chryssoy, G. Magiorkinis, V. Sypsa & A. Hatzakis. (2009) Quantitative Detection of the M204V Hepatitis B Virus Minor Variants by Amplification Refractory Mutation System Real-Time PCR Combined with Molecular Beacon Technology. Journal of Clinical Microbiology 47:8, pages 2544-2550.
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S. Gloria Selabe, Ernest Song, Rosemary J. Burnett & M. Jeffrey Mphahlele. (2009) Frequent detection of hepatitis B virus variants associated with lamivudine resistance in treated South African patients infected chronically with different HBV genotypes. Journal of Medical Virology 81:6, pages 996-1001.
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Richard A. HeipertzJr.Jr., Jason L. Starkey, Thomas G. Miller, Jianming Hu & Harriet C. Isom. (2009) trans-Complementation of HBV rtM204I mutant replication by HBV wild-type polymerase. Virology 388:1, pages 57-67.
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Feifei Wang, Honghai Wang, Hongbo Shen, Chengyan Meng, Xinhua Weng & Wenhong Zhang. (2009) Evolution of hepatitis B virus polymerase mutations in a patient with HBeAg-positive chronic hepatitis B virus treated with sequential monotherapy and add-on nucleoside/nucleotide analogues. Clinical Therapeutics 31:2, pages 360-366.
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Patrick TF Kennedy, Heather C Lee, Lukshmy Jeyalingam, Raza Malik, Peter Karayiannis, David Muir, Janice Main, Mark Thursz, Robert Goldin, Belinda Smith, Ashley Brown & Howard C Thomas. (2008) NICE Guidelines and a Treatment Algorithm for the Management of Chronic Hepatitis B: A Review of 12 Years Experience in West London. Antiviral Therapy 13:8, pages 1067-1076.
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Reiichiro Kuwahara, Ryukichi Kumashiro, Tatsuya Ide, Yuriko Koga, Teruko Hino, Akiko Hisamochi, Kazuo Tanaka, Kei Ogata, Hiroyuki Koga, Yukari Takao & Michio Sata. (2008) Predictive Factors Associated with the Progression to Hepatic Failure Caused by Lamivudine-Resistant HBV. Digestive Diseases and Sciences 53:11, pages 2999-3006.
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R. Orlando, G. Tosone, G. Portella, E. Veropalumbo, M. D’Onofrio & M. Piazza. (2007) Prolonged Persistence of Lamivudine-resistant Mutant and Emergence of New Lamivudine-resistant Mutants Two Years After Lamivudine Withdrawal in HBsAg-positive Chronic Hepatitis Patient: A Case Report. Infection 36:5, pages 472-474.
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Bo Feng, Lai Wei, Ming Chen & Liping Wang. (2008) Dynamic changes of hepatitis B virus polymerase gene including YMDD motif in lamivudine-treated patients with chronic hepatitis B. Microbiological Research 163:4, pages 487-492.
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Kathryn L Nash & Graeme JM Alexander. (2008) The case for combination antiviral therapy for chronic hepatitis B virus infection. The Lancet Infectious Diseases 8:7, pages 444-448.
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Jong-Kee Kim, Hyeon-Ji Lee, Young-Jo Lee, Jong-Yoon Chun, In-Kyoung Lee, Young-Suk Lim, Dong Jin Suh, Sun-Young Ko, Myeong Hee Kim & Heung-Bum Oh. (2008) Direct detection of lamivudine-resistant hepatitis B virus mutants by a multiplex PCR using dual-priming oligonucleotide primers. Journal of Virological Methods 149:1, pages 76-84.
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Wei-Zhen Xu. (2008) Construction and expression of eukaryotic plasmids containing lamivudine-resistant or wild-type strains of Hepatitis B Virus genotype C. World Journal of Gastroenterology 14:23, pages 3733.
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Marcelle Bottecchia, Nilo Ikuta, Christian Niel, Natalia M Araujo, Kycia MR Ó & Selma A Gomes. (2007) Lamivudine resistance and other mutations in the polymerase and surface antigen genes of hepatitis B virus associated with a fatal hepatic failure case. Journal of Gastroenterology and Hepatology 23:1, pages 67-72.
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Makoto Nakamuta, Kazuhiro Kotoh, Munechika Enjoji, Eiji Kajiwara, Junya Shimono, Akihide Masumoto, Toshihiro Maruyama, Norihiro Furusyo, Hideyuki Nomura, Hironori Sakai, Kazuhiro Takahashi, Koichi Azuma, Shinji Shimoda, Yuichi Tanabe & Jun Hayashi. (2007) Effects of lamivudine on serum albumin levels correlate with pretreatment HBV-DNA levels in cirrhotic patients. Comparative Hepatology 6:1.
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Yi-Hao Yen, Sheng-Nan Lu, Chien-Hung Chen, Jing-Houng Wang, Chun-Mei Wu, Chao-Hung Hung, Po-lin Tseng, Tsung-Hui Hu, Chi-Sin Changchien & Chuan-Mo Lee. (2007) Changes in serum hepatitis B e antigen (HBeAg) levels associated with the emergence of YMDD mutants in HBeAg non-seroconverted patients during lamivudine therapy. Liver International 27:10, pages 1349-1355.
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X. P. Pan, L. J. Li, W. B. Du, M. W. Li, H. C. Cao & J. F. Sheng. (2007) Differences of YMDD mutational patterns, precore/core promoter mutations, serum HBV DNA levels in lamivudine-resistant hepatitis B genotypes B and C. Journal of Viral Hepatitis 14:11, pages 767-774.
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Masaaki Takamura, Takafumi Ichida, Shogo Ohkoshi, Shunsuke Tsubata, Akihiko Osaki, Tomoya Aoyagi, Minoru Nomoto, Kazuhiro Uehara, Haruo Terada & Yutaka Aoyagi. (2007) Decompensated Lamivudine-resistant Hepatitis B Virus-related Cirrhosis Treated Successfully with Adefovir Dipivoxil Allowing Surgery for Hepatocellular Carcinoma. Internal Medicine 46:7, pages 367-371.
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Hee-Yeon Woo, Hyosoon Park, Byung-Ik Kim, Woo-Kyu Jeon, Yong Kyun Cho & Young Jae Kim. (2007) Comparison of Mass Spectrometric Analysis and TRUGENE™ HBV Genotyping for Monitoring Lamivudine Resistance in Chronic Hepatitis B Patients. Antiviral Therapy 12:1, pages 7-14.
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Marc Bourlière. (2006) Perspectives et stratégies futures dans la prise en charge de la résistance aux analogues antiviraux dans le traitement de l’hépatite chronique B. Gastroentérologie Clinique et Biologique 30:10, pages 34-36.
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Chien-Hung Chen, Jing-Houng Wang, Chuan-Mo Lee, Chao-Hung Hung, Tsung-Hui Hu, Jyh-Chwan Wang, Sheng-Nan Lu & Chi-Sin Changchien. (2005) Virological Response and Incidence of Adefovir Resistance in Lamivudine-Resistant Patients Treated with Adefovir Dipivoxil. Antiviral Therapy 11:6, pages 771-778.
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Y.-F. Liaw, C.-M. Lee, R.-N. Chien & C.-T. Yeh. (2006) Switching to adefovir monotherapy after emergence of lamivudine-resistant mutations in patients with liver cirrhosis. Journal of Viral Hepatitis 13:4, pages 250-255.
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Chang Hong Lee, Soo–Ok Kim, Kwan Soo Byun, Myung Soon Moon, Eun–Ok Kim, Jong Eun Yeon, Wangdon Yoo & Sun Pyo Hong. (2006) Predominance of Hepatitis B Virus YMDD Mutants Is Prognostic of Viral DNA Breakthrough. Gastroenterology 130:4, pages 1144-1152.
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Jung Woo Shin. (2006) Clinical significance of hepatitis B e antigen level easurement during long-term lamivudine therapy in chronic hepatitis B patients with e antigen positive. World Journal of Gastroenterology 12:41, pages 6693.
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