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Research Article

Role of Helicobacter pylori CagA + Infection in Determining Oxidative DNA Damage in Gastric Mucosa

Pages 409-413 | Published online: 08 Jul 2009

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Jannis Kountouras, Marina Boziki, Stergios A. Polyzos, Panagiotis Katsinelos, Emmanouel Gavalas, Christos Zeglinas, Dimitri Tzivras, Iordanis Romiopoulos, Nikolaos Giorgakis, Kyriaki Anastasiadou, Elizabeth Vardaka, Constantinos Kountouras, Evangelos Kazakos, Georgia Xiromerisiou, Efthimios Dardiotis & Georgia Deretzi. (2017) Impact of reactive oxygen species generation on Helicobacter pylori-related extragastric diseases: a hypothesis. Free Radical Research 51:1, pages 73-79.
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J. Henrik Simán, Lars Engstrand, Göran Berglund, Arne Forsgren & Claes-Henrik Florén. (2007) Helicobacter pylori and CagA seropositivity and its association with gastric and oesophageal carcinoma. Scandinavian Journal of Gastroenterology 42:8, pages 933-940.
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Articles from other publishers (31)

Utkarsh Jain, Kirti Saxena & Nidhi Chauhan. (2021) Helicobacter pylori induced reactive oxygen Species: A new and developing platform for detection . Helicobacter 26:3.
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Manikandan Palrasu, Elena Zaika, Wael El-Rifai, Jianwen Que & Alexander I. Zaika. (2021) Role of Bacterial and Viral Pathogens in Gastric Carcinogenesis. Cancers 13:8, pages 1878.
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Xiangyu Liu, Muhammad Irfan, Xingzhi Xu, Chi-Yen Tay & Barry J. Marshall. (2020) Helicobacter pylori infection induced genome instability and gastric cancer. Genome Instability & Disease 1:3, pages 129-142.
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Jennifer M. Noto, Joseph P. Zackular, Matthew G. Varga, Alberto Delgado, Judith Romero-Gallo, Matthew B. Scholz, M. Blanca Piazuelo, Eric P. Skaar & Richard M. PeekJr.Jr.. (2019) Modification of the Gastric Mucosal Microbiota by a Strain-Specific Helicobacter pylori Oncoprotein and Carcinogenic Histologic Phenotype. mBio 10:3.
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Johanna C Sierra, Mohammad Asim, Thomas G Verriere, M Blanca Piazuelo, Giovanni Suarez, Judith Romero-Gallo, Alberto G Delgado, Lydia E Wroblewski, Daniel P Barry, Richard M PeekJrJr, Alain P Gobert & Keith T Wilson. (2018) Epidermal growth factor receptor inhibition downregulates Helicobacter pylori -induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis . Gut 67:7, pages 1247-1260.
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Chuan Xie, Jian Yi, Jing Lu, Muwen Nie, Meifang Huang, Jianfang Rong, Zhenhua Zhu, Jiang Chen, Xiaoliang Zhou, Bimin Li, Haiming Chen, Nonghua Lu & Xu Shu. (2018) N -Acetylcysteine Reduces ROS-Mediated Oxidative DNA Damage and PI3K/Akt Pathway Activation Induced by Helicobacter pylori Infection . Oxidative Medicine and Cellular Longevity 2018, pages 1-9.
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Cheng Guo, Peili Ding, Cong Xie, Chenyang Ye, Minfeng Ye, Chi Pan, Xiaoji Cao, Suzhan Zhang & Shu Zheng. (2017) Potential application of the oxidative nucleic acid damage biomarkers in detection of diseases. Oncotarget 8:43, pages 75767-75777.
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Zheng Chen, Tianling Hu, Shoumin Zhu, Kenichi Mukaisho, Wael El-Rifai & Dun-Fa Peng. (2017) Glutathione peroxidase 7 suppresses cancer cell growth and is hypermethylated in gastric cancer. Oncotarget 8:33, pages 54345-54356.
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Alain P. Gobert & Keith T. Wilson. (2017) Polyamine- and NADPH-dependent generation of ROS during Helicobacter pylori infection: A blessing in disguise. Free Radical Biology and Medicine 105, pages 16-27.
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Thomas Van Hecke, John Van Camp & Stefaan De Smet. (2017) Oxidation During Digestion of Meat: Interactions with the Diet and Helicobacter pylori Gastritis, and Implications on Human Health . Comprehensive Reviews in Food Science and Food Safety 16:2, pages 214-233.
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Nurşen Başaran, Merve Bacanlı & A. Ahmet Başaran. 2017. Gastrointestinal Tissue. Gastrointestinal Tissue 355 362 .
Alain P. Gobert & Keith T. Wilson. 2017. Molecular Pathogenesis and Signal Transduction by Helicobacter pylori. Molecular Pathogenesis and Signal Transduction by Helicobacter pylori 27 52 .
S. Arimoto-Kobayashi, K. Ohta, Y. Yuhara, Y. Ayabe, T. Negishi, K. Okamoto, Y. Nakajima, T. Ishikawa, K. Oguma & T. Otsuka. (2015) Mutagenicity and clastogenicity of extracts of Helicobacter pylori detected by the Ames test and in the micronucleus test using human lymphoblastoid cells. Mutagenesis 30:4, pages 537-544.
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Yasir Raza, Adnan Khan, Amber Farooqui, Muhammad Mubarak, Alex Facista, Syed Shakeel Akhtar, Saeed Khan, Javed Iqbal Kazi, Carol Bernstein & Shahana Urooj Kazmi. (2014) Oxidative DNA Damage as a Potential Early Biomarker of Helicobacter pylori Associated Carcinogenesis. Pathology & Oncology Research 20:4, pages 839-846.
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Rodney E. Shackelford, Maisoun Qassim Abdelbaqi, Khaldoon Almhanna, Kenneth Meredith & Domenico Coppola. 2014. Molecular Pathology and Diagnostics of Cancer. Molecular Pathology and Diagnostics of Cancer 177 210 .
Fabio Farinati, Romilda Cardin, Marika Piciocchi, Kryssia Rodríguez-Castro, Gemma Maddalo & Massimo Rugge. 2014. Systems Biology of Free Radicals and Antioxidants. Systems Biology of Free Radicals and Antioxidants 1871 1891 .
Sung Hee Jang, Joo Weon Lim, Tomohiro Morio & Hyeyoung Kim. (2012) Lycopene inhibits Helicobacter pylori-induced ATM/ATR-dependent DNA damage response in gastric epithelial AGS cells. Free Radical Biology and Medicine 52:3, pages 607-615.
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Maciej Wnuk, Aleksander Myszka, Anna Lewinska, Iwona Tokarz, Katarzyna Solarska & Grzegorz Bartosz. (2010) Helicobacter pylori cagA Gene Polymorphism Affects the Total Antioxidant Capacity of Human Saliva . Helicobacter 15:1, pages 53-57.
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Tomomitsu Tahara, Tomoyuki Shibata, Fangyu Wang, Masakatsu Nakamura, Mikijyu Sakata, Hiroshi Nakano, Ichiro Hirata & Tomiyasu Arisawa. (2009) A genetic variant of the p22PHOX component of NADPH oxidase C242T is associated with reduced risk of functional dyspepsia in Helicobacter pylori-infected Japanese individuals. European Journal of Gastroenterology & Hepatology 21:12, pages 1363-1368.
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Fabio Farinati, Romilda Cardin, Mauro Cassaro, Marina Bortolami, Donato Nitti, Chiara Tieppo, Giovanni Zaninotto & Massimo Rugge. (2008) Helicobacter pylori, inflammation, oxidative damage and gastric cancer: a morphological, biological and molecular pathway. European Journal of Cancer Prevention 17:3, pages 195-200.
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Jacob J. Briedé, Raymond G.J. Pot, Ernst J. Kuipers, Arnoud H.M. Vliet, Jos C.S. Kleinjans & Johannes G. Kusters. (2005) The presence of the cag pathogenicity island is associated with increased superoxide anion radical scavenging activity by Helicobacter pylori . FEMS Immunology & Medical Microbiology 44:2, pages 227-232.
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Fabio Farinati, Romilda Cardin, Valentina M. Russo, Graziella Busatto, Monica Franco, Alessandra Falda, Claudia Mescoli & Massimo Rugge. (2004) Differential Effects of Helicobacter pylori Eradication on Oxidative DNA Damage at the Gastroesophageal Junction and at the Gastric Antrum . Cancer Epidemiology, Biomarkers & Prevention 13:11, pages 1722-1728.
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Gui-Fang Yang. (2004) Expression of nuclear factor-kappa B and target genes in gastric precancerous lesions and adenocarcinoma: Association with Helicobactor pylori cagA (+) infection . World Journal of Gastroenterology 10:4, pages 491.
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Chi-Sen Chang, Wei-Na Chen, Hui-Hsuan Lin, Cheng-Chung Wu & Chau-Jong Wang. (2004) Increased oxidative DNA damage, inducible nitric oxide synthase, nuclear factor κ B expression and enhanced antiapoptosis-related proteins in Helicobacter pylori- infected non-cardiac gastric adenocarcinoma . World Journal of Gastroenterology 10:15, pages 2232.
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Aleksandra Sokic-Milutinovic, Vera TodorovicN.N. & Tomica Milosavljevic. (2004) Pathogenesis of helicobacter pylori infection: Bacterium and host relationship. Srpski arhiv za celokupno lekarstvo 132:9-10, pages 340-344.
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Silvio Danese, Alfredo Papa, Antonio Gasbarrini, Riccardo Ricci & Nicola Maggiano. (2004) Helicobacter pylori eradication down-regulates matrix metalloproteinase-9 expression in chronic gastritis and gastric ulcer. Gastroenterology 126:1, pages 369-371.
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Fabio Farinati, Romilda Cardin, Valentina M. Russo, Graziella Busatto, Monica Franco & Massimo Rugge. (2003) Helicobacter pylori CagA Status, Mucosal Oxidative Damage and Gastritis Phenotype: A Potential Pathway to Cancer? . Helicobacter 8:3, pages 227-234.
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R. M. Mc Loughlin, S. S. Sebastian, H. J. O'Connor, M. Buckley & C. A. O'Morain. (2003) Test and treat or test and scope for Helicobacter pylori infection. Any change in gastric cancer prevention?. Alimentary Pharmacology & Therapeutics 17:s2, pages 82-88.
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Takeshi Ishikawa, Norimasa Yoshida, Harukuni Tokuda, Eiichiro Ichiishi, Masashi Kuchide, Satoshi Kokura, Yuji Naito, Shinya Toyokuni, Hoyoku Nishino & Toshikazu Yoshikawa. (2003) Tumor initiating activity of Helicobacter pylori water extract on mouse skin carcinogenesis. Cancer Letters 191:1, pages 41-47.
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Purvi C. Panchal, Joshua S. Forman, Darren R. Blumberg & Keith T. Wilson. (2003) Helicobacter pylori infection: pathogenesis. Current Opinion in Gastroenterology 19:1, pages 4-10.
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Antonia R. Sepulveda & Luiz Gonzaga V. Coelho. (2002) Helicobacter pylori and gastric malignancies . Helicobacter 7:s1, pages 37-42.
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