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Research Article

The Serological Gastric Biopsy: a Non-Endoscopical Diagnostic Approach in Management of the Dyspeptic Patient Significance for Primary Care Based on a Survey of the Literature

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Pages 22-26 | Published online: 08 Jul 2009

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Read on this site (3)

Xiao-Bo Liu, Zi-Ye Gao, Qing-Hui Zhang, Shu Jin, Bo Gao, Gong-Li Yang & Sheng-Bao Li. (2019) Serum pepsinogen assay is not recommended for the diagnosis of esophageal squamous cell carcinoma: a systematic review and meta-analysis. Cancer Management and Research 11, pages 5643-5654.
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Lars Agréus, Ernst J Kuipers, Limas Kupcinskas, Peter Malfertheiner, Francesco Di Mario, Marcis Leja, Varocha Mahachai, Niv Yaron, Martijn van Oijen, Guillermo Perez Perez, Massimo Rugge, Jukka Ronkainen, Mikko Salaspuro, Pentti Sipponen, Kentaro Sugano & Joseph Sung. (2012) Rationale in diagnosis and screening of atrophic gastritis with stomach-specific plasma biomarkers. Scandinavian Journal of Gastroenterology 47:2, pages 136-147.
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Pentti Sipponen & David Y. Graham. (2007) Importance of atrophic gastritis in diagnostics and prevention of gastric cancer: Application of plasma biomarkers. Scandinavian Journal of Gastroenterology 42:1, pages 2-10.
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Articles from other publishers (31)

Jingci Zhu, Yining He, Huang Feng, Yufeng Wang & Zili Ge. (2024) B12 deficiency‐related glossitis is highly associated with high gastrin‐17 and low pepsinogen I . Journal of Oral Pathology & Medicine 53:2, pages 142-149.
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Tao Liu, Shuang Chai, Mingyang Li, Xu Chen, Yutao Xie, Zehui Zhao, Jingjing Xie, Yunpeng Yu, Feng Gao, Feng Zhu & Lihua Yang. (2024) A nanoparticle-based sonodynamic therapy reduces Helicobacter pylori infection in mouse without disrupting gut microbiota. Nature Communications 15:1.
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Michele Russo, Kryssia Isabel Rodriguez-Castro, Marilisa Franceschi, Antonio Ferronato, Maria Piera Panozzo, Lorenzo Brozzi, Francesco Di Mario, Pellegrino Crafa, Giovanni Brandimarte & Antonio Tursi. (2023) Appropriateness of Proton Pump Inhibitor Prescription Evaluated by Using Serological Markers. International Journal of Molecular Sciences 24:3, pages 2378.
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Gianluca Esposito, Ludovica Dottori, Giulia Pivetta, Irene Ligato, Emanuele Dilaghi & Edith Lahner. (2022) Pernicious Anemia: The Hematological Presentation of a Multifaceted Disorder Caused by Cobalamin Deficiency. Nutrients 14:8, pages 1672.
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Xiaoyan Chen, Rong Wang, Xusheng Huang, Fei Yang & Shengyuan Yu. (2021) The Level of Serum Pepsinogen in Diagnosing and Evaluating the Severity of Subacute Combined Degeneration Due to Vitamin B12 Deficiency. Frontiers in Neurology 12.
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Marco Vincenzo Lenti, Massimo Rugge, Edith Lahner, Emanuela Miceli, Ban-Hock Toh, Robert M. Genta, Christophe De Block, Chaim Hershko & Antonio Di Sabatino. (2020) Autoimmune gastritis. Nature Reviews Disease Primers 6:1.
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Jae Hwang Cha & Jin Seok Jang. (2020) Clinical correlation between serum pepsinogen level and gastric atrophy in gastric neoplasm. The Korean Journal of Internal Medicine 35:3, pages 550-558.
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Ghalia Khoder, Jibran Muhammad, Ibrahim Mahmoud, Sameh Soliman & Christophe Burucoa. (2019) Prevalence of Helicobacter pylori and Its Associated Factors among Healthy Asymptomatic Residents in the United Arab Emirates. Pathogens 8:2, pages 44.
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Sara Massironi, Alessandra Zilli, Alessandra Elvevi & Pietro Invernizzi. (2019) The changing face of chronic autoimmune atrophic gastritis: an updated comprehensive perspective. Autoimmunity Reviews 18:3, pages 215-222.
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J.P. van Wijngaarden, R.A.M. Dhonukshe-Rutten, E.M. Brouwer-Brolsma, A.W. Enneman, K.M.A. Swart, S.C. van Dijk, P.H. in 't Veld, N.M. van Schoor, N. van der Velde, R. de Jonge, P. Lips, A.G. Uitterlinden & L.C.P.G.M. de Groot. (2017) Vitamin B12 intake and related biomarkers: Associations in a Dutch elderly population. The Journal of nutrition, health and aging 21:10, pages 1268-1276.
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Ban-Hock Toh. (2016) Pathophysiology and laboratory diagnosis of pernicious anemia. Immunologic Research 65:1, pages 326-330.
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Ban-Hock Toh. (2014) Diagnosis and classification of autoimmune gastritis. Autoimmunity Reviews 13:4-5, pages 459-462.
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Tae-Su KimEhn-Kyoung ChoiJihyun KimKyungha ShinSung-Pyo LeeYoungjin ChoiJoseph H. JeonYun-Bae Kim. (2014) Anti- Helicobacter pylori activities of FEMY-R7 composed of fucoidan and evening primrose extract in mice and humans . Laboratory Animal Research 30:3, pages 131.
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Ban-Hock Toh, James Chan, Tin Kyaw & Frank Alderuccio. (2010) Cutting Edge Issues in Autoimmune Gastritis. Clinical Reviews in Allergy & Immunology 42:3, pages 269-278.
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Xianghong Zhang, Liying Xue, Lingxiao Xing, Junling Wang, Jinfeng Cui, Jianmin Mi, Xin Xing, Juan Wang, Zhanjun Du, Junichi Misumi, Qingbao Tian & Liqin Wang. (2011) Low serum pepsinogen I and pepsinogen I/II ratio and Helicobacter pylori infection are associated with increased risk of gastric cancer: 14‐year follow up result in a rural Chinese community . International Journal of Cancer 130:7, pages 1614-1619.
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Antonio Antico, Marilina Tampoia, Danilo Villalta, Elio Tonutti, Renato Tozzoli & Nicola Bizzaro. (2012) Clinical Usefulness of the Serological Gastric Biopsy for the Diagnosis of Chronic Autoimmune Gastritis. Clinical and Developmental Immunology 2012, pages 1-5.
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Jun-Hyung ChoYoung Woon ChangYoung HwangboJaejun ShimJae Young JangHyo Jong KimByung-Ho Kim. (2011) Clinical Parameters Including Serum Pepsinogen Level and Management Strategy in Patients with Gastric Low-Grade Dysplasia. The Korean Journal of Helicobacter and Upper Gastrointestinal Research 11:1, pages 52.
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C. J. VAN MARREWIJK, M. G. H. VAN OIJEN, L. I. PALOHEIMO, G. A. J. FRANSEN, S. MUJAKOVIC, J. W. M. MURIS, M. E. NUMANS, N. J. DE WIT, D. E. GROBBEE, J. A. KNOTTNERUS, R. J. F. LAHEIJ & J. B. M. J. JANSEN. (2009) Influence of gastric mucosal status on success of stepwise acid suppressive therapy for dyspepsia. Alimentary Pharmacology & Therapeutics 30:1, pages 82-89.
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Jung Mook Kang, Nayoung Kim, Ji Youn Yoo, Young Soo Park, Dong Ho Lee, Hyun Young Kim, Hye Seung Lee, Gheeyoung Choe, Joo Sung Kim, Hyun Chae Jung & In Sung Song. (2008) The Role of Serum Pepsinogen and Gastrin Test for the Detection of Gastric Cancer in Korea. Helicobacter 13:2, pages 146-156.
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Hyojin ChaeJe-Hoon LeeJihyang LimMyungshin KimYonggoo KimKyungja HanChang-Suk KangSang-In ShimJin-Il KimSoo-Heon Park. (2008) Clinical Utility of Serum Pepsinogen Levels as a Screening Test of Atrophic Gastritis. The Korean Journal of Laboratory Medicine 28:3, pages 201.
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André Korstanje, Susanne van Eeden, Johan A. Offerhaus, Frans L. Waltman, Gijsbert den Hartog, Freek W. C. Roelandse, John H. M. Souverijn, Izak Biemond & Cornelis B. H. W. Lamers. (2008) Comparison Between Serology and Histology in the Diagnosis of Advanced Gastric Body Atrophy. Journal of Clinical Gastroenterology 42:1, pages 18-22.
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A. KORSTANJE, S. VAN EEDEN, G. J. A. OFFERHAUS, L. J. M. SABBE, G. DEN HARTOG, I. BIEMOND & C. B. H. W. LAMERS. (2006) The 13 carbon urea breath test for the diagnosis of Helicobacter pylori infection in subjects with atrophic gastritis: evaluation in a primary care setting . Alimentary Pharmacology & Therapeutics 24:4, pages 643-650.
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Andr?? Korstanje, Gijsbert den Hartog, Izak Biemond, Freek W.C. Roelandse, John H.M. Souverijn & Cornelis B.H.W. Lamers. (2006) Role of Helicobacter pylori and autoimmunity in serological atrophic corpus gastritis in a Dutch primary care community. European Journal of Gastroenterology & Hepatology 18:8, pages 911-916.
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Robert M Genta. (2006) Assessing risks for gastric cancer: New tools for pathologists. World Journal of Gastroenterology 12:35, pages 5622.
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B. Germaná, F. Di Mario, L.G. Cavallaro, A.M. Moussa, P. Lecis, S. Liatoupolou, G. Comparato, C. Carloni, G. Bertiato, M. Battiestel, N. Papa, G. Aragona, G.M. Cavestro, V. Iori, R. Merli, S. Bertolini, P. Caruana & A. Franzé. (2005) Clinical usefulness of serum pepsinogens I and II, gastrin-17 and anti-Helicobacter pylori antibodies in the management of dyspeptic patients in primary care. Digestive and Liver Disease 37:7, pages 501-508.
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Hajime Isomoto, Hiroaki Ueno, Yoshito Nishi, Toru Yasutake, Kenji Tanaka, Naoko Kawano, Ken Ohnita, Yohei Mizuta, Kenichiro Inoue, Masamitsu Nakazato & Shigeru Kohno. (2005) Circulating Ghrelin Levels in Patients with Various Upper Gastrointestinal Diseases. Digestive Diseases and Sciences 50:5, pages 833-838.
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Pei-Fang Ning. (2005) Dynamic expression of pepsinogen C in gastric cancer, precancerous lesions and Helicobacter pylori associated gastric diseases . World Journal of Gastroenterology 11:17, pages 2545.
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Yoshito Nishi. (2005) Concentrations of α- and β-defensins in gastric juice of patients with various gastroduodenal diseases. World Journal of Gastroenterology 11:1, pages 99.
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Peifang Ning, Liping Sun, Huijie Liu & Yuan Yuan. (2004) Expression of pepsinogen C in gastric cancer and precancerous diseases and its clinical significance. Chinese Journal of Clinical Oncology 1:6, pages 422-426.
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Kai Chun Wu, Hong Tao Li, Tai Dong Qiao, Cai Ning Li, Wan Sheng Ji, Feng Qi Tian, Xin Wang, Biao Luo Wang, Ji Yan Miao, Jie Ding & Dai Ming Fan. (2004) Diagnosis of atrophic body gastritis in Chinese patients by measuring serum pepsinogen. Chinese Journal of Digestive Diseases 5:1, pages 22-27.
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Magnus Sundbom, Erik Mårdh, Sven Mårdh, Margareta Öhrvall & Sven Gustavsson. (2003) Reduction in Serum Pepsinogen I After Roux-en-Y Gastric Bypass. Journal of Gastrointestinal Surgery 7:4, pages 529-535.
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