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Research Article

Gastric Acidity Protects Mice Against Prion Infection?

Pages 497-500 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Gary R. Martin, Keith A. Sharkey & Frank R. Jirik. (2015) Orally administered indomethacin acutely reduces cellular prion protein in the small intestine and modestly increases survival of mice exposed to infectious prions. Scandinavian Journal of Gastroenterology 50:5, pages 542-549.
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Tom C. Martinsen, Sylvie L. Benestad, Torfinn Moldal & Helge L. Waldum. (2011) Inhibitors of gastric acid secretion increase the risk of prion infection in mice. Scandinavian Journal of Gastroenterology 46:12, pages 1418-1422.
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Arne K Sandvik, Helge L Waldum & Eiliv Brenna. (2002) Long-term safety of proton pump inhibitors: risks of gastric neoplasia and infections. Expert Opinion on Drug Safety 1:1, pages 29-38.
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Articles from other publishers (20)

Alissa S. Higinbotham & Camilla W. Kilbane. (2024) The gastrointestinal tract and Parkinson’s disease. Frontiers in Cellular and Infection Microbiology 13.
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Clarissa J. Booth, Stuart Siegfried Lichtenberg, Richard J. Chappell & Joel A. Pedersen. (2021) Chemical Inactivation of Prions Is Altered by Binding to the Soil Mineral Montmorillonite. ACS Infectious Diseases 7:4, pages 859-870.
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Helge Waldum & Tom Christian Martinsen. (2021) Chronic diseases: what about infections of virus and prions via the gut? . Therapeutic Advances in Gastroenterology 14, pages 175628482110288.
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Martinsen, Fossmark & Waldum. (2019) The Phylogeny and Biological Function of Gastric Juice—Microbiological Consequences of Removing Gastric Acid. International Journal of Molecular Sciences 20:23, pages 6031.
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Reidar Fossmark, Tom C. Martinsen & Helge L. Waldum. (2019) Adverse Effects of Proton Pump Inhibitors—Evidence and Plausibility. International Journal of Molecular Sciences 20:20, pages 5203.
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Leon Fisher & Alexander Fisher. (2017) Acid-Suppressive Therapy and Risk of Infections: Pros and Cons. Clinical Drug Investigation 37:7, pages 587-624.
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H. L. Waldum, Ø. Hauso & R. Fossmark. (2013) The regulation of gastric acid secretion – clinical perspectives. Acta Physiologica 210:2, pages 239-256.
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Christopher M. Vickery, Katy E. Beck, Marion M. Simmons, Stephen A. C. Hawkins & John Spiropoulos. (2013) Disease characteristics of bovine spongiform encephalopathy following inoculation into mice via three different routes. International Journal of Experimental Pathology 94:5, pages 320-328.
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Kristin G. Nørsett, Astrid Lægreid, Waclaw Kusnierczyk, Mette Langaas, Sonja Ylving, Reidar Fossmark, Simen Myhre, Sture Falkmer, Helge L. Waldum & Arne K. Sandvik. (2008) Changes in gene expression of gastric mucosa during therapeutic acid inhibition. European Journal of Gastroenterology & Hepatology 20:7, pages 613-623.
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Michael T Bethune & Chaitan Khosla. (2008) Parallels between Pathogens and Gluten Peptides in Celiac Sprue. PLoS Pathogens 4:2, pages e34.
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Rodrigo Morales, Dennisse González, Claudio Soto & Joaqu_n Castilla. 2007. Microbial Food Contamination, Second Edition. Microbial Food Contamination, Second Edition.
Christopher J Johnson, Joel A Pedersen, Rick J Chappell, Debbie McKenzie & Judd M Aiken. (2007) Oral Transmissibility of Prion Disease Is Enhanced by Binding to Soil Particles. PLoS Pathogens 3:7, pages e93.
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T. C. Martinsen & H. L. Waldum. (2006) Gastric juice – a natural‐born killer. Alimentary Pharmacology & Therapeutics 23:11, pages 1677-1678.
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Thomas R. Appel, Ralf Lucassen, Martin H. Groschup, Marion Joncic, Michael Beekes & Detlev Riesner. (2006) Acid inactivation of prions: efficient at elevated temperature or high acid concentration. Journal of General Virology 87:5, pages 1385-1394.
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Christopher J Johnson, Kristen E Phillips, Peter T Schramm, Debbie McKenzie, Judd M Aiken & Joel A Pedersen. (2006) Prions Adhere to Soil Minerals and Remain Infectious. PLoS Pathogens 2:4, pages e32.
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Frank O Bastian. (2005) Spiroplasma as a Candidate Agent for the Transmissible Spongiform Encephalopathies. Journal of Neuropathology and Experimental Neurology 64:10, pages 833-838.
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Kristin G. Nørsett, Astrid Lægreid, Mette Langaas, Sara Wörlund, Reidar Fossmark, Helge L. Waldum & Arne K. Sandvik. (2005) Molecular characterization of rat gastric mucosal response to potent acid inhibition. Physiological Genomics 22:1, pages 24-32.
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Helge L. Waldum, Tom Chr. Martinsen & Eiliv Brenna. (2005) Nonulcer dyspepsia and proton pump inhibitors. Gastroenterology 128:3, pages 805.
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Tom C. Martinsen, Kåre Bergh & Helge L. Waldum. (2005) Gastric Juice: A Barrier Against Infectious Diseases. Basic & Clinical Pharmacology & Toxicology 96:2, pages 94-102.
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Mitchell L. Schubert. (2003) Gastric secretion. Current Opinion in Gastroenterology 19:6, pages 519-525.
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