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Scandinavian Journal of Gastroenterology Volume 37, 2002 - Issue 8
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Research Article

Cirrhotic Patients With or Without Hepatocellular Carcinoma Harbour AFP-Specific T-Lymphocytes That Can Be Activated in vitro by Human Alpha-Fetoprotein

P. Hanke
,
C. Rabe
,
M. Serwe
,
S. Böhm
,
C. Pagenstecher
,
T. Sauerbruch
&
W. H. Caselmann
 show all
Pages 949-955 | Published online: 08 Jul 2009

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Bruno Sangro, Daniel Palmer & Ignacio Melero. (2014) Immunotherapy of Hepatocellular Carcinoma. Hepatic Oncology 1:4, pages 433-446.
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Viktoria N Evdokimova & Lisa H Butterfield. (2008) α-Fetoprotein and other tumour-associated antigens for immunotherapy of hepatocellular cancer. Expert Opinion on Biological Therapy 8:3, pages 325-336.
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Xiao-Ping Wang, Qiao-Xia Wang, Huan-Ping Lin, Bing Xu, Qian Zhao & Kun Chen. (2016) Recombinant heat shock protein 70 functional peptide and alpha-fetoprotein epitope peptide vaccine elicits specific anti-tumor immunity. Oncotarget 7:44, pages 71274-71284.
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Xiao-Ping WangQiao-Xia WangHuan-Ping LinYa-Li WangYX Yang. (2013) Glycoprotein 96 and α-Fetoprotein Cross-Linking Complexes Elicited Specific Antitumor Immunity. Cancer Biotherapy and Radiopharmaceuticals 28:5, pages 406-414.
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Xiaoping Wang, Qiaoxia Wang, Huanping Lin, Sanzhong Li, Lijun Sun & Yixin Yang. (2013) HSP72 and gp96 in gastroenterological cancers. Clinica Chimica Acta 417, pages 73-79.
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Xiao Ping Wang, Huan Ping Lin & Qiao Xia Wang. (2012) Anti-Tumor Immunity Elicited by Peptide Complex-Alpha-Fetoprotein and Glycoprotein 96. Applied Mechanics and Materials 195-196, pages 397-401.
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Xiao-Ping WangHuan-Ping LinQiao-Xia WangYan Gu. (2012) Specific Antitumor Immunity Induced by Cross-linking Complex Heat Shock Protein 72 and Alpha-fetoprotein. Cancer Biotherapy and Radiopharmaceuticals 27:3, pages 189-197.
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Xiaoping Wang, Huanping Lin & Qiaoxia Wang. (2012) Specific Genetic Immunotherapy Induced by Recombinant Vaccine Alpha-Fetoprotein-Heat Shock Protein 70 Complex. Physics Procedia 33, pages 738-742.
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Huan Ping Lin, Xiao Ping Wang & Qiao Xia Wang. (2011) Anti-Tumor Immunotherapy Elicited by Cross-Link Peptide Vaccine Alpha-Fetoprotein and Heat Shock Protein 70 Complex. Advanced Materials Research 343-344, pages 378-383.
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Xiaoping Wang, Huanping Lin & Qiaoxia Wang. (2011) Anti-tumor Immunity Induced by Cross-link Complex Alpha- fetoprotein and Glycoprotein 96. Procedia Environmental Sciences 8, pages 440-445.
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Shahriar Behboudi, Sandra Boswell & Roger Williams. (2010) Cell-mediated immune responses to α-fetoprotein and other antigens in hepatocellular carcinoma. Liver International 30:4, pages 521-526.
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Shahriar Behboudi. (2010) Alpha-fetoprotein specific CD4 and CD8 T cell responses in patients with hepatocellular carcinoma. World Journal of Hepatology 2:7, pages 256.
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Yafeng Wan, Xiaopeng Ma, Xingrui Li & Jilin Yi. (2009) A novel immunotherapy to hepatocellular carcinoma: CD40-activated B lymphocytes transfected with AFPmRNA. Medical Hypotheses 73:5, pages 835-837.
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Xiaoping Wang, Lijie Zhang, Lijun Sun, Yongxue Zhou, Qiaoxia Wang, Huanping Lin, Xiaoping Ying & Lansheng Guo. (2009) Antitumor Immunity Induced by Recombinant Vaccine Alpha-Fetoprotein-Heat Shock Protein 70 Complex. Antitumor Immunity Induced by Recombinant Vaccine Alpha-Fetoprotein-Heat Shock Protein 70 Complex.
M. Rinaldi, S. Iurescia, D. Fioretti, A. Ponzetto & G. Carloni. (2009) Strategies for Successful Vaccination against Hepatocellular Carcinoma. International Journal of Immunopathology and Pharmacology 22:2, pages 269-277.
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Olivera J. Finn, Robert J. Binder, Anthony G. Brickner, Lisa H. Butterfield, Robert L. Ferris, Pawel Kalinski, Hideho Okada, Walter J. Storkus, Theresa L. Whiteside & Hassane M. Zarour. 2009. Tumor‐Associated Antigens. Tumor‐Associated Antigens 23 43 .
Gerald J. Mizejewski. (2008) Alpha-fetoprotein (AFP)-derived peptides as epitopes for hepatoma immunotherapy: a commentary. Cancer Immunology, Immunotherapy 58:2, pages 159-170.
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Daniel H. Palmer, Rachel S. Midgley, Noweeda Mirza, Elizabeth E. Torr, Forhad Ahmed, Jane C. Steele, Neil M. Steven, David J. Kerr, Lawrence S. Young & David H. Adams. (2009) A phase II study of adoptive immunotherapy using dendritic cells pulsed with tumor lysate in patients with hepatocellular carcinoma. Hepatology 49:1, pages 124-132.
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Robert Thimme, Michaela Neagu, Tobias Boettler, Christoph Neumann-Haefelin, Nadine Kersting, Michael Geissler, Frank Makowiec, Robert Obermaier, Ulrich T. Hopt, Hubert E. Blum & Hans Christian Spangenberg. (2008) Comprehensive analysis of the α-fetoprotein-specific CD8+ T cell responses in patients with hepatocellular carcinoma. Hepatology 48:6, pages 1821-1833.
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Qiao Xing, Xue-Wen Pang, Ji-Run Peng, Yan-Hui Yin, Yan Li, Xin Yu, Shu-Pei Zhou, Yu Zhang & Wei-Feng Chen. (2008) Identification of new cytotoxic T-lymphocyte epitopes from cancer testis antigen HCA587. Biochemical and Biophysical Research Communications 372:2, pages 331-335.
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Lisa H. Butterfield, Antoni Ribas, Douglas M. Potter & James S. Economou. (2007) Spontaneous and vaccine induced AFP-specific T cell phenotypes in subjects with AFP-positive hepatocellular cancer. Cancer Immunology, Immunotherapy 56:12, pages 1931-1943.
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Gerald J. Mizejewski. (2016) Physiology of Alpha-Fetoprotein as a Biomarker for Perinatal Distress: Relevance to Adverse Pregnancy Outcome. Experimental Biology and Medicine 232:8, pages 993-1004.
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Jeannette Cany, Audrey Avril, Virginie Pichard, Dominique Aubert, Nicolas Ferry & Sophie Conchon. (2007) A transgenic mouse with β-Galactosidase as a fetal liver self-antigen for immunotherapy studies. Journal of Hepatology 47:3, pages 396-403.
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Viktoria N. Evdokimova, Yang Liu, Douglas M. Potter & Lisa H. Butterfield. (2007) AFP-specific CD4+ Helper T-cell Responses in Healthy Donors and HCC Patients. Journal of Immunotherapy 30:4, pages 425-437.
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Lakshmana Ayaru, Stephen P. Pereira, Akeel Alisa, Ansar A. Pathan, Roger Williams, Brian Davidson, Andrew K. Burroughs, Tim Meyer & Shahriar Behboudi. (2007) Unmasking of α-Fetoprotein-Specific CD4+ T Cell Responses in Hepatocellular Carcinoma Patients Undergoing Embolization. The Journal of Immunology 178:3, pages 1914-1922.
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Gerald J. Mizejewski. (2007) The Alpha-Fetoprotein–Derived Growth Inhibitory Peptide 8-Mer Fragment: Review of a Novel Anticancer Agent. Cancer Biotherapy and Radiopharmaceuticals 22:1, pages 73-98.
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Tim F. Greten, Michael P. Manns & Firouzeh Korangy. (2006) Immunotherapy of hepatocellular carcinoma. Journal of Hepatology 45:6, pages 868-878.
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Giorgio Parmiani & Andrea Anichini. (2006) T cell infiltration and prognosis in HCC patients. Journal of Hepatology 45:2, pages 178-181.
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Maria A. González‐Carmona, Angela Märten, Per Hoffmann, Carlo Schneider, Elisabeth Sievers, Ingo G. H. Schmidt‐Wolf, Tilman Sauerbruch & Wolfgang H. Caselmann. (2006) Patient‐derived dendritic cells transduced with an a‐fetoprotein‐encoding adenovirus and co‐cultured with autologous cytokine‐induced lymphocytes induce a specific and strong immune response against hepatocellular carcinoma cells. Liver International 26:3, pages 369-379.
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Thjon J. Tang, Dragica Vukosavljevic, Harry L.A. Janssen, Rekha S. Binda, Shanta Mancham, Hugo W. Tilanus, Jan N.M. IJzermans, Hemmo Drexhage & Jaap Kwekkeboom. (2006) Aberrant composition of the dendritic cell population in hepatic lymph nodes of patients with hepatocellular carcinoma. Human Pathology 37:3, pages 332-338.
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Mona Y. Ali, Christian F. Grimm, Marcus Ritter, Leonhard Mohr, Hans-Peter Allgaier, Robert Weth, Wulf O. Bocher, Katja Endrulat, Hubert E. Blum & Michael Geissler. (2005) Activation of dendritic cells by local ablation of hepatocellular carcinoma. Journal of Hepatology 43:5, pages 817-822.
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Akeel Alisa, Annette Ives, Ansar A. Pathan, Cristina V. Navarrete, Roger Williams, Antonio Bertoletti & Shahriar Behboudi. (2005) Analysis of CD4+ T-Cell Responses to a Novel α-Fetoprotein-Derived Epitope in Hepatocellular Carcinoma Patients. Clinical Cancer Research 11:18, pages 6686-6694.
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Marcus Ritter, Mona Y. Ali, Christian F. Grimm, Robert Weth, Leonhard Mohr, Wulf O. Bocher, Katja Endrulat, Heiner Wedemeyer, Hubert E. Blum & Michael Geissler. (2004) Immunoregulation of dendritic and T cells by alpha-fetoprotein in patients with hepatocellular carcinoma. Journal of Hepatology 41:6, pages 999-1007.
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Lisa H. Butterfield. (2004) Immunotherapeutic strategies for hepatocellular carcinoma. Gastroenterology 127:5, pages S232-S241.
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Firouzeh Korangy, Lars A. Ormandy, Jörg S. Bleck, Jürgen Klempnauer, Ludwig Wilkens, Michael P. Manns & Tim F. Greten. (2004) Spontaneous Tumor-Specific Humoral and Cellular Immune Responses to NY-ESO-1 in Hepatocellular Carcinoma. Clinical Cancer Research 10:13, pages 4332-4341.
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Xiao-Ping Wang. (2004) Antitumor immunity induced by DNA vaccine encoding alpha-fetoprotein/heat shock protein 70. World Journal of Gastroenterology 10:21, pages 3197.
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Bing Li, Xiao-Ping Qian, Xue-Wen Pang, Wan-Zhong Zou, Yu-Ping Wang, Hong-Yan Wu & Wei-Feng Chen. (2003) HCA587 Antigen Expression in Normal Tissues and Cancers: Correlation with Tumor Differentiation in Hepatocellular Carcinoma. Laboratory Investigation 83:8, pages 1185-1192.
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Robin Steigerwald, Christian Rabe, Volker Schmitz, Ingo G. Schmidt-Wolf, Michael Alt & Wolfgang H. Caselmann. (2003) Requirements for Adeno-Associated Virus-Derived Non-Viral Vectors to Achieve Stable and Site-Specific Integration of Plasmid DNA in Liver Carcinoma Cells. Digestion 68:1, pages 13-23.
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V. Schmitz & W. H. Caselmann. 2003. Regionale Tumortherapie. Regionale Tumortherapie 303 308 .

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