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Scandinavian Journal of Gastroenterology Volume 38, 2003 - Issue 9
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Research Article

Pharmacological Monitoring of Azathioprine Therapy

Reuther L. O. Dept. of Clinical Pharmacology Gentofte University Hospital Copenhagen Denmark
,
Sonne J. Clinical Pharmacological Laboratory Glostrup University Hospital Copenhagen Denmark
,
Larsen N. E. Dept. of Gastroenterology Århus University Hospital Copenhagen Denmark
,
Larsen B. Dept. of Gastroenterology Herlev University Hospital Copenhagen Denmark
,
Christensen S. Dept. of Gastroenterology Hvidovre University Hospital Copenhagen Denmark
,
Rasmussen S. N. Dept. of Gastroenterology The University Hospital Rigshospitalet Copenhagen Denmark
,
Tofteng F. Dept. of Gastroenterology Gentofte University Hospital Copenhagen Denmark
,
Haaber A. Dept. of Gastroenterology Frederiksberg Hospital Copenhagen Denmark
,
Johansen N. Dept. of Medical Gastroenterology Odense University Hospital Copenhagen Denmark
,
Kjeldsen J. Pediatric Clinic II The University Hospital Rigshospitalet Copenhagen Denmark
&
Schmiegelow K. Dept. of Clinical Pharmacology Gentofte University Hospital Copenhagen Denmark
 show all
Pages 972-977 | Published online: 08 Jul 2009

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Sridhar Mani, Mohammed Ghalib, Imran Chaudhary & Sanjay Goel. (2009) Alterations of chemotherapeutic pharmacokinetic profiles by drug–drug interactions. Expert Opinion on Drug Metabolism & Toxicology 5:2, pages 109-130.
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O. Slanař, P. Chalupná, A. Novotný, M. Bortlík, Z. Krška & M. Lukáš. (2008) Fatal Myelotoxicity After Azathioprine Treatment. Nucleosides, Nucleotides & Nucleic Acids 27:6-7, pages 661-665.
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Imke Atreya & Markus F Neurath. (2008) Azathioprine in inflammatory bowel disease: improved molecular insights and resulting clinical implications. Expert Review of Gastroenterology & Hepatology 2:1, pages 23-34.
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E. G. Quetglas, A. Armuzzi, S. Wigge, G. Fiorino, L. Barnscheid, M. Froelich & Silvio Danese. (2015) Review article: The pharmacokinetics and pharmacodynamics of drugs used in inflammatory bowel disease treatment. European Journal of Clinical Pharmacology 71:7, pages 773-799.
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Melissa L. Haines, Yousef Ajlouni, Peter M. Irving, Miles P. Sparrow, Rosemary Rose, Richard B. Gearry & Peter R. Gibson. (2011) Clinical usefulness of therapeutic drug monitoring of thiopurines in patients with inadequately controlled inflammatory bowel disease. Inflammatory Bowel Diseases 17:6, pages 1301-1307.
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Yong Sung Choi, Jung Pil Suh, Kee Ho Song, Jae Bum Lee, Doo Seok Lee, In Taek Lee, Do Sun Kim & Doo Han Lee. (2011) A Case of Crohn’s Disease with Improvement after Azathioprine-Induced Pancytopenia. Case Reports in Gastroenterology 5:2, pages 344-349.
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Brian G Feagan & John WD McDonald. 2010. Evidence‐Based Gastroenterology and Hepatology. Evidence‐Based Gastroenterology and Hepatology 211 231 .
Nicole Jourdil, Xavier Fonrose, Roselyne Boulieu & Françoise Stanke-Labesque. (2010) Suivi thérapeutique pharmacologique des 6-thioguanine nucléotides dans les maladies inflammatoires cryptogéniques de l’intestin : intérêt et limites. Therapies 65:3, pages 177-186.
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Elena Toscano, Judit Cotta, Mercedes Robles, Ma Isabel Lucena & Raúl J. Andrade. (2010) Toxicidad hepática inducida por los nuevos fármacos inmunosupresores. Gastroenterología y Hepatología 33:1, pages 54-65.
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Javier P. Gisbert & Fernando Gomolln. (2008) Thiopurine-Induced Myelotoxicity in Patients With Inflammatory Bowel Disease: A Review. The American Journal of Gastroenterology 103:7, pages 1783-1800.
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Nabil Tahri. (2007) Observance thérapeutique et maladies inflammatoires chroniques de l'intestin. La Presse Médicale 36:9, pages 1236-1243.
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B. BOKEMEYER, A. TEML, C. ROGGEL, P. HARTMANN, C. FISCHER, E. SCHAEFFELER & M. SCHWAB. (2007) Adherence to thiopurine treatment in out‐patients with Crohn’s disease. Alimentary Pharmacology & Therapeutics 26:2, pages 217-225.
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Javier P. Gisbert, Pilar Niño, Luis Rodrigo, Carlos Cara & Luis G. Guijarro. (2006) Thiopurine Methyltransferase (TPMT) Activity and Adverse Effects of Azathioprine in Inflammatory Bowel Disease: Long-Term Follow-Up Study of 394 Patients. The American Journal of Gastroenterology 101:12, pages 2769-2776.
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Javier P. Gisbert, Yago González-Lama & José Maté. (2006) Monitorización de la tiopurina metiltransferasa y de los metabolitos tiopurínicos para optimizar el tratamiento con azatioprina en la enfermedad inflamatoria intestinal. Gastroenterología y Hepatología 29:9, pages 568-583.
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Sharon J. Gardiner & Evan J. Begg. (2006) Pharmacogenetics, Drug-Metabolizing Enzymes, and Clinical Practice. Pharmacological Reviews 58:3, pages 521-590.
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Albert J. Czaja & Herschel A. Carpenter. (2006) Thiopurine Methyltransferase Deficiency and Azathioprine Intolerance in Autoimmune Hepatitis. Digestive Diseases and Sciences 51:5, pages 968-975.
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Marie Pierik. (2006) Pharmacogenetics in inflammatory bowel disease. World Journal of Gastroenterology 12:23, pages 3657.
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John A Duley & Timothy H. J Florin. (2005) Thiopurine Therapies. Therapeutic Drug Monitoring 27:5, pages 647-654.
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RICHARD B GEARRY & MURRAY L BARCLAY. (2005) Azathioprine and 6‐mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease. Journal of Gastroenterology and Hepatology 20:8, pages 1149-1157.
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C. A. SIEGEL & B. E. SANDS. (2005) Review article: practical management of inflammatory bowel disease patients taking immunomodulators. Alimentary Pharmacology & Therapeutics 22:1, pages 1-16.
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Brian G Feagan & John WD McDonald. 2004. Evidence‐based Gastroenterology and Hepatology. Evidence‐based Gastroenterology and Hepatology 179 195 .
Margarete A. Fabre, Des C. Jones, Mike Bunce, Peter J. Morris, Peter J. Friend, Ken I. Welsh & Sara E. Marshall. (2004) The impact of thiopurine S-methyltransferase polymorphisms on azathioprine dose 1 year after renal transplantation. Transplant International 17:9, pages 531-539.
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