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Scandinavian Journal of Gastroenterology Volume 40, 2005 - Issue 6
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Original Article

Plasma acylated ghrelin levels correlate with subjective symptoms of functional dyspepsia in female patients

Toshiaki Shinomiya Department of Psychosomatic Internal Medicine, Kansai Medical University, Osaka, Japan
,
Mikihiko Fukunaga Department of Psychosomatic Internal Medicine, Kansai Medical University, Osaka, Japan
,
Takashi Akamizu Ghrelin Research Project, Department of Experimental Therapeutics, JapanCorrespondence[email protected]
,
Taiga Irako Ghrelin Research Project, Department of Experimental Therapeutics, Japan
,
Masayuki Yokode Department of Clinical Innovative Medicine, Translational Research Center, Kyoto University Hospital, Japan
,
Kenji Kangawa Ghrelin Research Project, Department of Experimental Therapeutics, Japan; Department of Biochemistry, National Cardiovascular Center Research Institute, Osaka, Japan
,
Yoshihide Nakai Department of Psychosomatic Internal Medicine, Kansai Medical University, Osaka, Japan
&
Yoshikatsu Nakai School of Health Sciences, Faculty of Medicine, Kyoto University, Japan
 show all
Pages 648-653 | Received 08 Sep 2004, Accepted 09 Nov 2004, Published online: 08 Jul 2009

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Shaman Rajindrajith, Judith Zeevenhooven, Niranga Manjuri Devanarayana, Bonaventure Jayasiri Crispus Perera & Marc A. Benninga. (2018) Functional abdominal pain disorders in children. Expert Review of Gastroenterology & Hepatology 12:4, pages 369-390.
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Alkesh V Zala, Marjorie M Walker & Nicholas J Talley. (2015) Emerging drugs for functional dyspepsia. Expert Opinion on Emerging Drugs 20:2, pages 221-233.
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Tetsuro Ohno, Mitsuhiro Yanai, Hiroyuki Ando, Yoshitaka Toyomasu, Atsushi Ogawa, Hiroki Morita, Kyoichi Ogata, Erito Mochiki, Takayuki Asao & Hiroyuki Kuwano. (2011) Rikkunshito, a traditional Japanese medicine, suppresses cisplatin-induced anorexia in humans. Clinical and Experimental Gastroenterology 4, pages 291-296.
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Young Sun Kim & Nayoung Kim. (2020) Functional Dyspepsia: A Narrative Review With a Focus on Sex-Gender Differences. Journal of Neurogastroenterology and Motility 26:3, pages 322-334.
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Yoon Jin Choi, Nayoung Kim, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Ji Hyun Park, Ryoung Hee Nam, Dong Ho Lee & Hyun Chae Jung. (2015) Increase in plasma acyl ghrelin levels is associated with abatement of dyspepsia following Helicobacter pylori eradication. Journal of Gastroenterology 51:6, pages 548-559.
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Paul Moayyedi. (2008) The Epidemiology of Obesity and Gastrointestinal and Other Diseases: An Overview. Digestive Diseases and Sciences 53:9, pages 2293-2299.
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N.M. Malik, G.B.T. Moore, R. Kaur, Y.-L. Liu, S.L. Wood, R.W. Morrow, G.J. Sanger & P.L.R. Andrews. (2008) Adaptive upregulation of gastric and hypothalamic ghrelin receptors and increased plasma ghrelin in a model of cancer chemotherapy-induced dyspepsia. Regulatory Peptides 148:1-3, pages 33-38.
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Dae Won Jun, Oh Young Lee, Young Yul Lee, Ho Soon Choi, Tae Hwa Kim & Byung Chul Yoon. (2007) Correlation Between Gastrointestinal Symptoms and Gastric Leptin and Ghrelin Expression in Patients with Gastritis. Digestive Diseases and Sciences 52:10, pages 2866-2872.
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C. Feinle‐bisset & M. Horowitz. (2006) Dietary factors in functional dyspepsia. Neurogastroenterology & Motility 18:8, pages 608-618.
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Hidekazu Suzuki, Toshihiro Nishizawa & Toshifumi Hibi. (2006) Therapeutic strategies for functional dyspepsia and the introduction of the Rome III classification. Journal of Gastroenterology 41:6, pages 513-523.
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