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Scandinavian Journal of Gastroenterology Volume 42, 2007 - Issue 2
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ORIGINAL ARTICLE

Efficacy and safety of 6-thioguanine in the management of inflammatory bowel disease

Asghar Qasim Adelaide and Meath Hospital, Tallaght, Trinity College, Dublin, 24, Ireland
,
Sharon McDonald Adelaide and Meath Hospital, Tallaght, Trinity College, Dublin, 24, Ireland
,
Shaji Sebastian Adelaide and Meath Hospital, Tallaght, Trinity College, Dublin, 24, Ireland
,
Ramona McLoughlin Adelaide and Meath Hospital, Tallaght, Trinity College, Dublin, 24, Ireland
,
Martin Buckley Adelaide and Meath Hospital, Tallaght, Trinity College, Dublin, 24, Ireland
,
Humphrey O'Connor Adelaide and Meath Hospital, Tallaght, Trinity College, Dublin, 24, Ireland
&
Colm O'Morain Adelaide and Meath Hospital, Tallaght, Trinity College, Dublin, 24, IrelandCorrespondence[email protected]
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Pages 194-199 | Received 14 Nov 2005, Published online: 08 Jul 2009

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Kirstin M. Taylor, Mark G. Ward, Paul A. Blaker & Miles P. Sparrow. (2017) Is there a role for thioguanine therapy in IBD in 2017 and beyond?. Expert Review of Gastroenterology & Hepatology 11:5, pages 473-486.
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Articles from other publishers (15)

Helena Gensmyr-Singer, Mårten Werner & Pontus Karling. (2024) The drug-survival of low-dose thioguanine in patients with inflammatory bowel disease: a retrospective observational study. Therapeutic Advances in Gastroenterology 17.
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Anuraag Jena, Pardhu B Neelam, Harshavardhan Telaprolu, Uday Kiran Mangipudi, Usha Dutta, Shaji Sebastian & Vishal Sharma. (2023) Effectiveness and safety of thioguanine as a maintenance therapy of inflammatory bowel disease: Systematic review, meta-analysis and meta-regression. Clinics and Research in Hepatology and Gastroenterology 47:7, pages 102155.
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Melek Simsek, Debbie S. Deben, Carmen S. Horjus, Melanie V. Bénard, Birgit I. Lissenberg‐Witte, Hans J. C. Buiter, Matthijs van Luin, Margien L. Seinen, Chris J. J. Mulder, Dennis R. Wong, Nanne K. H. de Boer & Adriaan A. van Bodegraven. (2019) Sustained effectiveness, safety and therapeutic drug monitoring of tioguanine in a cohort of 274 IBD patients intolerant for conventional therapies. Alimentary Pharmacology & Therapeutics 50:1, pages 54-65.
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Linea Natalie Toksvang, Magnus Strøh Schmidt, Sofie Arup, Rikke Hebo Larsen, Thomas Leth Frandsen, Kjeld Schmiegelow & Cecilie Utke Rank. (2019) Hepatotoxicity during 6-thioguanine treatment in inflammatory bowel disease and childhood acute lymphoblastic leukaemia: A systematic review. PLOS ONE 14:5, pages e0212157.
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Berrie Meijer, Chris J J Mulder, Gerd Bouma, Cyriel Y Ponsioen, C Janneke van der Woude, Andrea E van der Meulen, Dion S J Wintjens, Gerard Dijkstra, Frank Hoentjen, Bas Oldenburg, Adriaan A van Bodegraven & Nanne K H de Boer. (2018) Methotrexate and Thioguanine Rescue Therapy for Conventional Thiopurine Failing Ulcerative Colitis Patients: A Multi-center Database Study on Tolerability and Effectiveness. Inflammatory Bowel Diseases 24:7, pages 1558-1565.
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Ramya Movva, Alison Haywood, Sohil A Khan, Timothy HJ Florin & Iulia Oancea. (2017) Critical assessment of thioguanine treatment for inflammatory bowel diseases: Is it time to rehabilitate this treatment?. Journal of Digestive Diseases 18:9, pages 529-536.
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Berrie Meijer, Chris JJ Mulder, Godefridus J Peters, Adriaan A van Bodegraven & Nanne KH de Boer. (2016) Efficacy of thioguanine treatment in inflammatory bowel disease: A systematic review. World Journal of Gastroenterology 22:40, pages 9012.
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Niels Teich, Wolfgang Mohl, Bernd Bokemeyer, Burkhard Bündgens, Jürgen Büning, Stephan Miehlke, Dietrich Hüppe, Christian Maaser, Tobias Klugmann, Wolfgang Kruis, Britta Siegmund, Ulf Helwig, Joseph Weismüller, Attyla Drabik & Andreas Stallmach. (2016) Azathioprine-induced Acute Pancreatitis in Patients with Inflammatory Bowel Diseases—A Prospective Study on Incidence and Severity. Journal of Crohn's and Colitis 10:1, pages 61-68.
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Satoshi YamadaTakuya YoshinoMinoru MatsuuraMasamichi KimuraYorimitsu KoshikawaNaoki MinamiTakahiko ToyonagaYusuke HonzawaHiroshi Nakase. (2015) Efficacy and Safety of Long-Term Thiopurine Maintenance Treatment in Japanese Patients With Ulcerative Colitis. Intestinal Research 13:3, pages 250.
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Anastasia Konidari, Antonios Anagnostopoulos, Laura J. Bonnett, Munir Pirmohamed & Wael El‐Matary. (2014) Thiopurine monitoring in children with inflammatory bowel disease: a systematic review. British Journal of Clinical Pharmacology 78:3, pages 467-476.
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Miloslav Kverka, Pavel Rossmann, Helena Tlaskalova-Hogenova, Klara Klimesova, Bindia Jharap, Nanne K de Boer, Rene M Vos, Adriaan A van Bodegraven, Milan Lukas & Chris J Mulder. (2011) Safety and efficacy of the immunosuppressive agent 6-tioguanine in murine model of acute and chronic colitis. BMC Gastroenterology 11:1.
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S. C. Ng, F. K. L. Chan & J. J. Y. Sung. (2011) Review article: the role of non-biological drugs in refractory inflammatory bowel disease. Alimentary Pharmacology & Therapeutics 33:4, pages 417-427.
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Dirk P. van Asseldonk, Bindia Jharap, Dirk J. Kuik, Nanne K.H. de Boer, Barend D. Westerveld, Maurice G.V.M. Russel, Frank J.G.M. Kubben, Ad A. van Bodegraven & Chris J. Mulder. (2011) Prolonged thioguanine therapy is well tolerated and safe in the treatment of ulcerative colitis. Digestive and Liver Disease 43:2, pages 110-115.
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Siew C. Ng & Michael A. Kamm. (2009) Therapeutic strategies for the management of ulcerative colitis. Inflammatory Bowel Diseases 15:6, pages 935-950.
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S.H.C. Almer, H. Hjortswang & U. Hindorf. (2009) 6-Thioguanine therapy in Crohn′s disease—Observational data in Swedish patients. Digestive and Liver Disease 41:3, pages 194-200.
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