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Original Article

Proteinase-activated receptor 2 (PAR-2) in gastrointestinal and pancreatic pathophysiology, inflammation and neoplasia

, PhD , MD
Pages 902-909 | Received 28 Nov 2007, Published online: 08 Jul 2009

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Anna Solberg, Lena Holmdahl, Peter Falk, Roger Willén, Ingrid Palmgren & Marie-Louise Ivarsson. (2009) Progress of tissue injury in appendicitis involves the serine proteases uPA and PAI-1. Scandinavian Journal of Gastroenterology 44:5, pages 579-584.
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Helge L. Waldum. (2008) August issue of Scandinavian Journal of Gastroenterology. Scandinavian Journal of Gastroenterology 43:8, pages 899-901.
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Kjetil Søreide. (2008) Bacterial genotoxins, gene methylation, and RNA interference: Pointing to colorectal cancer as an infectious disease?. Scandinavian Journal of Gastroenterology 43:12, pages 1529-1533.
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Articles from other publishers (17)

Min Bai, Linna Zhao, Mengya Liu, Runfa Li, Yuping Yang, Yugui Zhang, Xiaomei Yuan, Yarong Li, Yongqiang Duan, Yaorong An & Yingxia Cheng. (2024) Deciphering the function of Xiangsha-Liujunzi-Tang in enhancing duodenal mucosal barrier by inhibiting MC/Tryptase/PAR-2 signaling pathway in functional dyspepsia rats. Journal of Ethnopharmacology 319, pages 116715.
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Tingting Cai, Xiang Wang, Bangjie Li, Fei Xiong, Hao Wu & Xinghao Yang. (2021) Deciphering the synergistic network regulation of active components from SiNiSan against irritable bowel syndrome via a comprehensive strategy: Combined effects of synephrine, paeoniflorin and naringin. Phytomedicine 86, pages 153527.
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Kjetil SøreideMarcus RoalsøJan Rune Aunan. (2020) Is There a Trojan Horse to Aggressive Pancreatic Cancer Biology? A Review of the Trypsin-PAR2 Axis to Proliferation, Early Invasion, and Metastasis. Journal of Pancreatic Cancer 6:1, pages 12-20.
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Elizabeth J. Hait & Douglas R. McDonald. (2018) Impact of Gastroesophageal Reflux Disease on Mucosal Immunity and Atopic Disorders. Clinical Reviews in Allergy & Immunology 57:2, pages 213-225.
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Suprabhat Mukherjee, Nikhilesh Joardar, Subhasree Sengupta & Santi P. Sinha Babu. (2018) Gut microbes as future therapeutics in treating inflammatory and infectious diseases: Lessons from recent findings. The Journal of Nutritional Biochemistry 61, pages 111-128.
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Suma Sarojini. 2018. Diet, Microbiome and Health. Diet, Microbiome and Health 1 31 .
Daniel Bergemalm, Robert Kruse, Maria Sapnara, Jonas Halfvarson & Elisabeth Hultgren Hörnquist. (2017) Elevated fecal peptidase D at onset of colitis in Galphai2-/- mice, a mouse model of IBD. PLOS ONE 12:3, pages e0174275.
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Dipti V. Tillu, Shayne N. Hassler, Carolina C. Burgos-Vega, Tammie L. Quinn, Robert E. Sorge, Gregory Dussor, Scott Boitano, Josef Vagner & Theodore J. Price. (2015) Protease-activated receptor 2 activation is sufficient to induce the transition to a chronic pain state. Pain 156:5, pages 859-867.
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Meredith A. J. Hullar, Andrea N. Burnett-Hartman & Johanna W. Lampe. 2014. Advances in Nutrition and Cancer. Advances in Nutrition and Cancer 377 399 .
E. S. Michael, A. Kuliopulos, L. Covic, M. L. Steer & G. Perides. (2013) Pharmacological inhibition of PAR2 with the pepducin P2pal-18S protects mice against acute experimental biliary pancreatitis. American Journal of Physiology-Gastrointestinal and Liver Physiology 304:5, pages G516-G526.
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Arne Kandulski & Peter Malfertheiner. (2011) Gastroesophageal reflux disease—from reflux episodes to mucosal inflammation. Nature Reviews Gastroenterology & Hepatology 9:1, pages 15-22.
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Scott Boitano, Andrea N. Flynn, Stephanie M. Schulz, Justin Hoffman, Theodore J. Price & Josef Vagner. (2011) Potent Agonists of the Protease Activated Receptor 2 (PAR 2 ) . Journal of Medicinal Chemistry 54:5, pages 1308-1313.
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Kjetil Søreide. 2011. Handbook of Epigenetics. Handbook of Epigenetics 477 494 .
Rhonda F Souza. (2010) Bringing GERD Management up to PAR-2. American Journal of Gastroenterology 105:9, pages 1944-1946.
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k. n. browning. (2010) Protease-activated receptors: novel central role in modulation of gastric functions. Neurogastroenterology & Motility 22:4, pages 361-365.
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A Gaber, M Johansson, U-H Stenman, K Hotakainen, F Pontén, B Glimelius, A Bjartell, K Jirström & H Birgisson. (2009) High expression of tumour-associated trypsin inhibitor correlates with liver metastasis and poor prognosis in colorectal cancer. British Journal of Cancer 100:10, pages 1540-1548.
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Kjetil Søreide, Bjørn S. Nedrebø, Jens-Christian Knapp, Tom B. Glomsaker, Jon Arne Søreide & Hartwig Kørner. (2009) Evolving molecular classification by genomic and proteomic biomarkers in colorectal cancer: Potential implications for the surgical oncologist. Surgical Oncology 18:1, pages 31-50.
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