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Review Article

Perforated peptic ulcer: How to improve outcome?

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Pages 15-22 | Received 22 Apr 2008, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Soheil Zorofchian Moghadamtousi, Elham Rouhollahi, Hamed Karimian, Mehran Fadaeinasab, Mahmood Ameen Abdulla & Habsah Abdul Kadir. (2014) Gastroprotective activity of Annona muricata leaves against ethanol-induced gastric injury in rats via Hsp70/Bax involvement. Drug Design, Development and Therapy 8, pages 2099-2111.
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Morten Hylander Møller, Morten Vester-Andersen & Reimar Wernich Thomsen. (2013) Long-term mortality following peptic ulcer perforation in the PULP trial. A nationwide follow-up study. Scandinavian Journal of Gastroenterology 48:2, pages 168-175.
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David Levarett Buck, Morten Vester-Andersen & Morten Hylander Møller. (2012) Accuracy of clinical prediction rules in peptic ulcer perforation: an observational study. Scandinavian Journal of Gastroenterology 47:1, pages 28-35.
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Morten Hylander Møller, Sven Adamsen, Reimar Wernich Thomsen & Ann Merete Møller. (2010) Preoperative prognostic factors for mortality in peptic ulcer perforation: a systematic review. Scandinavian Journal of Gastroenterology 45:7-8, pages 785-805.
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Articles from other publishers (37)

Tracy L. Hill, B. Duncan X. Lascelles & Anthony Blikslager. 2023. Small Animal Soft Tissue Surgery. Small Animal Soft Tissue Surgery 41 52 .
Goran AugustinGoran Augustin. 2023. Acute Abdomen During Pregnancy. Acute Abdomen During Pregnancy 739 774 .
Meraj Ahmed, Tariq Mansoor, Atia Zakaur Rab & Syed Amjad Ali Rizvi. (2021) Risk factors influencing postoperative outcome in patients with perforated peptic ulcer: a prospective cohort study. European Journal of Trauma and Emergency Surgery 48:1, pages 81-86.
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Yun-Suk Choi, Yoon-Seok Heo & Jin-Wook Yi. (2021) Clinical Characteristics of Primary Repair for Perforated Peptic Ulcer: 10-Year Experience in a Single Center. Journal of Clinical Medicine 10:8, pages 1790.
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A. V. Sazhin, G. B. Ivakhov, E. A. Stradymov, V. A. Petukhov & S. M. Titkova. (2020) Comparison of laparoscopic and open suturing of perforated peptic ulcer complicated by advanced peritonitis. Khirurgiya. Zhurnal im. N.I. Pirogova:3, pages 13.
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Naren KA Kumar & Stanley James. (2019) Risk Stratification in Perforated Peptic Ulcer: The Peptic Ulcer Perforation Score. SBV Journal of Basic, Clinical and Applied Health Science 2:3, pages 112-114.
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Armando Salim Munoz AbrahamHector OseiAlice MartinoSakina KazmiSaurabh SaxenaColleen M. FitzpatrickGustavo A. Villalona. (2019) Incidence and Outcomes of Perforated Peptic Ulcers in Children: Analysis of the Kid's Inpatient Database and Report of Two Cases Treated by Laparoscopic Omental Patch Repair. Journal of Laparoendoscopic & Advanced Surgical Techniques 29:2, pages 248-255.
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A. V. Sazhin, G. B. Ivakhov, E. A. Stradymov & V. A. Petukhov. (2019) Surgical treatment of perforated peptic ulcers complicated by diffuse peritonitis: laparotomy or laparoscopy? (Part 1). Endoskopicheskaya khirurgiya 25:3, pages 51.
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Rabea Hasadia, Yael Kopelman, Oded Olsha, Ricardo Alfici & Itamar Ashkenazi. (2018) Short- and long-term outcomes of surgical management of peptic ulcer complications in the era of proton pump inhibitors. European Journal of Trauma and Emergency Surgery 44:5, pages 795-801.
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Goran AugustinGoran Augustin. 2018. Acute Abdomen During Pregnancy. Acute Abdomen During Pregnancy 163 203 .
Rita Laforgia, Giovanni Balducci, Giuseppe Carbotta, Antonio Prestera, Maria Grazia Sederino, Giulia Casamassima, Marina Minafra, Pierluca Sallustio & Nicola Palasciano. (2017) Laparoscopic and Open Surgical Treatment in Gastroduodenal Perforations: Our Experience. Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 27:2, pages 113-115.
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A. V. Alekberzade, N. N. Krylov, E. A. Rustamov, D. A. Badalov & M. A. Popovtsev. (2017) Perforated peptic ulcer closure: laparoscopic or open?. Khirurgiya. Zhurnal im. N.I. Pirogova:2, pages 45.
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Ali K. Gokakin, Mustafa Atabey, Ayhan Koyuncu & Omer Topcu. (2016) Peptic Ulcer Perforation in Elderly: 10 years' Experience of a Single Institution. International Journal of Gerontology 10:4, pages 198-201.
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Ping-Lien Lay, Hsin-Hung Huang, Wei-Kuo Chang, Tsai-Yuan Hsieh, Tien-Yu Huang & Hsuan-Hwai Lin. (2016) Outcome of nonsurgical intervention in patients with perforated peptic ulcers. The American Journal of Emergency Medicine 34:8, pages 1556-1560.
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Ellen T. RocheAssunta FabozzoYuhan LeePanagiotis PolygerinosIngeborg FriehsLucia SchusterWilliam WhyteAlejandra Maria Casar BerazaluceAlejandra BuenoNora LangMaria J. N. PereiraEric FeinsSteven WassermanEoin D. O’CearbhaillNikolay V. VasilyevDavid J. MooneyJeffrey M. KarpPedro J. del NidoConor J. Walsh. (2015) A light-reflecting balloon catheter for atraumatic tissue defect repair. Science Translational Medicine 7:306.
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Ji-Hyun Kim, Hyung-Min Chin, You-Jin Bae & Kyong-Hwa Jun. (2015) Risk factors associated with conversion of laparoscopic simple closure in perforated duodenal ulcer. International Journal of Surgery 15, pages 40-44.
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M Wilhelmsen, M H Møller & S Rosenstock. (2015) Surgical complications after open and laparoscopic surgery for perforated peptic ulcer in a nationwide cohort. British Journal of Surgery 102:4, pages 382-387.
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Vishal G. Shelat, Saleem Ahmed, Clement L. K. Chia & Yee Lee Cheah. (2015) Strict Selection Criteria During Surgical Training Ensures Good Outcomes in Laparoscopic Omental Patch Repair (LOPR) for Perforated Peptic Ulcer (PPU). International Surgery 100:2, pages 370-375.
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N. V. KNUDSEN & M. H. MØLLER. (2015) Association of mortality with out-of-hours admission in patients with perforated peptic ulcer. Acta Anaesthesiologica Scandinavica 59:2, pages 248-254.
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K. Anbalakan, D. Chua, G.J. Pandya & V.G. Shelat. (2015) Five year experience in management of perforated peptic ulcer and validation of common mortality risk prediction models – Are existing models sufficient? A retrospective cohort study. International Journal of Surgery 14, pages 38-44.
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Shoko Natsuda, Yomi Nakashima, Ichiro Horie, Takao Ando & Atsushi Kawakami. (2015) Thyroid Storm Precipitated by Duodenal Ulcer Perforation. Case Reports in Endocrinology 2015, pages 1-3.
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Salomone Di Saverio, Marco Bassi, Nazareno Smerieri, Michele Masetti, Francesco Ferrara, Carlo Fabbri, Luca Ansaloni, Stefania Ghersi, Matteo Serenari, Federico Coccolini, Noel Naidoo, Massimo Sartelli, Gregorio Tugnoli, Fausto Catena, Vincenzo Cennamo & Elio Jovine. (2014) Diagnosis and treatment of perforated or bleeding peptic ulcers: 2013 WSES position paper. World Journal of Emergency Surgery 9:1.
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D L Buck & M H Møller. (2014) Influence of body mass index on mortality after surgery for perforated peptic ulcer. British Journal of Surgery 101:8, pages 993-999.
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Goran AugustinGoran Augustin. 2014. Acute Abdomen During Pregnancy. Acute Abdomen During Pregnancy 145 177 .
K Søreide, K Thorsen & J A Søreide. (2014) Strategies to improve the outcome of emergency surgery for perforated peptic ulcer. British Journal of Surgery 101:1, pages e51-e64.
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D L Buck, M Vester-Andersen & M H Møller. (2013) Surgical delay is a critical determinant of survival in perforated peptic ulcer. British Journal of Surgery 100:8, pages 1045-1049.
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M H Møller, H J Larsson, S Rosenstock, H Jørgensen, S P Johnsen, A H Madsen, S Adamsen, A G Jensen, E Zimmermann-Nielsen & R W Thomsen. (2013) Quality-of-care initiative in patients treated surgically for perforated peptic ulcer. British Journal of Surgery 100:4, pages 543-552.
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Tracy L. Hill, B. Duncan X. Lascelles & Anthony Blikslager. 2012. Small Animal Soft Tissue Surgery. Small Animal Soft Tissue Surgery 329 340 .
Yogesh K. Vashist, Emre F. Yekebas, Florian Gebauer, Michael Tachezy, Kai Bachmann, Alexandra König, Asad Kutup & Jakob R. Izbicki. (2012) Management of the difficult duodenal stump in penetrating duodenal ulcer disease: a comparative analysis of duodenojejunostomy with “classical” stump closure (Nissen–Bsteh). Langenbeck's Archives of Surgery 397:8, pages 1243-1249.
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Eduardo A. Bonin, Erica Moran, Christopher J. Gostout, Andrea L. McConico, Martin Zielinski & Juliane Bingener. (2011) Natural orifice transluminal endoscopic surgery for patients with perforated peptic ulcer. Surgical Endoscopy 26:6, pages 1534-1538.
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SeungJin Bae, Ki-Nam Shim, Nayoung Kim, Jung Mook Kang, Dong-Sook Kim, Kyoung-Min Kim, Yu Kyung Cho & Sung Woo Jung. (2012) Incidence and Short-term Mortality From Perforated Peptic Ulcer in Korea: A Population-Based Study. Journal of Epidemiology 22:6, pages 508-516.
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Kenneth Thorsen, Tom B. Glomsaker, Andreas von Meer, Kjetil Søreide & Jon Arne Søreide. (2011) Trends in Diagnosis and Surgical Management of Patients with Perforated Peptic Ulcer. Journal of Gastrointestinal Surgery 15:8, pages 1329-1335.
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M H Møller, S Adamsen, R W Thomsen & A M Møller. (2011) Multicentre trial of a perioperative protocol to reduce mortality in patients with peptic ulcer perforation. British Journal of Surgery 98:6, pages 802-810.
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M Hylander Møller. (2011) Multicenter trial of a perioperative protocol to reduce mortality in critically ill patients with peptic ulcer perforation: the PULP trial. Critical Care 15:S1.
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Selja Koskensalo & Ari Leppäniemi. (2010) Perforated Duodenal Ulcer: Has Anything Changed?. European Journal of Trauma and Emergency Surgery 36:2, pages 145-150.
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Rafael Boscolo-Berto, Claudio Lamon & Roberto Vezzaro. (2010) A Major Clinical Event Following Transperineal Prostate Biopsy: An Unexpected Duodenal Perforation. UroToday International Journal 03:02.
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Marilisa Franceschi, Francesco Di Mario, Gioacchino Leandro, Stefania Maggi & Alberto Pilotto. (2009) Acid-related disorders in the elderly. Best Practice & Research Clinical Gastroenterology 23:6, pages 839-848.
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