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Scandinavian Journal of Gastroenterology Volume 19, 1984 - Issue 3
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Original Articles

Pernicious Anaemia, Intragastric Bacterial Overgrowth, and Possible Consequences

R. W. StockbrueggerDept. of Gastroenterology, The Middlesex Hospital, and Bland Sutton Institute of Pathology, The Middlesex Hospital and Medical School, London; PHLS Centre for Applied Microbiology and Research, Bacterial Metabolism Research Laboratory, Porton Down, Salisbury, Wiltshire; and Leatherhead Food Research Association, Leatherhead, Surrey; UK
,
P. B. CottonDept. of Gastroenterology, The Middlesex Hospital, and Bland Sutton Institute of Pathology, The Middlesex Hospital and Medical School, London; PHLS Centre for Applied Microbiology and Research, Bacterial Metabolism Research Laboratory, Porton Down, Salisbury, Wiltshire; and Leatherhead Food Research Association, Leatherhead, Surrey; UK
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G. G. MenonDept. of Gastroenterology, The Middlesex Hospital, and Bland Sutton Institute of Pathology, The Middlesex Hospital and Medical School, London; PHLS Centre for Applied Microbiology and Research, Bacterial Metabolism Research Laboratory, Porton Down, Salisbury, Wiltshire; and Leatherhead Food Research Association, Leatherhead, Surrey; UK
,
J. O. W. BeilbyDept. of Gastroenterology, The Middlesex Hospital, and Bland Sutton Institute of Pathology, The Middlesex Hospital and Medical School, London; PHLS Centre for Applied Microbiology and Research, Bacterial Metabolism Research Laboratory, Porton Down, Salisbury, Wiltshire; and Leatherhead Food Research Association, Leatherhead, Surrey; UK
,
B. A. BartholomewDept. of Gastroenterology, The Middlesex Hospital, and Bland Sutton Institute of Pathology, The Middlesex Hospital and Medical School, London; PHLS Centre for Applied Microbiology and Research, Bacterial Metabolism Research Laboratory, Porton Down, Salisbury, Wiltshire; and Leatherhead Food Research Association, Leatherhead, Surrey; UK
,
M. J. HillDept. of Gastroenterology, The Middlesex Hospital, and Bland Sutton Institute of Pathology, The Middlesex Hospital and Medical School, London; PHLS Centre for Applied Microbiology and Research, Bacterial Metabolism Research Laboratory, Porton Down, Salisbury, Wiltshire; and Leatherhead Food Research Association, Leatherhead, Surrey; UK
&
C. L. WaltersDept. of Gastroenterology, The Middlesex Hospital, and Bland Sutton Institute of Pathology, The Middlesex Hospital and Medical School, London; PHLS Centre for Applied Microbiology and Research, Bacterial Metabolism Research Laboratory, Porton Down, Salisbury, Wiltshire; and Leatherhead Food Research Association, Leatherhead, Surrey; UK
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Pages 355-364 | Received 07 Feb 1983, Accepted 20 Jun 1983, Published online: 30 Apr 2018

Citations (53)

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Loris R. Lopetuso, Marco Napoli, Gianenrico Rizzatti, Franco Scaldaferri, Francesco Franceschi & Antonio Gasbarrini. (2018) Considering gut microbiota disturbance in the management of Helicobacter pylori infection. Expert Review of Gastroenterology & Hepatology 12:9, pages 899-906.
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Per M. Hellström, Panu Hendolin, Pertti Kaihovaara, Leif Kronberg, Axel Meierjohann, Anders Millerhovf, Lea Paloheimo, Heidi Sundelin, Kari Syrjänen, Dominic-Luc Webb & Mikko Salaspuro. (2017) Slow-release L-cysteine capsule prevents gastric mucosa exposure to carcinogenic acetaldehyde: results of a randomised single-blinded, cross-over study of Helicobacter-associated atrophic gastritis. Scandinavian Journal of Gastroenterology 52:2, pages 230-237.
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Lars Agréus, Ernst J Kuipers, Limas Kupcinskas, Peter Malfertheiner, Francesco Di Mario, Marcis Leja, Varocha Mahachai, Niv Yaron, Martijn van Oijen, Guillermo Perez Perez, Massimo Rugge, Jukka Ronkainen, Mikko Salaspuro, Pentti Sipponen, Kentaro Sugano & Joseph Sung. (2012) Rationale in diagnosis and screening of atrophic gastritis with stomach-specific plasma biomarkers. Scandinavian Journal of Gastroenterology 47:2, pages 136-147.
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Mikko Salaspuro. (2009) Acetaldehyde as a common denominator and cumulative carcinogen in digestive tract cancers. Scandinavian Journal of Gastroenterology 44:8, pages 912-925.
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A. MacRì, A. Versaci, S. Loddo, G. Scuderi, M. Travagliante, G. Trimarchi, D. Teti & C. Famulari. (2006) Serum levels of interleukin 1β, interleukin 8 and tumour necrosis factor α as markers of gastric cancer. Biomarkers 11:2, pages 184-193.
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L. Friis‐Hansen. (2006) Achlorhydria is associated with gastric microbial overgrowth and development of cancer: Lessons learned from the gastrin knockout mouse. Scandinavian Journal of Clinical and Laboratory Investigation 66:7, pages 607-622.
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Mikko P. Salaspuro. (2003) Acetaldehyde, Microbes, and Cancer of the Digestive Tract. Critical Reviews in Clinical Laboratory Sciences 40:2, pages 183-208.
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R. Walker. (1990) Nitrates, nitrites and N‐nitrosocompounds: A review of the occurrence in food and diet and the toxicological implications. Food Additives & Contaminants 7:6, pages 717-768.
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R. W. Stockbrügger, U. Armbrecht, J. W. Rode, A. J. Teall, V. G. Oberholzer, J. R. Croker & P. B. Cotton. (1990) The Bacterial Overgrowth Syndrome is Uncommon in Pernicious Anaemia: Results of a Follow-up Study. Microbial Ecology in Health and Disease 3:4, pages 209-215.
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R. W. Stockbruegger. (1985) Bacterial overgrowth as a consequence of reduced gastric acidity. Scandinavian Journal of Gastroenterology 20:sup111, pages 7-15.
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M. Hill. (1985) Normal and pathological microbial flora of the upper gastrointestinal tract. Scandinavian Journal of Gastroenterology 20:sup111, pages 1-5.
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U. Armbrecht, I. Bosaeus, R. Gillberg, S. Seeberg & R. Stockbruegger. (1985) Hydrogen (H2) Breath Test and Gastric Bacteria in Acid-Secreting Subjects and in Achlorhydric and Postgastrectomy Patients before and after Antimicrobial Treatment. Scandinavian Journal of Gastroenterology 20:7, pages 805-813.
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Lori Taylor, Andrew McCaddon & Bruce H. R. Wolffenbuttel. (2024) Creating a Framework for Treating Autoimmune Gastritis—The Case for Replacing Lost Acid. Nutrients 16:5, pages 662.
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Mikko Salaspuro. (2017) Key role of local acetaldehyde in upper GI tract carcinogenesis. Best Practice & Research Clinical Gastroenterology 31:5, pages 491-499.
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Konstantinos Fragkiadakis, Petros Ioannou, Emmanouil Barbounakis & George Samonis. (2017) Intra-abdominal abscesses by Lactococcus lactis ssp cremoris in an immunocompetent adult with severe periodontitis and pernicious anemia. IDCases 7, pages 27-29.
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Christopher V. Almario, David C. Metz, Kevin Haynes & Yu-Xiao Yang. (2015) Risk of community-acquired pneumonia in patients with a diagnosis of pernicious anemia. European Journal of Gastroenterology & Hepatology 27:11, pages 1259-1264.
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Satu Väkeväinen & Mikko Salaspuro. 2013. Alcohol, Nutrition, and Health Consequences. Alcohol, Nutrition, and Health Consequences 439 457 .
Emanuela Miceli, Marco Vincenzo Lenti, Donatella Padula, Ombretta Luinetti, Claudia Vattiato, Claudio Maria Monti, Michele Di Stefano & Gino Roberto Corazza. (2012) Common Features of Patients With Autoimmune Atrophic Gastritis. Clinical Gastroenterology and Hepatology 10:7, pages 812-814.
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Mikko Salaspuro. (2012) Interactions of alcohol and tobacco in gastrointestinal cancer. Journal of Gastroenterology and Hepatology 27:s2, pages 135-139.
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Mikko SALASPURO. (2011) Acetaldehyde and gastric cancer. Journal of Digestive Diseases 12:2, pages 51-59.
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Juanita L. Merchant & Yana Zavros. 2009. The Biology of Gastric Cancers. The Biology of Gastric Cancers 449 482 .
W. F. Caspary & J. Stein. 2006. Infektiologie des Gastrointestinaltraktes. Infektiologie des Gastrointestinaltraktes 277 285 .
Mikko Salaspuro. 2003. Nutrition and Alcohol. Nutrition and Alcohol 393 411 .
Sara Rollinson, Adam P. Levene, Fiona K. Mensah, Philippa L. Roddam, James M. Allan, Tim C. Diss, Eve Roman, Andrew Jack, Kenneth MacLennan, Michael F. Dixon & Gareth J. Morgan. (2003) Gastric marginal zone lymphoma is associated with polymorphisms in genes involved in inflammatory response and antioxidative capacity. Blood 102:3, pages 1007-1011.
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Mikko P. Salaspuro. (2003) Alcohol consumption and cancer of the gastrointestinal tract. Best Practice & Research Clinical Gastroenterology 17:4, pages 679-694.
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Ian LP Beales. (2002) Effect of Interlukin-1β on proliferation of gastric epithelial cells in culture. BMC Gastroenterology 2:1.
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Y. Zavros, G. Rieder, Amy Ferguson & J. L. Merchant. (2002) Gastritis and Hypergastrinemia Due to Acinetobacter lwoffii in Mice . Infection and Immunity 70:5, pages 2630-2639.
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Takahisa Furuta, Naohito Shirai, Misako Takashima, Fang Xiao & Haruhiko Sugimura. (2002) Effect of genotypic differences in interleukin-1 beta on gastric acid secretion in Japanese patients infected with helicobacter pylori. The American Journal of Medicine 112:2, pages 141-143.
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Yana Zavros, Gabriele Rieder, Amy Ferguson, Linda C. Samuelson & Juanita L. Merchant. (2002) Genetic or chemical hypochlorhydria is associated with inflammation that modulates parietal and G-cell populations in mice. Gastroenterology 122:1, pages 119-133.
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S. Sanduleanu, D. Jonkers, A. de Bruïne, W. Hameeteman & R.W. Stockbrügger. (2001) Changes in gastric mucosa and luminal environment during acid-suppressive therapy: a review in depth. Digestive and Liver Disease 33:8, pages 707-719.
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S. Sanduleanu, D. Jonkers, A. De Bruïne, W. Hameeteman & R. W. Stockbrügger. (2001) Double gastric infection with Helicobacter pylori and non‐ Helicobacter pylori bacteria during acid‐suppressive therapy: increase of pro‐inflammatory cytokines and development of atrophic gastritis . Alimentary Pharmacology & Therapeutics 15:8, pages 1163-1175.
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Dharam Agarwal & Helmut SeitzMikko Salaspuro. 2001. Alcohol in Health and Disease. Alcohol in Health and Disease 67 85 .
S. Sanduleanu, D. Jonkers, A. De Bruine, W. Hameeteman & R. W. Stockbrügger. (2008) Non‐ Helicobacter pylori bacterial flora during acid‐suppressive therapy: differential findings in gastric juice and gastric mucosa . Alimentary Pharmacology & Therapeutics 15:3, pages 379-388.
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S. Väkeväinen, J. Tillonen, M. Salaspuro, H. Jousimies‐Somer, H. Nuutinen & M. Färkkilä. (2001) Hypochlorhydria induced by a proton pump inhibitor leads to intragastric microbial production of acetaldehyde from ethanol. Alimentary Pharmacology & Therapeutics 14:11, pages 1511-1518.
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Emad M. El-Omar, Mary Carrington, Wong-Ho Chow, Kenneth E. L. McColl, Jay H. Bream, Howard A. Young, Jesus Herrera, Jolanta Lissowska, Chiu-Chin Yuan, Nathaniel Rothman, George Lanyon, Maureen Martin, Joseph F. FraumeniJrJr & Charles S. Rabkin. (2000) Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 404:6776, pages 398-402.
Crossref
Jörg Theisen, Dhiren Nehra, Diane Citron, Jan Johansson, Jeffrey A. Hagen, Peter F. Crookes, Steven R. DeMeester, Cedric G. Bremner, Tom R. DeMeester & Jeffrey H. Peters. (2000) Suppression of gastric acid secretion in patients with gastroesophageal reflux disease results in gastric bacterial overgrowth and deconjugation of bile acids. Journal of Gastrointestinal Surgery 4:1, pages 50-54.
Crossref
Williams, Sercombe, Lawson, Slater, Owen & Pounder. (2001) The effect of omeprazole dosing on the isolation of Helicobacter pylori from gastric aspirates . Alimentary Pharmacology & Therapeutics 13:9, pages 1161-1169.
Crossref
Craig Mowat, Andrew Carswell, Angela Wirz & Kenneth E.L. McColl. (1999) Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. Gastroenterology 116:4, pages 813-822.
Crossref
D. Jonkerst, E. Stobberingh, A. de Bruine, J.W. Arends & R. Stockbrügger. (1997) Evaluation of immunohistochemistry for the detection of Helicobacter pylori in gastric mucosal biopsies. Journal of Infection 35:2, pages 149-154.
Crossref
Robert-J. M. Brummer & Reinhold W. Stockbrügger. (1996) Effect of nizatidine 300 mg at night and omeprazole 20 mg in the morning on 24-hour intragastric pH and bacterial overgrowth in patients with acute duodenal ulcer. Digestive Diseases and Sciences 41:10, pages 2048-2054.
Crossref
Einar Husebye. (2009) Gastrointestinal motility disorders and bacterial overgrowth. Journal of Internal Medicine 237:4, pages 419-427.
Crossref
Neville D. Yeomans, Roger W. Brimblecombe, James Elder, Richard V. Heatley, J. J. Misiewicz, Timothy C. Northfield & Anthony Pottage. (1995) Effects of acid suppression on microbial flora of upper gut. Digestive Diseases and Sciences 40:S2, pages 81S-95S.
Crossref
John R. Saltzman, Kris V. Kowdley, Marcos C. Pedrosa, Thomas Sepe, Barbara Golner, Gayle Perrone & Robert M. Russell. (1994) Bacterial overgrowth without clinical malabsorption in elderly hypochlorhydric subjects. Gastroenterology 106:3, pages 615-623.
Crossref
N. D. Yeomans. 1994. Helicobacter pylori. Helicobacter pylori 475 482 .
R.V. Heatley & G.M. Sobala. (1993) Acid suppression and the gastric flora. Baillière's Clinical Gastroenterology 7:1, pages 167-181.
Crossref
E Husebye, V Skar, T Hoverstad & K Melby. (1992) Fasting hypochlorhydria with gram positive gastric flora is highly prevalent in healthy old people.. Gut 33:10, pages 1331-1337.
Crossref
S A Sarker & K Gyr. (1992) Non-immunological defence mechanisms of the gut.. Gut 33:7, pages 987-993.
Crossref
Herman Nilsson-Ehle, Sten Landahl, G�ran Lindstedt, Lisbeth Netterblad, Reinhold Stockbruegger, Jan Westin & Christer �hren. (1989) Low serum cobalamin levels in a population study of 70- and 75-year-old subjects. Digestive Diseases and Sciences 34:5, pages 716-723.
Crossref
D. Cattan, A. M. Roucayrol & J. Belaïche. 1989. Folates and Cobalamins. Folates and Cobalamins 85 103 .
MICHAEL HILL. 1988. Role of the Gut Flora in Toxicity and Cancer. Role of the Gut Flora in Toxicity and Cancer 461 502 .
A.K. MALLETT & I.R. ROWLAND. 1988. Role of the Gut Flora in Toxicity and Cancer. Role of the Gut Flora in Toxicity and Cancer 347 382 .
T.M. Coutts, A.J. Alldrick & I.R. Rowland. (1987) Use of continuous culture to study the gastric microflora of a hypochlorhydric patient. Toxicology in Vitro 1:1, pages 17-21.
Crossref
C A McNulty & R Wise. (1985) Gastric microflora.. BMJ 291:6492, pages 367-368.
Crossref

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