237
Views
169
CrossRef citations to date
0
Altmetric
Original Articles

Effects of Lactulose and Lactitol on Colonic Microflora and Enzymatic Activity

, &
Pages 41-44 | Published online: 01 Apr 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Yuqing Yang & Daniel D. Gallaher. (2005) Effect of Dried Plums on Colon Cancer Risk Factors in Rats. Nutrition and Cancer 53:1, pages 117-125.
Read now
Gertraud R Branner, Barbara M Böhmer, W Erhardt, Julia Henke & Dora A Roth-Maier. (2004) Investigation on the precaecal and faecal digestibility of lactulose and inulin and their influence on nutrient digestibility and microbial characteristics. Archives of Animal Nutrition 58:5, pages 353-366.
Read now
Irène Mangin, Yoram Bouhnik, Antonia Suau, Violaine Rochet, Laurent Raskine, Pascal Crenn, Franc¸ois Dyard, Jean-Claude Rambaud & Joël Doré. (2002) Molecular Analysis of Intestinal Microbiota Composition to Evaluate the Effect of PEG and Lactulose Laxatives in Humans. Microbial Ecology in Health and Disease 14:1, pages 54-62.
Read now
Pia Kontula, Lode Nollet, Maria Saarela, Terttu Vilpponen-Salmela, Willy Verstraete, Tiina Mattila-Sandholm & Atte von Wright. (2002) The Effect of Lactulose on the Survival of Lactobacillus rhamnosus in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME) and in vivo. Microbial Ecology in Health and Disease 14:2, pages 90-96.
Read now
Kieran M. Tuohy, Cherie J. Ziemer, Annett Klinder, Yvonne Knöbel, Beatrice L. Pool-Zobel & Glenn R. Gibson. (2002) A Human Volunteer Study to Determine the Prebiotic Effects of Lactulose Powder on Human Colonic Microbiota. Microbial Ecology in Health and Disease 14:3, pages 165-173.
Read now
Patricia L Conway. (2001) Prebiotics and human health: The state-of-the-art and future perspectives. Näringsforskning 45:1, pages 13-21.
Read now
M. Uribe, S. Morán, J. L. Poo, N. Méndez-Sánchez, L. Guevara, G. García-Ramos. (1998) Beneficial Effect of Carbohydrate Maldigestion Induced by a Disaccharidase Inhibitor (AO-128) in the Treatment of Chronic Portal-Systemic Encephalopathy: A Double-Blind, Randomized, Controlled Trial. Scandinavian Journal of Gastroenterology 33:10, pages 1099-1106.
Read now
M. A. Ainsworth, D. L. Hogan, R. C. Rapier, M. Amelsberg, A. D. Dreilinger, J. I. Isenberg. (1998) Acid/Base Transporters in Human Duodenal Enterocytes. Scandinavian Journal of Gastroenterology 33:10, pages 1039-1046.
Read now

Articles from other publishers (161)

Pulkit Mathur & Anjani Bakshi. (2023) Effect of non-nutritive sweeteners on insulin regulation, glycemic response, appetite and weight management: a systematic review. Nutrition & Food Science 54:1, pages 100-119.
Crossref
Zhou Chen, Defeng Guan, Zhengfeng Wang, Xin Li, Shi Dong, Junjun Huang & Wence Zhou. (2023) Microbiota in cancer: molecular mechanisms and therapeutic interventions. MedComm 4:6.
Crossref
Alaa E. Elkomy, Amina S. El-Saadany, Effat Y. Shreif, Amal A. Bayoumi, Marwa H. Abd El-Maged, Mahmoud Alagawany, Ahmed A. Saleh, Sungbo Cho, In Ho Kim & Hossam M. Eltahan. (2023) Anise and grape seed oils as a feed additive to improve the performance, immune response, and antioxidant activity and reduce caecal pathogenic microbes of quail. Archives Animal Breeding 66:4, pages 379-390.
Crossref
Hassan S. Elkomy, Ivan I. Koshich, Sahar F. Mahmoud & Magda I. Abo-Samaha. (2023) Use of lactulose as a prebiotic in laying hens: its effect on growth, egg production, egg quality, blood biochemistry, digestive enzymes, gene expression and intestinal morphology. BMC Veterinary Research 19:1.
Crossref
Alaa E. Elkomy, Tarek A. Sadaka, Saber S. Hassan, Omnia Shawky, Mohamed E. El-Speiy, Mohamed El-Beshkar, Mohammad A. M. Wadaan, Hatem M. El-Tahan, Sungbo Cho, In Ho Kim & Hossam M. El-Tahan. (2023) Improving productive performance, immunity, and health status of growing rabbits by using honey bee venom (Apis mellifera). Frontiers in Veterinary Science 10.
Crossref
Luis Vitetta, Nick N. Gorgani, Gemma Vitetta & Jeremy D. Henson. (2023) Prebiotics Progress Shifts in the Intestinal Microbiome That Benefits Patients with Type 2 Diabetes Mellitus. Biomolecules 13:9, pages 1307.
Crossref
Roman Maslennikov, Aliya Alieva, Elena Poluektova, Yury Zharikov, Andrey Suslov, Yana Letyagina, Ekaterina Vasileva, Anna Levshina, Evgenii Kozlov & Vladimir Ivashkin. (2023) Sarcopenia in cirrhosis: Prospects for therapy targeted to gut microbiota. World Journal of Gastroenterology 29:27, pages 4236-4251.
Crossref
Haoran Jiang, Miaomiao Cai, Boyuan Shen, Qiong Wang, Tongcun Zhang & Xiang Zhou. (2022) Synbiotics and Gut Microbiota: New Perspectives in the Treatment of Type 2 Diabetes Mellitus. Foods 11:16, pages 2438.
Crossref
De-feng Li, Mei-feng Yang, Hao-ming Xu, Min-zheng Zhu, Yuan Zhang, Cheng-mei Tian, Yu-qiang Nie, Jian-yao Wang, Yu-jie Liang, Jun Yao & Li-sheng Wang. (2022) Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease. Journal of Materials Chemistry B 10:31, pages 5853-5872.
Crossref
Akash Kumar, Bhupendra Prajapati & Jhilam Pramanik. (2022) Prebiotics as Adjunctive Therapy in Diabetes: A Review of Prebiotics in Diabetes. Current Nutraceuticals 3:3.
Crossref
Caiguang Liu, Shukai Zhan, Zhenyi Tian, Na Li, Tong Li, Dongxuan Wu, Zhirong Zeng & Xiaojun Zhuang. (2022) Food Additives Associated with Gut Microbiota Alterations in Inflammatory Bowel Disease: Friends or Enemies?. Nutrients 14:15, pages 3049.
Crossref
Ashwinipriyadarshini Megur, Eric Banan-Mwine Daliri, Daiva Baltriukienė & Aurelijus Burokas. (2022) Prebiotics as a Tool for the Prevention and Treatment of Obesity and Diabetes: Classification and Ability to Modulate the Gut Microbiota. International Journal of Molecular Sciences 23:11, pages 6097.
Crossref
S. Sudha, L. Inbathamizh & D. Prabavathy. 2022. Handbook of Nutraceuticals and Natural Products. Handbook of Nutraceuticals and Natural Products 269 313 .
Milena Bors, Robert Klewicki, Michał Sójka & Elżbieta Klewicka. (2022) Enzymatic Synthesis of the Fructosyl Derivative of Sorbitol. Processes 10:3, pages 594.
Crossref
Andrew C. Tolonen, Nicholas Beauchemin, Charlie Bayne, Lingyao Li, Jie Tan, Jackson Lee, Brian M. Meehan, Jeffrey Meisner, Yves Millet, Gabrielle LeBlanc, Robert Kottler, Erdmann Rapp, Chris Murphy, Peter J. Turnbaugh, Geoffrey von Maltzahn, Christopher M. Liu & Johan E. T. van Hylckama Vlieg. (2022) Synthetic glycans control gut microbiome structure and mitigate colitis in mice. Nature Communications 13:1.
Crossref
Keizo Hiraishi, Feiyan Zhao, Lin-Hai Kurahara, Xiaodong Li, Tetsuo Yamashita, Takeshi Hashimoto, Yoko Matsuda, Zhihong Sun, Heping Zhang & Katsuya Hirano. (2022) Lactulose Modulates the Structure of Gut Microbiota and Alleviates Colitis-Associated Tumorigenesis. Nutrients 14:3, pages 649.
Crossref
Jim Parker, Claire O'Brien & Jason Hawrelak. (2022) A narrative review of the role of gastrointestinal dysbiosis in the pathogenesis of polycystic ovary syndrome. Obstetrics & Gynecology Science 65:1, pages 14-28.
Crossref
Emanuele Rinninella, Marco Cintoni, Pauline Raoul, Gianluca Ianiro, Lucrezia Laterza, Francesca Romana Ponziani, Gabriele Pulcini, Antonio Gasbarrini & Maria Cristina Mele. 2022. Comprehensive Gut Microbiota. Comprehensive Gut Microbiota 354 373 .
Uday S. Annapure & Harsh B. Jadhav. 2022. Microbes for Natural Food Additives. Microbes for Natural Food Additives 75 112 .
Fenglian Ma, Yinglong Song, Mengying Sun, Arong Wang, Shujuan Jiang, Guangqing Mu & Yanfeng Tuo. (2021) Exopolysaccharide Produced by Lactiplantibacillus plantarum-12 Alleviates Intestinal Inflammation and Colon Cancer Symptoms by Modulating the Gut Microbiome and Metabolites of C57BL/6 Mice Treated by Azoxymethane/Dextran Sulfate Sodium Salt. Foods 10:12, pages 3060.
Crossref
Ayman M. Khalifah, Sara A. Abdalla, Waleed M. Dosoky, Mohamed G. Shehata & Mohamed M. Khalifah. (2021) Utilization of lemongrass essential oil supplementation on growth performance, meat quality, blood traits and caecum microflora of growing quails. Annals of Agricultural Sciences 66:2, pages 169-175.
Crossref
Haifeng Lu, Liang Chen, Xiaxia Pan, Yujun Yao, Hua Zhang, Xiaofei Zhu, Xiaobin Lou, Chunxia Zhu, Jun Wang, Lanjuan Li & Zhongwen Wu. (2021) Lactitol Supplementation Modulates Intestinal Microbiome in Liver Cirrhotic Patients. Frontiers in Medicine 8.
Crossref
Tarkan Karakan, Kieran Michael Tuohy & Gwendolyn Janssen-van Solingen. (2021) Low-Dose Lactulose as a Prebiotic for Improved Gut Health and Enhanced Mineral Absorption. Frontiers in Nutrition 8.
Crossref
David Piedrabuena, Ángel Rumbero, Elísabet Pires, Alejandro Leal-Duaso, Concepción Civera, María Fernández-Lobato & María J. Hernaiz. (2021) Enzymatic synthesis of novel fructosylated compounds by Ffase from Schwanniomyces occidentalis in green solvents . RSC Advances 11:39, pages 24312-24319.
Crossref
Wenjuan Liu, Zirong Dong, Kaiheng Liu, Yi Lu, Wei Wu, Jianping Qi & Zhongjian Chen. (2021) Targeting strategies of oral nano-delivery systems for treating inflammatory bowel disease. International Journal of Pharmaceutics 600, pages 120461.
Crossref
David Rodrigo-Frutos, Elena Jiménez-Ortega, David Piedrabuena, Mercedes Ramírez-Escudero, Noa Míguez, Francisco J. Plou, Julia Sanz-Aparicio & María Fernández-Lobato. (2021) New insights into the molecular mechanism behind mannitol and erythritol fructosylation by β-fructofuranosidase from Schwanniomyces occidentalis. Scientific Reports 11:1.
Crossref
Margaux R. Mora & Robin Dando. (2021) The sensory properties and metabolic impact of natural and synthetic sweeteners. Comprehensive Reviews in Food Science and Food Safety 20:2, pages 1554-1583.
Crossref
Y. SakaiH. HamanoH. OchiF. AbeK. MasudaH. Iino. (2021) Lactulose ingestion causes an increase in the abundance of gut-resident bifidobacteria in Japanese women: a randomised, double-blind, placebo-controlled crossover trial. Beneficial Microbes 12:1, pages 43-54.
Crossref
Peter de Cock. 2001. Kirk-Othmer Encyclopedia of Chemical Technology. Kirk-Othmer Encyclopedia of Chemical Technology 1 39 .
Emanuele Rinninella, Marco Cintoni, Pauline Raoul, Antonio Gasbarrini & Maria Cristina Mele. (2020) Food Additives, Gut Microbiota, and Irritable Bowel Syndrome: A Hidden Track. International Journal of Environmental Research and Public Health 17:23, pages 8816.
Crossref
Hada María Guevara-Alvarado, Néstor Gutiérrez-Méndez, Esther Carrillo-Pérez, Einar Vargas-Bello-Pérez & José Carlos Rodríguez-Figueroa. 2020. Lactose and Lactose Derivatives. Lactose and Lactose Derivatives.
Muhamad Hanif Rawi, Siti Aisyah Zaman, Khairul Faizal Pa’ee, Sui Sien Leong & Shahrul Razid Sarbini. (2020) Prebiotics metabolism by gut-isolated probiotics. Journal of Food Science and Technology 57:8, pages 2786-2799.
Crossref
Julio Plaza-Diaz, Belén Pastor-Villaescusa, Ascensión Rueda-Robles, Francisco Abadia-Molina & Francisco Javier Ruiz-Ojeda. (2020) Plausible Biological Interactions of Low- and Non-Calorie Sweeteners with the Intestinal Microbiota: An Update of Recent Studies. Nutrients 12:4, pages 1153.
Crossref
Michele Guarino, Annamaria Altomare, Sara Emerenziani, Claudia Di Rosa, Mentore Ribolsi, Paola Balestrieri, Paola Iovino, Giulia Rocchi & Michele Cicala. (2020) Mechanisms of Action of Prebiotics and Their Effects on Gastro-Intestinal Disorders in Adults. Nutrients 12:4, pages 1037.
Crossref
Jason A. Hawrelak. 2020. Textbook of Natural Medicine. Textbook of Natural Medicine 797 808.e4 .
Mengdi Song, Jie Zeng, Tian Jia, Haiyan Gao, Ruiyao Zhang, Jikai Jiang, Guanglei Li & Tongchao Su. (2019) Effects of sialylated lactulose on the mouse intestinal microbiome using Illumina high-throughput sequencing. Applied Microbiology and Biotechnology 103:21-22, pages 9067-9076.
Crossref
N. Bueno-Hernández, R. Vázquez-Frías, A.T. Abreu y Abreu, P. Almeda-Valdés, L.A. Barajas-Nava, R.I. Carmona-Sánchez, J. Chávez-Sáenz, A. Consuelo-Sánchez, A.J. Espinosa-Flores, V. Hernández-Rosiles, G. Hernández-Vez, M.E. Icaza-Chávez, A. Noble-Lugo, A. Romo-Romo, A. Ruiz-Margaín, M.A. Valdovinos-Díaz & F.E. Zárate-Mondragón. (2019) Review of the scientific evidence and technical opinion on noncaloric sweetener consumption in gastrointestinal diseases. Revista de Gastroenterología de México (English Edition) 84:4, pages 492-510.
Crossref
N. Bueno-Hernández, R. Vázquez-Frías, A.T. Abreu y Abreu, P. Almeda-Valdés, L.A. Barajas-Nava, R.I. Carmona-Sánchez, J. Chávez-Sáenz, A. Consuelo-Sánchez, A.J. Espinosa-Flores, V. Hernández-Rosiles, G. Hernández-Vez, M.E. Icaza-Chávez, A. Noble-Lugo, A. Romo-Romo, A. Ruiz-Margaín, M.A. Valdovinos-Díaz & F.E. Zárate-Mondragón. (2019) Revisión de la evidencia científica y opinión técnica sobre el consumo de edulcorantes no calóricos en enfermedades gastrointestinales. Revista de Gastroenterología de México 84:4, pages 492-510.
Crossref
Jakub Ruszkowski & Jacek M. Witkowski. (2019) Lactulose: Patient- and dose-dependent prebiotic properties in humans. Anaerobe 59, pages 100-106.
Crossref
Marisa da Fonseca Ferreira, Silke Salavati Schmitz, Jeffrey Joseph Schoenebeck, Dylan Neil Clements, Susan Mary Campbell, Donna Elaine Gaylor, Richard J. Mellanby, Adam George Gow & Mazdak Salavati. (2019) Lactulose drives a reversible reduction and qualitative modulation of the faecal microbiota diversity in healthy dogs. Scientific Reports 9:1.
Crossref
R. Mukherjee, M. van de. Kaa, J. Garssen, R. J. Pieters, A. D. Kraneveld & L. E. M. Willemsen. (2019) Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk. Food & Function 10:1, pages 33-37.
Crossref
Yohei SAKAI, Nobuo SEKI, Hirokazu HAMANO, Hiroshi OCHI, Fumiaki ABE, Fumiko SHIMIZU, Kazuya MASUDA & Hisakazu IINO. (2019) A study of the prebiotic effect of lactulose at low dosages in healthy Japanese women. Bioscience of Microbiota, Food and Health 38:2, pages 69-72.
Crossref
Francisco Javier Ruiz-Ojeda, Julio Plaza-Díaz, Maria Jose Sáez-Lara & Angel Gil. (2019) Effects of Sweeteners on the Gut Microbiota: A Review of Experimental Studies and Clinical Trials. Advances in Nutrition 10, pages S31-S48.
Crossref
Małgorzata Grembecka. 2019. Encyclopedia of Food Chemistry. Encyclopedia of Food Chemistry 265 275 .
Sandra Y. Wotzka, Markus Kreuzer, Lisa Maier, Mirjam Zünd, Markus Schlumberger, Bidong Nguyen, Mark Fox, Daniel Pohl, Henriette Heinrich, Gerhard Rogler, Luc Biedermann, Michael Scharl, Shinichi Sunagawa, Wolf-Dietrich Hardt & Benjamin Misselwitz. (2018) Microbiota stability in healthy individuals after single-dose lactulose challenge—A randomized controlled study. PLOS ONE 13:10, pages e0206214.
Crossref
Jasmin Steudle, Christiane Schön, Manfred Wargenau, Lioba Pauly, Susann Schwejda-Güttes, Barbara Gaigg, Angelika Kuchinka-Koch & John F Stover. (2018) Blood glucose response after oral intake of lactulose in healthy volunteers: A randomized, controlled, cross-over study. World Journal of Gastrointestinal Pharmacology and Therapeutics 9:3, pages 22-30.
Crossref
Justin L Carlson, Jennifer M Erickson, Beate B Lloyd & Joanne L Slavin. (2018) Health Effects and Sources of Prebiotic Dietary Fiber. Current Developments in Nutrition 2:3, pages nzy005.
Crossref
Sumit Sharma & Vivek R. Sinha. (2018) Current pharmaceutical strategies for efficient site specific delivery in inflamed distal intestinal mucosa. Journal of Controlled Release 272, pages 97-106.
Crossref
Ourdia Kareb, Claude P. Champagne, Julie Jean, Ahmed Gomaa & Mohammed Aïder. (2018) Effect of electro-activated sweet whey on growth of Bifidobacterium , Lactobacillus , and Streptococcus strains under model growth conditions. Food Research International 103, pages 316-325.
Crossref
Bryan Tungland. 2018. Human Microbiota in Health and Disease. Human Microbiota in Health and Disease 289 348 .
Małgorzata Grembecka. 2018. Sweeteners. Sweeteners 547 573 .
Melanie Bothe, Annet Maathuis, Susann Bellmann, Jos van der Vossen, Dirk Berressem, Annalena Koehler, Susann Schwejda-Guettes, Barbara Gaigg, Angelika Kuchinka-Koch & John Stover. (2017) Dose-Dependent Prebiotic Effect of Lactulose in a Computer-Controlled In Vitro Model of the Human Large Intestine. Nutrients 9:7, pages 767.
Crossref
Adrienne Lenhart & William D Chey. (2017) A Systematic Review of the Effects of Polyols on Gastrointestinal Health and Irritable Bowel Syndrome. Advances in Nutrition 8:4, pages 587-596.
Crossref
Hua Ling, Jee L. Foo, Gourvendu Saxena, Sanjay Swarup & Matthew W. Chang. 2017. Systems Biology. Systems Biology 191 214 .
Amin Salehi-Abargouei, Reza Ghiasvand & Mitra Hariri. (2017) Prebiotics, Prosynbiotics and Synbiotics: Can They Reduce Plasma Oxidative Stress Parameters? A Systematic Review. Probiotics and Antimicrobial Proteins 9:1, pages 1-11.
Crossref
Dorothy L. Ackerman, Kelly M. Craft & Steven D. Townsend. (2017) Infant food applications of complex carbohydrates: Structure, synthesis, and function. Carbohydrate Research 437, pages 16-27.
Crossref
Nazli Turkmen. 2017. Nutrients in Dairy and their Implications on Health and Disease. Nutrients in Dairy and their Implications on Health and Disease 441 449 .
Merlin W. Ariefdjohan, Abby Dilk, Onikia N. Brown-Esters & Dennis A. Savaiano. 2017. Nutrition in the Prevention and Treatment of Disease. Nutrition in the Prevention and Treatment of Disease 811 834 .
V. G. M. Prasad & Philip Abraham. (2016) Management of chronic constipation in patients with diabetes mellitus. Indian Journal of Gastroenterology 36:1, pages 11-22.
Crossref
Darrell W. Cockburn & Nicole M. Koropatkin. (2016) Polysaccharide Degradation by the Intestinal Microbiota and Its Influence on Human Health and Disease. Journal of Molecular Biology 428:16, pages 3230-3252.
Crossref
M. Mohammadi Gheisar, C.M. Nyachoti, J.D. Hancock & I.H. Kim. (2016) Effects of lactulose on growth, carcass characteristics, faecal microbiota, and blood constituents in broilers. Veterinární medicína 61:2, pages 90-96.
Crossref
Joran Verspreet, Bram Damen, Willem F. Broekaert, Kristin VerbekeJan A. Delcour & Christophe M. Courtin. (2016) A Critical Look at Prebiotics Within the Dietary Fiber Concept. Annual Review of Food Science and Technology 7:1, pages 167-190.
Crossref
Lauranne A.A.P. Derikx, Levinus A. Dieleman & Frank Hoentjen. (2016) Probiotics and prebiotics in ulcerative colitis. Best Practice & Research Clinical Gastroenterology 30:1, pages 55-71.
Crossref
C. Guerrero & A. Illanes. 2016. Lactose-Derived Prebiotics. Lactose-Derived Prebiotics 229 259 .
Małgorzata Grembecka. 2017. Sweeteners. Sweeteners 1 27 .
. (2015) Lactitol and the maintenance of normal defecation: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006. EFSA Journal 13:10, pages 4252.
Crossref
Aleksandra Malgorzata Urbanska, Xiaoying Zhang & Satya Prakash. (2015) Bioengineered Colorectal Cancer Drugs: Orally Delivered Anti-Inflammatory Agents. Cell Biochemistry and Biophysics 72:3, pages 757-769.
Crossref
Małgorzata Grembecka. (2015) Sugar alcohols—their role in the modern world of sweeteners: a review. European Food Research and Technology 241:1, pages 1-14.
Crossref
Connie M. Weaver. (2015) Diet, Gut Microbiome, and Bone Health. Current Osteoporosis Reports 13:2, pages 125-130.
Crossref
Diederick Meyer. 2015. 47 91 .
Kieran M. Tuohy, Duncan T. Brown, Annett Klinder, Adele Costabile & Francesca Fava. 2015. Diet-Microbe Interactions in the Gut. Diet-Microbe Interactions in the Gut 53 71 .
Ja Hyun Lee, Hah Young Yoo, Da Un Jung, Charnho Park, Yoon Seok Song, Chulhwan Park & Seung Wook Kim. (2014) Research Trend of Lactulose Production from Lactose. Korean Chemical Engineering Research 52:4, pages 407-412.
Crossref
J. H. Cho & I. H. Kim. (2013) Effects of lactulose supplementation on performance, blood profiles, excreta microbial shedding of Lactobacillus and Escherichia coli , relative organ weight and excreta noxious gas contents in broilers . Journal of Animal Physiology and Animal Nutrition 98:3, pages 424-430.
Crossref
Alfonso Clemente. 2014. Food Oligosaccharides. Food Oligosaccharides 238 254 .
Ikuko Kato, Joshua Startup & Jeffrey L. Ram. (2013) Fecal Biomarkers for Research on Dietary and Lifestyle Risk Factors in Colorectal Cancer Etiology. Current Colorectal Cancer Reports 10:1, pages 114-131.
Crossref
CHUNLEI CHEN, XIULI YU, HAIFENG LU, DANGSHENG XIAO, WEILING MAO & LANJUAN LI. (2013) Antioxidant protective effects of lactitol against endotoxemia in patients with chronic viral hepatitis. Molecular Medicine Reports 7:2, pages 401-405.
Crossref
Jason Hawrelak. 2013. Textbook of Natural Medicine. Textbook of Natural Medicine 966 978 .
Merlin W. Ariefdjohan, Onikia N. Brown-Esters & Dennis A. Savaiano. 2013. Nutrition in the Prevention and Treatment of Disease. Nutrition in the Prevention and Treatment of Disease 719 738 .
Gemma E. Walton, Jonathan R. Swann & Glenn R. Gibson. 2013. The Prokaryotes. The Prokaryotes 25 43 .
Marina Díez-Municio, Miguel Herrero, Maria Luisa Jimeno, Agustín Olano & F. Javier Moreno. (2012) Efficient Synthesis and Characterization of Lactulosucrose by Leuconostoc mesenteroides B-512F Dextransucrase . Journal of Agricultural and Food Chemistry 60:42, pages 10564-10571.
Crossref
Henna Röytiö, Kirsti Tiihonen & Arthur C. Ouwehand. 2012. Sweeteners and Sugar Alternatives in Food Technology. Sweeteners and Sugar Alternatives in Food Technology 63 76 .
Michelle J Clark, Kim Robien & Joanne L Slavin. (2012) Effect of prebiotics on biomarkers of colorectal cancer in humans: a systematic review. Nutrition Reviews 70:8, pages 436-443.
Crossref
Marika Björklund, Arthur C. Ouwehand, Sofia D. Forssten, Janne Nikkilä, Kirsti Tiihonen, Nina Rautonen & Sampo J. Lahtinen. (2011) Gut microbiota of healthy elderly NSAID users is selectively modified with the administration of Lactobacillus acidophilus NCFM and lactitol. AGE 34:4, pages 987-999.
Crossref
Koen Venema. (2012) Intestinal fermentation of lactose and prebiotic lactose derivatives, including human milk oligosaccharides. International Dairy Journal 22:2, pages 123-140.
Crossref
Nobuo Seki & Hitoshi Saito. (2012) Lactose as a source for lactulose and other functional lactose derivatives. International Dairy Journal 22:2, pages 110-115.
Crossref
Brittany M. Vester Boler & George C. FaheyJr.Jr.. 2012. Direct-Fed Microbials and Prebiotics for Animals. Direct-Fed Microbials and Prebiotics for Animals 13 26 .
Karen Windey, Vicky De Preter & Kristin Verbeke. (2011) Relevance of protein fermentation to gut health. Molecular Nutrition & Food Research 56:1, pages 184-196.
Crossref
Karin Förster-Fromme, Regina Schuster-Wolff-Bühring, Annette Hartwig, Aline Holder, Andreas Schwiertz, Stephan C. Bischoff & Jörg Hinrichs. (2011) A new enzymatically produced 1-lactulose: A pilot study to test the bifidogenic effects. International Dairy Journal 21:12, pages 940-948.
Crossref
Richard G McGee, Anouk Bakens, Kerrie Wiley, Stephen M Riordan & Angela C Webster. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Martin H. Floch. (2011) Intestinal Microecology in Health and Wellness. Journal of Clinical Gastroenterology 45, pages S108-S110.
Crossref
Vicky De Preter, Henrike M Hamer, Karen Windey & Kristin Verbeke. (2010) The impact of pre‐ and/or probiotics on human colonic metabolism: Does it affect human health?. Molecular Nutrition & Food Research 55:1, pages 46-57.
Crossref
R. Schuster-Wolff-Bühring, L. Fischer & J. Hinrichs. (2010) Production and physiological action of the disaccharide lactulose. International Dairy Journal 20:11, pages 731-741.
Crossref
. (2010) Scientific Opinion on the substantiation of health claims related to lactulose and decreasing potentially pathogenic gastro-intestinal microorganisms (ID 806) and reduction in intestinal transit time (ID 807) pursuant to Article 13(1) of Regulation (EC) N. EFSA Journal 8:10, pages 1806.
Crossref
Kieran M. Tuohy, Duncan T. Brown, Annett Klinder & Adele Costabile. (2010) Shaping the human microbiome with prebiotic foods – current perspectives for continued development. Food Science & Technology Bulletin: Functional Foods 7:4, pages 49-64.
Crossref
Jason A. HawrelakStephen P. Myers. (2010) Effects of Two Natural Medicine Formulations on Irritable Bowel Syndrome Symptoms: A Pilot Study. The Journal of Alternative and Complementary Medicine 16:10, pages 1065-1071.
Crossref
Mette Helvik Morken. (2010) POST-GIARDIASIS IRRITABEL TARM – ET FERMENTERINGSPROBLEM?. Norsk tidsskrift for ernæring 8:3, pages 8-10.
Crossref
Regina Schuster-Wolff-Bühring, Ronnie Michel & Jörg Hinrichs. (2010) A new liquid chromatography method for the simultaneous and sensitive quantification of lactose and lactulose in milk. Dairy Science & Technology.
Crossref
Marco Candela, Simone Maccaferri, Silvia Turroni, Paola Carnevali & Patrizia Brigidi. (2010) Functional intestinal microbiome, new frontiers in prebiotic design. International Journal of Food Microbiology 140:2-3, pages 93-101.
Crossref
Glenn R. Gibson, Karen P. Scott, Robert A. Rastall, Kieran M. Tuohy, Arland Hotchkiss, Alix Dubert-Ferrandon, Melanie Gareau, Eileen F. Murphy, Delphine Saulnier, Gunnar Loh, Sandra Macfarlane, Nathalie Delzenne, Yehuda Ringel, Gunhild Kozianowski, Robin Dickmann, Irene Lenoir-Wijnkoop, Carey Walker & Randal Buddington. (2010) Dietary prebiotics: current status and new definition. Food Science & Technology Bulletin: Functional Foods 7:1, pages 1-19.
Crossref
R.A. Rastall. (2010) Functional Oligosaccharides: Application and Manufacture. Annual Review of Food Science and Technology 1:1, pages 305-339.
Crossref
Renata Barczynska, Kamila Jochym, Katarzyna Slizewska, Janusz Kapusniak & Zdzislawa Libudzisz. (2010) The effect of citric acid-modified enzyme-resistant dextrin on growth and metabolism of selected strains of probiotic and other intestinal bacteria. Journal of Functional Foods 2:2, pages 126-133.
Crossref
Andrew Szilagyi. 2009. Handbook of Prebiotics and Probiotics Ingredients. Handbook of Prebiotics and Probiotics Ingredients.
Mukesh Yadav, Francesco Marotta, Hariom Yadav, Saji Menon & Shalini Jain. 2009. Handbook of Prebiotics and Probiotics Ingredients. Handbook of Prebiotics and Probiotics Ingredients.
. 2009. Handbook of Prebiotics and Probiotics Ingredients. Handbook of Prebiotics and Probiotics Ingredients 291 310 .
Cindy D. Davis & John A. Milner. (2009) Gastrointestinal microflora, food components and colon cancer prevention. The Journal of Nutritional Biochemistry 20:10, pages 743-752.
Crossref
Young Jin Baek & Byong H. Lee. 2009. Bioactive Components in Milk and Dairy Products. Bioactive Components in Milk and Dairy Products 287 310 .
Arthur C. Ouwehand, Kirsti Tiihonen, Markku Saarinen, Heli Putaala & Nina Rautonen. (2008) Influence of a combination of Lactobacillus acidophilus NCFM and lactitol on healthy elderly: intestinal and immune parameters . British Journal of Nutrition 101:3, pages 367-375.
Crossref
Yanbo Wang. (2009) Prebiotics: Present and future in food science and technology. Food Research International 42:1, pages 8-12.
Crossref
M.J. Playne & R.G. Crittenden. 2009. Advanced Dairy Chemistry. Advanced Dairy Chemistry 121 201 .
Ross Crittenden & Martin J. Playne. 2008. Handbook of Probiotics and Prebiotics. Handbook of Probiotics and Prebiotics 533 581 .
Macarena Gonzalez Santiago, Heiner C Bucher & Alain J Nordmann. (2008) Accuracy of drug advertisements in medical journals under new law regulating the marketing of pharmaceutical products in Switzerland. BMC Medical Informatics and Decision Making 8:1.
Crossref
Alix Dubert-Ferrandon, David S. Newburg & W. Allan Walker. (2008) Part 1-Prebiotics. Nutrition Today 43:6, pages 245-249.
Crossref
V De Preter, H Raemen, L Cloetens, E Houben, P Rutgeerts & K Verbeke. (2007) Effect of dietary intervention with different pre- and probiotics on intestinal bacterial enzyme activities. European Journal of Clinical Nutrition 62:2, pages 225-231.
Crossref
Sofia Kolida & Glenn Gibson. 2008. Handbook of Prebiotics. Handbook of Prebiotics 69 92 .
Marcel Roberfroid. 2008. Handbook of Prebiotics. Handbook of Prebiotics 39 68 .
Anne Hafer, Sigrid Krämer, Swantje Duncker, Martin Krüger, Michael P Manns & Stephan C Bischoff. (2007) Effect of oral lactulose on clinical and immunohistochemical parameters in patients with inflammatory bowel disease: a pilot study. BMC Gastroenterology 7:1.
Crossref
Robert Klewicki. (2007) The stability of gal-polyols and oligosaccharides during pasteurization at a low pH. LWT - Food Science and Technology 40:7, pages 1259-1265.
Crossref
Michelle Finney, Joanne Smullen, Howard A. Foster, Saskia Brokx & David M. Storey. (2007) Effects of low doses of lactitol on faecal microflora, pH, short chain fatty acids and gastrointestinal symptomology. European Journal of Nutrition 46:6, pages 307-314.
Crossref
Mohammed Aider & Damien de Halleux. (2007) Isomerization of lactose and lactulose production: review. Trends in Food Science & Technology 18:7, pages 356-364.
Crossref
M. Shahidul Islam, Ayae Nishiyama & Ei Sakaguchi. (2007) Sorbitol and lactitol reduce body fat and toxic ammonia levels in rats. Nutrition Research 27:7, pages 440-447.
Crossref
R. Klewicki. (2007) Effect of Selected Parameters of Lactose Hydrolysis in the Presence of β‐Galactosidase from Various Sources on the Synthesis of Galactosyl‐Polyol Derivatives. Engineering in Life Sciences 7:3, pages 268-274.
Crossref
Jacqueline Park & Martin H. Floch. (2007) Prebiotics, Probiotics, and Dietary Fiber in Gastrointestinal Disease. Gastroenterology Clinics of North America 36:1, pages 47-63.
Crossref
Alexandra Drakoularakou, Oliver Hasselwander, Melanie Edinburgh & Arthur C. Ouwehand. (2007) Lactitol, an emerging prebiotic: functional properties with a focus on digestive health. Food Science & Technology Bulletin: Functional Foods 3:7, pages 71-80.
Crossref
E. Myllyluoma, K. Kajander & M. Saxelin. 2007. Functional Dairy Products. Functional Dairy Products 63 89 .
S. Fleige, W. Preißinger, H.H.D. Meyer & M.W. Pfaffl. (2007) Effect of lactulose on growth performance and intestinal morphology of pre-ruminant calves using a milk replacer containing Enterococcus faecium. Animal 1:3, pages 367-373.
Crossref
Chunlei Chen, Lanjuan Li, Zhongwen Wu, Huguang Chen & Shuzhen Fu. (2007) Effects of lactitol on intestinal microflora and plasma endotoxin in patients with chronic viral hepatitis. Journal of Infection 54:1, pages 98-102.
Crossref
Kieran M. Tuohy & Glenn R. Gibson. 2006. Plant Secondary Metabolites. Plant Secondary Metabolites 174 207 .
Ulf Nilsson, Margareta Nyman, Siv Ahrné, Eilbhis O. Sullivan & Gerald Fitzgerald. (2006) Bifidobacterium lactis Bb-12 and Lactobacillus salivarius UCC500 Modify Carboxylic Acid Formation in the Hindgut of Rats Given Pectin, Inulin, and Lactitol. The Journal of Nutrition 136:8, pages 2175-2180.
Crossref
Ross Crittenden & Martin Playne. 2006. Gastrointestinal Microbiology. Gastrointestinal Microbiology 285 314 .
Wolfram M. Brück. 2006. Prebiotics: Development & Application. Prebiotics: Development & Application 157 179 .
Ross Crittenden. 2006. Prebiotics: Development & Application. Prebiotics: Development & Application 111 133 .
Jan Van Loo. (2005) Prebiotics: a nutritional concept gaining momentum in modern nutrition. Food Science <html_ent glyph="@amp;" ascii="&amp;"/> Technology Bulletin: Functional Foods 2:8, pages 83-100.
Crossref
Ulf Nilsson & Margareta Nyman. (2007) Short-chain fatty acid formation in the hindgut of rats fed oligosaccharides varying in monomeric composition, degree of polymerisation and solubility. British Journal of Nutrition 94:5, pages 705-713.
Crossref
Chiara C. Lim, Lynnette R. Ferguson & Gerald W. Tannock. (2005) Dietary fibres as “prebiotics”: Implications for colorectal cancer. Molecular Nutrition & Food Research 49:6, pages 609-619.
Crossref
Yoram Bouhnik, Laurent Raskine, Guy Simoneau, Eric Vicaut, Christel Neut, Bernard Flourié, Fred Brouns & Francis R Bornet. (2004) The capacity of nondigestible carbohydrates to stimulate fecal bifidobacteria in healthy humans: a double-blind, randomized, placebo-controlled, parallel-group, dose-response relation study. The American Journal of Clinical Nutrition 80:6, pages 1658-1664.
Crossref
Glenn R. Gibson, Hollie M. Probert, Jan Van Loo, Robert A. Rastall & Marcel B. Roberfroid. (2007) Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutrition Research Reviews 17:2, pages 259-275.
Crossref
Janet A Vogt, Katrin B Ishii-Schrade, Paul B Pencharz & Thomas MS Wolever. (2004) l-Rhamnose increases serum propionate after long-term supplementation, but lactulose does not raise serum acetate. The American Journal of Clinical Nutrition 80:5, pages 1254-1261.
Crossref
Jan A. E Van Loo. (2004) Prebiotics Promote Good Health. Journal of Clinical Gastroenterology 38:Supplement 2, pages S70-S75.
Crossref
Y. Bouhnik, C. Neut, L. Raskine, C. Michel, M. Riottot, C. Andrieux, F. Guillemot, F. Dyard & B. Flourié. (2004) Prospective, randomized, parallel‐group trial to evaluate the effects of lactulose and polyethylene glycol‐4000 on colonic flora in chronic idiopathic constipation. Alimentary Pharmacology & Therapeutics 19:8, pages 889-899.
Crossref
Y Bouhnik, A Attar, F A Joly, M Riottot, F Dyard & B Flourié. (2004) Lactulose ingestion increases faecal bifidobacterial counts: A randomised double-blind study in healthy humans. European Journal of Clinical Nutrition 58:3, pages 462-466.
Crossref
Wolfram M. Br�ck. (2004) Functional foods in infant formulae. Food Science <html_ent glyph="@amp;" ascii="&"/> Technology Bulletin: Functional Foods 1:9, pages 1-14.
Crossref
Riitta PUUPPONEN-PIMIA, Anna-Marja AURA, Sirpa KARPPINEN, Kirsi-Marja OKSMAN-CALDENTEY & Kaisa POUTANEN. (2004) Interactions between Plant Bioactive Food Ingredients and Intestinal Flora—Effects on Human Health. Bioscience and Microflora 23:2, pages 67-80.
Crossref
Geoffrey Livesey. (2007) Health potential of polyols as sugar replacers, with emphasis on low glycaemic properties. Nutrition Research Reviews 16:2, pages 163-191.
Crossref
Billur Demirogullari, Meltem Yalinay Cirak, Aylar Poyraz, Kaan Sonmez, Canan Kulah, Zafer Turkyilmaz, Ramazan Karabulut, Yavuz Yilmaz, A. Can Basaklar & Nuri Kale. (2003) Effects of lactulose and lactitol on coliform bacteria and bacterial translocation in the caecum during 72-h starvation in rats. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 135:3, pages 249-255.
Crossref
P HOTTEN, F MAROTTA, Y NAITO, E MINELLI, A HELMY, J LIGHTHOUSE, H FUJI & E FESCE. (2003) Effects of probiotics, lactitol and rifaximin on intestinal flora and fecal excretion of organic acids in cirrhotic patients. Chinese Journal of Digestive Diseases 4:1, pages 13-18.
Crossref
Francisco Guarner & Juan-R Malagelada. (2003) Gut flora in health and disease. The Lancet 361:9356, pages 512-519.
Crossref
Maria Saarela, Katri Hallamaa, Tiina Mattila-Sandholm & Jaana Mättö. (2003) The effect of lactose derivatives lactulose, lactitol and lactobionic acid on the functional and technological properties of potentially probiotic Lactobacillus strains. International Dairy Journal 13:4, pages 291-302.
Crossref
B. Martineau & D.P. Laflamme. (2002) Effect of diet on markers of intestinal health in dogs. Research in Veterinary Science 72:3, pages 223-227.
Crossref
Konstantinos C. Mountzouris, Anne L. McCartney & Glenn R. Gibson. (2007) Intestinal microflora of human infants and current trends for its nutritional modulation. British Journal of Nutrition 87:5, pages 405-420.
Crossref
B. Pool-Zobel, J. van Loo, I. Rowland & M. B. Roberfroid. (2007) Experimental evidences on the potential of prebiotic fructans to reduce the risk of colon cancer. British Journal of Nutrition 87:S2, pages S273-S281.
Crossref
S. KAJIWARA, H. GANDHI & Z. USTUNOL. (2002) Effect of Honey on the Growth of and Acid Production by Human Intestinal Bifidobacterium spp.: An In Vitro Comparison with Commercial Oligosaccharides and Inulin. Journal of Food Protection 65:1, pages 214-218.
Crossref
Ingrid Wollowski, Gerhard Rechkemmer & Beatrice L Pool-Zobel. (2001) Protective role of probiotics and prebiotics in colon cancer. The American Journal of Clinical Nutrition 73:2, pages 451s-455s.
Crossref
Sofia Kolida, K. Tuohy & Glenn R. Gibson. (2001) The human gut flora in nutrition and approaches for its dietary modulation. Nutrition Bulletin 25:3, pages 223-231.
Crossref
Rial D. Rolfe. (2000) The Role of Probiotic Cultures in the Control of Gastrointestinal Health. The Journal of Nutrition 130:2, pages 396S-402S.
Crossref
Yvan Vandenplas. (1999) Bacteria and yeasts in the treatment of acute and chronic infectious diarrhea. Part I. Bacteria. Clinical Microbiology and Infection 5:6, pages 299-307.
Crossref
Professor Brian Ratcliffe & Joanna McMillan. (2007) The potential for beneficial manipulation of the gut microflora by dietary means. Nutrition Bulletin 24:2, pages 82-91.
Crossref
John H. Cummings. (1998) Dietary carbohydrates and the colonic microflora. Current Opinion in Clinical Nutrition and Metabolic Care 1:5, pages 409-414.
Crossref
Jon A. Vanderhoof & Rosemary J. Young. (1998) Use of Probiotics in Childhood Gastrointestinal Disorders. Journal of Pediatric Gastroenterology & Nutrition 27:3, pages 323-332.
Crossref
S. J. Lewis & A. R. Freedman. (2003) Review article: the use of biotherapeutic agents in the prevention and treatment of gastrointestinal disease. Alimentary Pharmacology & Therapeutics 12:9, pages 807-822.
Crossref
Jon A. VanderhoofRosemary J. Young. (1998) Use of Probiotics in Childhood Gastrointestinal Disorders. Journal of Pediatric Gastroenterology and Nutrition 27:3, pages 323-332.
Crossref
S. Salminen, C. Bouley, M.-C. Boutron, J. H. Cummings, A. Franck, G. R. Gibson, E. Isolauri, M.-C. Moreau, M. Roberfroid & I. Rowland. (2007) Functional food science and gastrointestinal physiology and function. British Journal of Nutrition 80:S1, pages S147-S171.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.