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Scandinavian Journal of Gastroenterology Volume 51, 2016 - Issue 11
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Original Article

Pirfenidone inhibits the proliferation of fibroblasts from patients with active Crohn’s disease

Sara-Irini KadirDepartment of Hepatology and Gastroenterology, Gastro-Immuno Research Laboratory (GIRL), Aarhus University Hospital, Aarhus, Denmark;
,
Tue Wenzel KragstrupDepartment of Biomedicine, Aarhus University, Aarhus, Denmark
,
Anders DigeDepartment of Hepatology and Gastroenterology, Gastro-Immuno Research Laboratory (GIRL), Aarhus University Hospital, Aarhus, Denmark;
,
Simon Kok JensenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark
,
Jens Frederik DahlerupDepartment of Hepatology and Gastroenterology, Gastro-Immuno Research Laboratory (GIRL), Aarhus University Hospital, Aarhus, Denmark;
&
Jens KelsenDepartment of Hepatology and Gastroenterology, Gastro-Immuno Research Laboratory (GIRL), Aarhus University Hospital, Aarhus, Denmark; Correspondence[email protected]
Pages 1321-1325 | Received 28 Apr 2016, Accepted 28 Apr 2016, Published online: 16 May 2016

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Joseph Sleiman, Sara El Ouali, Taha Qazi, Benjamin Cohen, Scott R. Steele, Mark E. Baker & Florian Rieder. (2021) Prevention and Treatment of Stricturing Crohn’s Disease – Perspectives and Challenges. Expert Review of Gastroenterology & Hepatology 15:4, pages 401-411.
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Articles from other publishers (16)

Ioannis Drygiannakis, George Kolios, Eirini Filidou, Giorgos Bamias & Vassilis Valatas. (2024) Intestinal Stromal Cells in the Turmoil of Inflammation and Defective Connective Tissue Remodeling in Inflammatory Bowel Disease. Inflammatory Bowel Diseases.
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Helena Tavares de Sousa & Fernando Magro. (2023) How to Evaluate Fibrosis in IBD?. Diagnostics 13:13, pages 2188.
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Jiali Wang, Fushun Kou, Xiao Han, Lei Shi, Rui Shi, Zhibin Wang, Tangyou Mao & Junxiang Li. (2022) Inflammatory bowel disease and risk of idiopathic pulmonary fibrosis: A protocol for systematic review and meta-analysis. PLOS ONE 17:6, pages e0270297.
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Si-Nan Lin, Ren Mao, Chenchen Qian, Dominik Bettenworth, Jie Wang, Jiannan Li, David H. Bruining, Vipul Jairath, Brian G. Feagan, Min-Hu Chen & Florian Rieder. (2022) Development of antifibrotic therapy for stricturing Crohn’s disease: lessons from randomized trials in other fibrotic diseases. Physiological Reviews 102:2, pages 605-652.
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Silvia D’Alessio, Federica Ungaro, Daniele Noviello, Sara Lovisa, Laurent Peyrin-Biroulet & Silvio Danese. (2021) Revisiting fibrosis in inflammatory bowel disease: the gut thickens. Nature Reviews Gastroenterology & Hepatology 19:3, pages 169-184.
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Anna‐Lena Unterweger, Alena Rüscher, Marietta Seuß, Paula Winkelmann, Florian Beigel, Leandra Koletzko, Simone Breiteneicher, Matthias Siebeck, Roswitha Gropp & Attila Aszodi. (2021) NOD/scid IL‐2Rγ null mice reconstituted with peripheral blood mononuclear cells from patients with Crohn's disease reflect the human pathological phenotype . Immunity, Inflammation and Disease 9:4, pages 1631-1647.
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Anjana Bali & Monika Rani. 2021. Crohn’s Disease Recent Advances. Crohn’s Disease Recent Advances.
Christopher J Schmoyer, Jakob Saidman, Jaime L Bohl, Claire L Bierly, John F Kuemmerle & Stephen J Bickston. (2021) The Pathogenesis and Clinical Management of Stricturing Crohn Disease. Inflammatory Bowel Diseases 27:11, pages 1839-1852.
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Sarah Rank Rønnow, Rand Qais Dabbagh, Federica Genovese, Carmel B. Nanthakumar, Vikki J. Barrett, Robert B. Good, Sarah Brockbank, Simon Cruwys, Henrik Jessen, Grith Lykke Sorensen, Morten Asser Karsdal, Diana Julie Leeming & Jannie Marie Bülow Sand. (2020) Prolonged Scar-in-a-Jar: an in vitro screening tool for anti-fibrotic therapies using biomarkers of extracellular matrix synthesis. Respiratory Research 21:1.
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Jun Hwan Yoo, Stefan Holubar & Florian Rieder. (2020) Fibrostenotic strictures in Crohn’s disease. Intestinal Research 18:4, pages 379-401.
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Giovanni Latella & Angelo Viscido. (2020) Could Pirfenidone Also be Effective in Treating Intestinal Fibrosis?. Cells 9:8, pages 1762.
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Yingying Cui, Mengfan Zhang, Changsen Leng, Tjasso Blokzijl, Bernadien H. Jansen, Gerard Dijkstra & Klaas Nico Faber. (2020) Pirfenidone Inhibits Cell Proliferation and Collagen I Production of Primary Human Intestinal Fibroblasts. Cells 9:3, pages 775.
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Tuong N. Vu, Xuesong Chen, Hussein D. Foda, Gerald C. Smaldone & Nadia A. Hasaneen. (2019) Interferon-γ enhances the antifibrotic effects of pirfenidone by attenuating IPF lung fibroblast activation and differentiation. Respiratory Research 20:1.
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Julie Stougaard, Søren Lomholt, Pernille Ommen, Jens Kelsen & Tue W. Kragstrup. (2018) The antifibrotic drug pirfenidone inhibits spondyloarthritis fibroblast-like synoviocytes and osteoblasts in vitro. BMC Rheumatology 2:1.
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Yan-Wu Sun, Yi-Yi Zhang, Xin-Jie Ke, Xue-jing Wu, Zhi-Fen Chen & Pan Chi. (2018) Pirfenidone prevents radiation-induced intestinal fibrosis in rats by inhibiting fibroblast proliferation and differentiation and suppressing the TGF-β1/Smad/CTGF signaling pathway. European Journal of Pharmacology 822, pages 199-206.
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Guanwei Li, Jianan Ren, Qiongyuan Hu, Youming Deng, Guopu Chen, Kun Guo, Ranran Li, Yuan Li, Lei Wu, Gefei Wang, Guosheng Gu & Jieshou Li. (2016) Oral pirfenidone protects against fibrosis by inhibiting fibroblast proliferation and TGF-β signaling in a murine colitis model. Biochemical Pharmacology 117, pages 57-67.
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