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Original Article

Randomized clinical trial: a pilot study comparing efficacy of low-dose azathioprine and allopurinol to azathioprine on clinical outcomes in inflammatory bowel disease

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Pages 1470-1475 | Received 22 May 2016, Accepted 17 Jul 2016, Published online: 10 Aug 2016

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Read on this site (2)

Marianna Lucafò, Raffaella Franca, Davide Selvestrel, Debora Curci, Letizia Pugnetti, Giuliana Decorti & Gabriele Stocco. (2018) Pharmacogenetics of treatments for inflammatory bowel disease. Expert Opinion on Drug Metabolism & Toxicology 14:12, pages 1209-1223.
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Berrie Meijer, Margien L Seinen, Tessa Hosman, Ronald K Linskens, Jan-Kees Kneppelhout, Godefridus J Peters, Chris JJ Mulder, Adriaan A van Bodegraven & Nanne KH de Boer. (2018) High inter-individual variability of serum xanthine oxidoreductase activity in IBD patients. Nucleosides, Nucleotides & Nucleic Acids 37:6, pages 317-323.
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Articles from other publishers (20)

Alexander Keith Turbayne & Miles Patrick Sparrow. (2022) Low-Dose Azathioprine in Combination with Allopurinol: The Past, Present and Future of This Useful Duo. Digestive Diseases and Sciences 67:12, pages 5382-5391.
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Vishal Sharma, Saurabh Kedia & Vineet Ahuja. (2022) Personalized medicine to implementation science: Thiopurines set for the leap. JGH Open 6:10, pages 651-657.
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Femke Crouwel, Hans J C Buiter & Nanne K de Boer. (2022) The Thiopurine Tale: An Unexpected Journey. Journal of Crohn's and Colitis 16:7, pages 1177-1183.
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Suprabhat Giri & Sridhar Sundaram. (2022) Low Dose Azathioprine with Allopurinol in IBD: Early Days to Call It a Recipe for Success. Digestive Diseases and Sciences 67:8, pages 4263-4265.
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Pedro R. Chocair, Precil Diego Miranda de Menezes Neves, Sara Mohrbacher, Maurilio Pacheco Neto, Victor A. H. Sato, Érico S. Oliveira, Leonardo V. Barbosa, Alessandra M. Bales, Fagner Pereira da Silva, Américo L. Cuvello-Neto & John A. Duley. (2022) Case Report: Azathioprine: An Old and Wronged Immunosuppressant. Frontiers in Immunology 13.
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Marianne Kiszka-Kanowitz, Klaus Theede, Sandra Bohn Thomsen, Jacob Tveiten Bjerrum, Jørn Brynskov, Ida Benedikte Gottschalck, Elena Akimenko, Karen Lisa Hilsted, Anders Neumann, Signe Wildt, Lone Larsen, Jens Kristian Munk, Per Holger Ibsen, Huma Gul Rehana Janjua, Lise Lotte Gluud & Anette Mertz-Nielsen. (2022) Low-dose azathioprine and allopurinol versus azathioprine monotherapy in patients with ulcerative colitis (AAUC): An investigator-initiated, open, multicenter, parallel-arm, randomised controlled trial. eClinicalMedicine 45, pages 101332.
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Toshinori Hirai, Chihiro Shiraishi, Tomohiro Murata & Takuya Iwamoto. (2021) Drug-Drug Interaction between Azathioprine and Allopurinol in Patients with Chronic Kidney Disease: A Case Series Study. BPB Reports 4:5, pages 170-174.
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Satohiro Matsumoto & Hirosato Mashima. (2021) Real-World Long-Term Remission Maintenance for 10 Years With Thiopurines in Ulcerative Colitis. Crohn's & Colitis 360 3:1.
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Sandra Bohn Thomsen, Kristine Højgaard Allin, Johan Burisch, Camilla Bjørn Jensen, Susanne Hansen, Lise Lotte Gluud, Klaus Theede, Marianne Kiszka‐Kanowitz, Anette Mertz Nielsen & Tine Jess. (2020) Outcome of concomitant treatment with thiopurines and allopurinol in patients with inflammatory bowel disease: A nationwide Danish cohort study. United European Gastroenterology Journal 8:1, pages 68-76.
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Christopher Andrew Lamb, Nicholas A Kennedy, Tim Raine, Philip Anthony Hendy, Philip J Smith, Jimmy K Limdi, Bu’Hussain Hayee, Miranda C E Lomer, Gareth C Parkes, Christian Selinger, Kevin J Barrett, R Justin Davies, Cathy Bennett, Stuart Gittens, Malcolm G Dunlop, Omar Faiz, Aileen Fraser, Vikki Garrick, Paul D Johnston, Miles Parkes, Jeremy Sanderson, Helen Terry, Daniel R Gaya, Tariq H Iqbal, Stuart A Taylor, Melissa Smith, Matthew Brookes, Richard Hansen & A Barney Hawthorne. (2019) British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults. Gut 68:Suppl 3, pages s1-s106.
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Raphael P. Luber, Sailish Honap, Georgina Cunningham & Peter M. Irving. (2019) Can We Predict the Toxicity and Response to Thiopurines in Inflammatory Bowel Diseases?. Frontiers in Medicine 6.
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Joany E. Kreijne, Rozanne C. de Veer, Nanne K. de Boer, Gerard Dijkstra, Rachel West, Sofia A. W. Moorsel, Dirk J. de Jong, C. Janneke van der Woude & Annemarie C. de Vries. (2019) Real-life study of safety of thiopurine-allopurinol combination therapy in inflammatory bowel disease: myelotoxicity and hepatotoxicity rarely affect maintenance treatment. Alimentary Pharmacology & Therapeutics 50:4, pages 407-415.
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Rishi Bolia, Jeremy Rajanayagam & Winita Hardikar. (2018) Lower 6-MMP/6-TG Ratio May Be a Therapeutic Target in Pediatric Autoimmune Hepatitis. Journal of Pediatric Gastroenterology & Nutrition 67:6, pages 695-700.
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Sandra Bohn Thomsen, Marianne Kiszka-Kanowitz, Klaus Theede, Lise Lotte Gluud & Anette Mertz Nielsen. (2018) Optimized thiopurine therapy before withdrawal of anti-tumour necrosis factor-α in patients with Crohn’s disease. European Journal of Gastroenterology & Hepatology 30:10, pages 1155-1158.
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Abhinav Vasudevan, Lauren Beswick, Antony B. Friedman, Alicia Moltzen, James Haridy, Ajay Raghunath, Miles Sparrow & Daniel van Langenberg. (2018) Low-dose thiopurine with allopurinol co-therapy overcomes thiopurine intolerance and allows thiopurine continuation in inflammatory bowel disease. Digestive and Liver Disease 50:7, pages 682-688.
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Geoffrey C. Wall, Hamid Muktar, Cassandra Effken & Pramod B. Mahajan. (2018) Addition of Allopurinol for Altering Thiopurine Metabolism to Optimize Therapy in Patients with Inflammatory Bowel Disease. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 38:2, pages 259-270.
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Berrie Meijer, Margien L. Seinen, Remco van Egmond, Gerd Bouma, Chris J. J. Mulder, Adriaan A. van Bodegraven & Nanne K. H. de Boer. (2017) Optimizing Thiopurine Therapy in Inflammatory Bowel Disease Among 2 Real-life Intercept Cohorts. Inflammatory Bowel Diseases 23:11, pages 2011-2017.
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Abhinav Vasudevan, Peter R Gibson & Daniel R van Langenberg. (2017) Time to clinical response and remission for therapeutics in inflammatory bowel diseases: What should the clinician expect, what should patients be told?. World Journal of Gastroenterology 23:35, pages 6385-6402.
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Sally A. Coulthard, Phil Berry, Sarah McGarrity, Simon McLaughlin, Azhar Ansari & Christopher P. F. Redfern. (2017) Azathioprine with Allopurinol. Inflammatory Bowel Diseases 23:6, pages 946-955.
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Jordan E Axelrad, Abhik Roy, Garrett Lawlor, Burton Korelitz & Simon Lichtiger. (2016) Thiopurines and inflammatory bowel disease: Current evidence and a historical perspective. World Journal of Gastroenterology 22:46, pages 10103.
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