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Original Article

Diagnosing colorectal cancer and inflammatory bowel disease in primary care: The usefulness of tests for faecal haemoglobin, faecal calprotectin, anaemia and iron deficiency. A prospective study

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Pages 69-75 | Received 16 Jun 2016, Accepted 16 Aug 2016, Published online: 14 Sep 2016

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Read on this site (7)

Cecilia Högberg, Olof Cronberg, Hans Thulesius, Mikael Lilja, Stefan Jansson & Ulf Gunnarsson. (2022) Use of faecal immunochemical tests common in patients with suspected colorectal cancer but unrelated to travel distance to secondary care: a population-based study from Swedish primary care. Scandinavian Journal of Primary Health Care 40:4, pages 459-465.
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Anna Viola, Andrea Fontana, Alessandra Belvedere, Riccardo Scoglio, Giuseppe Costantino, Aldo Sitibondo, Marco Muscianisi, Santi Inferrera, Lucia Maria Bruno, Angela Alibrandi, Gianluca Trifirò & Walter Fries. (2020) Diagnostic accuracy of faecal calprotectin in a symptom-based algorithm for early diagnosis of inflammatory bowel disease adjusting for differential verification bias using a Bayesian approach. Scandinavian Journal of Gastroenterology 55:10, pages 1176-1184.
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Georgios Tsapournas, Per M. Hellström, Yang Cao & Louise I. Olsson. (2020) Diagnostic accuracy of a quantitative faecal immunochemical test vs. symptoms suspected for colorectal cancer in patients referred for colonoscopy. Scandinavian Journal of Gastroenterology 55:2, pages 184-192.
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Pontus Karling, David Lundgren, Vincy Eklöf, Richard Palmqvist & Johan Hultdin. (2019) Improved monitoring of inflammatory activity in patients with ulcerative colitis by combination of faecal tests for haemoglobin and calprotectin. Scandinavian Journal of Clinical and Laboratory Investigation 79:5, pages 341-346.
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James Turvill, Samantha Mellen, Laura Jeffery, Sarah Bevan, Ada Keding & Daniel Turnock. (2018) Diagnostic accuracy of one or two faecal haemoglobin and calprotectin measurements in patients with suspected colorectal cancer. Scandinavian Journal of Gastroenterology 53:12, pages 1526-1534.
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Jakob Søgaard Juul, Berit Andersen, Søren Laurberg, Anders Helles Carlsen, Frede Olesen & Peter Vedsted. (2018) Differences in diagnostic activity in general practice and findings for individuals invited to the danish screening programme for colorectal cancer: a population-based cohort study. Scandinavian Journal of Primary Health Care 36:3, pages 281-290.
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Cecilia Högberg, Lars Söderström & Mikael Lilja. (2017) Faecal immunochemical tests for the diagnosis of symptomatic colorectal cancer in primary care: the benefit of more than one sample. Scandinavian Journal of Primary Health Care 35:4, pages 369-372.
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Articles from other publishers (32)

James S. Hampton, Ryan P.W. Kenny, Colin J. Rees, William Hamilton, Claire Eastaugh, Catherine Richmond & Linda Sharp. (2023) The performance of FIT-based and other risk prediction models for colorectal neoplasia in symptomatic patients: a systematic review. eClinicalMedicine 64, pages 102204.
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Henrike Jacoba Brands, Brigit Van Dijk, Richard M. Brohet, Henderik L. van Westreenen, Jan Willem B. de Groot, Leon M. G. Moons & Wouter H. de Vos tot Nederveen Cappel. (2023) Possible Value of Faecal Immunochemical Test (FIT) When Added in Symptomatic Patients Referred for Colonoscopy: A Systematic Review. Cancers 15:7, pages 2011.
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Fiona A. Ross, James H. Park, David Mansouri, Emilie Combet, Paul G. Horgan, Donald C. McMillan & Campbell S. D. Roxburgh. (2022) The role of faecal calprotectin in diagnosis and staging of colorectal neoplasia: a systematic review and meta-analysis. BMC Gastroenterology 22:1.
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Karoline Freeman, Brian H. Willis, Ronan Ryan, Sian Taylor-Phillips & Aileen Clarke. (2022) Comparing outcomes from tailored meta-analysis with outcomes from a setting specific test accuracy study using routine data of faecal calprotectin testing for inflammatory bowel disease. BMC Medical Research Methodology 22:1.
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Noel Pin-Vieito, Coral Tejido-Sandoval, Natalia de Vicente-Bielza, Cristina Sánchez-Gómez & Joaquín Cubiella. (2022) Faecal immunochemical tests safely enhance rational use of resources during the assessment of suspected symptomatic colorectal cancer in primary care: systematic review and meta-analysis. Gut 71:5, pages 950-960.
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Helga E. Laszlo, Edward Seward, Ruth M. Ayling, Jennifer Lake, Aman Malhi, Clare Stephens, Kathy Pritchard-Jones, Donna Chung, Allan Hackshaw & Michael Machesney. (2021) Faecal immunochemical test for patients with ‘high-risk’ bowel symptoms: a large prospective cohort study and updated literature review. British Journal of Cancer 126:5, pages 736-743.
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Atefeh Nasir Kansestani, Mohammad Erfan Zare, Qingchao Tong & Jun Zhang. (2022) Comparison of faecal protein biomarkers' diagnostic accuracy for colorectal advanced neoplasms: a systematic review and meta-analysis. Scientific Reports 12:1.
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Fiona A. Ross, James H. Park, David Mansouri, Cariss Little, Domenic G. Di Rollo, Emilie Combet, Hester Van Wyk, Paul G. Horgan, Donald C. McMillan & Campbell S. D. Roxburgh. (2021) The role of faecal calprotectin in the identification of colorectal neoplasia in patients attending for screening colonoscopy. Colorectal Disease 24:2, pages 188-196.
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Hyun Jin Kim. (2022) Efficacy of Fecal Calprotectin Combined With Stool Hemoglobin in Differentiating Bacterial Origin in Acute Gastroenteritis. Pediatric Emergency Care 38:2, pages e670-e673.
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Nigel D’Souza, Kevin Monahan, Sally C. Benton, Lisa Wilde & Muti Abulafi. (2021) Finding the needle in the haystack: the diagnostic accuracy of the faecal immunochemical test for colorectal cancer in younger symptomatic patients. Colorectal Disease 23:10, pages 2539-2549.
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James L Turvill, Daniel Turnock, Dan Cottingham, Monica Haritakis, Laura Jeffery, Annabelle Girdwood, Tom Hearfield, Alex Mitchell & Ada Keding. (2021) The Fast Track FIT study: diagnostic accuracy of faecal immunochemical test for haemoglobin in patients with suspected colorectal cancer. British Journal of General Practice 71:709, pages e643-e651.
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Nadia El Kadmiri. (2021) Advances in Early Detection of Colorectal Cancer: A Focus on Non-invasive Biomarkers. Current Drug Targets 22:9, pages 1043-1053.
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Subashini Chandrapalan, Sofie Bosch, Joaquín Cubiella, Jordi Guardiola, Peter Kimani, Chris Mulder, Krishna Persaud, Tim G. J. de Meij, Donato F. Altomare, Herman Brenner, Nanne K. H. de Boer, Luigi Ricciardiello & Ramesh P. Arasaradnam. (2021) Systematic review with meta‐analysis: volatile organic compound analysis to improve faecal immunochemical testing in the detection of colorectal cancer. Alimentary Pharmacology & Therapeutics 54:1, pages 14-23.
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Karoline Freeman, Sian Taylor-Phillips, Brian H Willis, Ronan Ryan & Aileen Clarke. (2021) Test accuracy of faecal calprotectin for inflammatory bowel disease in UK primary care: a retrospective cohort study of the THIN data. BMJ Open 11:2, pages e044177.
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Cecilia Högberg, Ulf Gunnarsson, Stefan Jansson, Hans Thulesius, Olof Cronberg & Mikael Lilja. (2020) Diagnosing colorectal cancer in primary care: cohort study in Sweden of qualitative faecal immunochemical tests, haemoglobin levels, and platelet counts. British Journal of General Practice 70:701, pages e843-e851.
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Cecilia Högberg, Pontus Karling, Jörgen Rutegård & Mikael Lilja. (2020) Patient-reported and doctor-reported symptoms when faecal immunochemical tests are requested in primary care in the diagnosis of colorectal cancer and inflammatory bowel disease: a prospective study. BMC Family Practice 21:1.
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Cecilia Högberg, Ulf Gunnarsson, Olof Cronberg, Hans Thulesius, Mikael Lilja & Stefan Jansson. (2020) Qualitative faecal immunochemical tests (FITs) for diagnosing colorectal cancer in patients with histories of rectal bleeding in primary care: a cohort study. International Journal of Colorectal Disease 35:11, pages 2035-2040.
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Brian D. Nicholson, Tim James, Maria Paddon, Steve Justice, Jason L. Oke, James E. East & Brian Shine. (2020) Faecal immunochemical testing for adults with symptoms of colorectal cancer attending English primary care: a retrospective cohort study of 14 487 consecutive test requests. Alimentary Pharmacology & Therapeutics 52:6, pages 1031-1041.
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Lovisa Widbom, Kim Ekblom, Pontus Karling & Johan Hultdin. (2020) Patients developing inflammatory bowel disease have iron deficiency and lower plasma ferritin years before diagnosis: a nested case-control study. European Journal of Gastroenterology & Hepatology 32:9, pages 1147-1153.
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Zong-Ran Chen & Gang Liu. (2019) Fecal calprotectin and colorectal cancer. World Chinese Journal of Digestology 27:23, pages 1436-1440.
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Cristina Renzi, Georgios Lyratzopoulos, Willie Hamilton, Camille Maringe & Bernard Rachet. (2019) Contrasting effects of comorbidities on emergency colon cancer diagnosis: a longitudinal data-linkage study in England. BMC Health Services Research 19:1.
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Corinne Chmiel, Oliver Senn, Susann Hasler, Thomas Rosemann, Gerhard Rogler, Nadine Zahnd, Ryan Tandjung, Nathalie Scherz, Michael Christian Sulz & Stephan Vavricka. (2019) Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study. PLOS ONE 14:11, pages e0224961.
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Yoon‐Kyo An, David Prince, Fergus Gardiner, Teresa Neeman, Ecushla C Linedale, Jane M Andrews, Susan Connor & Jakob Begun. (2019) Faecal calprotectin testing for identifying patients with organic gastrointestinal disease: systematic review and meta‐analysis. Medical Journal of Australia 211:10, pages 461-467.
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Jana G. Hashash & Douglas J. Hartman. (2019) Inflammatory cells implicated in neoplasia development in idiopathic inflammatory bowel disease. Cellular Immunology 343, pages 103720.
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Noel Pin Vieito, Sara Zarraquiños & Joaquín Cubiella. (2019) High-risk symptoms and quantitative faecal immunochemical test accuracy: Systematic review and meta-analysis. World Journal of Gastroenterology 25:19, pages 2383-2401.
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Giles A.D. Major & David Gunn. (2019) Chronic diarrhoea in adults. Current Opinion in Gastroenterology 35:3, pages 206-212.
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Callum G. Fraser. (2019) Faecal immunochemical tests for haemoglobin (FIT) in the assessment of patients with lower abdominal symptoms: current controversies. Gastroenterología y Hepatología 42:4, pages 263-270.
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Callum G. Fraser. (2019) Faecal immunochemical tests for haemoglobin (FIT) in the assessment of patients with lower abdominal symptoms: current controversies. Gastroenterología y Hepatología (English Edition) 42:4, pages 263-270.
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Karoline Freeman, Brian H Willis, Hannah Fraser, Sian Taylor-Phillips & Aileen Clarke. (2019) Faecal calprotectin to detect inflammatory bowel disease: a systematic review and exploratory meta-analysis of test accuracy. BMJ Open 9:3, pages e027428.
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Cristina Renzi, Georgios Lyratzopoulos, Willie Hamilton & Bernard Rachet. (2019) Opportunities for reducing emergency diagnoses of colon cancer in women and men: A data-linkage study on pre-diagnostic symptomatic presentations and benign diagnoses. European Journal of Cancer Care 28:2, pages e13000.
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Edward Seward. (2019) Recent advances in colonoscopy. F1000Research 8, pages 1028.
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S Mashlab, P Large, W Laing, O Ng, M D’Auria, D Thurston, S Thomson, AG Acheson, DJ Humes & A Banerjea. (2018) Anaemia as a risk stratification tool for symptomatic patients referred via the two-week wait pathway for colorectal cancer. The Annals of The Royal College of Surgeons of England 100:5, pages 350-356.
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