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Original Article

The role of mitochondrial folate enzyme MTHFD1L in esophageal squamous cell carcinoma

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Pages 533-540 | Received 25 Oct 2017, Accepted 14 Nov 2017, Published online: 24 Nov 2017

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Lei Wang, Ya Yang, Xiu-Mei Wang, Cheng-Qun Wang, Yuan-Min Zhang & Bing-Liang Li. (2020) MTHFD1L as a folate cycle enzyme correlates with prognostic outcome and its knockdown impairs cell invasive behaviors in osteosarcoma via mediating the AKT/mTOR pathway. Journal of Receptors and Signal Transduction 40:6, pages 584-590.
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Hua Yu, Han Wang, Hai-Rong Xu, Yu-Chan Zhang, Xue-Bo Yu, Meng-Chao Wu, Guang-Zhi Jin & Wen-Ming Cong. (2019) Overexpression of MTHFD1 in hepatocellular carcinoma predicts poorer survival and recurrence. Future Oncology 15:15, pages 1771-1780.
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Articles from other publishers (20)

Bai Shu Zheng, Shun De Wang, Jun Yong Zhang & Cheng Guo Ge. (2024) Expression, Prognostic Value, and Immune Infiltration of MTHFD Family in Bladder Cancer. Current Cancer Drug Targets 24:2, pages 178-191.
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Isotta Bozzarelli, Arianna Orsini, Federica Isidori, Luca Mastracci, Deborah Malvi, Marialuisa Lugaresi, Silvia Fittipaldi, Livia Gozzellino, Annalisa Astolfi, Jari Räsänen, Antonia D’Errico, Riccardo Rosati, Roberto Fiocca, Marco Seri, Kausilia K. Krishnadath, Elena Bonora & Sandro Mattioli. (2024) miRNA–221 and miRNA–483–3p Dysregulation in Esophageal Adenocarcinoma. Cancers 16:3, pages 591.
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Zhe Qiao, Yu Li, Shaomin Li, Shiyuan Liu & Yao Cheng. (2024) Hypoxia-induced SHMT2 protein lactylation facilitates glycolysis and stemness of esophageal cancer cells. Molecular and Cellular Biochemistry.
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Ghazaleh Khalili-Tanha, Reza Mohit, Alireza Asadnia, Majid Khazaei, Mohammad Dashtiahangar, Mina Maftooh, Mohammadreza Nassiri, Seyed Mahdi Hassanian, Majid Ghayour-Mobarhan, Mohammad Ali Kiani, Gordon A. Ferns, Jyotsna Batra, Elham Nazari & Amir Avan. (2023) Identification of ZMYND19 as a novel biomarker of colorectal cancer: RNA-sequencing and machine learning analysis. Journal of Cell Communication and Signaling 17:4, pages 1469-1485.
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Jianfeng Zhou, Yushang Yang, Jiahan Cheng, Siyuan Luan, Xin Xiao, Xiaokun Li, Pinhao Fang, Yimin Gu, Qixin Shang, Hanlu Zhang, Longqi Chen, Xiaoxi Zeng & Yong Yuan. (2023) MTHFD1L confers a poor prognosis and malignant phenotype in esophageal squamous cell carcinoma by activating the ERK5 signaling pathway. Experimental Cell Research 427:1, pages 113584.
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Elham Nazari, Ghazaleh Pourali, Majid KhazaeiAlireza Asadnia, Mohammad Dashtiahangar, Reza Mohit, Mina Maftooh, Mohammadreza Nassiri, Seyed Mahdi Hassanian, Majid Ghayour-Mobarhan, Gordon A. Ferns, Soodabeh Shahidsales & Amir Avan. (2023) Identification of Potential Biomarkers in Stomach Adenocarcinoma using Machine Learning Approaches. Current Bioinformatics 18:4, pages 320-333.
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Xuan Wang, Zhengtong Lv, Haoran Xia, Xiaoxiao Guo, Jianye Wang, Jianlong Wang & Ming Liu. (2022) Biochemical recurrence related metabolic novel signature associates with immunity and ADT treatment responses in prostate cancer. Cancer Medicine 12:1, pages 862-878.
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Johanna Alexandra Tejada Moreno, Andrés Villegas Lanau, Lucia Madrigal Zapata, Ana Yulied Baena Pineda, Juan Velez Hernandez, Omer Campo Nieto, Alejandro Soto Ospina, Pedronel Araque Marín, Lavanya Rishishwar, Emily T. Norris, Aroon T. Chande, I. King Jordan & Gabriel Bedoya Berrio. (2022) Mutations in SORL1 and MTHFDL1 possibly contribute to the development of Alzheimer’s disease in a multigenerational Colombian Family. PLOS ONE 17:7, pages e0269955.
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Jianfeng Zhou, Yushang Yang, Hanlu Zhang, Siyuan Luan, Xin Xiao, Xiaokun Li, Pinhao Fang, Qixin Shang, Longqi Chen, Xiaoxi Zeng & Yong Yuan. (2022) Overexpressed COL3A1 has prognostic value in human esophageal squamous cell carcinoma and promotes the aggressiveness of esophageal squamous cell carcinoma by activating the NF-κB pathway. Biochemical and Biophysical Research Communications 613, pages 193-200.
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Nuzhat Sial, Jalil Ur Rehman, Saba Saeed, Mukhtiar Ahmad, Yasir Hameed, Muhammad Atif, Abdul Rehman, Rizwan Asif, Hamad Ahmed, Muhammad Safdar Hussain, Muhammad Rashid Khan, Atifa Ambreen & Ayesha Ambreen. (2022) Integrative analysis reveals methylenetetrahydrofolate dehydrogenase 1-like as an independent shared diagnostic and prognostic biomarker in five different human cancers. Bioscience Reports 42:1.
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Mohammad Faujul Kabir, Mary Grace Murray, Reshu Saxena, Alena Klochkova, Jasmine Cruz & Kelly A. Whelan. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 96 111 .
Li Cui, Xinyuan Zhao, Zhenning Jin, Hailin Wang, Shun‐Fa Yang & Shen Hu. (2021) Melatonin modulates metabolic remodeling in HNSCC by suppressing MTHFD1L‐formate axis. Journal of Pineal Research 71:4.
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Jian Wang, Ke Wang, Jin Liang, Jianqiu Jin, Xing Wang & Shu Yan. (2021) Chitosan-tripolyphosphate nanoparticles-mediated co-delivery of MTHFD1L shRNA and 5-aminolevulinic acid for combination photodynamic-gene therapy in oral cancer. Photodiagnosis and Photodynamic Therapy 36, pages 102581.
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Junhui Chen, Jie Yang, Qingchun Xu, Zhenyu Wang, Jun Wu, Liukui Pan, Kai Huang & Chen Wang. (2021) Integrated bioinformatics analysis identified MTHFD1L as a potential biomarker and correlated with immune infiltrates in hepatocellular carcinoma. Bioscience Reports 41:2.
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Khairul Syahputra, Per W. Kania, Azmi Al-Jubury, Huria Marnis, Heidi Mathiessen, Ron P. Dirks & Kurt Buchmann. (2020) Association between stress, metabolism, and growth in Ichthyophthirius multifiliis infected rainbow trout gills: Transcriptomic evidence. Aquaculture 526, pages 735384.
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Alyncia D. Robinson, Marie-Lisa Eich & Sooryanarayana Varambally. (2020) Dysregulation of de novo nucleotide biosynthetic pathway enzymes in cancer and targeting opportunities. Cancer Letters 470, pages 134-140.
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Hao Li, Xiaoyan Fu, Fan Yao, Tian Tian, Chunyang Wang & Ankui Yang. (2019) MTHFD1L-Mediated Redox Homeostasis Promotes Tumor Progression in Tongue Squamous Cell Carcinoma. Frontiers in Oncology 9.
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Marie-Lisa Eich, Maria Del Carmen Rodriguez Pena, Darshan Shimoga Chandrashekar, Alcides Chaux, Sumit Agarwal, Jennifer B. Gordetsky, James E. Ferguson, Guru P. Sonpavde, George J. Netto & Sooryanarayana Varambally. (2019) Expression and Role of Methylenetetrahydrofolate Dehydrogenase 1 Like (MTHFD1L) in Bladder Cancer. Translational Oncology 12:11, pages 1416-1424.
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Sumit Agarwal, Michael Behring, Kevin Hale, Sameer Al Diffalha, Kai Wang, Upender Manne & Sooryanarayana Varambally. (2019) MTHFD1L, A Folate Cycle Enzyme, Is Involved in Progression of Colorectal Cancer. Translational Oncology 12:11, pages 1461-1467.
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Lorenza Vitale, Valentina Serpieri, Mattia Lauriola, Allison Piovesan, Francesca Antonaros, Elena Cicchini, Chiara Locatelli, Guido Cocchi, Pierluigi Strippoli & Maria Caracausi. (2019) Human trisomy 21 fibroblasts rescue methotrexate toxic effect after treatment with 5‐methyl‐tetrahydrofolate and 5‐formyl‐tetrahydrofolate. Journal of Cellular Physiology 234:9, pages 15010-15024.
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