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Scandinavian Journal of Gastroenterology Volume 53, 2018 - Issue 9
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Original Article

Treatment of non-alcoholic steatohepatitis patients with vitamin D: a double-blinded, randomized, placebo-controlled pilot study

Andreas GeierDivision of Hepatology, Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany; ;Department of Gastroenterology & Hepatology, University Hospital Zurich, Zurich, Switzerland; Correspondence[email protected]
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Mareile EichingerClinical Trials Center, University Hospital Zurich, Zurich, Switzerland; View further author information
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Guido StirnimannUniversity Clinic for Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; View further author information
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David SemelaDepartment of Gastroenterology & Hepatology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland; View further author information
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Fabian TayClinical Trials Center, University Hospital Zurich, Zurich, Switzerland; View further author information
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Burkhardt SeifertDepartment of Biostatistics at Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich, Zurich, Switzerland; View further author information
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Oliver TschoppDepartment of Endocrinology and Diabetology, University Hospital and University of Zurich, Zurich, Switzerland; View further author information
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Heike BantelDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; View further author information
,
Daniel JahnDivision of Hepatology, Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany; View further author information
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Ewerton Marques MaggioDepartment of Pathology, University Hospital Zurich, Zurich, Switzerland; View further author information
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Lanja SalehDepartment of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland; View further author information
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Heike A. Bischoff-FerrariDepartment of Geriatrics and Aging Research, University of Zurich, SwitzerlandView further author information
,
Beat MüllhauptDepartment of Gastroenterology & Hepatology, University Hospital Zurich, Zurich, Switzerland; View further author information
&
Jean-François DufourClinical Trials Center, University Hospital Zurich, Zurich, Switzerland; View further author information
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Pages 1114-1120 | Received 09 May 2018, Accepted 10 Jul 2018, Published online: 29 Sep 2018

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Jingqi Liu, Yang Song, Ye Wang & Huashan Hong. (2023) Vitamin D/vitamin D receptor pathway in non-alcoholic fatty liver disease. Expert Opinion on Therapeutic Targets 27:11, pages 1145-1157.
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Fariborz Mansour-Ghanaei, Makan Pourmasoumi, Amir Hadi, Nahid Ramezani-Jolfaie & Farahnaz Joukar. (2020) The Efficacy of Vitamin D Supplementation against Nonalcoholic Fatty Liver Disease: A Meta-Analysis. Journal of Dietary Supplements 17:4, pages 467-485.
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Articles from other publishers (39)

Aolin Yang, Yanmei Chen, Yizhen Gao, Qingqing Lv, Yao Li, Fengna Li, Ruirui Yu, Ziyu Han, Shimiao Dai, Junying Zhu, Chenggang Yang, Shi Zhan, Litao Sun & Ji-Chang Zhou. (2024) Vitamin D 3 exacerbates steatosis while calcipotriol inhibits inflammation in non-alcoholic fatty liver disease in Sod1 knockout mice: a comparative study of two forms of vitamin D . Food & Function 15:8, pages 4614-4626.
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Eugene Chang. (2024) Vitamin D Mitigates Hepatic Fat Accumulation and Inflammation and Increases SIRT1/AMPK Expression in AML-12 Hepatocytes. Molecules 29:6, pages 1401.
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Hao Wang, Qianqian Ma, Youpeng Chen, Ling Luo, Junzhao Ye & Bihui Zhong. (2024) Optimized strategy among diet, exercise, and pharmacological interventions for nonalcoholic fatty liver disease: A network meta‐analysis of randomized controlled trials. Obesity Reviews.
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Yifan Wang, He Yi, Weixia Sun, Hekai Yu, Wenxuan Tao, Xiaojin Yu, Dianrong Jia, Yingzhao Liu, Stephen J. Pandol & Ling Li. (2024) Comparative Efficacy of Drug Interventions on NAFLD Over 24 Weeks: A Traditional and Network Meta-Analysis of Randomized Controlled Trials. Drugs.
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Soraiya Ebrahimpour-Koujan, Amir Ali Sohrabpour, Edward Giovannucci, Akram Vatannejad & Ahmad Esmaillzadeh. (2024) Effects of vitamin D supplementation on liver fibrogenic factors, vitamin D receptor and liver fibrogenic microRNAs in metabolic dysfunction-associated steatotic liver disease (MASLD) patients: an exploratory randomized clinical trial. Nutrition Journal 23:1.
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Bingning Dong. 2024. Feldman and Pike's Vitamin D. Feldman and Pike's Vitamin D 559 565 .
Tianyu Mao, Yiwen Sun, Xinyi Xu & Kang He. (2023) Overview and prospect of NAFLD: Significant roles of nutrients and dietary patterns in its progression or prevention. Hepatology Communications 7:10.
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Suxia Hu & Abdusemer Reyimu. (2023) Vitamin D Improves the Lipotoxicity of Liver Cells by Adjusting Epigenetic Characteristics of Genes. Hepatitis Monthly 23:1.
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Ji-Juan Zhang, Han-Cheng Yu, Yue Li, Yan-Bo Zhang, Ting-Ting Geng, Qi Lu, Yun-Fei Liao, Kun-Quan Guo, Liang Du, Hua-Ling Ruan, Kun Yang, Gang Liu & An Pan. (2022) Association between serum 25-hydroxy vitamin D concentrations and mortality among individuals with metabolic dysfunction–associated fatty liver disease: a prospective cohort study. The American Journal of Clinical Nutrition 116:5, pages 1409-1417.
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. (2022) Updated S2k Clinical Practice Guideline on Non-alcoholic Fatty Liver Disease (NAFLD) issued by the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS) – April 2022 – AWMF Registration No.: 021–025. Zeitschrift für Gastroenterologie 60:09, pages e733-e801.
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E. Roeb, A. Canbay, H. Bantel, J. Bojunga, J. de Laffolie, M. Demir, U. W. Denzer, A. Geier, W. P. Hofmann, C. Hudert, T. Karlas, M. Krawczyk, T. Longerich, T. Luedde, M. Roden, J. Schattenberg, M. Sterneck, A. Tannapfel, P. Lorenz & F. Tacke. (2022) Aktualisierte S2k-Leitlinie nicht-alkoholische Fettlebererkrankung der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) – April 2022 – AWMF-Registernummer: 021–025. Zeitschrift für Gastroenterologie 60:09, pages 1346-1421.
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Yejin Kim, Yoosoo Chang, Seungho Ryu, In Young Cho, Min-Jung Kwon, Won Sohn, Mi Kyung Kim, Sarah H Wild & Christopher D Byrne. (2022) Resolution of, and Risk of Incident Non-alcoholic Fatty Liver Disease With Changes in Serum 25-hydroxy Vitamin D Status. The Journal of Clinical Endocrinology & Metabolism 107:8, pages e3437-e3447.
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Enas A. Abd El‐Haleim & Nada A. Sallam. (2021) Vitamin D modulates hepatic microRNAs and mitigates tamoxifen‐induced steatohepatitis in female rats. Fundamental & Clinical Pharmacology 36:2, pages 338-349.
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Somaya Albhaisi & Mazen Noureddin. (2021) Current and Potential Therapies Targeting Inflammation in NASH. Frontiers in Endocrinology 12.
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Shahla Rezaei, Reza Tabrizi, Peyman Nowrouzi-Sohrabi, Mohammad Jalali, Mojtaba Shabani-Borujeni, Shayan Modaresi, Maryam Gholamalizadeh & Saeid Doaei. (2021) The Effects of Vitamin D Supplementation on Anthropometric and Biochemical Indices in Patients With Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis. Frontiers in Pharmacology 12.
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Jeniffer Danielle M. Dutra, Quelson Coelho Lisboa, Silvia Marinho Ferolla, Carolina Martinelli M. L. Carvalho, Camila Costa M. Mendes, Teresa Cristina A. Ferrari & Cláudia Alves Couto. (2021) Vitamin D levels are not associated with non-alcoholic fatty liver disease severity in a Brazilian population. International Journal for Vitamin and Nutrition Research 91:5-6, pages 411-418.
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Milica Bjelakovic, Dimitrinka Nikolova, Goran Bjelakovic & Christian Gluud. (2021) Vitamin D supplementation for chronic liver diseases in adults. Cochrane Database of Systematic Reviews 2021:10.
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Oluyemi Komolafe, Elena Buzzetti, Audrey Linden, Lawrence MJ Best, Angela M Madden, Danielle Roberts, Thomas JG Chase, Dominic Fritche, Suzanne C Freeman, Nicola J Cooper, Alex J Sutton, Elisabeth Jane Milne, Kathy Wright, Chavdar S Pavlov, Brian R Davidson, Emmanuel Tsochatzis & Kurinchi Selvan Gurusamy. (2021) Nutritional supplementation for nonalcohol-related fatty liver disease: a network meta-analysis. Cochrane Database of Systematic Reviews 2021:7.
Crossref
Po-Jung Chen, Toshiaki Nakano, Chia-Yun Lai, Kuei-Chen Chang, Chao-Long Chen & Shigeru Goto. (2021) Daily full spectrum light exposure prevents food allergy-like allergic diarrhea by modulating vitamin D3 and microbiota composition. npj Biofilms and Microbiomes 7:1.
Crossref
Anna Roskilly, Amy Hicks, Eleanor J. Taylor, Rebecca Jones, Richard Parker & Ian A. Rowe. (2020) Fibrosis progression rate in a systematic review of placebo‐treated nonalcoholic steatohepatitis. Liver International 41:5, pages 982-995.
Crossref
Laleh Mahmoudi, Sara Asadi, Zahra Al-Mousavi & Ramin Niknam. (2021) A randomized controlled clinical trial comparing calcitriol versus cholecalciferol supplementation to reduce insulin resistance in patients with non-alcoholic fatty liver disease. Clinical Nutrition 40:5, pages 2999-3005.
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Dimitrios A. Koutoukidis, Elizabeth Morris, John A. Henry, Yusra Shammoon, Matthew Zimmerman, Moscho Michalopoulou, Susan A. Jebb & Paul Aveyard. (2021) What proportion of people have a follow-up biopsy in randomized trials of treatments for non-alcoholic steatohepatitis?: A systematic review and meta-analysis. PLOS ONE 16:4, pages e0250385.
Crossref
Roman Huber. (2021) Integrative Behandlungsansätze bei chronischen Lebererkrankungen. Zeitschrift für Komplementärmedizin 13:02, pages 14-19.
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Vesna Lukenda Zanko, Viktor Domislovic, Vladimir Trkulja, Irena Krznaric‐Zrnic, Tamara Turk‐Wensveen, Zeljko Krznaric, Tajana Filipec Kanizaj, Delfa Radic‐Kristo, Lidija Bilic‐Zulle, Lidija Orlic, Petra Dinjar‐Kujundzic, Goran Poropat, Davor Stimac, Goran Hauser & Ivana Mikolasevic. (2020) Vitamin D for treatment of non‐alcoholic fatty liver disease detected by transient elastography: A randomized, double‐blind, placebo‐controlled trial. Diabetes, Obesity and Metabolism 22:11, pages 2097-2106.
Crossref
Ilaria Barchetta, Flavia Agata Cimini & Maria Gisella Cavallo. (2020) Vitamin D and Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD): An Update. Nutrients 12:11, pages 3302.
Crossref
Ying Cao, Xiang-Bing Shu, Zemin Yao, Guang Ji & Li Zhang. (2020) Is vitamin D receptor a druggable target for non-alcoholic steatohepatitis?. World Journal of Gastroenterology 26:38, pages 5812-5821.
Crossref
Lesli Kibler, Cailin R Heinze & Cynthia RL Webster. (2020) Serum vitamin D status in sick cats with and without cholestatic liver disease. Journal of Feline Medicine and Surgery 22:10, pages 944-952.
Crossref
Xiao-fei Guo, Chong Wang, Ting Yang, Shan Li, Ke-lei Li & Duo Li. (2020) Vitamin D and non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials. Food & Function 11:9, pages 7389-7399.
Crossref
Yali Wei, Shuli Wang, Yan Meng, Qingtao Yu, Qian Wang, Hongzhao Xu, Huacai Yuan, Xiaoxu Li & Liyong Chen. (2020) Effects of Vitamin D Supplementation in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis. International Journal of Endocrinology and Metabolism 18:3.
Crossref
Benoit Smeuninx, Ebru Boslem & Mark A. Febbraio. (2020) Current and Future Treatments in the Fight against Non-Alcoholic Fatty Liver Disease. Cancers 12:7, pages 1714.
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Yilan Zeng, Mei Luo, Liwei Pan, Yuan Chen, Siqi Guo, Dongxia Luo, Li Zhu, Yong Liu, Lisha Pan, Siya Xu, Ruofei Zhang, Chunyan Zhang, Pengfei Wu, Liangpeng Ge, Mazen Noureddin, Stephen J. Pandol & Yuan-Ping Han. (2020) Vitamin D signaling maintains intestinal innate immunity and gut microbiota: potential intervention for metabolic syndrome and NAFLD. American Journal of Physiology-Gastrointestinal and Liver Physiology 318:3, pages G542-G553.
Crossref
Daniel Jahn & Andreas Geier. 2020. Molecular Nutrition. Molecular Nutrition 651 671 .
Kate Hallsworth & Leon A. Adams. (2019) Lifestyle modification in NAFLD/NASH: Facts and figures. JHEP Reports 1:6, pages 468-479.
Crossref
Zixuan Zhang, James L. Thorne & J. Bernadette Moore. (2019) Vitamin D and nonalcoholic fatty liver disease. Current Opinion in Clinical Nutrition & Metabolic Care 22:6, pages 449-458.
Crossref
Flavia Agata Cimini, Ilaria Barchetta, Simone Carotti, Sergio Morini & Maria Gisella Cavallo. (2019) Overview of studies of the vitamin D/vitamin D receptor system in the development of non-alcoholic fatty liver disease. World Journal of Gastrointestinal Pathophysiology 10:2, pages 11-16.
Crossref
Daniel Jahn, Donata Dorbath, Anne-Kristin Schilling, Lisa Gildein, Chantal Meier, Raphael N. Vuille-dit-Bille, Johannes Schmitt, Daniel Kraus, James C. Fleet, Heike M. Hermanns & Andreas Geier. (2019) Intestinal vitamin D receptor modulates lipid metabolism, adipose tissue inflammation and liver steatosis in obese mice. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1865:6, pages 1567-1578.
Crossref
Abbas Ali Sangouni, Saeid Ghavamzadeh & Atena Jamalzehi. (2019) A narrative review on effects of vitamin D on main risk factors and severity of Non-Alcoholic Fatty Liver Disease. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 13:3, pages 2260-2265.
Crossref
Zeeshan Javed, Maria Papageorgiou, Harshal Deshmukh, Eric Kilpatrick, Vincent Mann, Lynsey Corless, George Abouda, Alan Rigby, Stephen Atkin & Thozhukat Sathyapalan. (2019) A Randomized, Controlled Trial of Vitamin D Supplementation on Cardiovascular Risk Factors, Hormones, and Liver Markers in Women with Polycystic Ovary Syndrome. Nutrients 11:1, pages 188.
Crossref
Daniel Jahn, Donata Dorbath, Stefan Kircher, Anika Nier, Ina Bergheim, Kaatje Lenaerts, Heike M. Hermanns & Andreas Geier. (2019) Beneficial Effects of Vitamin D Treatment in an Obese Mouse Model of Non-Alcoholic Steatohepatitis. Nutrients 11:1, pages 77.
Crossref

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