3,736
Views
50
CrossRef citations to date
0
Altmetric
Original Article

Higher anti-TNF serum levels are associated with perianal fistula closure in Crohn’s disease patients

, , , , , & show all
Pages 453-458 | Received 03 Dec 2018, Accepted 14 Mar 2019, Published online: 28 Apr 2019

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Anders Dige, Andreas Nordholm-Carstensen, Kikke Hagen, Helene Tarri Hougaard, Klaus Krogh, Jørgen Agnholt, Bodil Ginnerup Pedersen & Lilli Lundby. (2021) Effectiveness of infliximab treatment of complex idiopathic anal fistulas. Scandinavian Journal of Gastroenterology 56:4, pages 391-396.
Read now
Anne S Strik, Sophie E Berends & Mark Löwenberg. (2019) Therapeutic drug monitoring-based dosing of TNF inhibitors in inflammatory bowel disease: the way forward?. Expert Review of Clinical Pharmacology 12:9, pages 885-891.
Read now

Articles from other publishers (48)

Chandra Shekhar Boosani & Laxminarayana Burela. (2024) The Exacerbating Effects of the Tumor Necrosis Factor in Cardiovascular Stenosis: Intimal Hyperplasia. Cancers 16:7, pages 1435.
Crossref
J.K. Yamamoto-Furusho, J.G. López-Gómez, F.J. Bosques-Padilla, M.A. Martínez-Vázquez & J.L. De-León-Rendón. (2024) Primer consenso mexicano de la enfermedad de Crohn. Revista de Gastroenterología de México.
Crossref
Anke L. Nguyen, Peter R. Gibson, Richard N. Upton, Diane R. Mould & Miles P. Sparrow. (2023) Application of a Precision‐Dosing Model to a Real‐World Cohort of Patients on Infliximab Maintenance Therapy: Drug Usage and Cost Analysis. The Journal of Clinical Pharmacology 64:4, pages 399-409.
Crossref
Murillo Duarte-Silva, Rogério Serafim Parra, Marley Ribeiro Feitosa, Viviani Nardini, Sandra Regina Maruyama, José Joaquim Ribeiro da Rocha, Omar Feres & Cristina Ribeiro de Barros Cardoso. (2024) Leukocyte dysfunction and reduced CTLA-4 expression are associated with perianal Crohn’s disease. Clinical and Experimental Immunology.
Crossref
Francisco Rodríguez-Moranta, Federico Argüelles-Arias, Joaquín Hinojosa del Val, Marisa Iborra Colomino, M. Dolores Martín-Arranz, Luis Menchén Viso, Fernando Muñoz Núñez, Elena Ricart Gómez, José Germán Sánchez-Hernández, Teresa Valdés-Delgado, Jordi Guardiola Capón, Manuel Barreiro-de Acosta, Míriam Mañosa Ciria, Yamile Zabana Abdo & Ana Gutiérrez Casbas. (2024) Monitorización terapéutica de los fármacos biológicos en la enfermedad inflamatoria intestinal. Documento de Posicionamiento del Grupo Español de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa (GETECCU). Gastroenterología y Hepatología.
Crossref
Gaurav B. Nigam, Kelly Chatten, Ala Sharara, Talal Al-Taweel, Othman Alharbi, Hussein Elamin, Sameer Al Awadhi, Vito Annese & Jimmy K. Limdi. (2024) Attitudes, perceptions and barriers in implementing therapeutic drug monitoring for anti-TNFs in inflammatory bowel disease: a survey from the Middle East. Therapeutic Advances in Gastroenterology 17.
Crossref
Jeffrey D. McCurdy, Johnny H. Chen, Shane Golden, Atif Kukaswadia, G. Sarah Power, Ryan Ward & Laura E. Targownik. (2023) Perianal Fistulas Are Associated with Persistently Higher Direct Health Care Costs in Crohn’s Disease: A Population-Based Study. Digestive Diseases and Sciences 68:12, pages 4350-4359.
Crossref
Sulak Anandabaskaran, Luke Hanna, Nusrat Iqbal, Laura Constable, Phil Tozer & Ailsa Hart. (2023) Where Are We and Where to Next?—The Future of Perianal Crohn’s Disease Management. Journal of Clinical Medicine 12:19, pages 6379.
Crossref
Laura Maas, Ruiyi Gao, Vivy Cusumano, Ellen Spartz, Reezwana Chowdhury, Mahesh Krishna, Mark Lazarev, Joanna Melia, Florin Selaru, Sowmya Sharma, Berkeley Limketkai & Alyssa Parian. (2023) Superior Efficacy of Infliximab Versus Adalimumab for First-Line Treatment of Crohn’s Perianal Fistulae. Digestive Diseases and Sciences 68:10, pages 3994-4000.
Crossref
Arshdeep Singh, Vandana Midha, Gursimran Singh Kochhar, Bo Shen & Ajit Sood. (2023) Management of Perianal Fistulizing Crohn’s Disease. Inflammatory Bowel Diseases.
Crossref
Alyssa M. ParianMegan ObiPhillip FleshnerDavid A. Schwartz. (2023) Management of Perianal Crohn's Disease. American Journal of Gastroenterology 118:8, pages 1323-1331.
Crossref
Elise M. Meima - van Praag, Marte A.J. Becker, Kyra L. van Rijn, Karin A.T.G.M. Wasmann, Jaap Stoker, Geert R.A.M. D'Haens, Cyriel Y. Ponsioen, Krisztina B. Gecse, Marcel G.W. Dijkgraaf, Antonino Spinelli, Silvio Danese, Willem A. Bemelman & Christianne J. Buskens. (2023) Short-term anti-TNF therapy with surgical closure versus anti-TNF therapy alone for Crohn's perianal fistulas (PISA-II): long-term outcomes of an international, multicentre patient preference, randomised controlled trial. eClinicalMedicine 61, pages 102045.
Crossref
Niloofar Khoshnam-Rad, Homayoon Vahedi, Anahita Sadeghi, Mansoor Rastegarpanah, Soha Namazi, Amir Anushiravani, Ali Reza Sima, Shabnam Shahrokh, Sudabeh Alatab & Reza Malekzadeh. (2023) Iranian Consensus Guideline for Pharmacotherapy with Biologics and Small Molecules Drugs in Adults with Inflammatory Bowel Diseases. Middle East Journal of Digestive Diseases 15:2, pages 83-106.
Crossref
Hiroshi Nakase, Motohiro Esaki, Fumihito Hirai, Taku Kobayashi, Katsuyoshi Matsuoka, Minoru Matsuura, Makoto Naganuma, Masayuki Saruta, Kiichiro Tsuchiya, Motoi Uchino, Kenji Watanabe, Tadakazu Hisamatsu, Akira Andoh, Shigeki Bamba, Motohiro Esaki, Mikihiro Fujiya, Kitaro Futami, Keisuke Hata, Fumihito Hirai, Sakiko Hiraoka, Tadakazu Hisamatsu, Ryota Hokari, Shunji Ishihara, Soichiro Ishihara, Michio Itabashi, Yoichi Kakuta, Jun Kato, Shingo Kato, Takehiko Katsurada, Kazuya Kitamura, Kiyonori Kobayashi, Taku Kobayashi, Kazutaka Koganei, Atsuo Maemoto, Toshiyuki Matsui, Takayuki Matsumoto, Katsuyoshi Matsuoka, Minoru Matsuura, Satoshi Motoya, Masakazu Nagahori, Makoto Naganuma, Yuji Naito, Shiro Nakamura, Hiroshi Nakase, Haruhiko Ogata, Kazuichi Okazaki, Hirotake Sakuraba, Masayuki Saruta, Shinichiro Shinzaki, Ken Sugimoto, Akira Sugita, Yasuo Suzuki, Kenichi Takahashi, Tomohisa Takagi, Kento Takenaka, Ken Takeuchi, Kiichiro Tsuchiya, Tomoyuki Tsujikawa, Motoi Uchino, Fumiaki Ueno, Kenji Watanabe, Mamoru Watanabe, Takayuki Yamamoto, Kaoru Yokoyama, Atsushi Yoshida & Naoki Yoshimura. (2023) Treatment escalation and de-escalation decisions in Crohn’s disease: Delphi consensus recommendations from Japan, 2021. Journal of Gastroenterology 58:4, pages 313-345.
Crossref
Geert R. D’Haens & William J. Sandborn. (2023) Reply. Gastroenterology 164:1, pages 166-168.
Crossref
Jan-Michael A. Klapproth & Gary R. Lichtenstein. 2023. Pediatric Inflammatory Bowel Disease. Pediatric Inflammatory Bowel Disease 495 509 .
Andrew A. M. Singer, Annemarie Rompca, Samir K. GadepalliJeremy Adler. (2022) Predictors of Perianal Fistula Healing in Children With Newly Diagnosed Crohn Disease. Journal of Pediatric Gastroenterology & Nutrition 75:6, pages 709-716.
Crossref
Omar Badla, Raman Goit, Samia E Saddik, Sarah Dawood, Ahmad M Rabih, Ahmad Mohammed, Aishwarya Raman, Manish Uprety, Maria Calero, Maria Resah B Villanueva, Narges Joshaghani, Nicole Villa & Lubna Mohammed. (2022) The Multidisciplinary Management of Perianal Fistulas in Crohn’s Disease: A Systematic Review. Cureus.
Crossref
Liselotte Fierens, Claire Liefferinckx, Eveline Hoefkens, Triana Lobatòn, Erwin Dreesen, João Sabino & Marc Ferrante. (2022) Introduction of Subcutaneous Infliximab CT-P13 and Vedolizumab in Clinical Practice: A Multi-Stakeholder Position Statement Highlighting the Need for Post-Marketing Studies. Journal of Crohn's and Colitis 16:7, pages 1059-1069.
Crossref
Bonita Gu, Kavya Venkatesh, Astrid-Jane Williams, Watson Ng, Crispin Corte, Ali Gholamrezaei, Simon Ghaly, Wei Xuan, Sudarshan Paramsothy & Susan Connor. (2022) Higher infliximab and adalimumab trough levels are associated with fistula healing in patients with fistulising perianal Crohn’s disease. World Journal of Gastroenterology 28:23, pages 2597-2608.
Crossref
Laurie B. Grossberg, Adam S. Cheifetz & Konstantinos Papamichael. (2022) Therapeutic Drug Monitoring of Biologics in Crohn’s Disease. Gastroenterology Clinics of North America 51:2, pages 299-317.
Crossref
Michael De Gregorio, Tanya Lee, Krupa Krishnaprasad, Gregory Amos, Yoon-Kyo An, Matthew Bastian-Jordan, Jakob Begun, Nira Borok, Dougal J.M. Brown, Wa Cheung, Susan J. Connor, Jan Gerstenmaier, Lauren E. Gilbert, Robert Gilmore, Bonita Gu, Numan Kutaiba, Allan Lee, Gillian Mahy, Ashish Srinivasan, Lena Thin, Alexander J. Thompson, Christopher J. Welman, Eric X.Z. Yong, Peter De Cruz, Daniel van Langenberg, Miles P. Sparrow & Nik S. Ding. (2022) Higher Anti-tumor Necrosis Factor-α Levels Correlate With Improved Radiologic Outcomes in Crohn’s Perianal Fistulas. Clinical Gastroenterology and Hepatology 20:6, pages 1306-1314.
Crossref
Panu Wetwittayakhlang, Alex Al Khoury, Gustavo Drügg Hahn & Peter Laszlo Lakatos. (2022) The Optimal Management of Fistulizing Crohn’s Disease: Evidence beyond Randomized Clinical Trials. Journal of Clinical Medicine 11:11, pages 3045.
Crossref
Brindusa Truta. (2022) Therapeutic drug monitoring in inflammatory bowel disease: At the right time in the right place. World Journal of Gastroenterology 28:13, pages 1380-1383.
Crossref
Mir Zulqarnain, Parakkal Deepak & Andres J. Yarur. (2022) Therapeutic Drug Monitoring in Perianal Fistulizing Crohn’s Disease. Journal of Clinical Medicine 11:7, pages 1813.
Crossref
Laura Sirmai, Anne-Laure Pelletier, Nathalie Gault, Camille Zallot, Guillaume Bouguen, Dominique Bouchard, Pascale Roland Nicaise, Marine Peyneau, Sandrine Sironneau, Marcelo De Carvalho Bittencourt, Antoine Petitcollin, Pedro Fernandez, Xavier Roblin, Laurent Siproudhis & Laurent Abramowitz. (2022) Relationship between clinical remission of perianal fistulas in Crohn’s disease and serum adalimumab concentrations: A multi-center cross-sectional study. World Journal of Gastroenterology 28:9, pages 961-972.
Crossref
Samuel O. Adegbola, Magali Sarafian, Kapil Sahnan, Alexandros Pechlivanis, Robin K.S. Phillips, Janindra Warusavitarne, Omar Faiz, James Haddow, Charles Knowles, Phil Tozer, Elaine Holmes & Ailsa Hart. (2021) Lack of anti-TNF drugs levels in fistula tissue – a reason for nonresponse in Crohn’s perianal fistulating disease?. European Journal of Gastroenterology & Hepatology 34:1, pages 18-26.
Crossref
Jeroen Geldof, Nusrat Iqbal, Janindra Warusavitarne & Ailsa Hart. (2022) The Essential Role of a Multidisciplinary Approach in Inflammatory Bowel Diseases: Combined Medical-Surgical Treatment in Complex Perianal Fistulas in CD. Clinics in Colon and Rectal Surgery 35:01, pages 021-031.
Crossref
Cong DaiMin JiangYu-hong Huang. (2021) The Association Between Serum Infliximab Concentrations and Clinical Outcomes in Fistulizing Crohn's Disease. American Journal of Gastroenterology 116:12, pages 2481-2482.
Crossref
Rodrigo Bremer Nones, Phillip R. Fleshner, Natalia Sousa Freitas Queiroz, Adam S. Cheifetz, Antonino Spinelli, Silvio Danese, Laurent Peyrin-Biroulet, Konstantinos Papamichael & Paulo Gustavo Kotze. (2021) Therapeutic Drug Monitoring of Biologics in IBD: Essentials for the Surgical Patient. Journal of Clinical Medicine 10:23, pages 5642.
Crossref
Farah Albader, Petra Anna Golovics, Lorant Gonczi, Talat Bessissow, Waqqas Afif & Peter Laszlo Lakatos. (2021) Therapeutic drug monitoring in inflammatory bowel disease: The dawn of reactive monitoring. World Journal of Gastroenterology 27:37, pages 6231-6247.
Crossref
Mohammad Ali K. Motamedi, Sara Serahati, Luckshi Rajendran, Carl J. Brown, Manoj J. Raval, Ahmer Karimuddin, Amandeep Ghuman & Paul T. Phang. (2021) Long‐term outcomes after seton placement for perianal fistulas with and without Crohn’s disease. Colorectal Disease 23:9, pages 2407-2415.
Crossref
Vandita Y. Mattoo, Chamara Basnayake, William R. Connell, Nik Ding, Michael A. Kamm, Mark Lust, Ola Niewiadomski, Alexander Thompson & Emily K. Wright. (2021) Systematic review: efficacy of escalated maintenance anti‐tumour necrosis factor therapy in Crohn's disease. Alimentary Pharmacology & Therapeutics 54:3, pages 249-266.
Crossref
Eron Fabio Miranda, Rodrigo Bremer Nones & Paulo Gustavo Kotze. (2021) Correlation of serum levels of anti-tumor necrosis factor agents with perianal fistula healing in Crohn’s disease: a narrative review. Intestinal Research 19:3, pages 255-264.
Crossref
Abhinav Vasudevan, David H Bruining, Edward V Loftus, William Faubion, Eric C Ehman & Laura Raffals. (2021) Approach to medical therapy in perianal Crohn’s disease. World Journal of Gastroenterology 27:25, pages 3693-3704.
Crossref
Geert R D'Haens & Sander van Deventer. (2021) 25 years of anti-TNF treatment for inflammatory bowel disease: lessons from the past and a look to the future. Gut 70:7, pages 1396-1405.
Crossref
Tsunekazu Mizushima, Mihoko Ota, Yasushi Fujitani, Yuya Kanauchi & Ryuichi Iwakiri. (2021) Diagnostic Features of Perianal Fistula in Patients With Crohn’s Disease: Analysis of a Japanese Claims Database. Crohn's & Colitis 360 3:3.
Crossref
Elise Maria Meima - van Praag, Christianne Johanna Buskens, Roel Hompes & Wilhelmus Adrianus Bemelman. (2021) Surgical management of Crohn’s disease: a state of the art review. International Journal of Colorectal Disease 36:6, pages 1133-1145.
Crossref
Konstantinos PapamichaelNiels Vande CasteeleJenny JeyarajahVipul JairathMark T. OstermanAdam S. Cheifetz. (2021) Higher Postinduction Infliximab Concentrations Are Associated With Improved Clinical Outcomes in Fistulizing Crohn's Disease: An ACCENT-II Post Hoc Analysis. American Journal of Gastroenterology 116:5, pages 1007-1014.
Crossref
Wan-Ting Cao, Rong Huang, Ke-Fang Jiang, Xue-Hui Qiao, Jing-Jing Wang, Yi-Hong Fan & Yi Xu. (2021) Predictive value of blood concentration of biologics on endoscopic inactivity in inflammatory bowel disease: A systematic review. World Journal of Gastroenterology 27:9, pages 886-907.
Crossref
Gaurav B Nigam, Shadab Nayeemuddin, Evangelos Kontopantelis, Bu'Hussain Hayee & Jimmy K Limdi. (2021) UK National Survey of Gastroenterologists’ attitudes and barriers toward therapeutic drug monitoring of anti-TNF therapy in inflammatory bowel disease. Frontline Gastroenterology 12:1, pages 22-29.
Crossref
Amy L. Lightner, Benjamin Click, Takayuki Yamamoto, Antonino Spinelli & Paulo Kotze. (2020) Management of Isolated Anal Strictures in Crohn’s Disease. Diseases of the Colon & Rectum 63:12, pages 1639-1647.
Crossref
Felipe Bernardi Wolker, Julia Gabriela Oliveira Marchiori & Eron Fabio Miranda. (2021) Current management of fistulizing perianal Crohn’s disease based on serum anti-tumor necrosis factor levels and magnetic resonance imaging monitoring. Journal of Coloproctology 40:04, pages 421-424.
Crossref
Amy L. Lightner, Jean H. Ashburn, Mantaj S. Brar, Michele Carvello, Pramodh Chandrasinghe, Anthony de Buck van Overstraeten, Phillip R. Fleshner, Gaetano Gallo, Paulo Gustavo Kotze, Stefan D. Holubar, Lillian M. Reza, Antonino Spinelli, Scott A. Strong, Philip J. Tozer, Adam Truong, Janindra Warusavitarne, Takayuki Yamamoto & Karen Zaghiyan. (2020) Fistulizing Crohn's disease. Current Problems in Surgery 57:11, pages 100808.
Crossref
Elise M van Praag, Merel E Stellingwerf, Jarmila D W van der Bilt, Wilhelmus A Bemelman, Krisztina B Gecse & Christianne J Buskens. (2020) Ligation of the Intersphincteric Fistula Tract and Endorectal Advancement Flap for High Perianal Fistulas in Crohn’s Disease: A Retrospective Cohort Study. Journal of Crohn's and Colitis 14:6, pages 757-763.
Crossref
Rajan N. Patel, Gaurav B. Nigam, Raj G. Jatale, Devendra Desai, Govind Makharia, Vineet Ahuja & Jimmy K. Limdi. (2020) An Indian national survey of therapeutic drug monitoring with anti-tumor necrosis (TNF) medications in inflammatory bowel disease. Indian Journal of Gastroenterology 39:2, pages 176-185.
Crossref
Nikolas Plevris, Philip W. Jenkinson, Ian D. Arnott, Gareth R. Jones & Charlie W. Lees. (2020) Higher anti-tumor necrosis factor levels are associated with perianal fistula healing and fistula closure in Crohn’s disease. European Journal of Gastroenterology & Hepatology 32:1, pages 32-37.
Crossref
Joyce Wing Yan Mak, Whitney Tang, Terry Cheuk Fung Yip, Zhi Hua Ran, Shu Chen Wei, Vineet Ahuja, Sudheer Kumar, Wai Keung Leung, Ida Hilmi, Julajak Limsrivilai, Satimai Aniwan, Belsy C. Y. Lam, Kam Hon Chan, Ka Man Ng, Chi Man Leung, Michael K. K. Li, Fu Hang Lo, Alex Shun Fung Sze, Steven Woon Choy Tsang, Aric J. Hui, Juanda Leo Hartono & Siew C. Ng. (2019) Stopping anti‐tumour necrosis factor therapy in patients with perianal Crohn’s disease. Alimentary Pharmacology & Therapeutics 50:11-12, pages 1195-1203.
Crossref