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Scandinavian Journal of Gastroenterology Volume 56, 2021 - Issue 1
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Review

Efficacy of ustekinumab for active perianal fistulizing Crohn’s disease: a systematic review and meta-analysis of the current literature

Mohamed Attauabia Gastrounit, Medical Division, Copenhagen University Hospital, Hvidovre, Denmark;b Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, University of Copenhagen, Hvidovre Hospital, Hvidovre, Denmark;c Department of Gastroenterology and Hepatology, Herlev Hospital, University of Copenhagen, Copenhagen, DenmarkCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-0323-7030
ORCID Icon,
Johan Burischa Gastrounit, Medical Division, Copenhagen University Hospital, Hvidovre, Denmark;b Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, University of Copenhagen, Hvidovre Hospital, Hvidovre, Denmark
&
Jakob Benedict Seidelinc Department of Gastroenterology and Hepatology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
Pages 53-58 | Received 01 Nov 2020, Accepted 18 Nov 2020, Published online: 02 Dec 2020

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Hui Li, Lu Xie, Hongdi Yao, Lexing Zhang, Sanhong Liang & Wen Lyu. (2022) Successful Non-Operative Treatment of Enterovesical and Enterocutaneous Fistulas Due to Crohn’s Disease. International Medical Case Reports Journal 15, pages 117-124.
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Shana Rakowsky, Konstantinos Papamichael & Adam S. Cheifetz. (2022) Choosing the right biologic for complications of inflammatory bowel disease. Expert Review of Gastroenterology & Hepatology 16:3, pages 235-249.
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Articles from other publishers (35)

Arafa Djalal, Serre-Yu Wong, Jean-Frédéric Colombel, Ryan Ungaro & Maia Kayal. (2024) Problem with Hookups: Perianal Fistula After Ileal Pouch-Anal Anastomosis. Digestive Diseases and Sciences 69:4, pages 1102-1104.
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Manish Manrai, Atul Abhishek Jha, Saurabh Dawra & Aditya Vikram Pachisia. (2024) Biologics, Small Molecules and More in Inflammatory Bowel Disease: The Present and the Future. Future Pharmacology 4:1, pages 279-316.
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Tina Nie. (2024) Treating paediatric Crohn’s disease is challenging but new treatments hold promise. Drugs & Therapy Perspectives 40:3, pages 121-126.
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Malcolm Irani & Bincy Abraham. (2024) Choosing Therapy for Moderate to Severe Crohn’s Disease. Journal of the Canadian Association of Gastroenterology 7:1, pages 1-8.
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Jalpa Devi, David H. Ballard, Tina Aswani-Omprakash, Alyssa M. Parian & Parakkal Deepak. (2024) Perianal fistulizing Crohn’s disease: Current perspectives on diagnosis, monitoring and management with a focus on emerging therapies. Indian Journal of Gastroenterology 43:1, pages 48-63.
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Adrià Quesada-Simó, Francisco Giner, Lucas Barea-Moya, Alejandro Garrido-Marin, Alejandro Mínguez, Pilar Nos & Sara Gil-Perotín. (2024) Anti-CD20-Triggered Crohn’s-Like Disease with Severe Perianal Involvement in a Patient with Multiple Sclerosis: Case Report, Review of the Literature, and Potential Therapeutic Approach. Sclerosis 2:1, pages 7-12.
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Shannon ChangMegan MurphyLisa Malter. (2024) A Review of Available Medical Therapies to Treat Moderate-to-Severe Inflammatory Bowel Disease. American Journal of Gastroenterology 119:1, pages 55-80.
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Leticia ROSEVICS, Mariane Cristina SAVIO, Emilton LIMA JÚNIOR & Odery RAMOS JÚNIOR. (2023) FISTULIZING PERIANAL CROHN’S DISEASE: IS THE PATIENT’S SEX A BURDEN? A SYSTEMATIC REVIEW. Arquivos de Gastroenterologia 60:4, pages 490-524.
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Julie Gallagher, Joel R. Rosh & Benjamin Sahn. (2023) The Future of Advanced Therapies for Pediatric Crohn’s Disease. Pediatric Drugs 25:6, pages 621-633.
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C.E. Alcántara-Figueroa, E.F. Coronado-Rivera, E.F. Estela-Vásquez, D.C. Calderón-Cabrera & R.A. Alcántara-Ascón. (2023) Ustekinumab and remission in perianal Crohn's disease: A case report. Revista de Gastroenterología de México (English Edition) 88:4, pages 431-432.
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C.E. Alcántara-Figueroa, E.F. Coronado-Rivera, E.F. Estela-Vásquez, D.C. Calderón-Cabrera & R.A. Alcántara-Ascón. (2023) Ustekinumab y remisión en enfermedad de Crohn con compromiso perianal: reporte de un caso. Revista de Gastroenterología de México 88:4, pages 431-432.
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Marleen Bouhuys, Paola Mian & Patrick F. van Rheenen. (2023) Ustekinumab trough levels in children with Crohn’s disease refractory to anti-tumor necrosis factor agents: a prospective case series of off-label use. Frontiers in Pharmacology 14.
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Arshdeep Singh, Vandana Midha, Gursimran Singh Kochhar, Bo Shen & Ajit Sood. (2023) Management of Perianal Fistulizing Crohn’s Disease. Inflammatory Bowel Diseases.
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Alyssa M. ParianMegan ObiPhillip FleshnerDavid A. Schwartz. (2023) Management of Perianal Crohn's Disease. American Journal of Gastroenterology 118:8, pages 1323-1331.
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John Gubatan, Spencer Frost, Steven Levitte & Kian Keyashian. (2023) Rates and Predictors of Long-term Clinical Outcomes in Patients With Perianal Crohn’s Disease on Biologic Therapy. Journal of Clinical Gastroenterology 57:6, pages 617-623.
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Siyan Cao, Marco Colonna & Parakkal Deepak. (2023) Pathogenesis of Perianal Fistulising Crohn’s Disease: Current Knowledge, Gaps in Understanding, and Future Research Directions. Journal of Crohn's and Colitis 17:6, pages 1010-1022.
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M. V. Shapina. (2023) Theoretical aspects of prescribing ustekinumab as first-line therapy for Crohn’s disease. Meditsinskiy sovet = Medical Council:8, pages 175-180.
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Niloofar Khoshnam-Rad, Homayoon Vahedi, Anahita Sadeghi, Mansoor Rastegarpanah, Soha Namazi, Amir Anushiravani, Ali Reza Sima, Shabnam Shahrokh, Sudabeh Alatab & Reza Malekzadeh. (2023) Iranian Consensus Guideline for Pharmacotherapy with Biologics and Small Molecules Drugs in Adults with Inflammatory Bowel Diseases. Middle East Journal of Digestive Diseases 15:2, pages 83-106.
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Mohammad Shehab, Fatema Alrashed, Valérie Heron, Sophie Restellini & Talat Bessissow. (2023) Comparative Efficacy of Biologic Therapies for Inducing Response and Remission in Fistulizing Crohn’s Disease: Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. Inflammatory Bowel Diseases 29:3, pages 367-375.
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Rui Li. (2023) Approaches in the treatment of perianal fistula in Crohn disease. Journal of Coloproctology 43:01, pages 043-048.
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Jiayin Yao, Heng Zhang, Tao Su, Xiang Peng, Junzhang Zhao, Tao Liu, Wei Wang, Pinjin Hu, Min Zhi & Min Zhang. (2023) Ustekinumab Promotes Radiological Fistula Healing in Perianal Fistulizing Crohn’s Disease: A Retrospective Real-World Analysis. Journal of Clinical Medicine 12:3, pages 939.
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Naoto Saigusa & Jun-ichi Saigusa. (2023) Fistula Remission 8 Weeks after Induction of Biologics is an Independent Influencing Factor for Long-term Prognosis in Bio Naïve Patients with Crohn's Perianal Fistulasクローン病合併痔瘻において生物製剤導入後8週目の寛解が長期予後の予測因子である. Nippon Daicho Komonbyo Gakkai Zasshi 76:6, pages 426-431.
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Kira L. Newman, Laura A. Johnson, Ryan W. Stidham & Peter D. R. Higgins. (2023) Vedolizumab more likely to be discontinued than ustekinumab in anti-TNF-experienced patients with fistulizing Crohn’s disease. Therapeutic Advances in Gastroenterology 16, pages 175628482211482.
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Fabian Juliao-Baños, Laura Osorio, Jhon Carvajal, Gabriel Mosquera-Klinger, Anwar Medellín, Jorge Padrón, Belén de Molano, Fabián Puentes, Edwin Muñoz, Gustavo Reyes, Fabio Gil, Viviana Parra-Izquierdo & Héctor Sánchez. (2022) Características clínicas y tratamiento de la enfermedad de Crohn perianal fistulizante en Colombia: resultados de un registro multicéntrico. Gastroenterología y Hepatología 45:9, pages 690-696.
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Fabian Juliao-Baños, Laura Osorio, Jhon Carvajal, Gabriel Mosquera-Klinger, Anwar Medellín, Jorge Padrón, Belén de Molano, Fabián Puentes, Edwin Muñoz, Gustavo Reyes, Fabio Gil, Viviana Parra-Izquierdo & Héctor Sánchez. (2022) Clinical characteristics and treatment of perianal fistulising Crohn's disease in Colombia: Results of a multicentric registry. Gastroenterología y Hepatología (English Edition) 45:9, pages 690-696.
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Jeroen Geldof, Nusrat Iqbal, Jean-Frédéric LeBlanc, Sulak Anandabaskaran, Rachel Sawyer, Christianne Buskens, Willem Bemelman, Krisztina Gecse, Lilli Lundby, Amy L Lightner, Silvio Danese, Antonino Spinelli, Michele Carvello, Omar Faiz, Janindra Warusavitarne, Phillip Lung, Danny De Looze, André D'Hoore, Séverine Vermeire, Ailsa Hart & Phil Tozer. (2022) Classifying perianal fistulising Crohn's disease: an expert consensus to guide decision-making in daily practice and clinical trials. The Lancet Gastroenterology & Hepatology 7:6, pages 576-584.
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Panu Wetwittayakhlang, Alex Al Khoury, Gustavo Drügg Hahn & Peter Laszlo Lakatos. (2022) The Optimal Management of Fistulizing Crohn’s Disease: Evidence beyond Randomized Clinical Trials. Journal of Clinical Medicine 11:11, pages 3045.
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Ferdinando D’Amico, Laurent Peyrin-Biroulet & Silvio Danese. (2022) Ustekinumab in Crohn’s Disease: New Data for Positioning in Treatment Algorithm. Journal of Crohn's and Colitis 16:Supplement_2, pages ii30-ii41.
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Mir Zulqarnain, Parakkal Deepak & Andres J. Yarur. (2022) Therapeutic Drug Monitoring in Perianal Fistulizing Crohn’s Disease. Journal of Clinical Medicine 11:7, pages 1813.
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Gustavo Drügg Hahn, Petra Anna Golovics, Panu Wetwittayakhlang, Alex Al Khoury, Talat Bessissow & Peter Laszlo Lakatos. (2022) Is There a Best First Line Biological/Small Molecule in IBD: Are We Ready for Sequencing?. Biomedicines 10:4, pages 749.
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Christian Schineis, Johannes C. Lauscher, M. E. Kreis, Katharina Beyer & Benjamin Weixler. (2021) Flap-Techniken – heute noch „State of the Art“?Flap techniques—still state of the art today?. coloproctology 44:1, pages 17-22.
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Clare Yzet, Franck Brazier, Charles Sabbagh & Mathurin Fumery. (2022) Managing complex perianal disease after anti-TNF failure: Where to go next?. Current Research in Pharmacology and Drug Discovery 3, pages 100081.
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Gala M Godoy Brewer, George Salem, Muhammad A Afzal, Berkeley N Limketkai, Zadid Haq, Maryam Tajamal, Joanna Melia, Mark Lazarev, Florin M Selaru & Alyssa M. Parian. (2021) Ustekinumab is effective for perianal fistulising Crohn's disease: a real-world experience and systematic review with meta-analysis. BMJ Open Gastroenterology 8:1, pages e000702.
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Abhinav Vasudevan, David H Bruining, Edward V Loftus, William Faubion, Eric C Ehman & Laura Raffals. (2021) Approach to medical therapy in perianal Crohn’s disease. World Journal of Gastroenterology 27:25, pages 3693-3704.
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Joana Revés, Ryan C. Ungaro & Joana Torres. (2021) Unmet needs in inflammatory bowel disease. Current Research in Pharmacology and Drug Discovery 2, pages 100070.
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