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Research Article

Comparison of Indomethacin and Nimesulide, a Selective Cyclooxygenase-2 Inhibitor, on Key Pathophysiologic Steps in the Pathogenesis of Nonsteroidal Anti-Inflammatory Drug Enteropathy in the Rat

Pages 728-735 | Published online: 08 Jul 2009

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Read on this site (2)

Egil Fosslien. (2000) Biochemistry of Cyclooxygenase (COX)-2 Inhibitors and Molecular Pathology of COX-2 in Neoplasia. Critical Reviews in Clinical Laboratory Sciences 37:5, pages 431-502.
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J. A. Tibble, G. Sigthorsson, R. Foster, I. Bjarnason. (2000) Comparison of the Intestinal Toxicity of Celecoxib, a Selective COX-2 Inhibitor, and Indomethacin in the Experimental Rat. Scandinavian Journal of Gastroenterology 35:8, pages 802-807.
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Articles from other publishers (25)

Peiya Shen, Chunfeng Zhang, Enshi Hu, Zunting Pang, Yuan Gao, Shuai Qian, Jianjun Zhang, Yuanfeng Wei & Weili Heng. (2022) Gelation switch of polyamorphic indomethacin depending on the thermal procedure. European Journal of Pharmaceutics and Biopharmaceutics 177, pages 249-259.
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Ingvar Bjarnason, Carmelo Scarpignato, Erik Holmgren, Michael Olszewski, Kim D. Rainsford & Angel Lanas. (2018) Mechanisms of Damage to the Gastrointestinal Tract From Nonsteroidal Anti-Inflammatory Drugs. Gastroenterology 154:3, pages 500-514.
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Muzeeb Syed, Christian Skonberg & Steen Honoré Hansen. (2016) Mitochondrial toxicity of selective COX-2 inhibitors via inhibition of oxidative phosphorylation (ATP synthesis) in rat liver mitochondria. Toxicology in Vitro 32, pages 26-40.
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Zaher A. Radi. 2012. Comparative Pathophysiology and Toxicology of Cyclooxygenases. Comparative Pathophysiology and Toxicology of Cyclooxygenases 11 71 .
Cláudia Nunes, Gerald Brezesinski, Catarina Pereira-Leite, José L. F. C. Lima, Salette Reis & Marlene Lúcio. (2011) NSAIDs Interactions with Membranes: A Biophysical Approach. Langmuir 27:17, pages 10847-10858.
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Marie Meskell & Raj Ettarh. (2011) Immunohistochemical localisation of renal cyclooxygenase-1 expression in non-steroidal anti-inflammatory drug-treated mice. Experimental and Toxicologic Pathology 63:1-2, pages 39-42.
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Helenie Kefalakes, Theodoros J. Stylianides, George Amanakis & George Kolios. (2009) Exacerbation of inflammatory bowel diseases associated with the use of nonsteroidal anti-inflammatory drugs: myth or reality?. European Journal of Clinical Pharmacology 65:10, pages 963-970.
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Katherine R. Groschwitz & Simon P. Hogan. (2009) Intestinal barrier function: Molecular regulation and disease pathogenesis. Journal of Allergy and Clinical Immunology 124:1, pages 3-20.
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M. Alice McGarvey, Fardod O'Kelly & Rajunor R. Ettarh. (2007) Nimesulide Inhibits Crypt Epithelial Cell Proliferation at 6 Hours in the Small Intestine in CD-1 Mice. Digestive Diseases and Sciences 52:9, pages 2087-2094.
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L.C. Freeman, D.F. Narvaez, A. McCoy, F.B. von Stein, S. Young, K. Silver, S. Ganta, D. Koch, R. Hunter, R.F. Gilmour & J.D. Lillich. (2007) Depolarization and decreased surface expression of K+ channels contribute to NSAID-inhibition of intestinal restitution. Biochemical Pharmacology 74:1, pages 74-85.
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M. Alice McGarvey, Gary Bass & R. R. Ettarh. (2007) Nimesulide Alters Cell Recruitment into Mitosis in Murine Intestinal Crypts Without Influencing the Cell Production Rate. Digestive Diseases and Sciences 52:6, pages 1471-1478.
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Molly Jacob, Russel Foster, Gudmundur Sigthorsson, Robert Simpson & Ingvar Bjarnason. (2006) Role of bile in pathogenesis of indomethacin-induced enteropathy. Archives of Toxicology 81:4, pages 291-298.
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Zaher A. Radi & Nasir K. Khan. (2006) Effects of cyclooxygenase inhibition on the gastrointestinal tract. Experimental and Toxicologic Pathology 58:2-3, pages 163-173.
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I. Bjarnason, F. Bissoli, A. Conforti, L. Maiden, N. Moore, U. Moretti, K.D. Rainsford, K. Takeuchi & G.P. Velo. 2005. Nimesulide — Actions and Uses. Nimesulide — Actions and Uses 315 415 .
Brendan J.R. Whittle. (2004) Mechanisms underlying intestinal injury induced by anti-inflammatory COX inhibitors. European Journal of Pharmacology 500:1-3, pages 427-439.
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Brendan J. R. Whittle. (2003) Gastrointestinal effects of nonsteroidal anti-inflammatory drugs. Fundamental & Clinical Pharmacology 17:3, pages 301-313.
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Manja M. Krause, Martin D. Brand, Stefan Krauss, Christian Meisel, Hartmut Vergin, Gerd‐Rüdiger Burmester & Frank Buttgereit. (2003) Nonsteroidal antiinflammatory drugs and a selective cyclooxygenase 2 inhibitor uncouple mitochondria in intact cells. Arthritis & Rheumatism 48:5, pages 1438-1444.
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Julia Tomlinson & Anthony Blikslager. (2003) Role of nonsteroidal anti-inflammatory drugs in gastrointestinal tract injury and repair. Journal of the American Veterinary Medical Association 222:7, pages 946-951.
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Gudmundur Sigthorsson, Robert J. Simpson, Matthew Walley, Andrew Anthony, Russell Foster, Christoph Hotz–Behoftsitz, Abbas Palizban, Joaquim Pombo, Jo Watts, Scott G. Morham & Ingvar Bjarnason. (2002) COX-1 and 2, intestinal integrity, and pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in mice. Gastroenterology 122:7, pages 1913-1923.
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Urs A. Boelsterli. (2002) Mechanisms of NSAID-Induced Hepatotoxicity. Drug Safety 25:9, pages 633-648.
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I. Bjarnason, A. Cederborg, A. åkvist & S. Smale. 2002. Biology of the Intestine in Growing Animals. Biology of the Intestine in Growing Animals 657 693 .
Gudmundur Sigthorsson, Bjarni Thjodleifsson, Taher Mahmud & Ingvar Bjarnason. (2000) Gastrointestinal tolerability of nimesulide, a selective cyclooxygenase-2 inhibitor, in experimental animals and man. InflammoPharmacology 8:2, pages 175-187.
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Somasundaram, Sigthorsson, Simpson, Watts, Jacob, Tavares, Rafi, Roseth, Foster, Price, Wrigglesworth & Bjarnason. (2001) Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID‐enteropathy in the rat. Alimentary Pharmacology & Therapeutics 14:5, pages 639-650.
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Simon Smale, Jeremy Tibble & Ingvar Bjarnason. (2000) Small intestinal permeability. Current Opinion in Gastroenterology 16:2, pages 134-139.
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Leonid Koyfman, Jacob Kaplanski, Alan A. Artru, Daniel Talmor, Mazal Rubin & Yoram Shapira. (2000) Inhibition of Cyclooxygenase 2 by Nimesulide Decreases Prostaglandin E2 Formation But Does Not Alter Brain Edema or Clinical Recovery After Closed Head Injury in Rats. Journal of Neurosurgical Anesthesiology 12:1, pages 44-50.
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