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Scandinavian Journal of Gastroenterology Volume 34, 1999 - Issue 7
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Research Article

The Effects of Omeprazole on Intragastric pH, Intestinal Motility, and Gastric Emptying Rate

L. Rasmussen, E. Øster-JØrgensen, N. Qvist, S. A. Pedersen
Pages 671-675 | Published online: 08 Jul 2009

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Andreas Franke, Caroline Hepp, Hermann Harder, Christoph Beglinger & Manfred V. Singer. (2008) Esomeprazole reduces gastroesophageal reflux after beer consumption in healthy volunteers. Scandinavian Journal of Gastroenterology 43:12, pages 1425-1431.
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Zhongqi Dong, Jia Li, Fang Wu, Ping Zhao, Sue‐Chih Lee, Lillian Zhang, Paul Seo & Lei Zhang. (2020) Application of Physiologically‐Based Pharmacokinetic Modeling to Predict Gastric pH‐Dependent Drug–Drug Interactions for Weak Base Drugs. CPT: Pharmacometrics & Systems Pharmacology 9:8, pages 456-465.
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Kosuke Doki, Adam S. Darwich, Nikunjkumar Patel & Amin Rostami-Hodjegan. (2017) Virtual bioequivalence for achlorhydric subjects: The use of PBPK modelling to assess the formulation-dependent effect of achlorhydria. European Journal of Pharmaceutical Sciences 109, pages 111-120.
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Nayananjani Karunasena, Daniel N Margetson, Greg Neal, Martin J Whitaker & Richard JM Ross. (2017) Impact of food, alcohol and pH on modified-release hydrocortisone developed to treat congenital adrenal hyperplasia. European Journal of Endocrinology 176:4, pages 405-411.
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Hideki Mori, Hidekazu Suzuki, Juntaro Matsuzaki, Kanami Taniguchi, Toshiyuki Shimizu, Tsuyoshi Yamane, Tatsuhiro Masaoka & Takanori Kanai. (2017) Gender Difference of Gastric Emptying in Healthy Volunteers and Patients with Functional Dyspepsia. Digestion 95:1, pages 72-78.
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Neil J Parrott, Li J Yu, Ryusuke Takano, Mikiko Nakamura & Peter N. Morcos. (2016) Physiologically Based Absorption Modeling to Explore the Impact of Food and Gastric pH Changes on the Pharmacokinetics of Alectinib. The AAPS Journal 18:6, pages 1464-1474.
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Eran Israeli & Charles N. Bernstein. 2015. Yamada' s Textbook of Gastroenterology. Yamada' s Textbook of Gastroenterology 2399 2439 .
Lenard M. Lichtenberger, Deepa Bhattarai, Tri M. Phan, Elizabeth J. Dial & Karen Uray. (2015) Suppression of contractile activity in the small intestine by indomethacin and omeprazole. American Journal of Physiology-Gastrointestinal and Liver Physiology 308:9, pages G785-G793.
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F.J.O. Varum, G.B. Hatton & A.W. Basit. (2013) Food, physiology and drug delivery. International Journal of Pharmaceutics 457:2, pages 446-460.
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Daniel Paul Stupak, George G. Abdelsayed & Gregory N. Soloway. (2012) Motility Disorders of the Upper Gastrointestinal Tract in the Intensive Care Unit. Journal of Clinical Gastroenterology 46:6, pages 449-456.
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Tatsuya Yagi, Takafumi Naito, Yasuaki Mino, Kazuo Umemura & Junichi Kawakami. (2012) Impact of Concomitant Antacid Administration on Gabapentin Plasma Exposure and Oral Bioavailability in Healthy Adult Subjects. Drug Metabolism and Pharmacokinetics 27:2, pages 248-254.
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Toshihiko Tomita & Hiroto Miwa. (2011) Do Histamine-2 Receptor Antagonists and Proton Pump Inhibitors Really Have No Effect on the Gastric Emptying Rate?. Journal of Neurogastroenterology and Motility 17:4, pages 434.
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Takashi Nonaka, Takaomi Kessoku, Yuji Ogawa, Kento Imajyo, Shogo Yanagisawa, Tadahiko Shiba, Takashi Sakaguchi, Kazuhiro Atsukawa, Hisao Takahashi, Yusuke Sekino, Eiji Sakai, Takashi Uchiyama, Hiroshi Iida, Kunihiro Hosono, Hiroki Endo, Yasunari Sakamoto, Koji Fujita, Masato Yoneda, Tomoko Koide, Hirokazu Takahashi, Chikako Tokoro, Yasunobu Abe, Eiji Gotoh, Shin Maeda, Atsushi Nakajima & Masahiko Inamori. (2011) Effects of Histamine-2 Receptor Antagonists and Proton Pump Inhibitors on the Rate of Gastric Emptying: A Crossover Study Using a Continuous Real-Time C Breath Test (BreathID System). Journal of Neurogastroenterology and Motility 17:3, pages 287-293.
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Masaki Sanaka, Takatsugu Yamamoto & Yasushi Kuyama. (2009) Effects of Proton Pump Inhibitors on Gastric Emptying: A Systematic Review. Digestive Diseases and Sciences 55:9, pages 2431-2440.
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Felipe J.O. Varum, Hamid A. Merchant & Abdul W. Basit. (2010) Oral modified-release formulations in motion: The relationship between gastrointestinal transit and drug absorption. International Journal of Pharmaceutics 395:1-2, pages 26-36.
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Ichiro Yoshikawa, Makiko Nagato, Masahiro Yamasaki, Keiichiro Kume & Makoto Otsuki. (2009) Long-term treatment with proton pump inhibitor is associated with undesired weight gain. World Journal of Gastroenterology 15:38, pages 4794.
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Shiho Terai, Katsunori Iijima, Kiyotaka Asanuma, Nobuyuki Ara, Kaname Uno, Yasuhiko Abe, Tomoyuki Koike, Akira Imatani, Shuichi Ohara & Tooru Shimosegawa. (2009) Lack of Modulation of Gastric Emptying by Dietary Nitrate in Healthy Volunteers. The Tohoku Journal of Experimental Medicine 218:1, pages 73-79.
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L.C. Sanchez, S. Giguère, L.H. Javsicas, J. Bier, C.J. Walrond & A.Y. Womble. (2008) Effect of Age, Feeding, and Omeprazole Administration on Gastric Tonometry in Healthy Neonatal Foals. Journal of Veterinary Internal Medicine 22:2, pages 406-410.
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Marianne J Chapman, Nam Q Nguyen & Robert JL Fraser. (2007) Gastrointestinal motility and prokinetics in the critically ill. Current Opinion in Critical Care 13:2, pages 187-194.
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Yoshiko Takahashi, Yuji Amano, Takafumi Yuki, Takayuki Ose, Tatsuya Miyake, Yoshinori Kushiyama, Shuichi Sato, Shunji Ishihara & Yoshikazu Kinoshita. (2006) Influence of acid suppressants on gastric emptying: Cross‐over analysis in healthy volunteers. Journal of Gastroenterology and Hepatology 21:11, pages 1664-1668.
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A. B. M. GRUDELL, M. CAMILLERI, D. D. BURTON & D. A. STEPHENS. (2006) Effect of a proton pump inhibitor on postprandial gastric volume, emptying and symptoms in healthy human subjects: a pilot study. Alimentary Pharmacology & Therapeutics 24:7, pages 1037-1043.
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G. TOUGAS, D. L. EARNEST, Y. CHEN, C. VANDERKOY & M. ROJAVIN. (2005) Omeprazole delays gastric emptying in healthy volunteers: an effect prevented by tegaserod. Alimentary Pharmacology & Therapeutics 22:1, pages 59-65.
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Fumihiko Katagiri, Yuhki Sato, Hiroki Itoh & Masaharu Takeyama. (2005) Effects of Rabeprazole on Plasma Gastrointestinal Peptides in Healthy Humans. Journal of Health Science 51:4, pages 504-509.
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FULL‐YOUNG CHANG, CHING‐LIANG LU, CHIH‐YEN CHEN, JIING‐CHYUAN LUO, KANG LIH JIUN, SHOU‐DONG LEE & HAN CHANG WU. (2003) Stomach myoelectrical response of patients with gastroesophageal reflux disease receiving omeprazole treatment. Journal of Gastroenterology and Hepatology 18:12, pages 1399-1406.
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T. Kamada, K. Haruma, J. Hata, H. Kusunoki, A. Sasaki, M. Ito, S. Tanaka & M. Yoshihara. (2003) The long‐term effect of Helicobacter pylori eradication therapy on symptoms in dyspeptic patients with fundic atrophic gastritis. Alimentary Pharmacology & Therapeutics 18:2, pages 245-252.
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P. Netzer, A. Gut, R. Brundler, C. Gaia, F. Halter & W. Inauen. (2001) Influence of pantoprazole on oesophageal motility, and bile and acid reflux in patients with oesophagitis. Alimentary Pharmacology & Therapeutics 15:9, pages 1375-1384.
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Eamonn M.M. Quigley. (2000) Gastroduodenal motility. Current Opinion in Gastroenterology 16:6, pages 479-488.
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