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Research Article

Helicobacter pylori Induces Apoptosis in Gastric Mucosa through an Upregulation of Bax Expression in Humans

Pages 375-383 | Published online: 08 Jul 2009

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Sang Hui Chu, Joo Weon Lim, Dong Goo Kim, Eung-Seok Lee, Kyung Hwan Kim & Hyeyoung Kim. (2011) Down-regulation of Bcl-2 is mediated by NF-κB activation in Helicobacter pylori-induced apoptosis of gastric epithelial cells. Scandinavian Journal of Gastroenterology 46:2, pages 148-155.
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T. Vorobjova, H.-I. Maaroos, P. Sipponen, K. Villako, R. Uibo. (2001) Apoptosis in Different Compartments of Antrum and Corpus Mucosa in Chronic Helicobacter pylori Gastritis. An 18-Year Follow-up Study. Scandinavian Journal of Gastroenterology 36:2, pages 136-143.
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Md. Habibur Rahman, Johny Bajgai, Yoojin Cho, Ailyn Fadriquela, Subham Sharma, Trinh Thi Thuy, Syung Hyun Cho, Yun Ju Jeong, Seong Hoon Goh, Yundeok Kim, Cheol-Su Kim & Kyu-Jae Lee. (2023) Immune Redox Modulation Effects of Non-Electrolyzed Hypochlorous Acid Water on Helicobacter pylori-Infected C57BL/6 Mouse Model. Processes 11:5, pages 1474.
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Collins Waguia Kontchou & Georg Häcker. 2023. Mitochondria and Bacterial Pathogens Part A. Mitochondria and Bacterial Pathogens Part A 83 127 .
You-Cong Yin, Xiao-hui Li, Xuan Rao, Yuan-Jian Li & Jie Du. (2022) Involvement of microRNA/cystine/glutamate transporter in cold-stressed gastric mucosa injury. Frontiers in Pharmacology 13.
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Dagnachew Hailemariam, Tran H. Lam, Elda Dervishi, Grzegorz Zwierzchowski, David S. Wishart & Burim N. Ametaj. (2022) Combination of mouse prion protein with detoxified lipopolysaccharide triggers colon genes related to inflammatory, antibacterial, and apoptotic responses. Research in Veterinary Science 144, pages 98-107.
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Hye Kyung Kim, Myung-Gyou Kim & Kang-Hyun Leem. (2016) Extrusion process of Acanthopanax senticosus leaves enhances the gastroprotective effect of compound 48/80 on acute gastric mucosal lesion in rats. Journal of Traditional Chinese Medicine 36:2, pages 187-196.
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Juliana Carvalho Santos. (2015) Epigenetic regulation of DNA repair machinery in Helicobacter pylori -induced gastric carcinogenesis . World Journal of Gastroenterology 21:30, pages 9021.
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Trinidad Parra-Cid, Miryam Calvino-Fernández, Selma Benito-Martínez & Javier Pérez-Gisbert. 2014. Systems Biology of Free Radicals and Antioxidants. Systems Biology of Free Radicals and Antioxidants 1849 1870 .
Lars L Eftang, Ying Esbensen, Tone M Tannæs, Ida RK Bukholm & Geir Bukholm. (2012) Interleukin-8 is the single most up-regulated gene in whole genome profiling of H. pylori exposed gastric epithelial cells. BMC Microbiology 12:1, pages 9.
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Isabelle Joyce de Lima Silva-Fernandes, Markênia Kélia Santos Alves, Valeska Portela Lima, Marcos Antônio Pereira de Lima, Marcos Aurélio Pessoa Barros, Márcia Valéria Pitombeira Ferreira & Silvia Helena Barem Rabenhorst. (2011) Differential expression of MYC in H. pylori-related intestinal and diffuse gastric tumors. Virchows Archiv 458:6, pages 725-731.
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Joo Weon Lim & Hyeyoung Kim. (2010) Role of protease-activated receptor-2 on cell death and DNA fragmentation in Helicobacter pylori-infected gastric epithelial cells. Journal of Translational Medicine 8:1.
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Mohammed O. Altonsy, Simon C. Andrews & Kieran M. Tuohy. (2010) Differential induction of apoptosis in human colonic carcinoma cells (Caco-2) by Atopobium, and commensal, probiotic and enteropathogenic bacteria: Mediation by the mitochondrial pathway. International Journal of Food Microbiology 137:2-3, pages 190-203.
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Asima Bhattacharyya, Ranajoy Chattopadhyay, Brent R. Burnette, Janet V. Cross, Sankar Mitra, Peter B. Ernst, Kishor K. Bhakat & Sheila E. Crowe. (2009) Acetylation of Apurinic/Apyrimidinic Endonuclease-1 Regulates Helicobacterpylori-Mediated Gastric Epithelial Cell Apoptosis. Gastroenterology 136:7, pages 2258-2269.
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Pallab Maity, Kaushik Biswas, Ishita Chattopadhyay, Ranajit K. Banerjee & Uday Bandyopadhyay. (2009) The use of neem for controlling gastric hyperacidity and ulcer. Phytotherapy Research 23:6, pages 747-755.
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Elizabeth K. Balcer-Kubiczek & Michael C. Garofalo. 2009. Apoptosis in Carcinogenesis and Chemotherapy. Apoptosis in Carcinogenesis and Chemotherapy 157 192 .
Hassan Ashktorab, Rod H. Dashwood, Mohaiza M. Dashwood, Syed I. Zaidi, Stephen M. Hewitt, William R. Green, Edward L. Lee, Mohammadreza Daremipouran, Mehdi Nouraie, Reza Malekzadeh & Duane T. Smoot. (2008) H. pylori -Induced Apoptosis in Human Gastric Cancer Cells Mediated via the Release of Apoptosis-Inducing Factor from Mitochondria . Helicobacter 13:6, pages 506-517.
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Susan J Hagen, David X Yang, Kimihito Tashima, Nancy S Taylor & James G Fox. (2008) Epithelial cell expression of BCL-2 family proteins predicts mechanisms that regulate Helicobacter pylori-induced pathology in the mouse stomach. Laboratory Investigation 88:11, pages 1227-1244.
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Guoqing Xia, Regine Schneider-Stock, Antje Diestel, Caroline Habold, Sabine Krueger, Albert Roessner, Michael Naumann & Uwe Lendeckel. (2008) Helicobacter pylori regulates p21WAF1 by histone H4 acetylation. Biochemical and Biophysical Research Communications 369:2, pages 526-531.
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Valeska Portela Lima. (2008) H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas: Correlation with p53 mutation and c-Myc, Bcl-2 and Bax expression. World Journal of Gastroenterology 14:06, pages 884.
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Yong-Mei Zhang, Er-Qing Wei, Li Li, Wei-Li Qiao, Lin Wang & Jian-Fu Zhang. (2007) EXTRACELLULAR SIGNAL-REGULATED KINASE PATHWAYS MAY MEDIATE THE PROTECTIVE EFFECT OF ELECTRICAL STIMULATION OF THE PARAVENTRICULAR NUCLEUS AGAINST ISCHAEMIA?REPERFUSION INJURY OF THE GASTRIC MUCOSA. Clinical and Experimental Pharmacology and Physiology 34:8, pages 742-752.
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Susanne Holck, Inger L. Holm, Peter P. Holck, Marianne Pedersen, Annette Nørgaard, Svend Norn, Henrik Permin & Leif P. Andersen. (2007) Epithelial cell kinetics of the gastric mucosa during Helicobacter pylori infection . FEMS Immunology & Medical Microbiology 50:2, pages 206-212.
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Hao Zhang, Dian-Chun Fang, Chun-Hui Lan & Yuan-Hui Luo. (2007) Helicobacter pylori infection induces apoptosis in gastric cancer cells through the mitochondrial pathway. Journal of Gastroenterology and Hepatology 22:7, pages 1051-1056.
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Monica M.D.A. Cabral, Claudia M.C. Mendes, Lucia P.F. Castro, Christiane T. Cartelle, Juliana Guerra, Dulciene M.M. Queiroz & Ana M.M.F. Nogueira. (2006) Apoptosis in Helicobacter pylori Gastritis is Related to cagA Status. Helicobacter 11:5, pages 469-476.
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Panagiota Kitsanta, Konstantinos Triantafyllou, Maria Chatziargyriou, Charalambos Barbatzas & Spiros D. Ladas. (2005) Gastric Mucosa Epithelial Cell Kinetics Are Differentiated by Anatomic Site and Helicobacter Pylori Infection. Digestive Diseases and Sciences 50:6, pages 1087-1091.
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Chaitali Basak, Sushil Kumar Pathak, Asima Bhattacharyya, Shresh Pathak, Joyoti Basu & Manikuntala Kundu. (2005) The Secreted Peptidyl Prolyl cis,trans -Isomerase HP0175 of Helicobacter pylori Induces Apoptosis of Gastric Epithelial Cells in a TLR4- and Apoptosis Signal-Regulating Kinase 1-Dependent Manner . The Journal of Immunology 174:9, pages 5672-5680.
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Adrian Gologan, David Y. Graham & Antonia R. Sepulveda. (2005) Molecular Markers in Helicobacter pylori-Associated Gastric Carcinogenesis. Clinics in Laboratory Medicine 25:1, pages 197-222.
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Peter C Konturek. (2005) Helicobacter pylori upregulates prion protein expression in gastric mucosa: A possible link to prion disease . World Journal of Gastroenterology 11:48, pages 7651.
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Selim Aydemir. (2005) Effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure . World Journal of Gastroenterology 11:45, pages 7183.
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Jan Hendrik Martin, Andrej Potthoff, Susanne Ledig, Markus Cornberg, Oliver Jandl, Michael P. Manns, Stefan Kubicka, Peer Flemming, Christoph Athmann, Winfried Beil & Siegfried Wagner. (2004) Effect of H. pylori on the Expression of TRAIL, FasL and their Receptor Subtypes in Human Gastric Epithelial Cells and their Role in Apoptosis . Helicobacter 9:5, pages 371-386.
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Hao Zhang, Dian-Chun Fang, Rong-Quan Wang, Shi-Ming Yang, Hai-Feng Liu & Yuan-Hui Luo. (2004) Effect of Helicobacter pylori infection on expressions of Bcl-2 family members in gastric adenocarcinoma . World Journal of Gastroenterology 10:2, pages 227.
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SANG HUI CHU, JOO WEON LIM, KYUNG HWAN KIM & HYEYOUNG KIM. (2003) NF-κB and Bcl-2 in Helicobacter pylori -Induced Apoptosis in Gastric Epithelial Cells . Annals of the New York Academy of Sciences 1010:1, pages 568-572.
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Antonia R Sepulveda & David Y Graham. (2003) Role of Helicobacter pylori in gastric carcinogenesis. Hematology/Oncology Clinics of North America 17:2, pages 505-523.
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Il Ju Choi, Joo Sung Kim, Jung Mogg Kim, Hyun Chae Jung & In Sung Song. (2003) Effect of Inhibition of Extracellular Signal-Regulated Kinase 1 and 2 Pathway on Apoptosis and bcl-2 Expression in Helicobacter pylori -Infected AGS Cells . Infection and Immunity 71:2, pages 830-837.
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Jing Lan. (2003) Helicobacter pylori infection generated gastric cancer through p53-Rb tumor-suppressor system mutation and telomerase reactivation . World Journal of Gastroenterology 9:1, pages 54.
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Stanislaw J. Konturek, Peter C. Konturek, W. Bielanski, Elzbieta Karczewska, Monika Zuchowicz, Artur Hartwich, Jens F. Rehfeld, Jens P. Goetze & Eckhart G. Hahn. (2003) Serum Progastrin and Its Products, Gastric Acid Secretion and Serum Pepsinogen I in Gastric Cancer. Digestion 68:4, pages 169-177.
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A. Potthoff, S. Ledig, J. Martin, O. Jandl, M. Cornberg, B. Obst, W. Beil, M. P. Manns & S. Wagner. (2002) Significance of the Caspase Family in Helicobacter pylori Induced Gastric Epithelial Apoptosis . Helicobacter 7:6, pages 367-377.
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Hideo SuzukiAkinori YanakaTakeshi ShibaharaHirofumi MatsuiAkira NakaharaNaomi TanakaHiroshi MutoTakashi Momoi & Yasuo Uchiyama. (2002) Ammonia-induced apoptosis is accelerated at higher pH in gastric surface mucous cells. American Journal of Physiology-Gastrointestinal and Liver Physiology 283:4, pages G986-G995.
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Hassan Ashktorab, Mattew Neapolitano, Chandara Bomma, Cornel Allen, Amel Ahmed, Andre Dubois, Tammy Naab & Duane T. Smoot. (2002) In vivo and in vitro activation of caspase-8 and -3 associated with Helicobacter pylori infection. Microbes and Infection 4:7, pages 713-722.
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Antonia R Sepulveda & David Y Graham. (2002) Role of Helicobacter pylori in gastric carcinogenesis. Gastroenterology Clinics of North America 31:2, pages 517-535.
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Harry Hua-Xiang Xia & Nicholas J. Talley. (2001) Apoptosis in gastric epithelium induced by helicobacter pylori infection: implications in gastric carcinogenesis. The American Journal of Gastroenterology 96:1, pages 16-26.
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