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Research Article

Linezolid Versus Ceftriaxone/Cefpodoxime in Patients Hospitalized for the Treatment of Streptococcus pneumoniae Pneumonia

Pages 720-728 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Mohsen Heidari, Shirin Dashtbin, Arezoo Asadi, Parisa Asadollahi, Ali Khatib, Mohammad Amin Ebrahimi, Zahra Ghanbari, Atieh Darbandi, Roya Ghanavati & Reza Pakzad. (2024) Prevalence of linezolid resistance in Streptococcus pneumoniae isolates: a systematic review and meta-analysis. Future Microbiology 19:5, pages 449-459.
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João Paulo Telles, Juliette Cieslinski, Juliano Gasparetto & Felipe Francisco Tuon. (2019) Efficacy of Ceftriaxone 1 g daily Versus 2 g daily for The Treatment of Community-Acquired Pneumonia: A Systematic Review with Meta-Analysis. Expert Review of Anti-infective Therapy 17:7, pages 501-510.
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Sally Ager & Kate Gould. (2012) Clinical update on linezolid in the treatment of Gram-positive bacterial infections. Infection and Drug Resistance 5, pages 87-102.
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Vicenç Falcó, Ana Sánchez, Albert Pahissa & Jordi Rello. (2011) Emerging drugs for pneumococcal pneumonia. Expert Opinion on Emerging Drugs 16:3, pages 459-477.
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Eugenios I Metaxas & Matthew E Falagas. (2009) Update on the safety of linezolid. Expert Opinion on Drug Safety 8:4, pages 485-491.
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David J Herrmann, William J Peppard, Nathan A Ledeboer, Melissa L Theesfeld, John A Weigelt & Bryan J Buechel. (2008) Linezolid for the treatment of drug-resistant infections. Expert Review of Anti-infective Therapy 6:6, pages 825-848.
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Konstantinos Z Vardakas, Fotinie Ntziora & Matthew E Falagas. (2007) Linezolid: effectiveness and safety for approved and off-label indications. Expert Opinion on Pharmacotherapy 8:14, pages 2381-2400.
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P. W. de Feiter, J. A. Jacobs, M. J. H. M. Jacobs, C. Vink & S. van der Geest. (2005) Successful treatment of Staphylococcus epidermidis prosthetic valve endocarditis with linezolid after failure of treatment with oxacillin, gentamicin, rifampicin, vancomycin, and fusidic acid regimens. Scandinavian Journal of Infectious Diseases 37:3, pages 173-176.
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Dennis L Stevens, Brian Dotter & Karl Madaras-Kelly. (2004) A review of linezolid: the first oxazolidinone antibiotic. Expert Review of Anti-infective Therapy 2:1, pages 51-59.
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. (2004) News in Brief. Expert Review of Anti-infective Therapy 2:1, pages 5-8.
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Articles from other publishers (48)

Matteo Bassetti, Daniele R. Giacobbe, Laura Magnasco, Alberto Fantin, Antonio Vena & Nadia Castaldo. (2024) Antibiotic Strategies for Severe Community-Acquired Pneumonia. Seminars in Respiratory and Critical Care Medicine 45:02, pages 187-199.
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Anu Patel, Sarah B. Doernberg, Travis Zack, Atul J. Butte & Kendra K. Radtke. (2024) Predictive Modeling of Drug‐Related Adverse Events with Real‐World Data: A Case Study of Linezolid Hematologic Outcomes. Clinical Pharmacology & Therapeutics 115:4, pages 847-859.
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Eliezer Zachary Nussbaum, Sophia Koo & Camille N Kotton. (2024) Oral Antibiotics for Treatment of Gram-Negative Bacteremia in Solid Organ Transplant Recipients: A Propensity Score Weighted Retrospective Observational Study. Clinical Infectious Diseases.
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Matthew C. Phillips, Noah Wald-Dickler, Kusha Davar, Rachael Lee, Rachel Baden, Paul Holtom & Brad Spellberg. (2023) Choosing patients over placebos: oral transitional therapy vs. IV-only therapy for bacteraemia and infective endocarditis. Clinical Microbiology and Infection 29:9, pages 1126-1132.
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Kusha Davar, Devin Clark, Robert M Centor, Fernando Dominguez, Bassam Ghanem, Rachael Lee, Todd C Lee, Emily G McDonald, Matthew C Phillips, Parham Sendi & Brad Spellberg. (2023) Can the Future of ID Escape the Inertial Dogma of Its Past? The Exemplars of Shorter Is Better and Oral Is the New IV. Open Forum Infectious Diseases 10:1.
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Naveed Saleem, Francis Ryckaert, Timothy Arthur Chandos Snow, Giovanni Satta, Mervyn Singer & Nishkantha Arulkumaran. (2022) Mortality and clinical cure rates for pneumonia: a systematic review, meta-analysis, and trial sequential analysis of randomized control trials comparing bactericidal and bacteriostatic antibiotic treatments. Clinical Microbiology and Infection 28:7, pages 936-945.
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Noah Wald-Dickler, Paul D. Holtom, Matthew C. Phillips, Robert M. Centor, Rachael. A. Lee, Rachel Baden & Brad Spellberg. (2022) Oral Is the New IV. Challenging Decades of Blood and Bone Infection Dogma: A Systematic Review. The American Journal of Medicine 135:3, pages 369-379.e1.
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Abhijit M. Bal. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 201 212 .
Brad Spellberg, Henry F. Chambers, Daniel M. Musher, Thomas L. Walsh & Arnold S. Bayer. (2020) Evaluation of a Paradigm Shift From Intravenous Antibiotics to Oral Step-Down Therapy for the Treatment of Infective Endocarditis. JAMA Internal Medicine 180:5, pages 769.
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Amar Safdar & Donald Armstrong. 2019. Principles and Practice of Transplant Infectious Diseases. Principles and Practice of Transplant Infectious Diseases 419 445 .
Jesse D Sutton, Sena Sayood & Emily S Spivak. (2018) Top Questions in Uncomplicated, Non–Staphylococcus aureus Bacteremia. Open Forum Infectious Diseases 5:5.
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Konstantinos Z. Vardakas, Kyriakos K. Trigkidis, Eleni Boukouvala & Matthew E. Falagas. (2016) Clostridium difficile infection following systemic antibiotic administration in randomised controlled trials: a systematic review and meta-analysis. International Journal of Antimicrobial Agents 48:1, pages 1-10.
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Sayoko Kinoshita, Kyoichi Wada, Sachi Matsuda, Takeshi Kuwahara, Haruki Sunami, Takuma Sato, Osamu Seguchi, Masanobu Yanase, Takeshi Nakatani & Mitsutaka Takada. (2016) Interaction between Warfarin and Linezolid in Patients with Left Ventricular Assist System in Japan. Internal Medicine 55:7, pages 719-724.
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Johannes Nemeth, Gabriela Oesch & Stefan P. Kuster. (2015) Bacteriostatic versus bactericidal antibiotics for patients with serious bacterial infections: systematic review and meta-analysis. Journal of Antimicrobial Chemotherapy 70:2, pages 382-395.
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Samuel Y. Ash & John V.L. Sheffield. (2013) Pneumococcus. Medical Clinics of North America 97:4, pages 647-666.
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Jinjian Fu, Xiaohua Ye, Cha Chen & Sidong Chen. (2013) The Efficacy and Safety of Linezolid and Glycopeptides in the Treatment of Staphylococcus aureus Infections. PLoS ONE 8:3, pages e58240.
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Michael R. Barbachyn. 2012. Antibiotic Discovery and Development. Antibiotic Discovery and Development 271 299 .
R. Rivas, M. Barrera, L. González, V. Domínguez, R. Sánchez & M.M. Romero. (2011) Effectiveness and Use of Linezolid in Hospitalisation Wards. Farmacia Hospitalaria (English Edition) 35:6, pages 322-325.
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R. Rivas, M. Barrera, L. González, V. Domínguez, R. Sánchez & M.M. Romero. (2011) Efectividad y uso del linezolid en planta de hospitalización. Farmacia Hospitalaria 35:6, pages 322-325.
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Samuel Shelburne & Daniel M. Musher. 2011. Principles and Practice of Cancer Infectious Diseases. Principles and Practice of Cancer Infectious Diseases 409 421 .
Brett H. HeintzJenana Halilovic. (2010) Clinical Experience with Linezolid at a Large Academic Medical Center: A Case Series and Review of the Literature. Hospital Pharmacy 45:12, pages 916-926.
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Maria Saroglou, Stavros Tryfon, Georgios Ismailos, Ioannis Liapakis, Manolis Tzatzarakis, Aristidis Tsatsakis, Apostolos Papalois & Demosthenes Bouros. (2010) Pharmacokinetics of Linezolid and Ertapenem in experimental parapneumonic pleural effusion. Journal of Inflammation 7:1.
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M. Marian Ijzerman, Kenneth J. Tack & David B. Huang. (2010) Combined retrospective analysis of seven phase II and III trials of the efficacy of linezolid in the treatment of pneumonia caused by multidrug-resistant Streptococcus pneumoniae. Clinical Therapeutics 32:13, pages 2198-2206.
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E. Bouza. (2009) New therapeutic choices for infections caused by methicillin-resistant Staphylococcus aureus. Clinical Microbiology and Infection 15, pages 44-52.
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Thomas M. File & Donald E. Low. (2009) Unmet Needs for the Treatment of Moderate-to-Severe or Hospitalized Community-Acquired Pneumonia. Clinical Pulmonary Medicine 16:5, pages 243-251.
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Steven J. Brickner, Michael R. Barbachyn, Douglas K. Hutchinson & Peter R. Manninen. (2008) Linezolid (ZYVOX), the First Member of a Completely New Class of Antibacterial Agents for Treatment of Serious Gram-Positive Infections. Journal of Medicinal Chemistry 51:7, pages 1981-1990.
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Matthew E Falagas, Ilias I Siempos & Konstantinos Z Vardakas. (2008) Linezolid versus glycopeptide or β-lactam for treatment of Gram-positive bacterial infections: meta-analysis of randomised controlled trials. The Lancet Infectious Diseases 8:1, pages 53-66.
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P.M. Olaechea Astigarraga, J. Garnacho Montero, S. Grau Cerrato, O. Rodríguez Colomo, M. Palomar Martínez, R. Zaragoza Crespo, P. Muñoz García-Paredes, E. Cerdá Cerdá & F. Álvarez Lerma. (2007) Recomendaciones GEIPC-SEIMC y GTEI-SEMICYUC para el tratamiento antibiótico de infecciones por cocos grampositivos en el paciente crítico. Medicina Intensiva 31:6, pages 294-317.
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