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Scandinavian Journal of Infectious Diseases Volume 40, 2008 - Issue 1
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ORGINAL ARTICLES

Pharmacokinetics of linezolid in bone tissue investigated by in vivo microdialysis

Lars B. Stolle From the Clinical Institute, Aarhus University Hospital, Skejby Hospital, Aarhus N, Denmark; Department of Plastic Surgery, Aarhus University Hospital, Aarhus C, DenmarkCorrespondence[email protected]
,
Nele plock Department of Clinical Pharmacy, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany
,
Christian Joukhadar Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, Medical University of Vienna, Austria
,
Magnus Arpi Department of Clinical Microbiology, Herlev University Hospital, Herlev
,
Katrine J. Emmertsen From the Clinical Institute, Aarhus University Hospital, Skejby Hospital, Aarhus N, Denmark
,
Cornelia Buerger Department of Clinical Pharmacy, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany
,
Per Riegels-Nielsen Department of Orthopaedic Surgery, Esbjerg/Varde Hospital, Esbjerg, Denmark
&
Charlotte Kloft Department of Clinical Pharmacy, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany; Department of Clinical Pharmacy, Faculty of Pharmacy, Martin-Luther-Universitaet Halle-Wittenberg, Halle, Germany
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Pages 24-29 | Received 30 Oct 2006, Published online: 08 Jul 2009

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Yvonne Förster, Wenling Gao, Anne Demmrich, Ute Hempel, Lorenz C Hofbauer & Stefan Rammelt. (2013) Monitoring of the first stages of bone healing with microdialysis. Acta Orthopaedica 84:1, pages 76-81.
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Articles from other publishers (20)

Mats Bue, Maja B. Thomassen, Ole H. Larsen, Andrea R. Jørgensen, Maiken Stilling, Kjeld Søballe & Pelle Hanberg. (2019) Local Vancomycin Concentrations after Intra-articular Injection into the Knee Joint: An Experimental Porcine Study. The Journal of Knee Surgery 34:09, pages 936-940.
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Annick Menetrey, Annick Janin, John Pullman, J. Scott Overcash, Amina Haouala, François Leylavergne, Laurent Turbe, Frederick Wittke & Valérie Nicolas-Métral. (2019) Bone and Joint Tissue Penetration of the Staphylococcus -Selective Antibiotic Afabicin in Patients Undergoing Elective Hip Replacement Surgery . Antimicrobial Agents and Chemotherapy 63:3.
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L. Kruse Jensen, J. Koch, N. Lind Henriksen, Mats Bue, M. Tøttrup, P. Hanberg, K. Søballe & H. Elvang Jensen. (2017) Suppurative Inflammation and Local Tissue Destruction Reduce the Penetration of Cefuroxime to Infected Bone Implant Cavities. Journal of Comparative Pathology 157:4, pages 308-316.
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Iris K. Minichmayr, André Schaeftlein, Joseph L. Kuti, Markus Zeitlinger & Charlotte Kloft. (2016) Clinical Determinants of Target Non-Attainment of Linezolid in Plasma and Interstitial Space Fluid: A Pooled Population Pharmacokinetic Analysis with Focus on Critically Ill Patients. Clinical Pharmacokinetics 56:6, pages 617-633.
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Priscila Rosalba Oliveira, Vladimir Cordeiro Carvalho & Ana Lucia Munhoz Lima. (2017) Optimizing the treatment of osteomyelitis with antimicrobial drugs: current concepts. Current Orthopaedic Practice 28:2, pages 208-212.
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Susan J. Lewis & Bruce A. Mueller. (2014) Antibiotic Dosing in Patients With Acute Kidney Injury. Journal of Intensive Care Medicine 31:3, pages 164-176.
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Pelle Hanberg, Mats Bue, Hanne Birke Sørensen, Kjeld Søballe & Mikkel Tøttrup. (2016) Pharmacokinetics of single-dose cefuroxime in porcine intervertebral disc and vertebral cancellous bone determined by microdialysis. The Spine Journal 16:3, pages 432-438.
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Martin Andreas, Markus Zeitlinger, Wilfried Wisser, Walter Jaeger, Alexandra Maier-Salamon, Florian Thalhammer, Alfred Kocher, Joerg-Michael Hiesmayr, Guenther Laufer & Doris Hutschala. (2015) Cefazolin and linezolid penetration into sternal cancellous bone during coronary artery bypass grafting. European Journal of Cardio-Thoracic Surgery 48:5, pages 758-764.
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Mats Bue, Hanne Birke-Sørensen, Theis M. Thillemann, Tore F. Hardlei, Kjeld Søballe & Mikkel Tøttrup. (2015) Single-dose pharmacokinetics of vancomycin in porcine cancellous and cortical bone determined by microdialysis. International Journal of Antimicrobial Agents 46:4, pages 434-438.
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Mikkel Tøttrup, Bo M. Bibby, Tore F. Hardlei, Mats Bue, Sigrid Kerrn-Jespersen, Kurt Fuursted, Kjeld Søballe & Hanne Birke-Sørensen. (2015) Continuous versus Short-Term Infusion of Cefuroxime: Assessment of Concept Based on Plasma, Subcutaneous Tissue, and Bone Pharmacokinetics in an Animal Model. Antimicrobial Agents and Chemotherapy 59:1, pages 67-75.
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Mikkel Tøttrup, Tore Forsingdal Hardlei, Michael Bendtsen, Mats Bue, Birgitte Brock, Kurt Fuursted, Kjeld Søballe & Hanne Birke-Sørensen. (2014) Pharmacokinetics of Cefuroxime in Porcine Cortical and Cancellous Bone Determined by Microdialysis. Antimicrobial Agents and Chemotherapy 58:6, pages 3200-3205.
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Nina Dyrberg Lorenzen, Maiken Stilling, Michael Ulrich-Vinther, Niels Trolle-Andersen, Thomas Prynø, Kjeld Søballe & Hanne Birke-Sørensen. (2013) Increased post-operative ischemia in the femoral head found by microdialysis by the posterior surgical approach: a randomized clinical trial comparing surgical approaches in hip resurfacing arthroplasty. Archives of Orthopaedic and Trauma Surgery 133:12, pages 1735-1745.
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Florin Marcel Musteata. (2013) Recent progress in in-vivo sampling and analysis. TrAC Trends in Analytical Chemistry 45, pages 154-168.
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Martina Sahre, Sreedharan Sabarinath, Maria Grant, Christoph Seubert, Carisa DeAnda, Philippe Prokocimer & Hartmut Derendorf. (2012) Skin and soft tissue concentrations of tedizolid (formerly torezolid), a novel oxazolidinone, following a single oral dose in healthy volunteers. International Journal of Antimicrobial Agents 40:1, pages 51-54.
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Takafumi NAITO, Tatsuya YAGI & Junichi KAWAKAMI. (2012) S15-3. Interdisciplinary Approach to Anti-Infectious Pharmacotherapy in the Intensive Care Unit through the Therapeutic Drug Monitoring. Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 43:2, pages 111-112.
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Friederike Traunmüller, Michael V. Schintler, Stephan Spendel, Martin Popovic, Oliver Mauric, Erwin Scharnagl & Christian Joukhadar. (2010) Linezolid concentrations in infected soft tissue and bone following repetitive doses in diabetic patients with bacterial foot infections. International Journal of Antimicrobial Agents 36:1, pages 84-86.
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F. Traunmuller, M. V. Schintler, J. Metzler, S. Spendel, O. Mauric, M. Popovic, K. H. Konz, E. Scharnagl & C. Joukhadar. (2010) Soft tissue and bone penetration abilities of daptomycin in diabetic patients with bacterial foot infections. Journal of Antimicrobial Chemotherapy 65:6, pages 1252-1257.
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E. Bouza. (2009) New therapeutic choices for infections caused by methicillin-resistant Staphylococcus aureus. Clinical Microbiology and Infection 15, pages 44-52.
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M. V. Schintler, F. Traunmuller, J. Metzler, G. Kreuzwirt, S. Spendel, O. Mauric, M. Popovic, E. Scharnagl & C. Joukhadar. (2009) High fosfomycin concentrations in bone and peripheral soft tissue in diabetic patients presenting with bacterial foot infection. Journal of Antimicrobial Chemotherapy 64:3, pages 574-578.
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Florin Marcel Musteata. (2009) Pharmacokinetic applications of microdevices and microsampling techniques. Bioanalysis 1:1, pages 171-185.
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