669
Views
61
CrossRef citations to date
0
Altmetric
Original Article

Ethanol lock therapy to treat tunnelled central venous catheter-associated blood stream infections: Results from a prospective trial

, , , , , & show all
Pages 399-406 | Received 30 Jul 2007, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Nuria Fernández-Hidalgo & Benito Almirante. (2014) Antibiotic-lock therapy: a clinical viewpoint. Expert Review of Anti-infective Therapy 12:1, pages 117-129.
Read now
Mette Madsen & Steen Rosthøj. (2013) Impact of hydrochloric acid instillation on salvage of infected central venous catheters in children with acute lymphoblastic leukaemia. Scandinavian Journal of Infectious Diseases 45:1, pages 38-44.
Read now
P Brandon Bookstaver, Katherine R Gerrald & Robert R Moran. (2010) Clinical outcomes of antimicrobial lock solutions used in a treatment modality: a retrospective case series analysis. Clinical Pharmacology: Advances and Applications 2, pages 123-130.
Read now

Articles from other publishers (58)

Sishir Gang, Abhijit Konnur, Mohan Rajapurkar, Umapati Hegde, Hardik Patel, Jigar Patel & Nitiraj Shete. (2023) Role of short-dwell daily ethanol-lock therapy in the management of hemodialysis tunneled cuffed catheter-related bloodstream infection. The Journal of Vascular Access, pages 112972982211494.
Crossref
Kasi Visweswaran, Ranjani Ravi, Jasper Daniel David, Sampathkumar Krishnaswamy & Remyasri Akhil. (2021) Salvage of infected tunneled hemodialysis catheters using 70% ethanol lock solution: A brief report. Hemodialysis International 26:3.
Crossref
K.X. Sheng, P. Zhang, J.W. Li, J. Cheng, Y.C. He, M. Böhlke & J.H. Chen. (2020) Comparative efficacy and safety of lock solutions for the prevention of catheter-related complications including infectious and bleeding events in adult haemodialysis patients: a systematic review and network meta-analysis. Clinical Microbiology and Infection 26:5, pages 545-552.
Crossref
Kursat Gundogan, Nisha J. Dave, Daniel P. Griffith, Vivian M. Zhao, Therese A. McNally, Kirk A. Easley, Carla I. Haack, John R. Galloway & Thomas R. Ziegler. (2019) Ethanol Lock Therapy Markedly Reduces Catheter‐Related Blood Stream Infections in Adults Requiring Home Parenteral Nutrition: A Retrospective Study From a Tertiary Medical Center. Journal of Parenteral and Enteral Nutrition 44:4, pages 661-667.
Crossref
Beatriz Alonso, María Jesús Pérez-Granda, María Consuelo Latorre, Carmen Rodríguez, Carlos Sánchez-Carrillo, Patricia Muñoz & María Guembe. (2019) Is heparinized 40% ethanol lock solution efficient for reducing bacterial and fungal biofilms in an in vitro model?. PLOS ONE 14:7, pages e0219098.
Crossref
Sing Leung Lui, Desmond Yap, Vincent Cheng, Tak Mao Chan & Kwok Yung Yuen. (2019) Clinical practice guidelines for the provision of renal service in Hong Kong: Infection Control in Renal Service. Nephrology 24:S1, pages 98-129.
Crossref
Bradley R. Salonen, Sara L. Bonnes, Nishanth Vallumsetla, Jithinraj Edakkanambeth Varayil, Manpreet S. Mundi & Ryan T. Hurt. (2018) A prospective double blind randomized controlled study on the use of ethanol locks in HPN patients. Clinical Nutrition 37:4, pages 1181-1185.
Crossref
Eric McGrath, Wei Du & Madhvi Rajpurkar. (2017) Preemptive Ethanol Lock Therapy in Pediatric Hematology/Oncology Patients With Catheter-Associated Bloodstream Infection: Impact on Length of Stay, Cost, and Catheter Salvage. Clinical Pediatrics 57:3, pages 285-293.
Crossref
Martyn Dibb & Simon Lal. (2017) Home Parenteral Nutrition: Vascular Access and Related Complications. Nutrition in Clinical Practice 32:6, pages 769-776.
Crossref
Sofia Sofroniadou, Ioanna Revela, Alexandros Kouloubinis, Ioanna Makriniotou, Sinodi Zerbala, Despina Smirloglou, Petros Kalocheretis, Apostolos Drouzas, George Samonis & Christos Iatrou. (2017) Ethanol combined with heparin as a locking solution for the prevention of catheter related blood stream infections in hemodialysis patients: A prospective randomized study. Hemodialysis International 21:4, pages 498-506.
Crossref
Roland Alexander Blackwood, Mohamad Issa, Kristin Klein, Rajen Mody, Michelle Willers & Daniel Teitelbaum. (2017) Ethanol Lock Therapy for the Treatment of Intravenous Catheter Infections That Have Failed Standard Treatment. Journal of the Pediatric Infectious Diseases Society 6:1, pages 94-97.
Crossref
Daniel L. Landry, Randa A. Jaber, Nandheesha Hanumanthappa, George S. Lipkowitz, Michael H. O'Shea, Harry Bermudez, Adam P. Hathorne & Gregory L. Braden. (2015) Effects of Prolonged Ethanol Lock Exposure to Carbothane- and Silicone-based Hemodialysis Catheters: A 26-week Study. The Journal of Vascular Access 16:5, pages 367-371.
Crossref
Nobuhiro Takahashi, Masayoshi Shinjoh, Hirofumi Tomita, Akihiro Fujino, Kayoko Sugita, Yasuhiro Katohno, Tatsuo Kuroda & Ken Kikuchi. (2015) Catheter-related blood stream infection caused by Dermacoccus barathri, representing the first case of Dermacoccus infection in humans. Journal of Infection and Chemotherapy 21:8, pages 613-616.
Crossref
Emily Chesshyre, Zoy Goff, Asha Bowen & Jonathan Carapetis. (2015) The prevention, diagnosis and management of central venous line infections in children. Journal of Infection 71, pages S59-S75.
Crossref
Susan E. Beekmann & David K. Henderson. 2015. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases 3310 3324.e6 .
Hannah G. Piper & Paul W. Wales. 2015. Diet and Nutrition in Critical Care. Diet and Nutrition in Critical Care 1779 1790 .
Manu Chaudhary, Muhammad Fawad Bilal, Wei Du, Roland Chu, Madhvi Rajpurkar & Eric J. McGrath. (2014) The Impact of Ethanol Lock Therapy on Length of Stay and Catheter Salvage in Pediatric Catheter-Associated Bloodstream Infection. Clinical Pediatrics 53:11, pages 1069-1076.
Crossref
Leonard A. Mermel & Neha Alang. (2014) Adverse effects associated with ethanol catheter lock solutions: a systematic review. Journal of Antimicrobial Chemotherapy 69:10, pages 2611-2619.
Crossref
David Lebeaux, Jean-Marc Ghigo & Christophe Beloin. (2014) Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics. Microbiology and Molecular Biology Reviews 78:3, pages 510-543.
Crossref
David W. Kubiak, Erin T. Gilmore, Mary W. Buckley, Robert Lynch, Francisco M. Marty & Sophia Koo. (2014) Adjunctive management of central line-associated bloodstream infections with 70% ethanol-lock therapy. Journal of Antimicrobial Chemotherapy 69:6, pages 1665-1668.
Crossref
Marisela Tan, Jackie Lau & B. Joseph Guglielmo. (2014) Ethanol Locks in the Prevention and Treatment of Catheter-Related Bloodstream Infections. Annals of Pharmacotherapy 48:5, pages 607-615.
Crossref
María Jesús Pérez-Granda, José María Barrio, Patricia Muñoz, Javier Hortal, Cristina Rincón, Pablo Martin Rabadán, Maria Sagrario Pernia & Emilio Bouza. (2014) Ethanol Lock Therapy (E-Lock) in the Prevention of Catheter-Related Bloodstream Infections (CR-BSI) after Major Heart Surgery (MHS): A Randomized Clinical Trial. PLoS ONE 9:3, pages e91838.
Crossref
David Lebeaux, Nuria Fernández-Hidalgo, Ashwini Chauhan, Samuel Lee, Jean-Marc Ghigo, Benito Almirante & Christophe Beloin. (2014) Management of infections related to totally implantable venous-access ports: challenges and perspectives. The Lancet Infectious Diseases 14:2, pages 146-159.
Crossref
Hannah G. Piper & Paul W. Wales. 2014. Diet and Nutrition in Critical Care. Diet and Nutrition in Critical Care 1 15 .
Gernot Schilcher, Axel Schlagenhauf, Daniel Schneditz, Hubert Scharnagl, Werner Ribitsch, Robert Krause, Alexander R. Rosenkranz, Tatjana Stojakovic & Joerg H. Horina. (2013) Ethanol Causes Protein Precipitation—New Safety Issues for Catheter Locking Techniques. PLoS ONE 8:12, pages e84869.
Crossref
Thomas Bjarnsholt, Oana Ciofu, Søren Molin, Michael Givskov & Niels Høiby. (2013) Applying insights from biofilm biology to drug development — can a new approach be developed?. Nature Reviews Drug Discovery 12:10, pages 791-808.
Crossref
Joel Rosenblatt, Ruth Reitzel, Tanya Dvorak, Ying Jiang, Ray Y. Hachem & Issam I. Raad. (2013) Glyceryl Trinitrate Complements Citrate and Ethanol in a Novel Antimicrobial Catheter Lock Solution To Eradicate Biofilm Organisms. Antimicrobial Agents and Chemotherapy 57:8, pages 3555-3560.
Crossref
Nancy Kramer, Darcy Doellman, Michelle Curley & Jill L. Wall. (2013) Central Vascular Access Device Guidelines for Pediatric Home-Based Patients: Driving Best Practices. Journal of the Association for Vascular Access 18:2, pages 103-113.
Crossref
Brian M. Peters, Raven M. Ward, Hallie S. Rane, Samuel A. Lee & Mairi C. Noverr. (2013) Efficacy of Ethanol against Candida albicans and Staphylococcus aureus Polymicrobial Biofilms. Antimicrobial Agents and Chemotherapy 57:1, pages 74-82.
Crossref
Hannah G. Piper & Paul W. Wales. (2013) Prevention of catheter-related blood stream infections in children with intestinal failure. Current Opinion in Gastroenterology 29:1, pages 1-6.
Crossref
Joshua Wolf, Jerry L. Shenep, Vanessa Clifford, Nigel Curtis & Patricia M. Flynn. (2013) Ethanol lock therapy in pediatric hematology and oncology. Pediatric Blood & Cancer 60:1, pages 18-25.
Crossref
Matthew W. RallsR. Alexander Blackwood, Meghan A. ArnoldM. Luisa Partipilo, James Dimond & Daniel H. Teitelbaum. (2012) Drug Shortage–Associated Increase in Catheter-Related Blood Stream Infection in Children. Pediatrics 130:5, pages e1369-e1373.
Crossref
Bijo K. John, Maqsood A. Khan, Rex Speerhas, Kristen Rhoda, Cindy Hamilton, Robert DeChicco, Rocio Lopez, Ezra Steiger & Donald F. Kirby. (2011) Ethanol Lock Therapy in Reducing Catheter-Related Bloodstream Infections in Adult Home Parenteral Nutrition Patients. Journal of Parenteral and Enteral Nutrition 36:5, pages 603-610.
Crossref
Beatriz Passerini de Rossi, Laureana Feldman, María Saliba Pineda, Carlos Vay & Mirta Franco. (2012) Comparative in vitro efficacies of ethanol-, EDTA- and levofloxacin-based catheter lock solutions on eradication of Stenotrophomonas maltophilia biofilms. Journal of Medical Microbiology 61:9, pages 1248-1253.
Crossref
M.J. Aguilella-Vizcaíno, A.M. Cordero-Cruz, P. Gomis-Muñoz & J.M. Moreno-Villares. (2012) Sellado con alcohol al 70% en la infección asociada a catéter en nutrición parenteral domiciliaria. Farmacia Hospitalaria 36:5, pages 430-431.
Crossref
Carol Oliveira, Ahmed Nasr, Mary Brindle & Paul W. Wales. (2012) Ethanol Locks to Prevent Catheter-Related Bloodstream Infections in Parenteral Nutrition: A Meta-Analysis. Pediatrics 129:2, pages 318-329.
Crossref
Johann Peterson & John A. KernerJr.Jr.. (2011) New Advances in the Management of Children With Intestinal Failure. Journal of Parenteral and Enteral Nutrition 36:1_suppl, pages 36S-42S.
Crossref
Jamie L. Brooks & Kimberly K. Jefferson. 2012. Advances in Applied Microbiology Volume 81. Advances in Applied Microbiology Volume 81 63 87 .
Emily N. Kevan, Julia R. Simmons, Samuel A. Kocoshis, Mitchell B. Cohen & Jeffrey A. Rudolph. (2011) sTREM-1 and LBP in Central Venous Catheter–associated Bloodstream Infections in Pediatric Intestinal Failure. Journal of Pediatric Gastroenterology & Nutrition 53:6, pages 627-633.
Crossref
Kevin M. Valentine. (2011) Ethanol lock therapy for catheter-associated blood stream infections in a pediatric intensive care unit. Pediatric Critical Care Medicine 12:6, pages e292-e296.
Crossref
Eric J. McGrath, Ralph Salloum, Xinguang Chen, Yifan Jiang, Kathrina Boldt-MacDonald, Cristie Becker, Roland Chu & Jocelyn Y. Ang. (2011) Short-Dwell Ethanol Lock Therapy in Children Is Associated With Increased Clearance of Central Line–Associated Bloodstream Infections. Clinical Pediatrics 50:10, pages 943-951.
Crossref
Deepika Nehra, Erica M. Fallon & Mark Puder. (2011) The Prevention and Treatment of Intestinal Failure-associated Liver Disease in Neonates and Children. Surgical Clinics of North America 91:3, pages 543-563.
Crossref
Paul W. Wales, Christina Kosar, Megan Carricato, Nicole de Silva, Karen Lang & Yaron Avitzur. (2011) Ethanol lock therapy to reduce the incidence of catheter-related bloodstream infections in home parenteral nutrition patients with intestinal failure: preliminary experience. Journal of Pediatric Surgery 46:5, pages 951-956.
Crossref
Tamaki IWADE, Wataru SUMIDA & Yoshio WATANABE. (2011) A CASE OF ETHANOL-LOCK THERAPY FOR CANDIDA PARAPSILOSIS IN CATHETER-RELATED BLOOD STREAM INFECTION. Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 72:6, pages 1374-1377.
Crossref
Nasia Safdar & Dennis G. Maki. 2011. Principles and Practice of Cancer Infectious Diseases. Principles and Practice of Cancer Infectious Diseases 123 141 .
R. Vanholder, B. Canaud, R. Fluck, M. Jadoul, L. Labriola, A. Marti-Monros, J. Tordoir & W. Van Biesen. (2010) Diagnosis, prevention and treatment of haemodialysis catheter-related bloodstream infections (CRBSI): a position statement of European Renal Best Practice (ERBP). Clinical Kidney Journal 3:3, pages 234-246.
Crossref
Lennert Slobbe, Jeanette K. Doorduijn, Pieternella J. Lugtenburg, Abdelilah el Barzouhi, Eric Boersma, Willem B. van Leeuwen & Bart J. A. Rijnders. (2010) Prevention of Catheter-Related Bacteremia with a Daily Ethanol Lock in Patients with Tunnelled Catheters: A Randomized, Placebo-Controlled Trial. PLoS ONE 5:5, pages e10840.
Crossref
Hau D. Le, Erica M. Fallon, Vincent E. de Meijer, Alpin D. Malkan, Mark Puder & Kathleen M. Gura. (2010) Innovative parenteral and enteral nutrition therapy for intestinal failure. Seminars in Pediatric Surgery 19:1, pages 27-34.
Crossref
Lavern M. Vercaigne, Teresa A. Takla & J. Raghavan. (2018) Long-Term Effect of an Ethanol/Sodium Citrate Locking Solution on the Mechanical Properties of Hemodialysis Catheters. The Journal of Vascular Access 11:1, pages 12-16.
Crossref
SUSAN E. BEEKMANN & DAVID K. HENDERSON. 2010. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases 3697 3715 .
Jennifer K Broom, Stacey O'Shea, Sridevi Govindarajulu, E Geoffrey Playford, Carmel M Hawley, Nicole M Isbel, Scott B Campbell, David W Mudge, Sally Carpenter, Barbara C Johnson, Neil P Underwood & David W Johnson. (2009) Rationale and design of the HEALTHY-CATH trial: A randomised controlled trial of Heparin versus EthAnol Lock THerapY for the prevention of Catheter Associated infecTion in Haemodialysis patients. BMC Nephrology 10:1.
Crossref
M. RAJPURKAR, K. BOLDT-MACDONALD, R. MCLENON, M. U. CALLAGHAN, M. CHITLUR, J. M. LUSHER & C. BECKER. (2009) Ethanol lock therapy for the treatment of catheter-related infections in haemophilia patients. Haemophilia 15:6, pages 1267-1271.
Crossref
Melissa Maiefski, Mark E. Rupp & Elizabeth D. Hermsen. (2015) Ethanol Lock Technique: Review of the Literature. Infection Control & Hospital Epidemiology 30:11, pages 1096-1108.
Crossref
. (2009) References. Bone Marrow Transplantation 44:8, pages 537-557.
Crossref
Santiago Grau, María José Gil, Javier Mateu-de Antonio, Miguel Pera & Mónica Marín-Casino. (2009) Antibiotic-lock technique using daptomycin for subcutaneous injection ports in a patient on home parenteral nutrition. Journal of Infection 59:4, pages 298-299.
Crossref
Marcie Tomblyn, Tom Chiller, Hermann Einsele, Ronald Gress, Kent Sepkowitz, Jan Storek, John R. Wingard, Jo-Anne H. Young & Michael A. Boeckh. (2009) Guidelines for Preventing Infectious Complications among Hematopoietic Cell Transplantation Recipients: A Global Perspective. Biology of Blood and Marrow Transplantation 15:10, pages 1143-1238.
Crossref
Mohan Venkatesh, Liang Rong, Issam Raad & James Versalovic. (2009) Novel synergistic antibiofilm combinations for salvage of infected catheters. Journal of Medical Microbiology 58:7, pages 936-944.
Crossref
J. Sanders, A. Pithie, P. Ganly, L. Surgenor, R. Wilson, E. Merriman, G. Loudon, R. Judkins & S. Chambers. (2008) A prospective double-blind randomized trial comparing intraluminal ethanol with heparinized saline for the prevention of catheter-associated bloodstream infection in immunosuppressed haematology patients. Journal of Antimicrobial Chemotherapy 62:4, pages 809-815.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.