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Scandinavian Journal of Urology and Nephrology Volume 36, 2002 - Issue 1
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Research Article

Pharmacokinetics, Efficacy, and Safety of Intravesical Formulation of Oxybutynin in Patients with Detrusor Overactivity

Kari Lehtoranta Deaconess Institute in Helsinki, Helsinki
,
Hanna Tainio Department of Urology, Tampere University Hospital, and Medical School, University of Tampere, Tampere
,
Eeva Lukkari-Lax Leiras Oy, Clinical Research, Helsinki, Finland
,
Tiina Hakonen Leiras Oy, Clinical Research, Helsinki, Finland
&
Teuvo L. J. Tammela Department of Urology, Tampere University Hospital, and Medical School, University of Tampere, Tampere
Pages 18-24 | Published online: 09 Jul 2009

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Katie Scott, Roger R. Dmochowski & Priya Padmanabhan. (2016) Delivery methods for drugs used in the treatment of overactive bladder. Expert Opinion on Drug Delivery 13:3, pages 361-371.
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Rebecca J McCrery & Rodney A Appell. (2006) Oxybutynin: an overview of the available formulations. Therapeutics and Clinical Risk Management 2:1, pages 19-24.
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Arun Sahai, Mohammed Shamim Khan, Manit Arya, Jason John, Rajinder Singh & Hitendra RH Patel. (2006) The overactive bladder: review of current pharmacotherapy in adults. Part 1: pathophysiology and anticholinergic therapy. Expert Opinion on Pharmacotherapy 7:5, pages 509-527.
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Articles from other publishers (35)

Vineesha Veer, Russ Chess‐Williams & Christian Moro. (2023) Antimuscarinic actions on bladder urothelium and lamina propria contractions are similar to those observed in detrusor smooth muscle preparations. Neurourology and Urodynamics 42:5, pages 1080-1087.
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Anirban Ganguly, Shachi Tyagi, Christopher Chermansky, Anthony Kanai, Jonathan Beckel, Mamoru Hashimoto, Kang Jun Cho, Michael Chancellor, Jonathan Kaufman, Naoki Yoshimura & Pradeep Tyagi. (2023) Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options. Drugs & Aging 40:3, pages 241-261.
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Si-hong Shen, Xue Jia, Liao Peng, Xiao Zeng, Hong Shen & De-yi Luo. (2022) Intravesical oxybutynin therapy for patients with neurogenic detrusor overactivity: a systematic review and meta-analysis. International Urology and Nephrology 54:4, pages 737-747.
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Justin Loloi, Mustufa Babar, Kelvin P. Davies & Sylvia O. Suadicani. (2022) Nanotechnology as a tool to advance research and treatment of non-oncologic urogenital diseases. Therapeutic Advances in Urology 14, pages 175628722211090.
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Mohamed Wishahi. (2021) Lower urinary tract dysfunction in pediatrics progress to kidney disease in adolescents: Toward precision medicine in treatment. World Journal of Nephrology 10:4, pages 37-46.
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Melanie Kretschmar, Ahmed Abbas Suleiman, Petra Krause, Uwe Albrecht, Raimund Stein, Peter Rubenwolf, Uwe Fuhr & Max Taubert. (2021) A Population Pharmacokinetic Model of (R)‐ and (S‐) Oxybutynin and Its Active Metabolites After Oral and Intravesical Administration to Healthy Volunteers. The Journal of Clinical Pharmacology 61:7, pages 961-971.
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L Stothers, B Tsang, M Nigro, D Lazare & A Macnab. (2016) An integrative review of standardized clinical evaluation tool utilization in anticholinergic drug trials for neurogenic lower urinary tract dysfunction. Spinal Cord 54:12, pages 1114-1120.
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Annette Schröder, Uwe Albrecht, Jörg Schnitker, André Reitz & Raimund Stein. (2015) Efficacy, safety, and tolerability of intravesically administered 0.1% oxybutynin hydrochloride solution in adult patients with neurogenic bladder: A randomized, prospective, controlled multi‐center trial. Neurourology and Urodynamics 35:5, pages 582-588.
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Nicholas A. Williams, Kay M. Lee, Chris J. Allender, Jenna L. Bowen, Mark Gumbleton, Tim Harrah, Aditya Raja & Hrishi B. Joshi. (2015) Investigating Detrusor Muscle Concentrations of Oxybutynin After Intravesical Delivery in an Ex Vivo Porcine Model. Journal of Pharmaceutical Sciences 104:7, pages 2233-2240.
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Martien Humblet, Carla Verpoorten, Maria-Helena Christiaens, Herbert Hirche, Katrien Jansen, Gunnar Buyse & Jan D. van Gool. (2015) Long-term outcome of intravesical oxybutynin in children with detrusor-sphincter dyssynergia: With special reference to age-dependent parameters. Neurourology and Urodynamics 34:4, pages 336-342.
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A. Qarro, M. Asseban, K. Bazine, M. Najoui, J. Samir, Y. Ouhbi, A. Beddouch, M. Lezrek & M. Alami. (2014) Hyperactivité vésicale : physiopathologie et prise en charge. Journal de Réadaptation Médicale : Pratique et Formation en Médecine Physique et de Réadaptation 34:1, pages 23-34.
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Petra Krause, Uwe Fuhr, Jörg Schnitker, Uwe Albrecht, Raimund Stein & Peter Rubenwolf. (2013) Pharmacokinetics of Intravesical Versus Oral Oxybutynin in Healthy Adults: Results of an Open Label, Randomized, Prospective Clinical Study. Journal of Urology 190:5, pages 1791-1797.
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Manoj V. Rao & Arun K. Sharma. 2013. Stem Cells and Cancer Stem Cells, Volume 9. Stem Cells and Cancer Stem Cells, Volume 9 301 311 .
Priya Madhuvrata, Manju Singh, Zaid Hasafa & Mohamed Abdel-Fattah. (2012) Anticholinergic Drugs for Adult Neurogenic Detrusor Overactivity: A Systematic Review and Meta-analysis. European Urology 62:5, pages 816-830.
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Thomas Lehnert, Margit Weisser, Holger Till & Udo Rolle. (2011) The effects of long-term medical treatment combined with clean intermittent catheterization in children with neurogenic detrusor overactivity. International Urology and Nephrology 44:2, pages 335-341.
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Michael G. Oefelein. (2011) Safety and Tolerability Profiles of Anticholinergic Agents Used for the Treatment of Overactive Bladder. Drug Safety 34:9, pages 733-754.
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Cees Korstanje & Walter Krauwinkel. 2011. Urinary Tract. Urinary Tract 267 282 .
Won Hee PARK. (2010) Management of Low Compliant Bladder in Spinal Cord Injured Patients. LUTS: Lower Urinary Tract Symptoms 2:2, pages 61-70.
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Murat Ersoz, Necmettin Yildiz, Mufit Akyuz & Fusun Koseoglu. (2010) Efficacy of Combined Oral-Intravesical Oxybutynin Hydrochloride Treatment for Patients with Overactive Detrusors and Indwelling Urethral Catheters. Rehabilitation Nursing 35:2, pages 80-86.
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M. de Sèze, C. Delleci & A. Ruffion. (2009) Intérêt des thérapies intravésicales en neuro-urologieIntravesical drugs in the treatment of neurological bladder. Acta Endoscopica 39:1, pages 34-40.
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Christian Harkensee, Nikhil Vasdev, Andrew R. Gennery, Ian E. Willetts & Clive Taylor. (2008) Prevention and management of BK‐virus associated haemorrhagic cystitis in children following haematopoietic stem cell transplantation – a systematic review and evidence‐based guidance for clinical management. British Journal of Haematology 142:5, pages 717-731.
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Jean-Jacques Wyndaele. (2008) Conservative Treatment of Patients with Neurogenic Bladder. European Urology Supplements 7:8, pages 557-565.
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M. de Sèze, M. P. de Sèze, L. Wiart, E. Shao, S. Blazejewski, J. -P. Dosque & P. -A. Joseph. (2007) Les thérapies intravésicales en neuro-urologieIntravesical drugs in neurourology. Pelvi-périnéologie 2:4, pages 318-325.
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M. de Sèze, A. Ruffion & E. Chartier-Kastler. (2007) Chapitre C-l A - Traitement pharmacologique de l’hyperactivité détrusorienne neurologique : per os, en patch, en instillation endo-vésicale. Progrès en Urologie 17:3, pages 559-563.
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Haruhi MizushimaKazuya KinoshitaKoji AbeHitoshi IshizukaYasuhiko Yamada. (2007) Pharmacokinetics/Pharmacodynamics Analysis of the Relationship between the in Vivo Micturition Pressure and Receptor Occupancy of (R)-Oxybutynin and Its Metabolite in Rats. Biological and Pharmaceutical Bulletin 30:5, pages 955-962.
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Mandy Fader, Scott Glickman, Veronica Haggar, Rachel Barton, Rodney Brooks & James Malone-Lee. (2007) Intravesical Atropine Compared to Oral Oxybutynin for Neurogenic Detrusor Overactivity: A Double-Blind, Randomized Crossover Trial. Journal of Urology 177:1, pages 208-213.
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Robert J. Evans. (2006) Intravesical therapy for overactive bladder. Current Bladder Dysfunction Reports 1:1, pages 40-44.
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Eric S Rovner & Alan J Wein. (2016) Antimuscarinic Drugs for the Treatment of Female Urinary Incontinence. Women's Health 2:2, pages 251-265.
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Robert J. Evans. (2005) Intravesical Therapy for Overactive Bladder. Current Urology Reports 6:6, pages 429-433.
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Marcus L. Quek, Piers Barry, John P. Stein, Gary Lieskovsky & David A. Ginsberg. (2005) Combined radical prostatectomy and bladder augmentation for concomitant prostate cancer and detrusor instability. Urology 65:5, pages 964-967.
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Darren T. BeikoJames D. WattersonBodo E. KnudsenLinda NottStephen E. PautlerGerald B. BrockHassan RazviJohn D. Denstedt. (2004) Second Prize: Double-Blind Randomized Controlled Trial Assessing the Safety and Efficacy of Intravesical Agents for Ureteral Stent Symptoms after Extracorporeal Shockwave Lithotripsy. Journal of Endourology 18:8, pages 723-730.
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André Reitz & Brigitte Schurch. (2004) Intravesical therapy options for neurogenic detrusor overactivity. Spinal Cord 42:5, pages 267-272.
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Rodney A. Appell, Michael B. Chancellor, R. Howard Zobrist, Heather Thomas & Steven W. Sanders. (2003) Pharmacokinetics, Metabolism, and Saliva Output During Transdermal and Extended-Release Oral Oxybutynin Administration in Healthy Subjects. Mayo Clinic Proceedings 78:6, pages 696-702.
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David R P Guay. (2003) Clinical Pharmacokinetics of Drugs Used to Treat Urge Incontinence. Clinical Pharmacokinetics 42:14, pages 1243-1285.
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