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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 30, 2000 - Issue 20
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Original Articles

Preparation of N,N-Bis[2-[N',N'-Bis[(Tert-Butoxycarbonyl)Methyl]-Amino]Ethyl-L-Aspartic Acid: An Intermediate in the Synthesis of MRI Contrast Agents

J. C. Amedio Jr. Chemical Development, EPIX Medical, Inc., 71 Rogers St., Cambridge, MA, 02142--1118, USA
,
G. Van Wagenen Jr Chemical Development, EPIX Medical, Inc., 71 Rogers St., Cambridge, MA, 02142--1118, USA
,
G. Zavlin Chemical Development, EPIX Medical, Inc., 71 Rogers St., Cambridge, MA, 02142--1118, USA
,
Albert Gyorkos Hauser Laboratories, 5555 Airport Blvd, Boulder, CO, 80301--2339, USA
&
S. A. Peterson Hauser Laboratories, 5555 Airport Blvd, Boulder, CO, 80301--2339, USA
Pages 3755-3763 | Received 15 Jan 2000, Published online: 04 Dec 2007

Citations (10)

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Stéphane Meunier, Pierre Cristau & Frédéric Taran. (2005) New Nitrilotriacetic Acid and Ethylenediaminetetraacetic Acid Nitro Derivatives for the Synthesis of Bifunctional and Trifunctional Chelating Agents. Synthetic Communications 35:18, pages 2415-2425.
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Articles from other publishers (9)

Giovanni B. Giovenzana, Claudia Guanci, Silvia Demattio, Luciano Lattuada & Veronica Vincenzi. (2014) Synthesis of bifunctional chelating agents based on mono and diphosphonic derivatives of diethylenetriaminepentaacetic acid. Tetrahedron 70:32, pages 4809-4813.
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Jan Kotek, Vojtěch Kubíček, Petr Hermann & Ivan Lukeš. 2013. The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging. The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging 83 155 .
Sophie Laurent, Céline Henoumont, Luce Vander Elst & Robert N. Muller. (2012) Synthesis and Physicochemical Characterisation of Gd‐DTPA Derivatives as Contrast Agents for MRI. European Journal of Inorganic Chemistry 2012:12, pages 1889-1915.
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Katelyn M. AtkinsFrancisco M. MartínezAli NazemiTimothy J. SchollElizabeth R. Gillies. (2011) Poly( para -phenylene ethynylene)s functionalized with Gd(III) chelates as potential MRI contrast agents . Canadian Journal of Chemistry 89:1, pages 47-56.
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Luciano Lattuada, Alessandro Barge, Giancarlo Cravotto, Giovanni Battista Giovenzana & Lorenzo Tei. (2011) The synthesis and application of polyamino polycarboxylic bifunctional chelating agents. Chemical Society Reviews 40:5, pages 3019.
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Sophie Laurent, Luce Vander Elst, François Botteman & Robert N. Muller. (2008) An Assessment of the Potential Relationship between the Charge of Gd–DTPA Complexes and the Exchange Rate of the Water Coordinated to the Metal. European Journal of Inorganic Chemistry 2008:28, pages 4369-4379.
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Zhaoda Zhang, Matthew T. Greenfield, Marga Spiller, Thomas J. McMurry, Randall B. Lauffer & Peter Caravan. (2005) Multilocus Binding Increases the Relaxivity of Protein‐Bound MRI Contrast Agents. Angewandte Chemie International Edition 44:41, pages 6766-6769.
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Zhaoda Zhang, Matthew T. Greenfield, Marga Spiller, Thomas J. McMurry, Randall B. Lauffer & Peter Caravan. (2005) Multilocus Binding Increases the Relaxivity of Protein‐Bound MRI Contrast Agents. Angewandte Chemie 117:41, pages 6924-6927.
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Matthew R Lashley, Edmund J Niedzinski, Jane M Rogers, Michael S Denison & Michael H Nantz. (2002) Synthesis and estrogen receptor affinity of a 4-hydroxytamoxifen-Labeled ligand for diagnostic imaging. Bioorganic & Medicinal Chemistry 10:12, pages 4075-4082.
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